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| 1 | Epidemiology and risk factors of colorectal cancer in China显示文摘In China, colorectal cancer(CRC) ranked fourth and fifth in the highest incidence and mortality rates of all malignancies in 2018, respectively. Although these rates are below the world average, China placed first worldwide in the number of new CRC cases and CRC-related deaths because of its comparatively large population. This disease represents a threat to the health of population and incurs a heavy economic burden on the society and individuals. CRC has various risk factors, including age, sex, lifestyle, genetic factors, obesity, diabetes, gut microbiota status, and precancerous lesions. Furthermore, incidence and mortality rates of CRC are closely related to socioeconomic development levels, varying according to regional and population characteristics. Prevention is the main strategy to reduce incidence and mortality rates of CRC. This can be achieved through strategies stimulating lifestyle changes, healthy diet habits, and early screening for high-risk individuals. To reduce the burden of CRC, public health officials should promote prevention and management of modifiable risk factors through national policies. The rising incidence and mortality rates of CRC in China may be timely curbed by clarifying specific epidemiological characteristics, optimizing early screening strategies, and strictly implementing diagnosis and treatment guidelines. Thus, this study aimed to collect and report the current research status on epidemiology and risk factors of CRC in China. | Yong Yang Zihan Han Xin Li An Huang Jingyi Shi Jin Gu | 2020 | Chinese Journal of Cancer Research2020，32，6： | 42 |
| 2 | Expression and significance of fat mass and obesity associated gene and forkhead transcription factor O1 in non-alcoholic fatty liver disease显示文摘 | Zhang Jielei Li Shan Li Jingyi Han Chao Wang Zhifang Li Chong Wang Xiaoman Liu Zhenzhen Wen Jianguo Zheng Lili | 2014 | Chinese Medical Journal2014，，21： | 9 |
| 3 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 4 | Discovery of Lorandite TlAsS_2 at the Distal Au-Tl Deposit in a Skarn system,Fengshan Area,Middle-Lower Yangtze River,Eastern China显示文摘Objective Thallium has been used as an indicator element in geochemical exploration of searching for hydrothermal gold deposits.However,the T1 minerals and mineralization are rare in nature.Lorandite TlAsS_2,a relatively uncommon mineral,has been dominantly discovered in some Carlin gold deposits,and minor SbHg,U and Pb-Zn-Ag deposits.It is of a hydrothermal origin and was typically formed at relatively low temperatures.The relationships between these deposits containing lorandite and intrusions remain a | XIE Guiqing MAO Jingwen HAN Yingxiao JIAN Wei HAN Jingyi | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 7 |
| 5 | Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p显示文摘Background:Although Mex3 RNA-binding family member A(Mex3a)has demonstrated an important role in multiple cancers,its role and regulatory mechanism in CRC is unclear.In this study,we aimed to investigate the role and clinical significance of Mex3a in CRC and to explore its underlying mechanism.Methods:Western blotting and quantitative real-time polymerase chain reaction(qRT-PCR)were performed to detect the expression levels of genes.5-Ethynyl-2’-deoxyuridine(EDU)and transwell assays were utilized to examine CRC cell proliferation and metastatic ability.The R software was used to do hierarchical clustering analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.Overexpression and rescue experiments which included U0126,a specific mitogen activated protein kinase kinase/extracellular regulated protein kinase(MEK/ERK)inhibitor,and PX-478,a hypoxia-inducible factor 1 subunit alpha(HIF-1α)inhibitor,were used to study the molecularmechanisms of Mex3a in CRC cells.Co-immunoprecipitation(Co-IP)assay was performed to detect the interaction between two proteins.Bioinformatics analysis including available public database and Starbase software(starbase.sysu.edu.cn)were used to evaluate the expression and prognostic significance of genes.TargetScan(www.targetscan.org)and the miRDB(mirdb.org)website were used to predict the