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| 1 | ^(40)Ar/^(39)Ar Thermochronological Constraints on the Timing of Collisional Orogeny in the Mian-Lite Collision Belt,Southern Qinling Mountains显示文摘Silurian, Devonian and Carboniferous geological bodies in the Mianxian-Lueyang (Mian-Lue) collisional belt (MLB) and its neighbouring areas, southern Qinling Mountains, China, show similar characteristics of having undergone deformation of two stages. The earlier one, which is inferred to be related to collisional orogeny between the Yangtze and Sino-Korean palaeocontinents based on previous geological data, is responsible for large-scale, north-verging recumbent folds and overthrusts, and associated with low greenschist fades metamorphism. 40Ar/39Ar dating of three muscovite samples taken from different localities yields plateau ages of 226.9±0.9 and 219.5±1.4 Ma and an apparent age of 194.5±3.0 Ma. Thus, the late Triassic collision between the Yangtze and Sino-Korean palaeocontinents has been constrained. | LI Jinyi, WANG Zongqi and ZHAO Min Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037 | 1999 | Acta Geologica Sinica(English Edition)1999，73，2： | 23 |
| 2 | Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332显示文摘Dear Editor,Since December 2019,the pandemic of coronavirus disease 2019(COVID-19)has taken a heavy toll on global health,creating an urgent need to develop effective strategies for prevention and treatment.The etiological agent,known as severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected nearly 229.2 million people worldwide with more than 4.7 million deaths as of September 15,2021.Older age and preexisting health conditions are associated with worse clinical prognosis including higher mortality rates(Zhou et al.,2020).The global race to combat this pandemic has led to rapid deployment of numerous effective vaccines against SARS-CoV-2(Tregoning et al.,2021).However,the emergence of viral variants,including the Delta variant(B.1.617.2),compromised vaccine effectiveness with resurgence of SARS-CoV-2 infection among highly vaccinated population(Keehner et al.,2021).Therefore,development of therapeutics against the more conserved viral targets would be essential to contain the spread of COVID-19 and reduce mortality. | Yao Zhao Chao Fang Qi Zhang Ruxue Zhang Xiangbo Zhao Yinkai Duan Haofeng Wang Yan Zhu Lu Feng Jinyi Zhao Maolin Shao Xiuna Yang Leike Zhang Chao Peng Kailin Yang Dawei Ma Zihe Rao Haitao Yang | 2022 | Protein & Cell2022，13，9： | 6 |
| 3 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 4 | Wheat-RegNet:An encyclopedia of common wheat hierarchical regulatory networks显示文摘Dear Editor,Common wheat(Triticum aestivum,2n=6×=42,AABBDD)is the staple crop worldwide.Elucidating the gene regulatory network provides essential information for mechanism studies and targeted manipulation of gene activity for breeding.However,it is a challenging task given the extremely large(16 Gb)and complicated allohexaploid genome of common wheat.Integrating multi-omics data is a compelling approach to construct the hierarchical regulatory network. | Tengfei Tang Shilong Tian Haoyu Wang Xiaotong Lv Yilin Xie Jinyi Liu Meiyue Wang Fei Zhao Wenli Zhang Hao Li Yijing Zhang | 2023 | Molecular Plant2023，16，2： | 1 |
| 5 | Rapid and reliable detection of 11 food-borne pathogens using thin- film biosensor chips 显示文摘 | Bai Sulan Zhao Jinyi Zhang Yaochuan | 2010 | Applied Microbiology and Bio- technology2010，86，3： | 1 |
| 6 | BrΦnsted acid-promoted ‘on-water’ C(sp^3)-H functionalization fot the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction显示文摘The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules,which have showed broad and interesting biological activities.The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community.In this communication,we report an efficient BrΦnsted acid-promoted C(sp^3)-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine,2-formylbenzoic acid and various anilines.The title compounds were generated in high to excellent yields(up to 96%)regardless of the electronic nature and steric effects of the substituents.In this reaction,an isoindolinone scaffold,one C-C single bond,and two C-N bonds were formed simultaneously with high atom economy.In this work,we have envisioned that the methyl group linked to the electron-deficient Nheterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry.Besides,the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. | Shuo Yuan Sixi Wang Min Zhao Danqing Zhang Jinjie Chen Jian-Xin Li Jingya Zhang Yihui Song Jinyi Wang Bin Yu Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
| 7 | Hierarchical structures,surface morphology and mechanical elasticity of lamellar crystals dominated by halogen effects显示文摘To understand the deformation mechanism of molecular crystals under mechanical forces will accelerate the molecular design and preparation of deformable crystals.Herein,the relationship between structural halogenation and molecular-level stacking,micro/nanoscale surface morphology,and macroscopic mechanical properties are investigated.Elastic crystals of halo-pyrimidinyl carbazoles(CzM-Cl,CzM-Br and CzM-I)with lamellar structure and brittle crystal(CzM-F)were quantitatively analyzed by crystal energy framework(CEF)providing the inter/intralayer interaction energy(Inter/Intra-IE).It is revealed that the elastic crystals bend under external force as a result from stronger Intra-IE to prevent cleavage and weaker Inter-IE for the short-range movement of molecules on the slip plane.This research will provide an insight for the molecular design of flexible crystals and facilitate the development of next-generation smart crystal materials. | Chuanxin Wei Jianfeng Wang Yanni Zhang Xuehua Ding Yanze Jiang Qiang Zhao Jinyi Lin Jianfeng Zhao Linghai Xie Wei Huang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 8 | Erratum to:Forecasts on CMB lensing observations with AliCPT-1显示文摘One of the authors regrets that there was an omission of affiliation in this published article[1].The affiliation information of author Yi-WenWu only included the institution name for the author,and it is advised to add the university as the author’s second affiliation,which is the 16th affiliation of this article. