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| 1 | The Genetic Architecture of Flowering Time and Photoperiod Sensitivity in Maize as Revealed by QTL Review and Meta Analysis显示文摘The control of flowering is not only important for reproduction,but also plays a key role in the processes of domestication and adaptation.To reveal the genetic architecture for flowering time and photoperiod sensitivity,a comprehensive evaluation of the relevant literature was performed and followed by meta analysis.A total of 25 synthetic consensus quantitative trait loci(QTL)and four hot-spot genomic regions were identified for photoperiod sensitivity including 11 genes related to photoperiod response or flower morphogenesis and development.Besides,a comparative analysis of the QTL for flowering time and photoperiod sensitivity highlighted the regions containing shared and unique QTL for the two traits.Candidate genes associated with maize flowering were identified through integrated analysis of the homologous genes for flowering time in plants and the consensus QTL regions for photoperiod sensitivity in maize(Zea mays L.).Our results suggest that the combination of literature review,meta-analysis and homologous blast is an efficient approach to identify new candidate genes and create a global view of the genetic architecture for maize photoperiodic flowering.Sequences of candidate genes can be used to develop molecular markers for various models of marker-assisted selection,such as marker-assisted recurrent selection and genomic selection that can contribute significantly to crop environmental adaptation. | Jie Xu Yaxi Liu Jian Liu Moju Cao Jing Wang Hai Lan Yunbi Xu Yanli Lu Guangtang Pan Tingzhao Rong | 2012 | Journal of Integrative Plant Biology2012，54，6： | 14 |
| 2 | A self-organizing multimodal multi-objective pigeon-inspired optimization algorithm显示文摘Multi-objective optimization algorithms have recently attracted much attention as they can solve problems involving two or more conflicting objectives effectively and efficiently. However, most existing studies focus on improving the performance of the solutions in the objective spaces. This paper proposes a novel multimodal multi-objective pigeon-inspired optimization(MMOPIO) algorithm where some mechanisms are designed for the distribution of the solutions in the decision spaces. First, MMOPIO employs an improved pigeon-inspired optimization(PIO) based on consolidation parameters for simplifying the structure of the standard PIO. Second, the self-organizing map(SOM) is combined with the improved PIO for better control of the decision spaces, and thus, contributes to building a good neighborhood relation for the improved PIO.Finally, the elite learning strategy and the special crowding distance calculation mechanisms are used to prevent premature convergence and obtain solutions with uniform distribution, respectively. We evaluate the performance of the proposed MMOPIO in comparison to five state-of-the-art multi-objective optimization algorithms on some test instances, and demonstrate the superiority of MMOPIO in solving multimodal multi-objective optimization problems. | Yi HU Jie WANG Jing LIANG Kunjie YU Hui SONG Qianqian GUO Caitong YUE Yanli WANG | 2019 | Science China(Information Sciences)2019，62，7： | 10 |
| 3 | Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B显示文摘The 5-year survival rate of lung cancer is one of the lowest among various malignant tumors.Long noncoding RNAs(lncRNAs),noncoding RNAs longer than 200 nucleotides,can function either as tumor suppressors or as oncogenes.The aim of this study is to investigate the function of lncRNA LINC01296 and its molecular mechanism in non-small-cell lung cancer(NSCLC).According to the Gene Expression Omnibus database,10 differentially expressed lncRNAs in NSCLC cells and patient tissues are upregulated.LINC01296 is the one with the most significant overexpression.Knockdown of LINC01296 inhibits the growth and migration,arrests the cell cycle,and promotes the apoptosis of NSCLC cells.Knocking down LINC01296 in vivo suppresses tumor growth and metastasis.LINC01296 also acts as the sponge of miR-143-3p.Lowering the expression of LINC01296 leads to decreased expression of autophagy-related 2B,ATG2B,a target gene of miR-143-3p.Moreover,downregulation of LINC01296 promotes paclitaxel sensitivity in NSCLC.These results demonstrated that the LINC01296/miR-143-3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance.Our study may provide new ideas for the further research of clinical chemotherapy of NSCLC in the near future. | Yanli Li Hui Zhang Jing Guo Wanqiu Li Xianyi Wang Caiyan Zhang Qiangling Sun Zhongliang Ma | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 8 |
