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| 1 | Clinical application of a new device for minimally invasive circumcision显示文摘瞄准:与 phimosis 或过量包皮在不同年龄的男病人的治疗学习一台可处理的割礼设备的临床的效果。方法:在 5 和 95 年的年龄之间的 1200 个病人在在 2005 年 10 月和 2007 年 9 月之间的 2 年的时期用这个过程经历了割礼。这些盒子, 904 有过量包皮, 296 是 phimosis 的盒子。结果:在 96.33% 盒子中,切口愈合了,离开没有使好化妆结果留下疤痕并且生产的内部包皮的最小的数量。没有到系带的设备脱臼或损坏的事件。平均起作用的时间为 phimosis 是为过量包皮,和 3.5 min 的 2.5 min。在穿设备的 7 天期间,对中等浮肿温和与 phimosis 与过量包皮并且在那些的 2.58 % 发生在盒子的 10.08 % 。在系带的浮肿在 1.67% 病人被看见,并且仅仅, 0.67% 有切口的感染。86.25% 病人的一个总数由于阴茎勃起报导了疼痛。在设备的移动以后, 0.58% 案例有在切口附近的最小的流血,并且 2.42% 弯屈裂开。结论:新设备能与 phimosis 和过量包皮被用于病人的一个压到优势的多数。这种技术相对简单表现,并且经历了这个手术的病人有很少的复杂并发症。抗菌素没比用常规方法被割除的那些被要求,病人们报导了更少的疼痛。有这台设备的割礼要求最小的组织操作,并且比用常规技术的割礼更快、安全。 | Yi-Feng Peng Yue Cheng Guo-Yao Wang Suo-Qun Wang Chao Jia Ben-Hai Yang Ru Zhu Shu-Chuan Jian Qing-Wen Li Da-Wei Geng | 2008 | Asian Journal of Andrology2008，10，3： | 105 |
| 2 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 3 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 4 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 5 | Effect of vegetation on soil water retention and storage in a semi-arid alpine forest catchment显示文摘The runoff generated from mountainous regions is recognized as the main water source for inland river basins in arid environments. Thus, the mechanisms by which catchments retain water in soils are to be understood. The water storage capacity of soil depends on its depth and capacity to retain water under gravitational drainage and evapotranspiration. The latter can be studied through soil water retention curve (SWRC), which is closely related to soil properties such as texture, bulk density, porosity, soil organic carbon content, and so on. The present study represented SWRCs using HYDRUS-1D. In the present study, we measured physical and hydraulic properties of soil samples collected from Sabina przewalskii forest (south-facing slope with highest solar radiation), shrubs (west-facing slope with medium radiation), and Picea crassifolia forest (north-facing slope with lowest radiation), and analyzed the differences in soil water storage capacity of these soil samples. Soil water content of those three vegetation covers were also measured to validate the soil water storage capacity and to analyze the relationship between soil organic matter content and soil water content. Statistical analysis showed that different vegetation covers could lead to different soil bulk densities and differences in soil water retention on the three slope aspects. Sand content, porosity, and organic carbon content of the P. crassifolia forest were relatively greater compared with those of the S. przewalskii forest and shrubs. However, silt content and soil bulk density were relatively smaller than those in the S. przewalskii forest and shrubs. In addition, there was a significant linear positive relationship between averaged soil water content and soil organic matter content (P<0.0001). However, this relationship is not significant in the P. crassifolia forest. As depicted in the SWRCs, the water storage capacity of the soil was 39.14% and 37.38% higher in the P. crassifolia forest than in the S. przewalskii forest and shrubs, respectively, at a similar soil depth. | Chao WANG ChuanYan ZHAO ZhongLin XU Yang WANG HuanHua PENG | 2013 | Journal of Arid Land2013，5，2： | 25 |
| 6 | Single-photon computational 3D imaging at 45 km显示文摘Single-photon light detection and ranging(lidar)offers single-photon sensitivity and picosecond timing resolution,which is desirable for high-precision three-dimensional(3 D)imaging over long distances.Despite important progress,further extending the imaging range presents enormous challenges because only a few echo photons return and are mixed with strong noise.Here,we tackled these challenges by constructing a high-efficiency,low-noise coaxial single-photon lidar system and developing a long-range-tailored computational algorithm that provides high photon efficiency and good noise tolerance.Using this technique,we experimentally demonstrated active single-photon 3 D imaging at a distance of up to 45 km in an urban environment,with a low return-signal level of^1 photon per pixel.Our system is feasible for imaging at a few hundreds of kilometers by refining the setup,and thus represents a step towards low-power and high-resolution lidar over extra-long ranges. | ZHENG-PING LI XIN HUANG YUAN CAO BIN WANG YU-HUAI LI WEIJIE JIN CHAO YU JUN ZHANG QIANG ZHANG CHENG-ZHI PENG FEIHU XU AND JIAN-WEI PAN | 2020 | Photonics Research2020，8，9： | 24 |
