|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 3 | Study on biodegradable polymer materials based on poly(lactic acid)显示文摘 | Wei Zhong Ge Jinjie Gu Zhenyu | 1999 | Journal of Applied Polymer Science1999，74，16： | 1 |
| 4 | A Brain-Spleen Axis Regulates Humoral Immunity显示文摘A happy mood helps to build a flourishing immune system.Interactions between the nervous and immune systems have attracted the interest of researchers for decades.It is well known that external stressors can activate the hypothalamus to regulate immune responses via the hypothalamic-pituitary-adrenal cortex(HPA)axis[1].As well,inflammatory stimuli can activate a rapid antiinflammatory reflex via the cholinergic vagus nerve pathway. | Bin Zhang Jinjie Zhong Zhihua Gao | 2021 | Neuroscience Bulletin2021，37，3： | 1 |
| 5 | A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated silicon nanowire arrays显示文摘 | Jinjie Yin Xiang Qi Liwen Yang Guolin Hao Jun Li Jianxin Zhong | 2011 | Electrochimica Acta2011，，11： | 1 |
| 6 | Study on biodegradable polymer materials based on poly(lactic acid)显示文摘 | Zhong Wei Ge Jinjie Gu Zhenyu | 1999 | Journal of Applied Polymer Science1999，74，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员