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| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | Alterations of the Ca2+ signaling pathway in pancreatic beta-cells isolated from db/db mice显示文摘 | Kuo Liang Wen Du Jingze Lu Fei Li Lu Yang Yanhong Xue Bertil Hille Liangyi Chen | 2014 | Protein & Cell2014，5，10： | 2 |
| 3 | hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells显示文摘 | Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma Jingze Lu Tao Xu Junjie Hou Eli Song | 2018 | Protein & Cell2018，9，10： | 2 |
| 4 | HID-1 is a peripheral membrane protein primarily associated with the medial-and transGolgi apparatus显示文摘Caenorhabditis elegans hid-1 gene was first identified in a screen for mutants with a high-temperature-induced dauer formation(Hid)phenotype.Despite the fact that the hid-1 gene encodes a novel protein(HID-1)which is highly conserved from Caenorhabditis elegans to mammals,the domain structure,subcellular localization,and exact function of HID-1 remain unknown.Previous studies and various bioinformatic softwares predicted that HID-1 contained many transmembrane domains but no known functional domain.In this study,we revealed that mammalian HID-1 localized to the medial-and transGolgi apparatus as well as the cytosol,and the localization was sensitive to brefeldin A treatment.Next,we demonstrated that HID-1 was a peripheral membrane protein and dynamically shuttled between the Golgi apparatus and the cytosol.Finally,we verified that a conserved N-terminal myristoylation site was required for HID-1 binding to the Golgi apparatus.We propose that HID-1 is probably involved in the intracellular trafficking within the Golgi region. | Lifen Wang Yi Zhan Eli Song Yong Yu Yaming Jiu Wen Du Jingze Lu Pingsheng Liu Pingyong Xu Tao Xu | 2011 | Protein & Cell2011，2，1： | 1 |
| 5 | A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese显示文摘The human face is a heritable surface with many complex sensory organs.In recent years,many genetic loci associated with facial features have been reported in different populations,yet there is a lack of studies on the Han Chinese population.Here,we report a genome-wide association study of 3D normal human faces of 2,659 Han Chinese with autosegment phenotypes of facial morphology.We identify singlenucleotide polymorphisms(SNPs)encompassing four genomic regions showing significant associations with different facial regions,including SNPs in DENND1 B associated with the chin,SNPs among PISRT1 associated with eyes,SNPs between DCHS2 and SFRP2 associated with the nose,and SNPs in VPS13 B associated with the nose.We replicate 24 SNPs from previously reported genetic loci in different populations,whose candidate genes are DCHS2,SUPT3 H,HOXD1,SOX9,PAX3,and EDAR.These results provide a more comprehensive understanding of the genetic basis of variation in human facial morphology. | Yin Huang Dan Li Lu Qiao Yu Liu Qianqian Peng Sijie Wu Manfei Zhang Yajun Yang Jingze Tan Shuhua Xu Li Jin Sijia Wang Kun Tang Stefan Grunewald | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
| 6 | Genetic evidence supports demic diffusion of Han culture显示文摘 | LI Hui LU Daru SONG Xiufeng ZHANG Feng HE Yungang LI Feng GAO Yang MAO Xianyun ZHANG Liang QIAN Ji TAN Jingze JIN Jianzhong HUANG Wei DEKA Ranjan SU Bing CHAKRABORTY Ranajit JIN Li | | NATURE0，2004，： | 1 |
| 7 | Effects of urea-N and CO_(2) coupling fertilization on the growth,photosynthesis,yield and anthocyanin content of hydroponic purple cabbage Brassica campestris ssp.chinensis显示文摘Water and fertilizer coupling is a high-efficiency technology for the development of facility agriculture.However,the interaction effect of nitrogen(N)and air carbon dioxide(CO_(2))on hydroponic purple cabbage,especially on its leaf anthocyanins under hydroponic solution systems,remains unexplored.In this study,six treatments were set as C0N0,C0N2,C0N4,C1N0,C1N2 and C1N4,with N0,N2 and N4 being 0.0 g/L,0.2 g/L and 0.4 g/L exogenous urea-N to hydroponic solution dilution,respectively.C0 and C1 were set as with and without CO_(2)fertilizer(i.e.,800 g CO_(2)agent added one week after transplanting and 600 g CO_(2)agent added when the plant reached 15 cm in height),respectively.Pot experiments were conducted to investigate the interaction effect of N and air CO_(2)(N×CO_(2))on the growth,photosynthesis,yield and anthocyanin content of hydroponic purple cabbage Brassica campestris ssp.chinensis.The results showed N×CO_(2)extremely significantly influenced plant height(H),net photosynthetic rate(Pn),stomatal conductance(Gs),intercellular oxidation concentration(Ci),transpiration rate(Tr),leaf water use efficiency(LWUE)and yield.The C1N0 treatment had the largest yield at 262.5 g/plant,with higher values for root length,root weight,plant height and leaf number than the other treatments.The Pn,Ci and Tr of C1N4 were the highest at 3.05μmol CO_(2)/m2·s,352.8μmol CO_(2)/m2·s and 2.31 mmol H2O/m2·s,respectively.The C1N2 treatment received the largest Gs value of 0.70 mol H2O/m2·s and the largest Tr of 2.31 mmol H2O/m2·s.There was the highest LWUE for C0N2(1.41)and the highest anthocyanin content for C1N2(1.35 mg/kg).There was a significant negative correlation between leaf number and anthocyanin(r=-0.414,p<0.05).The findings demonstrated that adding CO_(2)fertilizer and 0.2 g/L exogenous urea-N to hydroponic solution dilution is a potential N×CO_(2)coupling strategy to increase anthocyanin and the yield of purple cabbage. | Danyan Chen Yuanyuan Feng Ya Liu Juan Hu Shilong Li Jingze Ma Xinyu Lu Xiaorui Jiang Shuhui Sun Zhi Yang Changyi Wang | 2023 | International Journal of Agricultural and Biological Engineering2023，16，5： | 0 |
| 8 | Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells显示文摘Although bulk endocytosis has been found in a number of neuronal and endocrine cells,the molecular mechanism and physiological function of bulk endocytosis remain elusive.In pancreatic beta cells,we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization.Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca^(2+) entry and suppressed by the inhibition of dynamin function.Moreover,defects in bulklike endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice,which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability. | Du Wen Yanhong Xue Kuo Liang Tianyi Yuan Jingze Lu Wei Zhao Tao Xu Liangyi Chen | 2012 | Protein & Cell2012，3，8： | 0 |
| 9 | I-BAR protein IRSp53 regulates clathrin-independent endocytosis in a biphasic manner显示文摘Endocytosis is a fundamental cellular activity that plays crucial roles in a variety of biological processes,including nutrient uptake,signal transduction,immune response,morphogenesis,neurotransmission,cell migration and tissue development[1–3].Endocytosis has been classified into two subtypes:the | Xinyu Zhu Xiaojun Xu Kang Du Jingze Lu Eli Song | 2018 | Science Bulletin2018，63，3： | 0 |
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