| 7 | Impact of social isolation and resident intruder stress on aggressive behavior in the male rat显示文摘Stress studies frequently utilize physical stressors to establish animal models of stress.In the majority of cases,these models are not consistent with human circumstances.The present study simulated a social isolation plus resident intruder stress model in the rat.The rats were subjected to daily social isolation and resident intruder stress for 2 weeks.Behaviors were then tested.Rats subjected to social stress exhibited different aggressive behavior styles;some rats had greater scores on composite aggression behaviors,as well as locomotor and exploratory activity,but lower scores on latency than others.The high-aggressive group exhibited predominantly anger-out,while the low-aggressive group exhibited anger-in.Results suggest that social isolation plus resident intruder may serve as an appropriate model for anger-in and anger-out emotion modeling in the rat. | Sheng Wei Huiyun Zhang Jie Gao Ling Xue Peng Sun Yubin Chao Gang Xue Mingqi Qiao | 2010 | Neural Regeneration Research2010，5，15： | 23 |
| 8 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 9 | Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis显示文摘AIM: To investigate the cyclooxygenase-2 (COX-2)expression level in human HepG2, Bel-7402 and SMMC-7721hepatoma cell lines and the molecular mechanism of COX-2 selective inhibitor celecoxib-induced cell growth inhibition and cell apoptosis.METHODS: Hepatoma cells were cultured and treated with celecoxib. Cell in situ hybridization (ISH) and immunocytochemistry were used to detect COX-2 mRNA and protein expression. Proliferating cell nuclear antigen and phosphorylated Akt were also detected by immunocytochemistry assay. Cell growth rates were assessed by 3-(4, 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium (MTT) bromide colorimetric assay. Celecoxibinduced cell apoptosis was measured by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and flow cytometry (FCM). The phosphorylated Akt and activated fragments of caspase-9, caspase-3 were examined by Western blotting analysis.RESULTS: Increased COX-2 mRNA and protein expression were detected in all three hepatoma cell lines. Celecoxib could significantly inhibit cell growth and the inhibitory effect was in a dose- and time-dependent manner evidenced by MTr assays and morphological changes.The apoptotic index measured by TUNEL increased correspondingly with the increased concentration of celecoxib and the reaction time. With 50 μmol/L celecoxib treatment for 24 h, the apoptotic index of HepG2, BEL-7402and SMMC-7721 cells was 25.01±3.08%, 26.40±3.05%,and 30.60±2.89%, respectively. Western blotting analysis showed remarkable activation of caspase-9, caspase-3and dephosphorylation of Akt (Thr308). Immunocytochemistry also showed the reduction of PCNA expression and phosphorylation Akt (Thr308) after treatment with celecoxib.CONCLUSION: COX-2 mRNA and protein overexpression in HepG2, Bel-7402 and SMMC-7721 cell lines correlate with the increased cell growth rate. Celecoxib can inhibit proliferation and induce apoptosis of hepatoma cell strains in a dose- and time-dependent manner. | Ning-Bo Liu Tao Peng Chao Pan Yu-Yu Yao Bo Shen Jing Leng | 2005 | World Journal of Gastroenterology2005，11，40： | 20 |
| 10 | Subsoiling and Ridge Tillage Alleviate the High Temperature Stress in Spring Maize in the North China Plain显示文摘High temperature stress(HTS)on spring maize(Zea mays L.)during the filling stage is the key factor that limits the yield increase in the North China Plain(NCP).Subsoiling(SS)and ridge tillage(R)were introduced to enhance the ability of spring maize to resist HTS during the filling stage.The field experiments were conducted during the 2011 and 2012 maize growing seasons at Wuqiao County,Hebei Province,China.Compared with rotary tillage(RT),the net photosynthetic rate,stomatal conductance,transpiration rate,and chlorophyll relative content(SPAD)of maize leaves was increased by 40.0,42.6,12.8,and 29.7%under SS,and increased by 20.4,20.0,5.4,and 14.2%under R,repectively.However,the treatments reduce the intercellular