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| 1 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 2 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 3 | Prevalence and risk factors for eye diseases, blindness, and low vision in Lhasa, Tibet显示文摘AIM: To determine the prevalence and risk factors for eye diseases, blindness, and low vision in Tibet, and to assist the development of eye disease prevention and treatment schemes.METHODS: We carried out a survey of eye diseases among a population living at high altitude. A total of 1 115 Tibetan permanent residents aged 40 years or older from the towns and villages of Qushui County, Lhasa Prefecture, Tibet Autonomous Region, participated in this study. All participants completed a detailed questio-nnaire, and underwent presenting and pinhole visual acuity tests,and a comprehensive ophthalmic examination.RESULTS: There were 187 blind eyes (8.43%), 231 eyes with low vision (10.41% ). The leading cause of visual impairment was cataract of 55.0% (101/187) blindness and of 50.2% (116/231) low vision, followed by fundus lesions of 22.9% blindness and 23.8% low vision, while only a low prevalence of glaucoma of 9.6% blindness and 1.7% low vision was observed. The analysis of 2 219 eyes showed that the most common external eye disease was pterygium (27.2%) in Tibet.CONCLUSION: The high prevalence of blindness and low vision in the Tibetan population at high altitude is a serious public health issue. There is a need to establish and maintain an appropriate effective eye care program in Tibet. | Gui-Qin Wang Zong-Xi Bai Jing Shi Sang Luo Hong-Fa Chang Xiao-Yong Sai | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 11 |
| 4 | Red River barrier and Pleistocene climatic fluctuations shaped the genetic structure of Microhyla fissipes complex (Anura: Microhylidae) in southern China and Indochina显示文摘 | Zhi-Yong YUAN Chatmongkon SUWANNAPOOM Fang YAN Nikolay A. POYARKOV JR Sang Ngoc NGUYEN Hong-man CHEN Siriwadee CHOMDEJ Robert W, MURPHY Jing CHE | 2016 | Current Zoology2016，62，6： | 11 |
| 5 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 6 | Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-β1 and peroxisome proliferator-activated receptor γ in alcoholic cardiomyopathy显示文摘背景 Tenascinx,只在成纤维细胞表示的细胞外的矩阵 glycoprotein,能调停纤维变性面对骨胶原。因此,我们在便于心肌的纤维变性并且经由转变生长 factor-l1 和 peroxisome 的心脏的改变调查了它的潜在的角色在含酒精的心肌症(ACM ) 的激活 proliferator 的受体(TGF1-PPAR ) 小径 .Methods 试验性的动物被划分成控制(组 A ) , tenascinx 大美人组织(组 B ) 收到酒精。六个月柱子处理,心脏的喷射部分(EF ) ,部分弄短(FS ) ,左室结束扩张内部直径(LVEDd ) 和骨胶原列部分(CVF ) 被观察。 Tenascinx , smad-3 , TGF1 , smad-7 和 PPAR 蛋白质表达式层次被六个月帖子处理, EF 和 FS 珍视的西方的 blotting.Results 检测比的在组 B 是更高的在组 A ( P 0.05 和 P 0.01 ,分别地),当 LVEDd 和 CVF 在组 B 是更低的时( P 0.05 和 P 0.01 ,分别地)。当 smad-7 和 PPARY 层次比在组 B (P0.01 ) 低时, Tenascinx, smad-3 和 TGF1 蛋白质表示层次在组 A 是更高的,作为由 immunohistochemistry 并且西方的弄污测量了。Tenascinx 蛋白质表示否定地与 EF, FS, smad-7 和 PPAR 被相关,并且断然与 LVEDd, CVF, smad-3,和 TGF1 (P 0.001 ).Conclusion Tenascinx 相关经由 TGF1 的 upregulation 和 PPAR 的 downregulation 是心肌的纤维变性和 ACM 开发的一个开始者。 | JING Ling ZHOU Li-jun ZHANG Feng-min LI Wei-min SANG Ying | 2011 | Chinese Medical Journal2011，，3： | 9 |
| 7 | Celastrol specifically inhibits the activation of NLRP3 inflammasome显示文摘Dear Editor,Inflammasomes are vital components of the innate immune system that survey microbial infections or sterile challenges in the cytosol(de Zoete et al.,2014).A typical inflammasome is composed of a sensor protein such as NOD like receptor(NLR)or AIM2 like receptor(ALR),the | Xuesong Sang Yihui Chen Wei Chen Jing Xie Guangxun Meng Jin Zhong Taisheng Li Ailing Lu | 2018 | Science China(Life Sciences)2018，61，3： | 9 |
| 8 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 9 | Coal analysis using the pulsed neutron generator显示文摘A prototype of elemental analyzer for coal has been developed by using a PFTNA (pulse fast thermalneutron analysis) system. The PFTNA technology is based on the reactions such as (n, γ), (n, n'γ), (n, Pγ), etc. byexamining the characteristic gamma rays emitted. In our prototype a pulsed neutron generator provides 14 MeV pulseneutrons, which contribute to the separation of spectrum Ⅱ (the sum of capture and activation spectrum) fiom spec-trum Ⅰ (the sum of inelastic, capture and activation spectrum), and thus to the measurement of C and O contents incoal. Data management is completed by computer program using the least-square regression method. The experimentin Changshan Power Plant for 3 months showed that the precision of calorific value, whole water, volatile content andash content is 0.5 k J/kg, 1.0 wt%, 2.0 wt% and 1.5 wt%, respectively. | JING Shi-Wei, LIU Lin-Mao, GU De-Shan, QIAO Shuang, SANG Hai-Feng, ZHANG Yong-Xiang, ZHANG Zhong-Hua,CAO Xi-Zheng, TIAN Yu-Bing, CHI Yan-Tao, ZHAO Xin-Hui (The Radiation Technology Institute of the Northeast Normal University, Changchun 130024) | 2003 | Nuclear Science and Techniques2003，14，4： | 6 |
