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| 1 | Decreased osteogenesis of adult mesenchymal stem cel s by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis显示文摘Age related defect of the osteogenic differentiation of mesenchymal stem cells(MSCs) plays a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli for osteoblast differentiation.Here, we compared the osteogenic potential of MSCs from young and adult rats under three rounds of 2 h of cyclic stretch of 2.5% elongation at 1 Hz on 3 consecutive days. Cyclic stretch induced a significant osteogenic differentiation of MSCs from young rats, while a compromised osteogenesis in MSCs from the adult rats.Accordingly, there were much more reactive oxygen species(ROS) production in adult MSCs under cyclic stretch compared to young MSCs. Moreover, ROS scavenger N-acetylcysteine rescued the osteogenic differentiation of adult MSCs under cyclic stretch. Gene expression analysis revealed that superoxide dismutase 1(SOD1) was significantly downregulated in those MSCs from adult rats. In summary, our data suggest that reduced SOD1 may result in excessive ROS production in adult MSCs under cyclic stretch, and thus manipulation of the MSCs from the adult donors with antioxidant would improve their osteogenic ability. | Jiali Tan Xin Xu Zhongchun Tong Jiong lin Qiujun Yu Yao Lin Wei Kuang | 2015 | Bone Research2015，3，1： | 15 |
| 2 | Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation显示文摘Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population.Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor(TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells(BMSCs), induces mi R-146 a and decreases Smad4. Moreover,overexpression of mi R-146 a inhibited the osteogenic ability of BMSCs, whereas blocking mi R-146 a partially rescued the osteogenesis deficiency under TNF-α treatment. Molecularly, mi R-146 a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 30-untranslated region, and restoration of Smad4 reversed the inhibitory effects of mi R-146 a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-α inhibits osteogenesis via upregulation of mi R-146 a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of mi R-146 a maybe a potential strategy to improve osteogenesis in the context of osteoporosis. | Wei Kuang Liwei Zheng Xin Xu Yao Lin Jiong Lin Jiahua Wu Jiali Tan | 2017 | Bone Research2017，5，4： | 13 |
| 3 | Treatment of urethral strictures using lingual mucosas urethroplasty: experience of 92 cases显示文摘复杂尿道的苛评的背景 Urethroplasty 是一个困难的过程,并且没有在出版文学描述的广泛地接受的标准途径。我们为在 2006 年 8 月和 2009 年 4 月之间的尿道的 strictures.Methods 的修理用语言的 mucosa 接枝(LMG ) 评估了 urethroplasty 的功效和安全,尿道的苛评的 92 个盒子(长度从 2.5 厘米到 18 厘米,平均数 6.5 厘米) 用 LMG 被对待。92 个病人, 38 与长片断的尿道的苛评(9-18 厘米) 经历了与包皮拍动相结合的双 LMG 或 LMG 或口腔的 mucosal 接枝 urethroplasty.Results 后续手术后地被获得 3-33 月(平均数 17.2 月) 。复杂并发症发生在 8 个病人,包括在 4 个病人的尿管;周期性的苛评 post-operatively 在 3-4 月在 4 个病人发展了。留下的病人 voided 井手术后地,与在 14.3 ml/s 和 54.6 ml/s (平均数 28.4 ml/s ) 之间的山峰流动 .Conclusions 舌头是为前面的 mucosal 苛评的修理的接枝材料的优秀来源。双 LMG 替换 urethroplasty 能成功地对待更长的、更复杂的尿道的苛评。 | XU Yue-min FU Qiang SA Ying-long ZHANG Jiong JIN Chong-rui SI Jie-min SONG Lu-jie | 2010 | Chinese Medical Journal2010，，4： | 13 |
| 4 | STOP-Bang questionnaire is superior to Epworth sleepiness scales,Berlin questionnaire, and STOP questionnaire in screening obstructive sleep apnea hypopnea syndrome patients显示文摘 | Luo Jinmei Huang Rong Zhong Xu Xiao Yi Zhou Jiong | 2014 | Chinese Medical Journal2014，，17： | 10 |
| 5 | Value of STOP-Bang questionnaire in screening patients with obstructive sleep apnea hypopnea syndrome in sleep disordered breathing clinic显示文摘 | Luo Jinmei Huang Rong Zhong Xu Xiao Yi Zhou Jiong | 2014 | Chinese Medical Journal2014，，10： | 10 |
| 6 | A prospective comparison of molecular assay and touch imprint cytology for intraoperative evaluation of sentinel lymph nodes显示文摘哨兵淋巴的背景精确 intraoperative 诊断节点(SLN ) 转移在一样的操作期间为腋的淋巴节点解剖启用病人的选择,为第二操作减少需要。试图有希望地比较 GeneSearchTM 胸淋巴节点(十亿) 的现在的学习有为 SLNs.Methods SLN 的 intraoperative 评估的触摸印记细胞学(TIC ) 的试金是在 1.5-3.0 公里片的 sectioned。TIC 在所有片和十亿试金上被执行,手术后的组织学评估在不同轮流出现节点片上被执行。十亿试金的全面性能与相对 90 个病人的一个总数在学习注册了的手术后的组织学 results.Results 的 TIC 的相比。为十亿试金和 TIC 的完全的 intraoperative 数据在 86 个病人被收集。十亿试金的敏感,特性,和全面精确性是82%,97%,和92%,分别地在一个per 病人基础上与那些相比百分之百,是67%的 TIC 并且十亿试金的90% .Conclusions 性能比 TIC 的优异, TIC 的另外的应用程序没帮助改进 intraoperative 评价的全部的敏感和精确性。宫外的胸织物的存在可能是一个可能的原因假为十亿试金积极。另外,没有增加病理学家的工作量,十亿个试金补充组织病理学说评价和罐头最小化采样错误。 | CHEN Jia-jian YANG Ben-long CHEN Jia-ying ZHANG Jia-xin LI Da-li XU Wei-ping XU Xiao-li YANG Wen-tao SHAO Zhi-min SHEN Zhen-zhou WANG Yong-sheng WU Jiong | 2011 | Chinese Medical Journal2011，，4： | 10 |
