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| 1 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 2 | Research on Pressure Tactile Sensing Technology Based on Fiber Bragg Grating Array显示文摘一个压力触觉的传感器基于纤维布拉格栅栏(FBG ) ,数组在这篇论文,和它的有弹性的身体的数字模拟被介绍被有限元素软件(ANSYS ) 实现。根据模拟,纤维布拉格栅栏绳在灵活硅酮被植入认识到传感器制造过程,并且一个严峻的系统被造。一系列刻度测试经由高精确被做通用出版社机器。触觉的传感器数组察觉了外部压力,它被纤维栅栏解调仪器使解调,并且三尺寸的图画被规划视觉上显示位置和尺寸。同时,传感器的一个动态接触实验为模仿在未知环境遇到另外的目标的机器人被进行。试验性的结果证明传感器有好线性,重覆性,并且有动态反应的好效果,并且它的压力敏感是 0.03 nm/N。另外,传感器也有反电磁的干扰的优点,好灵活性,简单结构,低等等花费,它被期望以后在便携人工的皮肤被过去常。 | Jinxue SONG Qi JIANG Yuanyang HUANG Yibin LI Yuxi JIA Xuewen RONG Rui SONG Hongbin LIU | 2015 | Photonic Sensors2015，5，3： | 8 |
| 3 | Electrospinning organic solvent resistant preoxidized poly(acrylonitrile)nanofiber membrane and its properties显示文摘A high performance preoxidized poly(acrylonitrile)(O-PAN)nanofiber membrane with excellent solvent resistance,thermal stability and flexibility was fabricated by the preoxidation of electrospun PAN nanofiber membrane.The performance of resultant O-PAN nanofiber membrane was optimized by altering the PAN concentration and preoxidation temperature.The results showed that the O-PAN nanofiber membrane which made from PAN concentration of 14%(mass)and preoxidation temperature of 250.0℃ have a more optimal comprehensive performance.In the long-term separation test of SiO2 particle(1 μm)in DMAc suspension,the permeate flux of O-PAN nanofiber membrane stabilized at 227.91 L·m^(-2)·h^(-1)(25℃,0.05 MPa)while the SiO2 rejection above 99.6%,which showed excellent solvent resistance and separation performance.In order to further explore the application of the O-PAN nanofiber membrane,the OPAN nanofiber membrane was treated with fluoride and used in oil/water separation process.The O-PAN nanofiber membrane after hydrophobic treatment showed excellent hydrophobicity and good oil/water separation performance with the permeate flux about 969.59 L·m^(-2)·h^(-1)while the separation efficiency above 96.1%.The O-PAN nanofiber membrane exhibited a potential application prospect in harsh environment separation. | Zhiwei Du Jinxue Cheng Qinglin Huang Mingxing Chen Changfa Xiao | 2023 | Chinese Journal of Chemical Engineering2023，53，1： | 1 |
| 4 | Highly sensitive humidity sensors based on hexagonal boron nitride nanosheets for contactless sensing显示文摘Humidity sensors with high sensitivity,rapid response,and facile fabrication process for contactless sensing applications have received considerable attention in recent years.Herein,humidity sensors based on hexagonal boron nitride(h-BN)nanosheets that are synthesized by a facile ultrasonic process have been fabricated,which display an ultrahigh sensitivity of 28,384%at 85%relative humidity(RH),rapid response/recovery time(3.0/5.5 s),and long-term stability in a wide humidity detection range(11%-85%RH),superior to most of the reported humidity sensors.The high sensitivity can be ascribed to the massive hydrophilic functional groups absorbed on the h-BN nanosheet surface.Benefiting from the high humidity sensing performances,contactless Morse code messaging and human writing and speech recognition have been demonstrated.This work demonstrates the great potential of the high-performance h-BN nanosheet-based humidity sensors for future contactless sensing devices. | Hang Liu Jinxu Qin Xigui Yang Chaofan Lv Wentao Huang Fukui Li Chuang Zhang Yanran Wu Lin Dong Chongxin Shan | 2023 | Nano Research2023，16，7： | 0 |
| 5 | Lentiviral-mediated siRNA against osteopotin in U251 glioma cell line显示文摘Background:It has been reported that the expression of SPP1, the mRNA for osteopontin (OPN), is increased in a number of transformed cell lines and some tumors. Increased serum and plasma OPN levels were associated with advanced-stage carcinomas of the lung, breast, colon and prostate. The extent of OPN expression may be correlated with the malignancy degree of gliomas, but the specific role of OPN in the malignancy of gliomas remains to be clarified. Methods:In this study, we used a lentiviral system, which could induce a long-lasting down-regulation of gene expression, to knock down the OPN gene in human glioma cell line U251. And then we observed the proliferation and apoptosis of glioma cells. Results:OPN mRNA and protein were successfully knocked down in U251 cells, and the expression of caspase-3 and caspase-9 were increased about by 2 folds in OPN down-regulated U251 cells. 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT) assay showed that OPN down-regulation did not affect the proliferation of U251 cells. Conclusion:Our findings indicate that OPN might play a role in apoptosis, but not in cell proliferation in U251 glioma cells. | Xu Tao Chen Juxiang Lu Yicheng Zhou Jinxu Yan Yong Hu Guohan Luo Chun Huang Yan | 2010 | Journal of Medical Colleges of PLA(China)2010，25，1： | 0 |
| 6 | Biologically inspired anthraquinone redox centers and biomass graphene for renewable colloidal gels toward ultrahigh-performance flexible micro-supercapacitors显示文摘Biomass carbon and small redox biomolecules are attractive materials for green,sustainable energy storage devices owing to their environmentally friendly,low-cost,scalable,and novel sources.However,most devices manufactured using these materials have low specific capacitance,poor cycle stability,short lifetime,complexity,and low precision of device fabrication.Herein,we report the directed self-assembly of mononuclear anthraquinone(MAQ)derivatives and porous lignin-based graphene oxide(PLGO)into a renewable colloidal gel through noncovalent interactions.These self-assembled gel electrode materials exhibited high capacitance(484.8 F g^(−1) at a current density of 1 A g^(−1))and could be further printed as flexible micro-supercapacitors(FMSCs)with arbitrary patterns and a relatively high resolution on specific substrates.The FMSCs exhibited excellent areal capacitance(43.6 mF cm^(−2)),energy and power densities(6.1μWh cm^(−2) and 50μW cm^(−2),respectively),and cycle stability(>10,000 cycles).Furthermore,the printed FMSCs and integrated FMSC arrays exhibited remarkable flexibility while maintaining a stable capacitance.The proposed approach can be applied to other quinone biomolecules and biomass-based carbon materials.This study provides a basis for fabricating green and sustainable energy storage device architectures with high capacitance,long-term cycling,high scalability,and high precision. | Tiansheng Wang Shunyou Hu Yuanyuan Hu Dong Wu Hao Wu Jinxu Huang Hao Wang Weiwei Zhao Wen Yu Mi Wang Jie Xu Jiaheng Zhang | 2023 | Journal of Materials Science & Technology2023，，20： | 0 |
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