| 10 | SENP3 regulates the global protein turnover and the Spl level via antagonizing SUM02/ 3-targeted ubiquitination and degradation显示文摘 | Ming Wang Jing Sang Yanhua Ren Kejia Liu Xinyi Liu Jian Zhang Haolu Wang Jian Wang Amir Orian Jie Yang Jing Yi | 2016 | Protein & Cell2016，7，1： | 5 |
| 11 | Influence of liquid water on coalbed methane adsorption:An experimental research on coal reservoirs in the south of Qinshui Basin显示文摘Using Isothermal Adsorption/Desorption System Model IS-100 and Electrohydraulic Servo Rock System Model MTS815 as the main apparatuses and collecting samples from the major coal reservoirs in the south of Qinshui Basin, a hot point region of coalbed methane exploration, the paper carries out systematical comparisons of the isothermal adsorption experimental data for injection water coal samples, equilibrium moisture samples and dry coal samples, probes and establishes an experimental method of injection water coal sample preparation and isothermal experiment to simulate real reservoir conditions, and then summaries the experimental regulations and discusses the mechanism of liquid water influencing coal methane adsorption. Results of the experiment indicate that: The Langmuir volume of injection water coal samples is notably larger than that of equilibrium moisture samples, as well as larger than or equivalent to that of dry coal samples; the Langmuir pressure of injection water coal samples is the highest, the next is equilibrium moisture samples, while the dry samples is the lowest, of which the experimental results of injection water samples to simulate real reservoir conditions are more close to the fact. Under the conditions of in-position reservoirs, liquid water in coals has evident influence on methane adsorption ability of coal matrix, which can increase the adsorbability of coal and make the adsorption regulation fit to Langmuir model better. Its major reason is the increase of wetting coal matrix adsorbability. The above experimental results overthrow the conventional cognition that liquid water has no influence on coalbed methane adsorption, which may lead to an improvement of the coalbed methane isothermal adsorption experimental method and of the reliability of coalbed methane resource evaluation and prediction. | Shuxun Sang Yanming Zhu Jing Zhang Xiaodong Zhang Shiyin Zhang | 2005 | Chinese Science Bulletin2005，50，S1： | 4 |
| 12 | A comparative study of the chemical kinetic characteristics of small methyl esters in diffusion flame extinction显示文摘 | Pascal Diévart Sang Hee Won Jing Gong Stephen Dooley Yiguang Ju | 2013 | Proceedings of the Combustion Institute2013，，1： | 2 |
| 13 | Protein phosphatase PP4 is overexpressed in human breast and lung tumors显示文摘 | Bo Wang Ailian Zhao Lingling Sun Xueyan Zhong Jianing Zhong Haibo Wang Minhua Cai Jing Li Yi Xu Ji Liao Jianli Sang Dipanj an Chowdhury Gerd P Pfeifer Yun Yen Xingzhi Xu | 2008 | Cell Research2008，18，9： | 2 |
| 14 | Catheter ablation for atrial fibrillation is associated with reduced risk of mortality in the elderly:a prospective cohort study and propensity score analysis显示文摘Background It is unclear whether catheter ablation(CA)for atrial fibrillation(AF)affects the long-term prognosis in the elderly.This study aims to evaluate the relationship between CA and long-term outcomes in elderly patients with AF.Methods Patients more than 75 years old with non-valvular AF were prospectively enrolled between August 2011 and December 2017 in the Chinese Atrial Fibrillation Registry Study.Participants who underwent CA at baseline were propensity score matched(1:1)with those who did not receive CA.The outcome events included all-cause mortality,cardiovascular mortality,stroke/transient ischemic attack(TIA),and cardiovascular hospitalization.Results Overall,this cohort included 571 ablated patients and 571 non-ablated patients with similar characteristics on 18 