| 7 | Optical tuning of exciton and trion emissions in monolayer phosphorene显示文摘Monolayer phosphorene provides a unique two-dimensional(2D)platform to investigate the fundamental dynamics of excitons and trions(charged excitons)in reduced dimensions.However,owing to its high instability,unambiguous identification of monolayer phosphorene has been elusive.Consequently,many important fundamental properties,such as exciton dynamics,remain underexplored.We report a rapid,noninvasive,and highly accurate approach based on optical interferometry to determine the layer number of phosphorene,and confirm the results with reliable photoluminescence measurements.Furthermore,we successfully probed the dynamics of excitons and trions in monolayer phosphorene by controlling the photo-carrier injection in a relatively low excitation power range.Based on our measured optical gap and the previously measured electronic energy gap,we determined the exciton binding energy to be~0.3 eV for the monolayer phosphorene on SiO_(2)/Si substrate,which agrees well with theoretical predictions.A huge trion binding energy of~100 meV was first observed in monolayer phosphorene,which is around five times higher than that in transition metal dichalcogenide(TMD)monolayer semiconductor,such as MoS_(2).The carrier lifetime of exciton emission in monolayer phosphorene was measured to be,220 ps,which is comparable to those in other 2D TMD semiconductors.Our results open new avenues for exploring fundamental phenomena and novel optoelectronic applications using monolayer phosphorene. | Jiong Yang Renjing Xu Jiajie Pei Ye Win Myint Fan Wang Zhu Wang Shuang Zhang Zongfu Yu Yuerui Lu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 8 | Transrectal ultrasonography-guided transperineal bilateral seminal vesicle puncture and continuous irrigation for the treatment of intractable hematospermia显示文摘 | ZHANG Xin-ru GU Bao-jun XU Yue-min CHEN Rong ZHANG Jiong QIAO Yong | 2008 | Chinese Medical Journal2008，，11： | 7 |
| 9 | Optimal b value of diffusion-weighted imaging on a 3.0T magnetic resonance scanner in Crohn's disease显示文摘AIM:To determine the optimal b value of diffusionweighted imaging for detecting active inflammation in Crohn's disease.METHODS:Thirty-one patients clinically diagnosed with active Crohn’s disease were referred for magnetic resonance examination.All patients were scanned on a3.0T magnetic resonance scanner using the same protocol involving four different b values(800,1500,2000and 2500 s/mm2).The diagnostic effect of diffusionweighted imaging was evaluated and compared with endoscopic findings.The diffusion-weighted image quality of four b value groups was evaluated and apparent diffusion coefficient was measured for both nor-mal and inflammatory intestinal segments.RESULTS:The contrast-to-noise ratio and signal-tonoise ratio were not satisfied when b value 2000 or2500 s/mm2 was adopted(36.52±14.95 vs 34.78±24.83,P>0.05;53.58±23.45 vs 47.58±29.67,P>0.05).The qualitative image quality was not enough to meet diagnostic requirement.No matter which b value was chosen,the apparent diffusion coefficient of inflammatory intestinal segments was significantly lower than that of normal intestinal segments(1.38±0.28 vs 2.00±0.38,P<0.01;1.09±0.20 vs 1.50±0.28,P<0.01;0.95±0.19 vs 1.34±0.28,P<0.01;0.88±0.14 vs 1.20±0.21,P<0.01).The lesion detection rate(90.32%),diagnostic sensitivity(81.18%)and specificity(95.10%)would be appropriate when b value 1500 s/mm2 was adopted.CONCLUSION:High b value is suitable for intestinal DW examination on a high field MR scanner. | Qi Feng Yun-Qi Yan Jiong Zhu Jin-Lu Tong Jian-Rong Xu | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 10 | Updating magnetic resonance imaging of small bowel:Imaging protocols and clinical indications显示文摘High soft tissue contrast resolution,acquisition of multi-planar images and the possibility to obtain functional information make magnetic resonance an interesting imaging technique to evaluate the small bowel disease.The absence of ionizing radiation is an important feature of magnetic resonance imaging(MRI) examinations because inflammatory diseases such as Crohn's disease(CD) are studied most frequently,which are prevalent among children and young adults.MRI,using modern equipment and a rigorous technical approach,can offer detailed morphologic information and functional data on the small bowel.This article discusses the MRI protocols for small bowel and the MR imaging findings of small bowel diseases,such as CD and small bowel neoplasms. | Jiong Zhu Jian-Rong Xu Hong-Xia Gong Yan Zhou | 2008 | World Journal of Gastroenterology2008，14，21： | 4 |