CO2concentration under HTS.The SS and R treatments increased the relative water content(RWC)by 11.9 and6.2%,and the water use efficiency(WUE)by 24.3 and 14.3%,respectively,compared with RT.The SS treatment increased the root length density and soil moisture in the 0-80 cm soil profile,whereas the R treatment increased the root length density and soil moisture in the 0-40 cm soil profile compared with the RT treatment.Compared with 2011,the number of days with temperatures 33°C was more 2 d and the mean day temperature was higher 0.9°C than that in 2012,whereas the plant yield decreased by 2.5,8.5 and 10.9%,the net photosynthetic rate reduced by 7.5,10.5 and 18.0%,the RWC reduced by 3.9,5.6 and6.2%,and the WUE at leaf level reduced by 1.8,5.2 and 13.1%in the SS,R and RT treatments,respectively.Both the root length density and the soil moisture also decreased at different levels.The yield,photosynthetic rate,plant water status,root length density,and soil moisture under the SS and R treatments declined less than that under the RT treatment.The results indicated that SS and R can enhance the HTS resistance of spring maize during the filling stage,and led to higher yield by directly improving soil moisture and root growth and indirectly improving plant water status,photosynthesis and grain filling.The study can provide a theoretical basis for improving yield of maize by adjusting soil tillage in the NCP. | TAO Zhi-qiang SUI Peng CHEN Yuan-quan LI Chao NIE Zi-jin YUAN Shu-fen SHI Jiang-tao GAO Wang-sheng | 2013 | Journal of Integrative Agriculture2013，12，12： | 20 |
| 11 | A hybrid dynamic programming-rule based algorithm for real-time energy optimization of plug-in hybrid electric bus显示文摘The optimization of the control strategy of a plug-in hybrid electric bus(PHEB) for the repeatedly driven bus route is a key technique to improve the fuel economy. The widely used rule-based(RB) control strategy is lacking in the global optimization property, while the global optimization algorithms have an unacceptable computation complexity for real-time application. Therefore, a novel hybrid dynamic programming-rule based(DPRB) algorithm is brought forward to solve the global energy optimization problem in a real-time controller of PHEB. Firstly, a control grid is built up for a given typical city bus route, according to the station locations and discrete levels of battery state of charge(SOC). Moreover, the decision variables for the energy optimization at each point of the control grid might be deduced from an off-line dynamic programming(DP) with the historical running information of the driving cycle. Meanwhile, the genetic algorithm(GA) is adopted to replace the quantization process of DP permissible control set to reduce the computation burden. Secondly, with the optimized decision variables as control parameters according to the position and battery SOC of a PHEB, a RB control is used as an implementable controller for the energy management. Simulation results demonstrate that the proposed DPRB might distribute electric energy more reasonably throughout the bus route, compared with the optimized RB. The proposed hybrid algorithm might give a practicable solution, which is a tradeoff between the applicability of RB and the global optimization property of DP. | ZHANG Ya Hui JIAO Xiao Hong LI Liang YANG Chao ZHANG Li Peng SONG Jian | 2014 | Science China(Technological Sciences)2014，57，12： | 20 |
| 12 | Porous Graphene Microflowers for High-Performance Microwave Absorption显示文摘Graphene has shown great potential in microwave absorption(MA) owing to its high surface area, low density,tunable electrical conductivity and good chemical stability.To fully realize graphenes& MA ability, the microstructure of graphene should be carefully addressed. Here we prepared graphene microflowers(Gmfs) with highly porous structure for high-performance MA filler material. The efficient absorption bandwidth(reflection loss B-10 dB) reaches 5.59 GHz and the minimum reflection loss is up to -42.9 dB, showing significant increment compared with stacked graphene. Such performance is higher than most graphene-based materials in the literature. Besides, the low filling content(10 wt%) and low density(40–50 mg cm^(-3))are beneficial for the practical applications. Without compounding with magnetic materials or conductive polymers,Gmfs show outstanding MA performance with the aid of rational microstructure design. Furthermore, Gmfs exhibit advantages in facile processibility and large-scale production compared with other porous graphene materials including aerogels and foams. | Chen Chen Jiabin Xi Erzhen Zhou Li Peng Zichen Chen Chao Gao | 2018 | Nano-Micro Letters2018，10，2： | 20 |
