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| 1 | Comparison of the Global Energy Cycle between Chinese Reanalysis Interim and ECMWF Reanalysis显示文摘The global energy cycle is a diagnostic metric widely used to gauge the quality of datasets. In this paper, the 'Mixed Space-Time Domain' method for diagnosis of energy cycle is evaluated by using newly developed datasets-the Chinese Reanalysis Interim (CRAI) and ECMWF Reanalysis version 5 (ERA5), over a 7-yr period (2010-16) on seasonal and monthly timescales. The results show that the energy components calculated from the two reanalysis datasets are highly consistent;however, some components in the global energy integral from CRAI are slightly larger than those from ERA5. The main discrepancy in the energy components stems from the conversion of baroclinic process, whereas the dominant difference originates from the conversion from stationary eddy available potential energy to stationary eddy kinetic energy (CES), which is caused by systematic differences in the temperature and vertical velocity in low-mid latitudes of the Northern Hemisphere and near the Antarctic, where there exist complex terrains. Furthermore, the monthly analysis reveals that the general discrepancy in the temporal variation between the two datasets also lie mainly in the CES as well as corresponding generation and dissipation rates. | Bin ZHAO Bo ZHANG Chunxiang SHI Jingwei LIU Lipeng JIANG | 2019 | Journal of Meteorological Research2019，33，3： | 14 |
| 2 | Contributions of Local and Remote Atmospheric Moisture Fluxes to East China Precipitation Estimated from CRA-40 Reanalysis显示文摘China Meteorological Administration(CMA) recently released its 40-yr(1979–2018) global Chinese reanalysis(CRA-40) dataset. To assess performance of the CRA-40 data in quantifying the regional water cycle, contributions of local and remote atmospheric moisture fluxes to precipitation in East China derived from CRA-40 are compared with those derived from the ECMWF reanalysis version 5(ERA-5). Observed precipitation and evaporation data are also used for validation. As for mean precipitation, CRA-40 matches the observation better in winter and spring than in summer, with a larger wet bias(1.41 mm day^(-1)) in summer than that in ERA-5(0.97 mm day^(-1)), particularly over South China. The conservation of atmospheric water vapor over East China measured by CRA-40 is comparable to that of ERA-5. Both reanalyses show a dominant role of the remote moisture transport in the East China precipitation.In comparison, the annual precipitation induced by the moisture influx from the west of the study domain in CRA-40 is 80 mm less than that in ERA-5. The recycling ratio of annual mean precipitation in CRA-40 is approximately21.1%, slightly larger than that in ERA-5(20.1%). The maximum difference of each hydrological component between the two datasets appears in the summer horizontal moisture influx(3.57 ×10^(7) kg s^(-1);ERA-5 is larger) and winter runoff(1.84 ×10^(7) kg s^(-1);CRA-40 is larger). CRA-40 shows better performance than ERA-5 in capturing the interannual variability of precipitation over East China, as evinced by a higher correlation coefficient with the observation(0.77 versus 0.33). The trend of summer precipitation since 2011 is better reproduced in CRA-40. Both reanalyses show prominent contribution of the southern moisture influx to the interannual variation of precipitation. This study demonstrates the reliability of CRA-40 in representing the hydrological cycle over East China and provides a useful reference for future application of CRA-40 in water cycle studies. | Dan ZHAO Lixia ZHANG Tianjun ZHOU Jingwei LIU | 2021 | Journal of Meteorological Research2021，35，1： | 8 |