| 4 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 5 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 6 | Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers显示文摘Background: Insulin-like factor 2(IGF2) plays an important role in embryonic growth process by modulating intermediary metabolism and cell proliferation. Folic acid is involved in one carbon metabolism and contributes to DNA methylation which is related to gene expression. The purpose of this study was to explore whether folic acid could regulate IGF2 expression via epigenetic mechanism and further promote embryonic growth of new-hatched broilers.Methods: In the present study, 360 fertile eggs were selected and randomly assigned to four treatments. On11 embryonic day of incubation(E11), 0, 50, 100 and 150 μg folic acid were injected into eggs respectively.After hatched, growth performance of broilers were calculated. Hepatic IGF2 expression, methylation level and chromatin structure of promoter region were analyzed.Results: Results have showed that IGF2 expression was up-regulated in 150 μg folic acid group(P < 0.05) and other two dose of folic acid did not affect gene expression(P > 0.05). Meanwhile, methylation level of IGF2 promoter were lower in 100 and 150 μg groups, which was consistent with lower expression of DNA methyltransferase1(DNMT1)(P < 0.05). What's more, chromatin looseness of IGF2 promoter was higher in 150 μg group than control group(P < 0.05). Further, birth weight(BW), liver and bursa index of new-hatched chickens in 150 μg folic acid group were higher than the other groups(P < 0.05). There were positive correlations between hepatic IGF2 expression and BW and organs index(P < 0.05).Conclusion: In conclusion, our data have demonstrated that 150 μg folic acid injection on E11 could up-regulate IGF2 expression by modulating DNA hypomethylation and improving chromatin accessibility in the gene promoter region,and ulteriorly facilitate embryonic growth and organ development of broilers. | Yanli Liu Lihui Zhi Jing Shen Shizhao Li Junhu Yao Xiaojun Yang | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 5 |
| 7 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 8 | Microscopic phase field study of the antisite defect of Ni_3 Al in binary Ni-Al alloys显示文摘The temporal evolution feature of a microscopic phase field model is utilized to study the antisite defects of L1 2-Ni 3 Al;this is quite different from other physicist’ interests.There are mainly two points in brief.Firstly,antisite defects Ni Al and Al Ni ,which are caused by the deviation from the stoichiometric Ni 3 Al,coexist in the Ni 3 Al phase.The surplus Ni atom in the Ni-rich side is prone to substitute Al thus producing the antisite defect Ni Al that maintains the stability of the L1 2 structure.In other case,the surplus Al atom in the Al-rich side is accommodated by a Ni sublattice consequently giving rise to antisite defect Al Ni .The calculated equilibrium occupancy probability of Ni Al is much higher than that of Al Ni .This point is generally in line with other theoretical and experimental works.Additionally,both Ni Al and Al Ni have a strong negative correlation to time step during the disorder-order transformation.Since the initial value of Ni Al and Al Ni on each site of the matrix is right at the concentration that we set,we can observe the decrease process of Ni Al and Al Ni from the initial disordered high anti-structure state to their respective equilibrium state,i.e.to the result of the ordering process further coarsening. | ZHANG Jing ,CHEN Zheng,LU YanLi,ZHANG MingYi & WANG YongXin State Key Laboratory of Solidification Processing School of Material Science and Engineering,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 3 |
| 9 | The Contribution of Opal-Associated Phosphorus to Bioavailable Phosphorus in Surface and Core Sediments in the East China Sea显示文摘To improve the burial flux calculations of bioavailable phosphorus(P) and study opal-associated P(Opal-P) in the East China Sea(ECS), surface and core sediments were collected in the Changjiang Estuary(CE) and the south of the Cheju Island. In this study, sedimentary P was operationally divided into seven different forms using modified sedimentary extraction(SEDEX) technique: LSor-P(exchangeable or loosely sorbed P), Fe-P(easily reducible or reactive ferric Fe-bound P), CFA-P(authigenic carbonate fluorapatite and biogenic apatite and CaCO_3-bound P), Detr-P(detrital apatite), Org-P(organic