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| 1 | A novel fault tolerant permanent magnet synchronous motor with improved optimal torque control for aerospace application显示文摘Improving fault tolerant performance of permanent magnet synchronous motor has always been the central issue of the electrically supplied actuator for aerospace application. In this paper, a novel fault tolerant permanent magnet synchronous motor is proposed, which is characterized by two stators and two rotors on the same shaft with a circumferential displacement of mechanical angle of 4.5. It helps to reduce the cogging torque. Each segment of the stator and the rotor can be considered as an 8-pole/10-slot five-phase permanent magnet synchronous motor with concentrated, single-layer and alternate teeth wound winding, which enhance the fault isolation capacity of the motor. Furthermore, the motor has high phase inductance to restrain the short-circuit current. In addition, an improved optimal torque control strategy is proposed to make the motor work well under the open-circuit fault and short-circuit fault conditions. Simulation and experiment results show that the proposed fault tolerant motor system has excellent fault tolerant capacity, which is able to operate continuously under the third open-circuit fault and second shortcircuit fault condition without system performance degradation, which was not available earlier. | Guo Hong Xu Jinquan Kuang Xiaolin | 2015 | Chinese Journal of Aeronautics2015，28，2： | 16 |
| 2 | Fault tolerant control with torque limitation based on fault mode for ten-phase permanent magnet synchronous motor显示文摘This paper proposes a novel fault tolerant control with torque limitation based on the fault mode for the ten-phase permanent magnet synchronous motor(PMSM) under various open-circuit and short-circuit fault conditions, which includes the optimal torque control and the torque limitation control based on the fault mode. The optimal torque control is adopted to guarantee the ripple-free electromagnetic torque operation for the ten-phase motor system under the post-fault condition. Furthermore, we systematically analyze the load capacity of the ten-phase motor system under different fault modes. And a torque limitation control approach based on the fault mode is proposed, which was not available earlier. This approach is able to ensure the safety operation of the faulted motor system in long operating time without causing the overheat fault. The simulation result confirms that the proposed fault tolerant control for the ten-phase motor system is able to guarantee the ripple-free electromagnetic torque and the safety operation in long operating time under the normal and fault conditions. | Guo Hong Xu Jinquan | 2015 | Chinese Journal of Aeronautics2015，28，5： | 4 |
| 3 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 4 | Guaranteeing the Fault Transient Performance of Aerospace Multiphase Permanent Magnet Motor System: an Adaptive Robust Speed Control Approach显示文摘To enhance the fault transient performance of aerospace multiphase permanent magnet synchronous motor(PMSM)system,an adaptive robust speed control is proposed regardless of the phase open-circuit(OC)and short-circuit(SC)fault in this paper,which can be applied for both the redundant motor system and fault tolerant motor system.For aerospace multiphase PMSM system,besides external load disturbance and system parameter perturbation,there inevitably exists the electromagnetic torque ripple in fault transient process,which can degrade the system performance and even cause the system instability.To cope with this issue,the electromagnet torque ripple of the multiphase PMSM system in fault transient process is first analyzed.Then,by considering the electromagnet torque fluctuation caused by fault transient as a system uncertainty,a novel adaptive robust speed control scheme is proposed,while the adaptive law is constructed to emulate the total system uncertainty bound,which include the load disturbance,the parameter variation,and the electromagnetic torque fluctuation due to fault transient.The resulting control can ensure the speed control performance even in fault transient process regardless of the uncertainty,in which no prior estimation of the uncertainty bound is required.In addition,the proposed adaptive robust speed control is demonstrated by a six-phase PMSM experimental platform.The novelty of this research is to explore a novel adaptive robust speed control to strengthen the fault tolerance performance of multiphase PMSM system even in fault transient process,which requires no prior estimation of the uncertainty bound. | Jinquan Xu Boyi Zhang Hao Fang Hong Guo | 2020 | CES Transactions on Electrical Machines and Systems2020，4，2： | 2 |
| 5 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity显示文摘Triple-negative breast cancer(TNBC)is the most challenging subtype of breast cancer.Various endeavor has been made to explore the molecular biology basis of TNBC.Herein,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in TNBC.KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor prognosis.In functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and invasiveness.RNA-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further experiments.CXCL8 depletion inhibited the tumorigenesis and progression of TNBC.Additionally,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in vivo.Furthermore,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of cells.Moreover,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 protein.Taken together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and progression.KTN1 may be a potential molecular target for the development of TNBC treatment. | Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 6 | Syphilis screening andintervention in 500 000 pregnant women in Shenzhen, the People,sRepublic of China显示文摘 | Cheng Jinquan Zhou Hua Hong Fuchang | 2007 | Sex Transm Infect2007，83，5： | 1 |
| 7 | Plasmon-enhanced broad-band quantum-cutting of NaBaPO4:Eu^2+,Er^3+phosphors with silver nano-particles显示文摘NaBaPO4:Eu^2+,Er^3+phosphors and Ag nano-particles(NPs)were prepared by the solid-state reaction and chemical reduction method,respectively.The fluorescence spectra and decay curves demonstrate the effective energy transfer from Eu^2+to Er^3+and the existence of three-photon quantum-cutting through two-step cross-relaxation of Er^3+.The quantum-cutting emission is peaked at 1534 nm with a broad excitation band centered at 352 nm,Plasmon-enhanced quantum-cutting of NaBaPO4:Eu^2+,Er^3+phosphors was realized by decorating Ag NPs.The largest enhancement factor is 1.395.It is hopeful to improve the photovoltaic conversion efficiency of Ge solar cells by using this phosphor. | Jinquan Hong Lin Lin Xiaoyan Li Zhuohong Feng Lili Huang Qing Qin Zhiqiang Zheng | 2020 | Journal of Rare Earths2020，38，11： | 1 |