| 3 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 4 | Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing显示文摘Background: RNA editing is a co/posttranscriptional modification mechanism that increases the diversity of transcripts, with potential functional consequences. The advent of next-generation sequencing technologies has enabled the identification of RNA edits at unprecedented throughput and resolution. However, our knowledge of RNA editing in swine is still limited.Results: Here, we utilized RES-Scanner to identify RNA editing sites in the brain, subcutaneous fat, heart, liver,muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome resequencing datasets. In total, we identified 74863 editing sites, and 92.1% of these sites caused adenosine-to-guanosine(A-to-G) conversion. Most A-to-G sites were located in noncoding regions and generally had low editing levels. In total, 151 A-to-G sites were detected in coding regions(CDS), including 94 sites that could lead to nonsynonymous amino acid changes. We provide further evidence supporting a previous observation that pig transcriptomes are highly editable at PRE-1 elements. The number of A-to-G editing sites ranged from 4155(muscle) to 25001(brain) across the seven tissues. The expression levels of the ADAR enzymes could explain some but not all of this variation across tissues. The functional analysis of the genes with tissuespecific editing sites in each tissue revealed that RNA editing might play important roles in tissue function.Specifically, more pathways showed significant enrichment in the fat and liver than in other tissues, while no pathway was enriched in the muscle.Conclusions: This study identified a total of 74863 nonredundant RNA editing sites in seven tissues and revealed the potential importance of RNA editing in tissue function. Our findings largely extend the porcine editome and enhance our understanding of RNA editing in swine. | Yuebo Zhang Longchao Zhang Jingwei Yue Xia Wei Ligang Wang Xin Liu Hongmei Gao Xinhua Hou Fuping Zhao Hua Yan Lixian Wang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 5 | Estimation of Sunflower Seed Yield Using Partial Least Squares Regression and Artificial Neural Network Models显示文摘Statistical models can efficiently establish the relationships between crop growth and environmental conditions while explicitly quantifying uncertainties. This study aimed to test the efficiency of statistical models established using partial least squares regression(PLSR) and artificial neural network(ANN) in predicting seed yields of sunflower(Helianthus annuus). Two-year field trial data on sunflower growth under different salinity levels and nitrogen(N) application rates in the Yichang Experimental Station in Hetao Irrigation District, Inner Mongolia, China, were used to calibrate and validate the statistical models. The variable importance in projection score was calculated in order to select the sensitive crop indices for seed yield prediction. We found that when the most sensitive indices were used as inputs for seed yield estimation, the PLSR could attain a comparable accuracy(root mean square error(RMSE) = 0.93 t ha-1, coefficient of determination(R^2) = 0.69) to that when using all measured indices(RMSE = 0.81 t ha-1,R^2= 0.77). The ANN model outperformed the PLSR for yield prediction with different combinations of inputs of both microplots and field data. The results indicated that sunflower seed yield could be reasonably estimated by using a small number of crop characteristic indices under complex environmental conditions and management options(e.g., saline soils and N application). Since leaf area index and plant height were found to be the most sensitive crop indices for sunflower seed yield prediction, remotely sensed data and the ANN model may be joined for regional crop yield simulation. | ZENG Wenzhi XU Chi Gang ZHAO WU Jingwei HUANG Jiesheng | 2018 | Pedosphere2018，28，5： | 4 |
| 6 | Polar Influence of the Organic Modifiers on the Structure of Montmorillonite in Epoxy Nanocomposites显示文摘The epoxy nanocomposites with similar amines(CH_3(CH_2)_(17)NH_2 and CH_3(CH_2)_(17)N(CH_3)_3CI) treated montmorillonite clays have been investigated by wide-angle X-ray scattering,transmission electron microscopy(TEM),differential scanning calorimetry(DSC) and thermal gravimetric analysis(TGA).Different nanocomposite structures,intercalation and exfoliation were formed by the reaction of octadecyltrimethylammonium chloride-exchanged and octadecylamine-exchanged clays with epoxy resin and phenalkamine as the curing agent,respectively.Results showed that the exfoliated nanocomposite can be obtained when octadecylamine with the lower polarity was used as a modifier.However,the intercalated nanocomposite can be obtained when octadecyltrimethylammonium chloride with higher polarity was used as a modifier. | Fu-Chun Liu En-Hou Han Wei Ke Nan Tang Junbiao Wan Guilai Yin Jingwei Deng Kangwen Zhao | 2013 | Journal of Materials Science & Technology2013，29，11： | 3 |
