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| 1 | Ensemble data assimilation and prediction of typhoon and associated hazards using TEDAPS:evaluation for 2015-2018 seasons显示文摘The initial condition accuracy is a major concern for tropical cyclone(TC)numerical forecast.The ensemble-based data assimilation techniques have shown great promise to initialize TC forecast.In addition to initial condition uncertainty,representing model errors(e.g.physics deficiencies)is another important issue in an ensemble forecasting system.To improve TC prediction from both deterministic and probabilistic standpoints,a Typhoon Ensemble Data Assimilation and Prediction System(TEDAPS)using an ensemble-based data assimilation scheme and a multi-physics approach based on Weather Research and Forecasting(WRF)model,has been developed in Shanghai Typhoon Institute and running realtime since 2015.Performance of TED APS in the prediction of track,intensity and associated disaster has been evaluated for the Western North Pacific TCs in the years of 2015-2018,and compared against the NCEP GEFS.TED APS produces markedly better intensity forecast by effectively reducing the weak biases and therefore the degree of underdispersion compared to GEFS.The errors of TED APS track forecasts are comparative with(slightly worse than)those of GEFS at longer(shorter)forecast leads.TEDAPS ensemble-mean exhibits advantage over deterministic forecast in track forecasts at long lead times,whereas this superiority is limited to typhoon or weaker TCs in intensity forecasts due to systematical underestimation.Four case-studies for three landfalling cyclones and one recurving cyclone demonstrate the capacities of TEDAPS in predicting some challenging TCs,as well as in capturing the forecast uncertainty and the potential threat from TC-associated hazards. | Hong LI Jingyao LUO Mengting XU | 2019 | Frontiers of Earth Science2019，13，4： | 3 |
| 2 | Neural-Fuzzy-Based Adaptive Sliding Mode Automatic Steering Control of Vision-based Unmanned Electric Vehicles显示文摘This paper presents a novel neural-fuzzy-based adaptive sliding mode automatic steering control strategy to improve the driving performance of vision-based unmanned electric vehicles with time-varying and uncertain parameters.Primarily,the kinematic and dynamic models which accurately express the steering behaviors of vehicles are constructed,and in which the relationship between the look-ahead time and vehicle velocity is revealed.Then,in order to overcome the external disturbances,parametric uncertainties and time-varying features of vehicles,a neural-fuzzy-based adaptive sliding mode automatic steering controller is proposed to supervise the lateral dynamic behavior of unmanned electric vehicles,which includes an equivalent control law and an adaptive variable structure control law.In this novel automatic steering control system of vehicles,a neural network system is utilized for approximating the switching control gain of variable structure control law,and a fuzzy inference system is presented to adjust the thickness of boundary layer in real-time.The stability of closed-loop neural-fuzzy-based adaptive sliding mode automatic steering control system is proven using the Lyapunov theory.Finally,the results illustrate that the presented control scheme has the excellent properties in term of error convergence and robustness. | Jinghua Guo Keqiang Li Jingjing Fan Yugong Luo Jingyao Wang | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 3 | Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual-and auditory-related nervous tissues, in a macaque model of type 2 diabetes显示文摘The present study detected distribution and expression of nerve growth factor and inducible nitric oxide synthase in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes using immunohistochemistry. Results showed that nerve growth factor expression decreased, but inducible nitric oxide synthase expression increased, in the mesencephalon and diencephalon, as well as visual- and auditory- related nervous tissues. These results suggested that nerve growth factor and inducible nitric oxide synthase play an important role in regulating the development of diabetic visual- and auditory-related diseases. | Qihui Luo Wentao Liu Jingyao Chen Mingshu Wang Wen Zeng Zhengli Chen Anchun Cheng | 2012 | Neural Regeneration Research2012，7，4： | 2 |