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 9 | Optimization of CNC Turning Machining Parameters Based on Bp-DWMOPSO Algorithm显示文摘Cutting parameters have a significant impact on the machining effect.In order to reduce the machining time and improve the machining quality,this paper proposes an optimization algorithm based on Bp neural networkImproved Multi-Objective Particle Swarm(Bp-DWMOPSO).Firstly,this paper analyzes the existing problems in the traditional multi-objective particle swarm algorithm.Secondly,the Bp neural network model and the dynamic weight multi-objective particle swarm algorithm model are established.Finally,the Bp-DWMOPSO algorithm is designed based on the established models.In order to verify the effectiveness of the algorithm,this paper obtains the required data through equal probability orthogonal experiments on a typical Computer Numerical Control(CNC)turning machining case and uses the Bp-DWMOPSO algorithm for optimization.The experimental results show that the Cutting speed is 69.4 mm/min,the Feed speed is 0.05 mm/r,and the Depth of cut is 0.5 mm.The results show that the Bp-DWMOPSO algorithm can find the cutting parameters with a higher material removal rate and lower spindle load while ensuring the machining quality.This method provides a new idea for the optimization of turning machining parameters. | Jiang Li Jiutao Zhao Qinhui Liu Laizheng Zhu Jinyi Guo Weijiu Zhang | 2023 | Computers, Materials & Continua2023，77，10： | 0 |
| 10 | Clinical Diagnosis and Treatment Recommendations for Immune Checkpoint Inhibitor-Associated Myocarditis显示文摘Immune checkpoint inhibitors(ICIs)are often beneficial in the treatment of multiple types of malignant tumors.However,ICI-associated myocarditis has introduced new clinical challenges.This report highlights the key clinical issues of ICI-associated myocarditis,such as risk factors,diagnosis and differential diagnosis,clinical classification and treatment,monitoring of outcomes,and restart of treatment.Additionally,practical guidance and suggestions for the diagnosis and treatment of ICI-associated myocarditis are proposed with reference to the relevant consensuses or guidelines and newly published evidence-based studies in China and other countries in combination with clinical experience of physicians from Shanghai,China. | Yan WANG Huiyong CHEN Jinyi LIN Jiahui CHEN Yuhong ZHOU Yingmei ZHANG Hongwei ZHANG Wei ZHU Jie HU Gang ZHAO Xiangdong YANG Shisuo DU Xiaoyu LI Guoming SHI Jie CUI Wei WU Jing LI Chi ZHANG Cong WANG Rongle LIU Zheng LI Chunhui WANG Leilei CHENG Junbo GE | 2022 | Clinical Cancer Bulletin2022，1，3： | 0 |
| 11 | Forecasts on CMB lensing observations with AliCPT-1显示文摘Ali CPT-1 is the first Chinese cosmic microwave background(CMB) experiment aiming for the high-precision measurement of CMB B-mode polarization. The telescope, currently under deployment in Tibet, will observe in two frequency bands centered at 90 and 150 GHz. We forecast the CMB lensing reconstruction, lensing-galaxy, and lensing-cosmic infrared background(CIB) cross-correlation signal-to-noise ratio(SNR) for Ali CPT-1. We consider two stages with different integrated observation times, namely “4 module*yr”(first stage) and “48 module*yr”(final stage). For lensing reconstruction, we use three different quadratic estimators, namely temperature-only, polarization-only and minimum-variance(MV) estimators, using curved sky geometry. We take into account the impacts of inhomogeneous hit counts and mean-field bias due to incomplete sky coverage.In the first stage, our results show that the 150 GHz channel can measure the lensing signals at 15σ significance with the MV estimator. In the final stage, the measurement significance will increase to 31σ. We also combine the two frequency data in the harmonic domain to optimize the SNR. Our results show that the coadding procedure can significantly reduce the reconstruction bias in the high multiple range. Owning to the high quality of the polarization data in the final stage of Ali CPT-1, the EB estimator will dominate the lensing reconstruction in this stage. We also estimate the SNR of cross-correlations between Ali CPT-1 CMB lensing and other tracers of the large scale structure of the universe. For its cross-correlation with Dark Energy Spectroscopic Instrument(DESI) galaxies/quasars, we report the cross-correlation SNR = 10-20 for the four redshift bins at 0.05 < z < 2.1. In the first stage, the total SNR is approximately 32. In the final stage, the lensing-galaxy cross-correlation can reach SNR = 52. For lensing-CIB cross-correlation, in the first stage, the cross-correlations between Ali CPT-1 lensing and Planck CIB 353, 545 and857 GHz channels are approximately SNR = 18, 19, and 23, respectively. In the final stage, the cross-correlations can reach SNR = 25, 33 and 42. Due to the strong correlations between frequency bands, the total lensing-CIB cross-correlations by combining the three frequencies in Planck CIBs are SNR = 23 and 43 for the Ali CPT-1 first and final stages, respectively. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 0 |
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