| 7 | Facile construction of two-dimensional coordination polymers with a well-designed redox-active organic linker for improved lithium ion battery performance显示文摘A well-designed redox-active organic linker,pyrazine-2,3,5,6-tetracarboxylate(H_4pztc)with brimming active sites for lithium ions storage was utilized to construct coordination polymers(CPs)via a facile hydrothermal reaction.Those two isostructural two-dimensional(2D)CPs,namely[M_2(pztc)(H_2O)_6]_n(M=Co for 1 and Ni for 2),delivered excellent reversible capacities and stable cycling performance as anodes in lithium ion batteries.As demonstrated in electrochemical studies,1 and 2 can achieve highly reversible capacities of 815 and 536 mA h g^(-1)at 200 mA g^(-1)for 150 cycles,respectively,best performed for the reported2D-CP-based anode materials.The electrochemical mechanism studies showed that the remarkable performances can be ascribed to the synergistic Li-storage redox reactions of metal centers and organic moieties.Our work highlights the opportunities of using a well-designed organic ligand to construct low-dimensional CPs as new type of electrode materials for advanced lithium ion batteries. | Jingwei Liu Lin Zhang Huanhuan Li Peng Zhao Peng Ren Wei Shi Peng Cheng | 2019 | Science China Chemistry2019，62，5： | 3 |
| 8 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 9 | Evolution from small molecule to nano-drug delivery systems:An emerging approach for cancer therapy of ursolic acid显示文摘Ursolic acid(UA),a natural pentacyclic triterpenoid,possesses widespread biological and pharmacological activities.However,drawbacks such as low bioavailability,poor targeting and rapid metabolism greatly hinder its further clinical application.Recently,with the development of nanotechnology,various UA nanosystems have emerged as promising strategies for effective cancer therapy.This article reviews various types of UA-based nanodelivery systems,primarily with emphasis placed on novel UA-based carrier-free nanodrugs,which are considered to be innovative methods for cancer therapy.Moreover,this review presents carrier-free nano-drugs that co-assembled of UA and photosensitizers that displayed synergistic antitumor performance.Finally,the article also describes the development and challenges of UA nanosystems for future research in this field.Overall,the information presented in this review will provide new insight into the rational utilization of nano-drugs in cancer therapy. | Jingwei Shao Yifan Fang Ruirui Zhao Fangmin Chen Mingyue Yang Jiali Jiang Zixuan Chen Xiaotian Yuan Lee Jia | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 10 | Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK31P1显示文摘Osteosarcoma 是恶意的主要骨头肿瘤的最经常的类型。尽管许多努力被作了, osteosarcoma 的幸存率仍然保持未得到满足。长非编码的 RNA (lncRNAs ) 被表明了包括肿瘤与许多疾病被联系,并且在 pathophysiological 过程的一个宽数组的规定包含了。Colon-cancer-associated transcript-1 (CCAT1 ) 首先在结肠癌被识别并且随后被报导了在肿瘤前进执行许多功能。现在的学习试图包括地在 osteosarcoma 房间探索 CCAT1 和它的内在的机制的生物功能。我们的调查结果表明 CCAT1 是在 osteosarcoma 纸巾和房间的 upregulated,并且经由调整 miR-148a/phosphatidyl 肌醇 3-kinase 交往涉及 osteosarcoma 的增长和移植蛋白质 1 (PIK3IP1 ) 发信号小径。 | Jingwei Zhao Liming Cheng | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 3 |
| 11 | Micromanufacturing of composite materials:a review显示文摘Composite materials exhibit advantages from the combination of multiple properties,which cannot be achieved by a monolithic material.At present,the use of composite materials in miniaturized scale is receiving much attention in the fields of medicine,electronics,aerospace,and microtooling.A common method for producing miniaturized composite parts is micromanufacturing.There has been,however,no comprehensive literature published that reviews,compares,and discusses the ongoing micromanufacturing methods for producing miniaturized composite components.This study identifies the major micromanufacturing methods used with composite materials,categorizes their subclasses,and highlights the latest developments,new trends,and effects of key factors on the productivity,quality,and cost of manufacturing composite materials.A comparative study is presented that shows the potential and versatility associated with producing composite materials along with possible future applications.This review will be helpful in promoting micromanufacturing technology for fabricating miniaturized products made of composite materials to meet the growing industrial demand. | Mahadi Hasan Jingwei Zhao Zhengyi Jiang | 2019 | International Journal of Extreme Manufacturing2019，1，1： | 3 |