combination site between microRNA and target mRNA.BALB/c nude micewere used to study the function of Mex3a and hsa-miR-6887-3p in vivo.Results:Clinicopathological and immunohistochemical(IHC)studies of 101 CRC tissues and 79 normal tissues demonstrated that Mex3a was a significant prognostic factor for overall survival(OS)in CRC patients.Mex3a knockdown substantially inhibited the migration,invasion,and proliferation of CRC cells.Transcriptome analysis and mechanism verification showed that Mex3a regulated the RAP1 GTPase activating protein(RAP1GAP)/MEK/ERK/HIF-1αpathway.Furthermore,RAP1GAP was identified to interact with Mex3a in Co-IP experiments.Bioinformatics and dual-luciferase reporter experiments revealed that hsa-miR-6887-3p could bind to the 3’-untranslated regions(3’-UTR)of the Mex3amRNA.hsa-miR-6887-3p downregulated Mex3a expression and inhibited the tumorigenesis of CRC both in vitro and in vivo.Conclusions:Our study demonstrated that the hsa-miR-6887-3p/Mex3a/RAP1GAP signaling axis was a key regulator of CRC and Mex3a has the potential to be a new diagnostic marker and treatment target for CRC. | Haixia Li Jinghui Liang Jiang Wang Jingyi Han Shuang Li Kai Huang Chuanyong Liu | 2021 | Cancer Communications2021，41，6： | 5 |
| 6 | CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis显示文摘躲避 TGF -- 调停的生长抑制经常在肝与 tumorigenesis 被联系,包括 hepatocellular 癌(HCC ) 。更好在 HCC 开始和前进理解功能和 TGF- 的内在的分子的机制,我们执行了定序的 transcriptome (RNA-Seq ) 识别 TGF- 的目标基因。CXXC5, CXXC 类型锌手指的一个成员包含域的蛋白质家庭,在 Hep3B HCC 房间作为新奇 TGF- 目标基因被识别。稀释的 CXXC5 击倒 TGF- 目标基因和改善 TGF 的实质的部分的表示 -- 导致的生长抑制或 Hep3B 细胞的 apoptosis,建议那 CXXC5 为 TGF 被要求 -- HCC 的调停的抑制前进。TCGA 数据库的分析显示那 CXXC5 表情在正常纸巾与那相比在 HCC 织物样品的多数被减少。而且, CXXC5 与 histone deacetylase HDAC1 联系并且竞争它和 Smad2/3 的相互作用,从而在 TGF- 发信号上废除 HDAC1 的禁止的效果。这些观察一起建议 CXXC5 可以由支持经由一个积极反馈环发信号的 TGF- 充当肿瘤 suppressor,并且揭示策略让 HCC 绕过 TGF -- 由破坏积极反馈规定的调停的 cytostasis。我们的调查结果在表明规定的 TGF- 上打开新灯并且在 HCC 开发表明 CXXC5 的函数。 | Xiaohua Yan Jingyi Wu Quanlong Jiang Hao Cheng Jing-Dong J. Han Ye-Guang Chen | 2018 | Journal of Molecular Cell Biology2018，10，1： | 3 |
| 7 | Multicomponent transition metal oxides and(oxy)hydroxides for oxygen evolution显示文摘Oxygen evolution reaction(OER)is the core electrode reaction in energy-related technologies,such as electrolytic water,electrocatalytic carbon dioxide reduction,rechargeable metal-air batteries,and renewable fuel cells.Development of well-stocked,cost-effective,and high-performance OER electrocatalysts is the key to the improvement of energy efficiency and the large-scale commercial implementation of these technologies.Multicomponent transition metal oxides and(oxy)hydroxides are the most promising OER catalysts due to their low cost,adjustable structure,high electrocatalytic activity,and outstanding durability.In this review,a brief overview about the mechanisms of OER is first offered,accompanied with the theory and calculation criteria.Then,the latest advances in the rational design of the related OER electrocatalysts and the modulation of the electronic structure of active sites are comprehensively summarized.Specifically,various strategies(including element doping,defect engineering,and fabrication of binderless catalysts)used to improve the OER performance are detailedly discussed,emphasizing the structure–function relationships.Finally,the challenges and perspectives on this promising field are proposed. | Jingyi Han Jingqi Guan | 2023 | Nano Research2023，16，2： | 2 |
| 8 | A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2显示文摘 | Yan Wang Jingyi Ma Sheung Ching Chow Chi Han Li Zhangang Xiao Ru Feng Jie Fu Yangchao Chen | 2014 | Tumor Biology2014，，1： | 1 |
| 9 | Hexachloro-benzene sources,levels and human exposure in the environment of Chi-na显示文摘 | GUANG WANG YONGLONG LU JINGYI HAN | 2010 | Environment international2010，36，1： | 1 |
| 10 | Multivariate Analysis of Interactions Between Phytoplankton Biomass and Environmental Variables in Taihu Lake, China显示文摘 | Xiaolong Wang Yonglong Lu Guizhen He Jingyi Han Tieyu Wang | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 1 |