| 13 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 14 | Poverty alleviation through e-commerce:Village involvement and demonstration policies in rural China显示文摘The diffusion of e-commerce has played a significant role in recent rural economic development in China.E-commerce is also considered as an efficient channel to alleviate poverty in rural China.Voluminous studies have investigated the contribution of e-commerce to agricultural development,yet it is lacking empirical evidence as to the effects of e-commerce on rural poverty alleviation.Since the year of 2014,in order to develop rural e-commerce,Chinese government launched the National Rural E-commerce Comprehensive Demonstration Project.This gradual involvement policy offered a natural experiment for evaluation of e-commerce.Based on village-level survey data from rural China and Heckit method,our study finds that rural e-commerce has a significantly positive effect on rural income.Moreover,the effect is inverted U-shaped for the relative-poverty villages.The estimation of the propensity scores matching model confirms that the results are robust.The following policy recommendations are proposed:(1)policy support to rural e-commerce should prioritize the povertystricken villages.By doing so,the marginal income effects of e-commerce will be maximized.(2)Investment in internet infrastructure and establishment of human resources for e-commerce in rural areas will have spillover effects,increasing rural income through the'digital dividend'. | PENG Chao MA Biao ZHANG Chen | 2021 | Journal of Integrative Agriculture2021，20，4： | 18 |
| 15 | Wheel/rail dynamic interaction due to excitation of rail corrugation in high-speed railway显示文摘Characteristics of wheel-rail dynamic interaction due to the rail corrugation in a high-speed railway are analyzed based on the theory of vehicle-track coupled dynamics in this paper.Influences of the corrugation wavelength and depth on the wheel-rail dynamic performance are investigated.The results show that,under the excitation of a measured rail corrugation,the wheel-rail dynamic interaction of high-speed railway is enhanced obviously,and the high-frequency dynamic force between wheel and rail is generated,which has an obvious impact on the vibrations of the wheelset and rail,and little effect on the vibration of the frame and carbody.If the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the growth of the corrugation wavelength,otherwise,it will decrease.However,the wheel-rail vertical force keeps increasing with the growth of corrugation depth.Furthermore,if the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the decrease of the running speed,otherwise,it will decrease.It is also found that the critical wavelength of corrugation increases with the growth of the corrugation depth and the running speed,and the critical depth of corrugation is nonlinearly related to the sensitive wavelength. | WANG Kai Yun LIU Peng Fei ZHAI Wan Ming HUANG Chao CHEN Zai Gang GAO JianMin | 2015 | Science China(Technological Sciences)2015，58，2： | 17 |
| 16 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 17 | Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage显示文摘Ferroptosis is a form of iron-dependent regulated cell death.Evidence of its existence and the effects of its inhibitors on subarachnoid hemorrhage(SAH)is still lacking.In the present study,we found that liproxstatin-1 protected HT22 cells against hemin-induced injury by protecting mitochondrial functions and ameliorating lipid peroxidation.In in vivo experiments,we demonstrated the presence of characteristic shrunken mitochondria in ipsilateral cortical neurons after SAH.Moreover,liproxstatin-1 attenuated the neurological deficits and brain edema,reduced neuronal cell death,and restored the redox equilibrium after SAH.The inhibition of ferroptosis by liproxstatin-1 was associated with the preservation of glutathione peroxidase 4 and the downregulation of acylCoA synthetase long-chain family member 4 as well as cyclooxygenase 2.In addition,liproxstatin-1 decreased the activation of microglia and the release of IL-6,IL-1 b,and TNF-a.These data enhance our understanding of cell death after SAH and shed light on future preclinical studies. | Yang Cao Yin Li Chao He Feng Yan Jian-Ru Li Hang-Zhe Xu Jian-Feng Zhuang Hang Zhou Yu-Cong Peng Xiong-Jie Fu Xiao-Yang Lu Yuan Yao Yu-Yu Wei Yun Tong Yi-Fu Zhou Lin Wang | 2021 | Neuroscience Bulletin2021，37，4： | 16 |