| 12 | Advances in preparation,application in contaminant removal,and environmental risks of biochar-based catalysts:a review显示文摘As a carbon-rich material produced by pyrolysis of biomass,biochar features low cost,large specific surface area,and widely available feedstocks based on the functional diversity and environmental-friendly properties,it has received increasing attention in the fields of pollutant removal due to three win-win effects of water remediation,carbon sequestration and reutilization of wastes.To design excellent biochar-based catalysts for environmental applications,one must understand recent advances in the catalysts for contaminant removal.This review focuses on the current application of biochar-based catalysts in redox systems,Fenton-like systems,sonocatalytic systems and photocatalytic systems.Besides in-depth discussion in effects of preparation conditions on physicochemical characteristics of biochars,the review supplements new preparation technologies of biochar and biochar-based catalysts.Most importantly,the advantages/shortcomings,catalysis mechanisms,as well as the pollutant removal ability of different types of biochar-based catalysts are discussed.The environmental risks of the catalyst applications are also elaborated on.Future research on biochar-based catalyst production and its environmental applications is discussed.The review provides a good overview of the current advances of biochar-based catalysts in pollutant control and the future research directions. | Bowen Yang Jiawei Dai Yuan Zhao Jingwei Wu Caiya Ji Yuhu Zhang | 2022 | Biochar2022，4，1： | 2 |
| 13 | Subdivision and age of the Yanchang Formation and the Middle/Upper Triassic boundary in Ordos Basin, North China显示文摘The Yanchang Formation is extensively developed in the Ordos Basin and its surrounding regions. As one of the best terrestrial Triassic sequences in China and the major oil-gas bearing formations in the Ordos Basin, its age determination and stratigraphic assignment are important in geological survey and oil-gas exploration. It had been attributed to the Late Triassic and regarded as the typical representative of the Upper Triassic in northern China for a long time, although some scholars had already proposed that the lower part of this formation should be of the Middle Triassic age in the mid-late 20 th century. In this paper, we suggest that the lower and middle parts of the Yanchang Formation should be of the Ladinian and the bottom possibly belongs to the late Anisian of the Middle Triassic, mainly based on new fossils found in it and high resolution radiometric dating results. The main source rocks, namely the oil shales and mudstones of the Chang-7, are of the Ladinian Age. The upper part of the Yanchang Formation, namely the Chang-6 and the above parts, belongs to the Late Triassic. The uppermost of the Triassic is missed in most parts of the Ordos Basin. The Middle-Upper Triassic Series boundary lies in the Yanchang Formation, equivalent to the boundary between Chang-7 and Chang-6. The Ladinian is an important palaeoenvironmental turning point in the Ordos Basin. Palaeoenvironmental changes in the basin are coincidence with that of the Sichuan Basin and the main tectonic movement of the Qinling Mountains. It indicates that tectonic activities of the Qinling Mountains are related to the big palaeoenvironmental changes in both the Ordos and Sichuan Basins, which are caused by the same structural dynamic system during the Ladinian. | Shenghui DENG Yuanzheng LU Zhong LUO Ru FAN Xin LI Yi ZHAO Xueying MA Rukai ZHU Jingwei CUI | 2018 | Science China Earth Sciences2018，61，10： | 2 |