| 11 | Climate Warming Mitigation from Nationally Determined Contributions显示文摘Individual countries are requested to submit nationally determined contributions(NDCs)to alleviate global warming in the Paris Agreement.However,the global climate effects and regional contributions are not explicitly considered in the countries’decision-making process.In this study,we evaluate the global temperature slowdown of the NDC scenario(ΔT=0.6°C)and attribute the global temperature slowdown to certain regions of the world with a compact earth system model.Considering reductions in CO_(2),CH_(4),N_(2)O,BC,and SO_(2),the R5OECD(the Organization for Economic Co-operation and Development in 1990)and R5ASIA(Asian countries)are the top two contributors to global warming mitigation,accounting for 39.3%and 36.8%,respectively.R5LAM(Latin America and the Caribbean)and R5MAF(the Middle East and Africa)followed behind,with contributions of 11.5%and 8.9%,respectively.The remaining 3.5%is attributed to R5REF(the Reforming Economies).Carbon Dioxide emission reduction is the decisive factor of regional contributions,but not the only one.Other greenhouse gases are also important,especially for R5MAF.The contribution of short-lived aerosols is small but significant,notably SO_(2)reduction in R5ASIA.We argue that additional species beyond CO_(2)need to be considered,including short-lived pollutants,when planning a route to mitigate climate change.It needs to be emphasized that there is still a gap to achieve the Paris Agreement 2-degree target with current NDC efforts,let alone the ambitious 1.5-degree target.All countries need to pursue stricter reduction policies for a more sustainable world. | Bo FU Jingyi LI Thomas GASSER Philippe CIAIS Shilong PIAO Shu TAO Guofeng SHEN Yuqin LAI Luchao HAN Bengang LI | 2022 | Advances in Atmospheric Sciences2022，39，8： | 1 |
| 12 | Hexachlorobenzene sources, levels and human exposure in the environment of China 显示文摘 | WANG Guang LU Yonglong HAN Jingyi | 2010 | Environment International2010，36，1： | 1 |
| 13 | Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer显示文摘γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens,making them attractive candidates for CAR-T-cell therapy.Unlike aβT cells and other immune cells,γδ T cells are superior in MHC non-restriction,selective cell recruitment,and rapid activation.However,clinical trials have shown limited clinical benefits,and the adoptive transplantation of γδ T cells has often fallen short of expectations.We hypothesized that the limited effectiveness of γδ T cells in eradicating tumor cells may be attributed to the inhibitory tumor microenvironment induced by the suppressive PD-1/PD-L1 axis.Herein,we constructed novel armored γδ T cells capable of secreting humanized anti-PD-1 antibodies,referred to as'Lv-PD1-ys T cells.Lv-PD1-γδ T cells showed improved proliferation and enhanced cytotoxicity against tumor cells,resulting in augmented therapeutic effects and survival benefits in ovarian tumor-bearing mice.These engineered cells demonstrated a prolonged in vivo survival of more than 29 days,without any potential for tumorigenicity in immunodeficient NOD/SCID/null mice.We also found that Lv-PD1-γδ T cells exhibited excellent tolerance and safety in humanized NOD/SCID/null mice.With attenuated or eliminated immunosuppression and maximized cytotoxicity efficacy by the local secretion of anti-PD1 antibodies in tumors,Lv-PD1-γδ T cells can serve as a promising'off-the-shelf'cell therapy against cancers. | Yue Wang Jingyi Han Dongdong Wang Menghua Cai Yi Xu Yu Hu Hui Chen Wei He Jianmin Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 14 | Diatomic Fe-Co catalysts synergistically catalyze oxygen evolution reaction显示文摘The design of diatomic catalysts with uniformly dispersed metal atoms is expected to improve catalytic performance,which is conducive to the intensive comprehending of the synergistic mechanism between dual-metal sites for the oxygen evolution reaction(OER)at the atomic level.Herein,we design a strategy to immobilize bimetallic Fe-Co atoms onto nitrogen-doped graphene to obtain a diatomic catalyst(DA-FC-NG)with FeN_(3)-CoN_(3) configuration.The DA-FC-NG shows excellent OER activity with a low overpotential(η_(10)=268 mV),which is superior to commercial iridium dioxide catalysts.Theoretical calculations uncover that the excellent activity of DA-FC-NG is due to the interaction between Fe and Co diatoms,which causes charge rearrangement and induces the adsorption of intermediates on the Fe-O-Co bridge structure,thus improving the catalytic OER performance.This work is of great significance for the design of highly active diatomic catalysts to replace noble metal catalysts for energy-related applications. | Tianmi Tang Jingyi Han Zhenlu Wang Xiaodi Niu Jingqi Guan | 2024 | Nano Research2024，17，5： | 0 |