P), Opal-P and Ref-P(refractory P). The data revealed that the concentrations of the seven different P forms rank as Detr-P > CFA-P > Org-P > Ref-P > Opal-P > Fe-P > LSor-P in surface sediments and CFA-P > Detr-P > Org-P > Ref-P > Fe-P > Opal-P > LSor-P in core sediments. The distributions of the total phosphorus(TP), TIP, CFA-P, Detr-P are similar and decrease from the CE to the south of the Cheju Island. Meanwhile, Org-P and Opal-P exhibit different distribution trends; this may be affected by the grain size and TOM. The concentrations of potentially bioavailable P are 9.6-13.0 μmol g^(-1) and 10.0-13.6 μmol g^(-1), representing 61%-70% and 41%-64% of the TP in surface and core sediments, respectively. The concentrations of Opal-P are 0.6-2.3 μmol g^(-1) and 0.6-1.4 μmol g^(-1) in surface and core sediments, accounting for 5.3%-19.8% and 4.2%-10.6% of bioavailable P, respectively. The total burial fluxes of Opal-P and bioavailable P are 1.4×10~9 mol yr^(-1) and 1.1×10~10 mol yr^(-1) in the ECS, respectively. Opal-P represents about 12.7% of potentially bioavailable P, which should be recognized when studying P cycling in marine ecosystems. | LI Huanxin HE Huijun YANG Shifeng LIU Yanli CHE Hong LI Mujian ZHANG Jing | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 10 | Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells显示文摘Whereas the critical roles of innate lymphoid cells(ILCs)in adult are increasingly appreciated,their developmental hierarchy in early human fetus remains largely elusive.In this study,we sorted human hematopoietic stem/progenitor cells,lymphoid progenitors,putative ILC progenitor/precursors and mature ILCs in the fetal hematopoietic,lymphoid and non-lymphoid tissues,from 8 to 12 post-conception weeks,for single-cell RNA-sequencing,followed by computational analysis and functional validation at bulk and single-cell levels.We delineated the early phase of ILC lineage commitment from hematopoietic stem/progenitor cells,which mainly occurred in fetal liver and intestine.We further unveiled interleukin-3 receptor as a surface marker for the lymphoid progenitors in fetal liver with T,B,ILC and myeloid potentials,while IL-3RA–lymphoid progenitors were predominantly B-lineage committed.Notably,we determined the heterogeneity and tissue distribution of each ILC subpopulation,revealing the proliferating characteristics shared by the precursors of each ILC subtype.Additionally,a novel unconventional ILC2 subpopulation(CRTH2–CCR9+ILC2)was identified in fetal thymus.Taken together,our study illuminates the precise cellular and molecular features underlying the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity. | Chen Liu Yandong Gong Han Zhang Hua Yang Yang Zeng Zhilei Bian Qian Xin Zhijie Bai Man Zhang Jian He Jing Yan Jie Zhou Zongcheng Li Yanli Ni Aiqing Wen Yu Lan Hongbo Hu Bing Liu | 2021 | Cell Research2021，31，10： | 2 |
| 11 | Assessment of the Tessier and BCR sequential extraction procedures for elemental partitioning of Ca, Fe, Mn, Al,and Ti and their application to surface sediments from Chinese continental shelf显示文摘Surface sediments can integrate a wide variety of information of seawater in marginal seas, e.g., the Quaternary sedimentary shelf such as the East China Sea(ECS) and Yellow Sea(YS). The Tessier and BCR sequential extraction procedures(SEPs) have been widely applied for extraction of various geochemical phases from sediments. To choose a suitable SEP for phase extraction of sediments from the above Quaternary sedimentary shelf, efficiency and selectivity experiments were conducted on typical individual minerals and the applicability of each SEP was assessed for natural sediments(the natural sediment standard GSD-9 and three surface sediment samples). The geochemical represented elements(Ca, Fe, Mn, Al, and Ti) were measured using both SEPs. Both SEPs have good dissolution efficiency and selectivity for the targeted geochemical phases; the optimized extractant volume for each fraction was determined. The Tessier SEP is particularly recommended for the study of adsorption-desorption process. The application of the Tessier SEP to surface sediments can furnish valuable information, including the productivity conditions(via the reducible fraction Mn) and sedimentary environments(via the carbonate fraction Ca). These results confirm that the Tessier SEP is suitable for elemental fractionation in sediments from the Chinese continental shelf. | LIU Yanli ZHANG Jing HE Huijun | 2018 | Acta Oceanologica Sinica2018，37，5： | 2 |