| 14 | The landscape of chromatin accessibility in skeletal muscle during embryonic development in pigs显示文摘Background:The development of skeletal muscle in pigs during the embryonic stage is precisely regulated by transcriptional mechanisms,which depend on chromatin accessibility.However,how chromatin accessibility plays a regulatory role during embryonic skeletal muscle development in pigs has not been reported.To gain insight into the landscape of chromatin accessibility and the associated genome-wide transcriptome during embryonic muscle development,we performed ATAC-seq and RNA-seq analyses of skeletal muscle from pig embryos at 45,70 and 100 days post coitus(dpc).Results:In total,21,638,35,447 and 60,181 unique regions(or peaks)were found across the embryos at 45 dpc(LW45),70 dpc(LW70)and 100 dpc(LW100),respectively.More than 91%of the peaks were annotated within−1 kb to 100 bp of transcription start sites(TSSs).First,widespread increases in specific accessible chromatin regions(ACRs)from embryos at 45 to 100 dpc suggested that the regulatory mechanisms became increasingly complicated during embryonic development.Second,the findings from integrated ATAC-seq and RNA-seq analyses showed that not only the numbers but also the intensities of ACRs could control the expression of associated genes.Moreover,the motif screening of stage-specific ACRs revealed some transcription factors that regulate muscle developmentrelated genes,such as MyoG,Mef2c,and Mef2d.Several potential transcriptional repressors,including E2F6,OTX2 and CTCF,were identified among the genes that exhibited different regulation trends between the ATAC-seq and RNA-seq data.Conclusions:This work indicates that chromatin accessibility plays an important regulatory role in the embryonic muscle development of pigs and regulates the temporal and spatial expression patterns of key genes in muscle development by influencing the binding of transcription factors.Our results contribute to a better understanding of the regulatory dynamics of genes involved in pig embryonic skeletal muscle development. | Jingwei Yue Xinhua Hou Xin Liu Ligang Wang Hongmei Gao Fuping Zhao Lijun Shi Liangyu Shi Hua Yan Tianyu Deng Jianfei Gong Lixian Wang Longchao Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 15 | Coarsening Behavior of Al_3(Sc, Zr) Precipitates and Its Influence on Recrystallization Temperature of Al-Mg-Sc-Zr Alloy显示文摘Effects of intermediate annealing temperature and time after hot working on recrystallization temperature (Tr) of Al-Mg-Sc-Zr alloy subjected to further cold working were investigated. It was found that Tr of cold worked alloy dropped with the rise of intermediate annealing temperature or extension of annealing time, due to coarsening of Al3(Sc, Zr) particles during intermediate annealing. After annealed at 550°C for 1 h or 475°C for 50 h, Tr is nearly same as that in a Sc, Zr free 5A06 alloy. Coarsening mechanism was also discussed. After hot rolling, residual dislocations promoted diffusion of Sc and Zr atoms at the elevated temperature of the intermediate annealing. Easier diffusion sped the growth of the Al3(Sc, Zr) particles, resulting in a coherency loss and quantity reduction of the particles. | Gang Du Jingwei Deng Desheng Yan Mingjiu Zhao Lijian Rong | 2009 | Journal of Materials Science & Technology2009，25，6： | 2 |
| 16 | Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors显示文摘 | CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 17 | Experimental Investigation on Micro Deep Drawing of Stainless Steel Foils with Different Microstructural Characteristics显示文摘In the present work,austenitic stainless steel(ASS)304 foils with a thickness of 50μm were first annealed at temperatures ranging from 700 to 1100℃for 1 h to obtain different microstructural characteristics.Then the effects of microstructural characteristics on the formability of ASS 304 foils and the quality of drawn cups using micro deep drawing(MDD)were studied,and the mechanism involved was discussed.The results show that the as-received ASS 304 foil has a poor formability and cannot be used to form a cup using MDD.Serious wrinkling problem occurs on the drawn cup,and the height profile distribution on the mouth and the symmetry of the drawn cup is quite non-uniform when the annealing temperature is 700℃.At annealing temperatures of 900 and 950℃,the drawn cups are both characterized with very few wrinkles,and the distribution of height profile,symmetry