| 15 | Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue using Deep Learning显示文摘The immunohistochemical(IHC)staining of the human epidermal growth factor receptor 2(HER2)biomarker is widely practiced in breast tissue analysis,preclinical studies,and diagnostic decisions,guiding cancer treatment and investigation of pathogenesis.HER2 staining demands laborious tissue treatment and chemical processing performed by a histotechnologist,which typically takes one day to prepare in a laboratory,increasing analysis time and associated costs.Here,we describe a deep learning-based virtual HER2 IHC staining method using a conditional generative adversarial network that is trained to rapidly transform autofluorescence microscopic images of unlabeled/label-free breast tissue sections into bright-field equivalent microscopic images,matching the standard HER2 IHC staining that is chemically performed on the same tissue sections.The efficacy of this virtual HER2 staining framework was demonstrated by quantitative analysis,in which three board-certified breast pathologists blindly graded the HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images(WSIs)to reveal that the HER2 scores determined by inspecting virtual IHC images are as accurate as their immunohistochemically stained counterparts.A second quantitative blinded study performed by the same diagnosticians further revealed that the virtually stained HER2 images exhibit a comparable staining quality in the level of nuclear detail,membrane clearness,and absence of staining artifacts with respect to their immunohistochemically stained counterparts.This virtual HER2 staining framework bypasses the costly,laborious,and time-consuming IHC staining procedures in laboratory and can be extended to other types of biomarkers to accelerate the IHC tissue staining used in life sciences and biomedical workflow. | Bijie Bai Hongda Wang Yuzhu Li Kevin de Haan Francesco Colonnese Yujie Wan Jingyi Zuo Ngan B.Doan Xiaoran Zhang Yijie Zhang Jingxi Li Xilin Yang Wenjie Dong Morgan Angus Darrow Elham Kamangar Han Sung Lee Yair Rivenson Aydogan Ozcan | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 16 | Interface engineering of Fe-Sn-Co sulfide/oxyhydroxide heterostructural electrocatalyst for synergistic water splitting显示文摘To realize large-scale hydrogen production by electrolysis of water,it is essential to develop non-precious metal catalysts for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).Here,we fabricate Sn-,Fe-,and Co-based sulfide/oxyhydroxide heterostructural catalyst on nickel foam(FeSnCo_(0.2)S_(x)O_(y)/NF)by solvothermal method.The FeSnCo_(0.2)S_(x)O_(y)/NF requires low overpotentials of 48 and 186 mV at 10 mA·cm^(-2),respectively,for HER and OER.When it is assembled into an electrolytic cell as a bifunctional electrocatalyst,it only needs 1.54 V to reach 10 mA·cm^(-2),far better than IrO_(2)||Pt/C electrolyzer.The formation of sulfide/hydroxide heterostructural interfaces improves the electron transfer and reduces the reaction energy barrier,thus promoting the electrocatalytic processes. | Siyu Chen Ting Zhang Jingyi Han Hui Qi Shihui Jiao Changmin Hou Jingqi Guan | 2024 | Nano Research Energy2024，3，2： | 0 |
| 17 | Air Pollution Health Impact Monitoring and Health Risk Assessment Technology and Its Application-China,2006-2019显示文摘Air pollution is a significant risk factor contributing to the burden of disease in China.Health risk assessment and management are important to reduce the impact of air pollution on public health.To help formulate standardized health risk assessment techniques,a series of studies were conducted from 2006 to 2019.Through systematic review,study of molecular mechanisms,epidemiological investigation,and health effect monitoring,the overall project established a monitoring and evaluation indicator system,a comprehensive information platform,software for automatic data cleaning,and standardized health risk assessment techniques.Technical specifications have been issued by the National Health Commission for promoting health risk assessments across China.This paper introduces the project,the research approach,its main research accomplishments,innovations,and public health significance,and describes directions for further research. | Jingxiu Han Dongqun Xu Donggang Xu Xu Yang Qin Wang Mingqing Chen Wenrong Xia Weiwei Xing Chunyu Xu Yue Liu Junrui Chang Wenliang Fu Shuxin Hao Na Li Xiaoyan Dong Yunpu Li Congshen Meng Jingyi Liu | 2022 | China CDC weekly2022，4，26： | 0 |