| 12 | Effects of root dominate over aboveground litter on soil microbial biomass in global forest ecosystems显示文摘Background:Inputs of above-and belowground litter into forest soils are changing at an unprecedented rate due to continuing human disturbances and climate change.Microorganisms drive the soil carbon(C)cycle,but the roles of above-and belowground litter in regulating the soil microbial community have not been evaluated at a global scale.Methods:Here,we conducted a meta-analysis based on 68 aboveground litter removal and root exclusion studies across forest ecosystems to quantify the roles of above-and belowground litter on soil microbial community and compare their relative importance.Results:Aboveground litter removal significantly declined soil microbial biomass by 4.9%but root exclusion inhibited it stronger,up to 11.7%.Moreover,the aboveground litter removal significantly raised fungi by 10.1%without altering bacteria,leading to a 46.7%increase in the fungi-to-bacteria(F/B)ratio.Differently,root exclusion significantly decreased the fungi by 26.2%but increased the bacteria by 5.7%,causing a 13.3%decrease in the F/B ratio.Specifically,root exclusion significantly inhibited arbuscular mycorrhizal fungi,ectomycorrhizal fungi,and actinomycetes by 22.9%,43.8%,and 7.9%,respectively.The negative effects of aboveground litter removal on microbial biomass increased with mean annual temperature and precipitation,whereas that of root exclusion on microbial biomass did not change with climatic factors but amplified with treatment duration.More importantly,greater effects of root exclusion on microbial biomass than aboveground litter removal were consistent across diverse forest biomes(expect boreal forests)and durations.Conclusions:These data provide a global evidence that root litter inputs exert a larger control on microbial biomass than aboveground litter inputs in forest ecosystems.Our study also highlights that changes in above-and belowground litter inputs could alter soil C stability differently by shifting the microbial community structure in the opposite direction.These findings are useful for predicting microbe-mediated C processes in response to changes in forest management or climate. | Yanli Jing Peng Tian Qingkui Wang Weibin Li Zhaolin Sun Hong Yang | 2021 | Forest Ecosystems2021，8，3： | 2 |
| 13 | Effects of Planting Mode on Growth, Yield and Quality of Mini-watermelon under Soilless Cultivation显示文摘[Objective]The paper was to screen out planting mode suitable for mini-watermelon in spring greenhouses under soilless cultivation.[Method]The effects of single row planting with one main vine and one lateral vein,double row planting with one main vine and one lateral vein,and double row planting with two lateral veins on the growth period,growth,fruit quality and yield of mini-watermelon were studied.[Result]The planting mode of single row planting with one main vine and one lateral vein was adopted.The earliest date of harvest was May 28;the fruit-setting rate was 106.3%;and the single fruit weight was 1.33 kg.The lowest abnormal fruit rate was 0.73%;the highest yield was 54465.45 kg/hm^2,and the central sugar content was the highest of 12.95%.[Conclusion]Single row planting mode under soilless cultivation has certain demonstration and popularization prospect. | Zhang Ying Ma Chao Zeng Jianbo Zhu Li Chen Yanli Li Yunfei Li Jing You Xuesong | 2019 | Plant Diseases and Pests2019，10，4： | 1 |
| 14 | Range-Only UWB SLAM for Indoor Robot Localization Employing Multi-Interval EFIR Rauch-Tung-Striebel Smoother显示文摘For improving the localization accuracy,a multi-interval extended finite impulse response(EFIR)-based Rauch-Tung-Striebel(R-T-S)smoother is proposed for the range-only ultra wide band(UWB)simultaneous localization and mapping(SLAM)for robot localization.In this mode,the EFIR R-T-S(ERTS)smoother employs EFIR filter as the forward filter and the R-T-S smoothing method to smooth the EFIR filter’s output.When the east or the north position is considered as stance,the ERTS is used to smooth the position directly.Moreover,the estimation of the UWB Reference Nodes’(RNs’)position is smoothed by the R-T-S smooth method in parallel.The test illustrates that the proposedmulti-interval ERTS smoothing for range-only UWB SLAMis able to provide accurate estimation.Compared with the EFIR filter,the proposed method improves the localization accuracy by about 25.35%and 40.66%in east and north directions,respectively. | Yanli Gao Wanfeng Ma Jing Cao Jianling Qu Yuan Xu | 2022 | Computer Modeling in Engineering & Sciences2022，，2： | 1 |