| 18 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 19 | Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas显示文摘背景 MicroRNAs (miRNAs ) 是小 noncoding 其异常表示可以在许多恶意被观察的规章的 RNA。然而,很少数据在人的主要 medulloblastomas 上是还可得到的。这个工作试图识别那,并且在 carcinogenesis.Methods 期间探索一个可能的角色 miRNAs 将异常地从一样的病人与非肿胀的小脑纸巾相比在肿瘤纸巾被表示高产量 microRNA microarray 在人的主要 medulloblastoma 标本被执行调查差别表示 miRNAs ,并且某 miRNAs 用即时量的 RT-PCR 方法被验证。另外,为大多数的预言的目标基因显著地击倒 -- 或起来调整的 miRNAs 被分析由用最新修改的整体 algorithm.Results,九 miRNA 种是在 medulloblastoma 标本对正常非肿胀的小脑纸巾表示的差别。这些, 4 完了表示, 5 在下面表示。变化从 0.02 褶层到 6.61 褶层。这些调查结果为新奇并且一直不是的很重要的 deregulated miRNAs (miR-17, rniR-lO0, miR-lO6b,和 miR-218 ) 用即时量的 RT-PCR 被证实以前出版了。有趣地,大多数为这些 miRNAs 的预言的目标基因涉及 medulloblastoma carcinogenesis.Conclusions MiRNAs 差别在人的 medulloblastoma 和非肿胀的小脑织物之间被表示。MiRNAs 可以在 medulloblastoma 的 tumorigenesis 起一个作用并且也许在未来为新奇治疗学的策略用作潜在的目标。 | LIU Wei GONG Yan-hua CHAO Teng-fei PENG Xiao-zhong YUAN Jian-gang MA Zhen-yu JIA Ge ZHAO Ji-zong | 2009 | Chinese Medical Journal2009，，20： | 15 |
| 20 | The causes and impacts for heat stress in spring maize during grain filling in the North China Plain--A review显示文摘High-temperature stress(HTS) at the grain-filling stage in spring maize(Zea mays L.) is the main obstacle to increasing productivity in the North China Plain(NCP). To solve this problem, the physiological mechanisms of HTS, and its causes and impacts, must be understood. The HTS threshold of the duration and rate in grain filling, photosynthetic characteristics(e.g., the thermal stability of thylakoid membrane, chlorophyll and electron transfer, photosynthetic carbon assimilation), water status(e.g., leaf water potential, turgor and leaf relative water content) and signal transduction in maize are reviewed. The HTS threshold for spring maize is highly desirable to be appraised to prevent damages by unfavorable temperatures during grain filling in this region. HTS has negative impacts on maize photosynthesis by damaging the stability of the thylakoid membrane structure and degrading chlorophyll, which reduces light energy absorption, transfer and photosynthetic carbon assimilation. In addition, photosynthesis can be deleteriously affected due to inhibited root growth under HTS in which plants decrease their water-absorbing capacity, leaf water potential, turgor, leaf relative water content, and stomatal conductance. Inhibited photosynthesis decrease the supply of photosynthates to the grain, leading to falling of kernel weight and even grain yield. However, maize does not respond passively to HTS. The plant transduces the abscisic acid(ABA) signal to express heat shock proteins(HSPs), which are molecular chaperones that participate in protein refolding and degradation caused by HTS. HSPs stabilize target protein configurations and indirectly improve thylakoid membrane structure stability, light energy absorption and passing, electron transport, and fixed carbon assimilation, leading to improved photosynthesis. ABA also induces stomatal closure to maintain a good water status for photosynthesis. Based on understanding of such mechanisms, strategies for alleviating HTS at the grain-filling stage in spring maize are summarized. Eight strategies have the potential to improve the ability of spring maize to avoid or tolerate HTS in this study, e.g., adjusting sowing date to avoidHTS, breeding heat-tolerance varieties, and tillage methods, optimizing irrigation, heat acclimation, regulating chemicals, nutritional management, and planting geometric design to tolerate HTS. Based on the single technology breakthrough, a comprehensive integrated technical system is needed to improve heat tolerance and increase the spring maize yield in the NCP. | TAO Zhi-qiang CHEN Yuan-quan LI Chao ZOU Juan-xiu YAN Peng YUAN Shu-fen WU Xia SUI Peng | 2016 | Journal of Integrative Agriculture2016，15，12： | 15 |
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