and mouth thickness are uniform on the mouths of the drawn cups.The wrinkling becomes increasingly significant with a further increase of annealing temperature from 950 to 1100℃.The optimal annealing temperatures obtained in this study are 900 and 950℃for reducing the generation of wrinkling,and therefore improving the quality of drawn cups.With non-optimized microstructure,the distribution of the compressive stress in the circumferential direction of the drawn foils becomes inhomogeneous,which is thought to be the cause of the occurrence of localized deformation till wrinkling during MDD. | Jingwei Zhao Tao Wang Fanghui Jia Zhou Li Cunlong Zhou Qingxue Huang Zhengyi Jiang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 18 | Spinal cord injury:molecular mechanisms and therapeutic interventions显示文摘Spinal cord injury(SCI)remains a severe condition with an extremely high disability rate.The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system.In the past few decades,researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling. | Xiao Hu Wei Xu Yilong Ren Zhaojie Wang Xiaolie He Runzhi Huang Bei Ma Jingwei Zhao Rongrong Zhu Liming Cheng | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 19 | Guidelines for navigation-assisted spine surgery显示文摘Spinal surgery is a technically demanding and challenging procedure because of the complicated anatomical structures of the spine and its proximity to several important tissues.Surgical landmarks and fluoroscopy have been used for pedicle screw insertion but are found to produce inaccuracies in placement.Improving the safety and accuracy of spinal surgery has increasingly become a clinical concern.Computerassisted navigation is an extension and application of precision medicine in orthopaedic surgery and has significantly improved the accuracy of spinal surgery.However,no clinical guidelines have been published for this relatively new and fast-growing technique,thus potentially limiting its adoption.In accordance with the consensus of consultant specialists,literature reviews,and our local experience,these guidelines include the basic concepts of the navigation system,workflow of navigation-assisted spinal surgery,some common pitfalls,and recommended solutions.This work helps to standardize navigation-assisted spinal surgery,improve its clinical efficiency and precision,and shorten the clinical learning curve. | Wei Tian Bo Liu Da He Yajun Liu Xiaoguang Han Jingwei Zhao Mingxing Fan | 2020 | Frontiers of Medicine2020，14，4： | 1 |
| 20 | Calcineurin B-like protein 5(SiCBL5)in Setaria italica enhances salt tolerance by regulating Na^(+)homeostasis显示文摘Salinity,a major abiotic stress,reduces plant growth and severely limits agricultural productivity.Plants regulate salt uptake via calcineurin B-like proteins(CBLs).Although extensive studies of the functions of CBLs in response to salt stress have been conducted in Arabidopsis,their functions in Setaria italica are still poorly understood.The foxtail millet genome encodes seven CBLs,of which only SiCBL4 was shown to be involved in salt response.Overexpression of SiCBL5 in Arabidopsis thaliana sos3-1 mutant rescued its salt hypersensitivity phenotype,but that of other SiCBLs(SiCBL1,SiCBL2,SiCBL3,SiCBL6,and SiCBL7)did not rescue the salt hypersensitivity of the Atsos3-1 mutant.SiCBL5 harbors an N-myristoylation motif and is located in the plasma membrane.Overexpression of SiCBL5 in foxtail millet increased its salt tolerance,but its knockdown increased salt hypersensitivity.Yeast two-hybrid and firefly luciferase complementation imaging assays showed that SiCBL5 physically interacted with SiCIPK24 in vitro and in vivo.Cooverexpression of SiCBL5,SiCIPK24,and SiSOS1 in yeast conferred a high-salt-tolerance phenotype.Compared to wild-type plants under salt stress conditions,SiCBL5 overexpressors showed lower accumulations of Na^(+) and stronger Na^(+) efflux,whereas RNAi-SiCBL5 plants showed higher accumulations of Na^(+) and weaker Na^(+) efflux.These results indicate that SiCBL5 confers salt tolerance in foxtail millet by modulating Na^(+) homeostasis. | Jingwei Yan Lan Yang Ya Liu Yingdi Zhao Tong Han Xingfen Miao Aying Zhang | 2022 | The Crop Journal2022，10，1： | 1 |
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