| 15 | Crystal structures of human IPP isomer- ase: new insights into the catalytic mechanism 显示文摘 | Cheng Zhang Lin Liu Hang Xu Zhiyi Weil Yanli Wang Ya- jing Lin Weimin Gong | 2007 | Journal of Molecular Biology2007，366，： | 1 |
| 16 | Carbon Nanodots Featuring Efficient FRET for Real‐Time Monitoring of Drug Delivery and Two‐Photon Imaging显示文摘 | Jing Tang Biao Kong Hao Wu Ming Xu Yongcheng Wang Yanli Wang Dongyuan Zhao Gengfeng Zheng | 2013 | Mater2013，，45： | 1 |
| 17 | Crystal structure of Cas1 in complex with branched DNA显示文摘Cas1 is a key component of the CRISPR adaptation complex,which captures and integrates foreign DNA into the CRISPR array,resulting in the generation of new spacers.We have determined crystal structures of Thermus thermophilus Cas1 involved in new spacer acquisition both in complex with branched DNA and in the free state.Cas1 forms an asymmetric dimer without DNA.Conversely,two asymmetrical dimers bound to two branched DNAs result in the formation of a DNA-mediated tetramer,dimer of structurally asymmetrical dimers,in which the two subunits markedly present different conformations.In the DNA binding complex,the N-terminal domain adopts different orientations with respect to the C-terminal domain in the two monomers that form the dimer.Substrate binding triggers a conformational change in the loop 164–177 segment.This loop is also involved in the 3′fork arm and 5′fork arm strand recognition in monomer A and B,respectively.This study provides important insights into the molecular mechanism of new spacer adaptation. | Jing Yang Jiazhi Li Jiuyu Wang Gang Sheng Min Wang Hongtu Zhao Yanhua Yang Yanli Wang | 2020 | Science China(Life Sciences)2020，63，4： | 1 |
| 18 | Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease(Tg2576)显示文摘Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.The aim of this study was to investigate Cajal-Retzius cells in Alzheimer's disease pathology.Results revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695(transgenic(Tg) 2576 mice).Numerous reelin-positive neurons were positive for activated caspase 3 in Tg2576 mice,suggesting that Cajal-Retzius neuronal loss occurred via apoptosis in this Alzheimer's disease model.Compared with wild type,the number of Cajal-Retzius cells was significantly lower in Tg2576 mice.Western blot analysis confirmed that reelin levels were markedly lower in Tg2576 mice than in wild-type mice.The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral deficits.Overall,these data indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease. | Dongming Yu Wenjuan Fan Ping Wu Jiexin Deng Jing Liu Yanli Niu Mingshan Li Jinbo Deng | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 19 | PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids显示文摘To the Editor:Proteolysis Targeting Chimera(PROTAC)is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome.Since PROTACs can degrade target proteins without high affinity,it is natural to speculate that this technology can be used to identify the targets of natural products。Although a recent study reported the employment of PROTACs to explore the unknown non-kinase target of a multi-kinase inhibitor sorafenib,whether PROTACs can be used to find the potential targets of natural products remains unexplored. | Yanli Wu Yueying Yang Wang Wang Dejuan Sun Jing Liang Man Zhu Hua Li Lixia Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 20 | Preparation of Ag@CuFe_(2)O_(4)@TiO_(2) nanocomposite films and its performance of photoelectrochemical cathodic protection显示文摘A Ag@CuFe_(2)O_(4)@TiO_(2) nanocomposite film with high performance of photogenerated cathodic protection was prepared by hydrothermal and photoreduction methods.The results showed that when the CuFe_(2)O_(4) hydrothermal reaction time was 6 h and the AgNO_(3) concentration was 0.1 M,the Ag@CuFe_(2)O_(4)@TiO_(2) nanocomposite material performed the best cathodic protection capability for 304 stainless steel(304SS).In this case,the protective potential achieved-930 mV(versus SCE)associated with the photocurrent density of 475μA/cm^(2),which was 14.8 times that of pure TiO_(2) nanowires.In the dark,the nanocomposite provided cathodic protection of up to 485 mV for 304SS.Due to the heterogeneous junctions at the two interfaces among the three kinds of nanocomposite materials,the build-in electric field was fabricated,which promoted the separation efficiency of photogenerated electrons and holes and effectively improved the photochemical cathodic protection of 304SS. | Ning Wang Jing Wang Mengnan Liu Chengyue Ge Baorong Hou Yanli Ning Yiteng Hu | 2022 | Journal of Materials Science & Technology2022，，5： | 1 |
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