| 18 | First Technical Specifications for Health Risk Assessment of Ambient Air Pollution in China显示文摘The Global Burden of Disease study showed that air pollution is the fourth risk factor for attributable deaths(1)and a major public health problem in China.Therefore,the Chinese government has taken a series of measures to control air pollution.However,the attributable disease burden of air pollution can be effectively reduced only by integrating health into air pollution control policies.Health risk assessment comprehensively considered the impact of atmospheric pollution levels,pollutant toxicity,exposure-response coefficients,and the characteristics of exposed population.It may provide a scientific basis for formulating policies for air pollution prevention and control,revising standards of ambient air quality,and putting forward targeted measures for public health protection. | Jingxiu Han Junrui Chang Jingyi Liu Congshen Meng Dongqun Xu | 2021 | China CDC weekly2021，3，33： | 0 |
| 19 | The d-orbital regulation of isolated manganese sites for enhanced oxygen evolution显示文摘Developing transition metal-nitrogen-carbon materials(M-N-C)as electrocatalysts for the oxygen evolution reaction(OER)is significant for low-cost energy conversion systems.Further d-orbital adjustment of M center in M-N-C is beneficial to the improvement of OER performance.Herein,we synthesize a single-Mn-atom catalyst based on carbon skeleton(Mn_(1)-N_(2)S_(2)C_(x))with isolated Mn-N_(2)S_(2)sites,which exhibits high alkaline OER activity(η10=280 mV),low Tafel slope(44 mV·dec^(−1)),and excellent stability.Theoretical calculations reveal the pivotal function of isolated Mn-N_(2)S_(2)sites in promoting OER,including the adsorption kinetics of intermediates and activation mechanism of active sites.The doping of S causes the increase in both charge density and work function of active Mn center,and ortho-Mn_(1)-N_(2)S_(2)C_(x)expresses the fastest OER kinetics due to the asymmetric plane. | Xue Bai Jingyi Han Xiaodi Niu Jingqi Guan | 2023 | Nano Research2023，16，8： | 0 |
| 20 | Surface reconstruction and structural transformation of twodimensional Ni-Fe MOFs for oxygen evolution in seawater media显示文摘As a four-electron transfer reaction,oxygen evolution reaction(OER)is limited by large overpotential and slow kinetics.Here,we in-situ synthesized two-dimensional(2D)Ni-Fe metal-organic framework nanosheets on nickel foam(NixFe-TPA/NF,TPA=terephthalic acid)for oxygen evolution in alkaline and alkaline seawater electrolytes.In 1 M KOH,Ni3Fe-TPA/NF shows a low overpotential(η10)of 189 mV at 10 mA·cm^(-2) and an ultra-low overpotential of only 260 mV at 500 mA·cm^(-2).In alkaline seawater,Ni3Fe-TPA/NF still provides impressive OER performance,with anη10 of 265 mV.In-situ Raman characterization results show that the phase transition occurs during the OER,and Ni3FeOOH with more oxygen vacancies is in-situ formed,reducing the OER energy barrier.Density functional theory(DFT)reveals that the synergy between Ni and Fe reduces the energy barrier and accelerates the rate-determining step.In addition,the ultra-thin 2D sheet structure and the close combination of Ni3FeOOH and highly conductive NF support ensure the high catalytic OER activity.Therefore,the surface reconstruction and structural modification strategy can be used to design and prepare high-performance OER electrocatalysts for energy-related applications. | Liyuan Xiao Xue Bai Jingyi Han Tianmi Tang Siyu Chen Hui Qi Changmin Hou Fuquan Bai Zhenlu Wang Jingqi Guan | 2024 | Nano Research2024，17，4： | 0 |
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