| 4 | Predictability and dynamics of the rapid intensification of Super Typhoon Lekima (2019)显示文摘This study explores the effect of the initial axisymmetric wind structure and moisture on the predictability of the peak intensity of Typhoon Lekima(2019)through a 20-member ensemble forecast using the WRF model.The ensemble members are separated into Strong and Weak groups according to the maximum 10-m wind speed at 48 h.In our study of Lekima(2019),the initial intensity defined by maximum 10-m wind speed is not a good predictor of the intensity forecast.The peak intensity uncertainty is sensitive to the initial primary circulation outside the radius of maximum wind(RMW)and the initial secondary circulation.With greater absolute angular momentum(AAM)beyond the RMW directly related to stronger primary circulation,and stronger radial inflow,Strong group is found to have larger AAM import in lowlevel,helping to spin up the TC.Initial moisture in innercore is also critical to the intensity predictability through the development of inner-core convection.The aggregation and merger of convection,leading to the TC intensification,is influenced by both radial advection and gradient of system-scale vortex vorticity.Three sensitivity experiments are conducted to study the effect of model uncertainty in terms of model horizontal grid resolution on intensity forecast.The horizontal grid resolution greatly impacts the predictability of Lekima’s intensity,and the finer resolution is helpful to simulate the intensification and capture the observed peak value. | Mengting XU Hong LI Jingyao LUO Hairong BEN Yijie ZHU | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 5 | Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs-EBP interaction recover NAFLD through enhancing mitochondrial function in mice显示文摘Nonalcoholic fatty liver disease(NAFLD),especially nonalcoholic steatohepatitis(NASH),is a common hepatic manifestation of metabolic syndrome.However,there are no effective therapy to treat this devastating disease.Accumulating evidence suggests that the generation of elastin-derived peptides(EDPs)and the inhibition of adiponectin receptors(Adipo R)1/2 plays essential roles in hepatic lipid metabolism and liver fibrosis.We recently reported that the AdipoR1/2 dual agonist JT003 significantly degraded the extracellular matrix(ECM)and ameliorated liver fibrosis.However,the degradation of the ECM lead to the generation of EDPs,which could further alter liver homeostasis negatively.Thus,in this study,we successfully combined AdipoR1/2 agonist JT003 with V14,which acted as an inhibitor of EDPs-EBP interaction to overcome the defect of ECM degradation.We found that combination of JT003 and V14 possessed excellent synergistic benefits on ameliorating NASH and liver fibrosis than either alone since they compensate the shortage of each other.These effects are induced by the enhancement of the mitochondrial antioxidant capacity,mitophagy,and mitochondrial biogenesis via AMPK pathway.Furthermore,specific suppression of AMPK could block the effects of the combination of JT003 and V14 on reduced oxidative stress,increased mitophagy and mitochondrial biogenesis.These positive results suggested that this administration of combination of AdipoR1/2 dual agonist and inhibitor of EDPs-EBP interaction can be recommended alternatively for an effective and promising therapeutic strategy for the treatment of NAFLD and NASH related fibrosis. | Nazi Song Hongjiao Xu Shuohan Wu Suijia Luo Jingyao Xu Qian Zhao Rui Wang Xianxing Jiang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 6 | An adaptive cascade trajectory tracking control for over-actuated autonomous electric vehicles with input saturation显示文摘This paper presented a novel adaptive cascade nonlinear trajectory tracking control scheme of over-actuated autonomous electric vehicles involving input saturation. First, a nonlinear vehicle dynamic model with input saturation is established, which can accurately describe the features of uncertainties and coupling of autonomous electric vehicles, and the hyperbolic tangent function is designed to estimate the saturation function for dealing with the input saturation problem. Then, a novel adaptive cascade trajectory tracking control scheme is designed. An adaptive neural network-based terminal sliding control law is proposed for producing the generalized force/moment in real-time, the asymptotic stability of this adaptive control system is proven by Lyapunov theory, and a quasi-newton distribution law is designed to determine the optimum tire forces that guarantee the actual generalized forces/moment are close to the desired values. Finally, simulation results demonstrate the effectiveness of the proposed control scheme. | GUO JingHua LUO YuGong WANG JingYao LI KeQiang CHEN Tao | 2019 | Science China(Technological Sciences)2019，62，12： | 0 |
| 7 | Application of Color Psychology in Korean Brand Identity Design-Etude House显示文摘The purpose of this analysis is to delve into the application of color psychology in the logo design of Korean cosmetic brands,using Etude House as an example for an exhaustive analysis.By examining the history of the Etude House brand,the evolution of the logo design,and the changes in color choices,we analyze the traditional concepts of color symbolism in Korean culture and the culture of color in contemporary society in order to reveal the important role of color in cosmetic brand image.Through an in-depth analysis of the use of color in Etude House’s brand identity,we further analyze the impact of color on consumer emotions and purchasing behavior,as well as the potential impact of brand identity changes on market performance.Finally,the conclusions of the analysis summarize the practical application of color psychology in Etude House’s brand logo design,suggest recommendations for other Korean cosmetic brands to draw upon in their logo design,and discuss future directions. | Jingyao Luo Choi Albort Young | 2024 | Cultural and Religious Studies2024，12，1： | 0 |