| 8 | Dynamic neighborhood genetic learning particle swarm optimization for high-power-density electric propulsion motor显示文摘To maximize the power density of the electric propulsion motor in aerospace application,this paper proposes a novel Dynamic Neighborhood Genetic Learning Particle Swarm Optimization(DNGL-PSO)for the motor design,which can deal with the insufficient population diversity and non-global optimal solution issues.The DNGL-PSO framework is composed of the dynamic neighborhood module and the particle update module.To improve the population diversity,the dynamic neighborhood strategy is first proposed,which combines the local neighborhood exemplar generation mechanism and the shuffling mechanism.The local neighborhood exemplar generation mechanism enlarges the search range of the algorithm in the solution space,thus obtaining highquality exemplars.Meanwhile,when the global optimal solution cannot update its fitness value,the shuffling mechanism module is triggered to dynamically change the local neighborhood members.The roulette wheel selection operator is introduced into the shuffling mechanism to ensure that particles with larger fitness value are selected with a higher probability and remain in the local neighborhood.Then,the global learning based particle update approach is proposed,which can achieve a good balance between the expansion of the search range in the early stage and the acceleration of local convergence in the later stage.Finally,the optimization design of the electric propulsion motor is conducted to verify the effectiveness of the proposed DNGL-PSO.The simulation results show that the proposed DNGL-PSO has excellent adaptability,optimization efficiency and global optimization capability,while the optimized electric propulsion motor has a high power density of 5.207 kW/kg with the efficiency of 96.12%. | Jinquan XU Huapeng LIN Hong GUO | 2022 | Chinese Journal of Aeronautics2022，35，12： | 1 |
| 9 | Research on a six-phase permanent magnet synchronous motor system at dual-redundant and fault tolerant modes in aviation application显示文摘With the development of more/all electrical aircraft technology, an electro-mechanical actuator(EMA) is more and more used in an aircraft actuation system. The motor system, as the crucial part of an EMA, usually adopts the redundancy technology or fault tolerance technology to improve the reliability. To compare the performances of these two motor systems, a 10-pole/12-slot six-phase permanent magnet synchronous motor(PMSM) is designed with the concentrated single-layer winding, which is able to operate at dual-redundant and fault tolerant modes.Furthermore, the position servo performances of the six-phase PMSM at dual-redundant and fault tolerant modes are analyzed, including the normal and fault conditions. In addition, a variable structure proportional-integral-derivative(PID) control strategy is proposed to solve the performance degradation problem caused by phase current saturation. Simulation and experimental results show that the fault tolerant PMSM has a better position servo performance than the dual-redundant PMSM, and the variable structure PID control strategy is able to improve the performance due to phase current saturation. | Xiaolin KUANG Hong GUO Jinquan XU Tong ZHOU | 2017 | Chinese Journal of Aeronautics2017，30，4： | 1 |
| 10 | Modeling and analysis of oil frictional loss in wet-type permanent magnet synchronous motor for aerospace electro-hydrostatic actuator显示文摘To improve the power density and simplify the seal structure,the Wet-Type Permanent Magnet Synchronous Motor(WTPMSM)technique has been applied to aerospace Electro-Hydrostatic Actuators(EHA).In a WTPMSM,the stator and the rotor are both immersed in the aviation hydraulic oil.Although the heat dissipation performance of the WTPMSM can be enhanced,the aviation hydraulic oil will cost an extra oil frictional loss in the narrow airgap of the WTPMSM.This paper proposes an accurate oil frictional loss model for the WTPMSM,in which the wide speed range(0–20 kr/min)and the narrowness of the airgap(0.5–1.5 mm)are its features.Firstly,the mechanism of the oil frictional loss in the airgap of the WTPMSM is revealed.Then an accurate oil frictional loss model is proposed considering the nonlinear influence caused by the Taylor vortex.Furthermore,the influence of motor dimensions on oil frictional loss is analyzed.Finally,the proposed oil frictional loss model is verified by experiments,which provides a guideline for engineers to follow in the WTPMSM design. | Jinquan XU Wenbo JIN Hong GUO Tian YU Wenhu FAN Zongxia JIAO | 2023 | Chinese Journal of Aeronautics2023，36，11： | 0 |
| 11 | Design and analysis of a novel hybrid cooling method of high-speed high-power permanent magnet assisted synchronous reluctance starter/generator in aviation applications显示文摘To improve the heat dissipation performance,this paper proposes a novel hybrid cooling method for high-speed high-power Permanent Magnet assisted Synchronous Reluctance Starter/Generator(PMa Syn R S/G)in aerospace applications.The hybrid cooling structure with oil circulation in the housing,oil spray at winding ends and rotor end surface is firstly proposed for the PMa Syn R S/G.Then the accurate loss calculation of the PMa Syn R S/G is proposed,which includes air gap friction loss under oil spray cooling,copper loss,stator and rotor core loss,permanent magnet eddy current loss and bearing loss.The parameter sensitivity analysis of the hybrid cooling structure is proposed,while the equivalent thermal network model of the PMa Syn R S/G is established considering the uneven spraying at the winding ends.Finally,the effectiveness of the proposed hybrid cooling method is demonstrated on a 40 k W/24000 r/min PMa Syn R S/G experimental platform. | Hong GUO Xu HE Jinquan XU Wei TIAN Xiaofeng DING Laicai JU Dehong LI | 2023 | Chinese Journal of Aeronautics2023，36，3： | 0 |
| 12 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
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