dimensions.During a mean follow-up of 39.75±19.98 months(minimum six months),24 patients died in the ablation group,compared with 60 deaths in the non-ablation group[hazard ratio(HR)=0.49,95%confidence interval(CI):0.30-0.79,P=0.0024].Besides,6 ablated and 29 non-ablated subjects died of cardiovascular disease(HR=0.25,95%CI:0.11-0.61,P=0.0022).A total of 27 ablated and 40 non-ablated patients suffered stroke/TIA(HR=0.79,95%CI:0.48-1.28,P=0.3431).In addition,140 ablated and 194 non-ablated participants suffered cardiovascular hospitalization(HR=0.84,95%CI:0.67-1.04,P=0.1084).Subgroup analyses according to gender,type of AF,time since onset of AF,and anticoagulants exposure in initiation did not show significant heterogeneity.Conclusions In elderly patients with AF,CA may be associated with a lower incidence of all-cause and cardiovascular mortality. | Xin SU Xin DU Shang-Xin LU Chao JIANG Jing DU Shi-Jun XIA Zhao-Jie DONG Zhao-Xu JIA De-Yong LONG Cai-Hua SANG Ri-Bo TANG Nian LIU Song-Nan LI Rong BAI Jian-Zeng DONG Chang-Sheng MA | 2020 | Journal of Geriatric Cardiology2020，17，12： | 2 |
| 15 | 呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值显示文摘[据Hepatology Research 2021年4月报道]题:呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值(作者Jing J等)慢加急性肝衰竭(ACLF)是导致慢性失代偿肝病患者死亡的重要原因之一,也是国内外临床肝病研究领域的热点和难题。部分ACLF患者在治疗“黄金窗”阶段通过积极救治,能够获得可逆性的恢复,因此早期预测ACLF预后对患者及早施救以及重症化防控十分有益。 | 景婧 牛明 王睿林 JING J SANG X YOU S | 2021 | 临床肝胆病杂志2021，37，7： | 2 |
| 16 | Long-term follow-up of optic neuropathy in chronic low cerebrospinal fluid pressure monkeys: the Beijing Intracranial and Intraocular Pressure(iCOP) Study显示文摘Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness. | Jing Li Diya Yang Jacky MKKwong Jidi Fu Ruowu Hou Jost BJonas Huaizhou Wang Zheng Zhang Weiwei Chen Zhen Li Jinghong Sang Xiaobin Xie Ruojin Ren Robert NWeinreb Ningli Wang | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 17 | Antagonistic interaction between male-killing and cytoplasmic incompatibility induced by Cardinium and Wolbachia in the whitefly,Bemisia tabaci显示文摘Cardinium and Wolbachia are maternally inherited bacterial symbionts of arthropods that can manipulate host reproduction by increasing the fitness of infected females.Here,we report that Cardinium and Wolbachia coinfection induced male-killing and cytoplasmic incompatibility(CI)when they coexisted in a cryptic species of whitefly,Bemisia tabaci Asia II7.Cardinium and Wolbachia symbionts were either singly or simul-taneously localized in the bacteriocytes placed in the abdomen of B.tabaci nymphs and adults.Cardinium-Wolbachia coinfection induced male-killing and resulted in a higher female sex ratio in the intraspecific amphigenetic progeny of Asia II7 IcwH and IcwL lines;interestingly,male-illing induction was enhanced with increased Cardinium titer.Moreover,single infection of Wolbachia induced partial CI in the Asia II7 Iw line and resulted in reduced fecundity,higher embryonic mortality,and lower female sex ratio.The uninfected Asia II7 Iu line had significantly higher fecundity,lower embryonic and nymphal mortalities,and a lower level of CI than both the Wolbachia infected Asia II7 Iw line and the Cardinium--Wolbachia-coinfected Asia II7 IcwH line.Our findings indicate that Cardinium-Wolbachia coinfection induced male-killing,which may have had antag-onistic effects on Wolbachia-induced CI in the Asia II7 whiteflies.For the first time,our study revealed that B.tabaci Asia II7 reproduction is co-manipulated by Cardinium and Wolbachia endosymbionts. | Ning Lv Jing Peng Xin-Yi Chen Chang-Fei Guo Wen Sang Xing-Min Wang Muhammad ZAhmed Yong-Yu Xu Bao-Li Qiu | 2021 | Insect Science2021，28，2： | 2 |
| 18 | The downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progression显示文摘 | Xinliang Zhou Yudong Wang Baoen Shan Jing Han Haifeng Zhu Yalei Lv Xiaojie Fan Meixiang Sang Xian-De Liu Wei Liu | 2015 | Medical Oncology2015，，1： | 2 |
| 19 | Assessment of the determination of asodicarbonamide and its decomposition produet semiearbazide:investigation of variation in flour and flour products 显示文摘 | YE Jing WANG Xianghong SANG Yaxin | 2011 | Food and Feed Chemistry2011，59，17： | 1 |
| 20 | Detection of low caloric power of coal by pulse fast-thermal neutron analysis显示文摘 | GU DE SHAN JING SHI WEI SANG HAl FENG | 2004 | Journal of Radioanalytical and Nuclear Chemistry2004，262，2： | 1 |
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