| 8 | Effects of Antimony Stress on Root Growth,Antimony Accumulation and Physiological Characteristics of Ramie(Boehmeria nivea(L.) Gaudich.)显示文摘[Objectives]This study was conducted to investigate the toxicity of heavy metal antimony(Sb) to ramie(Boehmeria nivea(L.) Gaudich.) and the tolerance response in ramie. [Methods] A pot experiment was conducted to study the effects of Sb stress on root growth and Sb accumulation and transport of the root system of cultivated ramie Zhongzhu No.1, as well as on the physiological characteristics of ramie leaves. [Results] The plant height and root dry weight and volume of Zhongzhu No.1 showed an effect of 'promoting at low concentrations and inhibiting at high concentrations' with the increase of Sb concentration, and decreased significantly at the concentration of 4 000 mg/kg, but no obvious toxic growth symptoms were observed. The content of Sb in roots(289.7-508.6 mg/kg) and the root-shoot transfer factor(0.09-0.57) of Zhongzhu No.1 increased with the increase of soil Sb concentration, but the change of Sb bioconcentration factor in roots was opposite, indicating that high concentrations of Sb in soil could promote the absorption of Sb in roots and the transport of Sb to the aboveground part, but the Sb enrichment capacity of roots was relatively reduced with the increase of soil Sb. Sb stress had a certain impact on the physiological characteristics of ramie leaves. With the increase of Sb treatment concentration, MDA, POD and SOD showed a change trend of 'first increasing and then decreasing', while CAT gradually increased, indicating that Sb stress caused changes in the physiological characteristics of ramie leaves, thereby affecting plant growth and development. [Conclusions] This study provides a theoretical basis for ecological restoration of ramie in mining areas. | Jiecheng HAN Yaxuan LIU Xingguo ZHAN Jingyao LUO Fulong YANG Jing ZHOU Guiyuan MENG | 2023 | Agricultural Biotechnology2023，12，1： | 0 |
| 9 | Inhibition of H_(2)O_(2)-induced apoptosis of GC2-spg cells by functionalized selenium nanoparticles with lentinan through ROSmediated ERK/p53 signaling pathways显示文摘AH_(2)O_(2)-induced oxidative stress injury cell model was established to investigate the antioxidant effect of nanoselenium on mouse spermatocyte lines and the regulation mechanism of the expression level and activity of seleniumcontaining antioxidant enzymes induced by oxidative stress.A safe and effective nano-drug system of functionalized selenium-containing nanoparticles(SeNPs)was developed with lentinan(LNT)(SeNPs@LNT).Mice spermatocyte line GC2-spg cells were treated with SeNPs@LNT(1,2,4,8,16,32μM)for 24-72 h to evaluate the cytotoxicity of selenium.GC2-spg cells were randomly divided into the following groups:control,hydrogen peroxide(H_(2)O_(2)),SeNPs@LNT,and H_(2)O_(2)+SeNPs@LNT groups.H_(2)O_(2)+SeNPs@LNT group was pretreated with SeNPs@LNT 4μM for 12 h,followed by H_(2)O_(2)600μM for 8 h.The cell viability decreased in the H_(2)O_(2) group and increased significantly in the SeNPs@LNT group.Compared with the H_(2)O_(2) group,the SeNPs@LNT+H_(2)O_(2) group exhibited obvious red fluorescence,indicating a higher level of mitochondrial membrane potential.The content of intracellular reactive oxygen species(ROS)in the SeNPs@LNT group reduced significantly,and the intensity of green fluorescence in the SeNPs@LNT+H_(2)O_(2) group decreased significantly compared with the H_(2)O_(2) group,indicating the inhibitory effect of SeNPs@LNT on the generation of ROS-induced oxidative stress.The activity of GPx and SOD increased significantly in the SeNPs@LNT group.The expression of p53 decreased significantly under the intervention of nano-selenium,and GPx1 expression increased.In the oxidative stress group,the expressions of DNA damage-related proteins and apoptosis-related proteins were higher than those in other groups.Thus,SeNPs@LNT can promote GC2-spg cell proliferation,improve GPx and SOD activities,remove intracellular ROS,and reduce mitochondrial damage and functional abnormalities caused by oxidative stress by regulating the ERK and p53 protein levels.SeNPs@LNT has good biological activity and antioxidant effect,which can be used to protect the male reproductive system from oxidative stress. | MIAOMIAO LI DANYANG CHEN JUNYI KE RUILIN ZHENG JINGYAO SU ZILIN ZHENG JIEYI LUO HANRAN MAI FAN JIANG YANXIA QU XIAOQIONG GU BING ZHU YINGHUA LI LIANDONG ZUO | 2023 | BIOCELL2023，47，2： | 0 |
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