| 11 | A comparative study of buccal mucosa graft and penile pedical flap for reconstruction of anterior urethral strictures显示文摘 | SA Ying-long XU Yue-min QIAN Yong JIN San-bo FU Qiang ZHANG Xin-ru ZHANG Jiong GU Bao-jun | 2010 | Chinese Medical Journal2010，，3： | 4 |
| 12 | Consumer Credit Risk Management in an Emerging Market: The Case of China显示文摘With the liberalization of the financial service sector mandated by China’s access to the WTO, China’s credit card market has received a great deal of attention from global financial institutions. This paper examines the enormous growth opportunities and key barriers facing the development of the credit card industry in China, and discusses the importance and tools of consumer credit risk management. In the process of rapid expansion of China’s consumer credit card industry, credit risk management should be treated as a top priority to avoid a pile up of bad debt in credit card receivables. This requires the development of an updated and comprehensive national consumer credit database and the use of credit risk modeling and scoring in predicting consumer behavior. As structured finance develops in China, the securitization of credit card receivables into asset-backed securities might also serve as an alternative to traditional credit risk management. | Xiaoqing Eleanor Xu Jiong Liu | 2006 | China & World Economy2006，14，3： | 3 |
| 13 | Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder显示文摘背景注意赤字活动过度混乱( ADHD )在童年期间是最普通的心理混乱之一,由活动过度, impulsivity 和疏忽的核心症状描绘了并且自己把大负担放在孩子上,他们的家庭和 society.Osmotic 释放口头的系统 methylphenidate (OROS哩/时)开发克服一些限制的一次每日的控制版本明确的表达与立即版本的 methylphenidate (红外哩/时)被联系 .It | ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI Yuan-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG Feng ZHU Xiao-hua YAO Yan-bin | 2011 | Chinese Medical Journal2011，，20： | 2 |
| 14 | CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis显示文摘AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in mice.METHODS:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the anus.Colonic morphology was examined by hematoxylin and eosin staining.Colonic cytokines were determined by enzyme-linked immunosorbent assay.Myeloperoxidase(MPO) activity(indicator of inflammatory infiltration) was observed spectrophotometrically.Gut permeability was assessed by mucosal-to-serosal clearance of fluorescein isothiocyanate-conjugated dextran 4000(FD4) in everted gut sacs.The apoptosis of colonic epithelium was assessed by Hoechst-33342 staining.To further elucidate the role of CXCR4 in colonic inflammation,we also investigated the effect of AMD3100 on migration and cytokine production of isolated peripheral blood mononuclear cells(PBMCs).RESULTS:DSS-induced colitis was characterized by morphologic changes,as well as increased colonic cytokines,inflammatory infiltration,epithelial apoptosis,and intestinal permeability in mice.In AMD3100-treated mice,epithelial destruction,inflammatory infiltration,and submucosal edema were markedly reduced;colonic tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interferon-γ(IFN-γ) levels,as well as MPO activity were significantly decreased.Increased intestinal permeability in DSS-treated mice was signif icantly reduced by AMD3100.The number of apoptotic cells in colitis mice was markedly increased after DSS administration,and decreased when treated with the CXCR4 antagonist AMD3100.In pre-activated PBMCs,CXCL12 stimulation signif icantly increased the migration of PBMCs,and was inhibited by AMD3100.Moderately increased TNF-α,IL-6,and IFN-γ from CXCL12-treated PBMCs were also reduced by AMD3100.CONCLUSION:The CXCR4 antagonist AMD3100 exerts therapeutic effects on experimental colitis by inhibiting colonic inflammation and enhancing epithelial barrier integrity. | Xia, Xian-Ming Wang, Fang-Yu Xu, Wen-An Wang, Zhen-Kai Liu, Jiong Lu, You-Ke Jin, Xin-Xin Lu, Heng Shen, Yun-Zhu | 2010 | World Journal of Gastroenterology2010，16，23： | 2 |
| 15 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 16 | Prognostic Nomogram for Patients with Hepatitis E Virus-related Acute Liver Failure:A Multicenter Study in China显示文摘Background and Aims:Timely and effective assessment scoring systems for predicting the mortality of patients with hepatitis E virus-related acute liver failure(HEV-ALF)are urgently needed.The present study aimed to establish an effective nomogram for predicting the mortality of HEV-ALF patients.Methods:The nomogram was based on a cross-sectional set of 404 HEV-ALF patients who were identified and enrolled from a cohort of 650 patients with liver failure.To compare the performance with that of the model for end-stage liver disease(MELD)scoring and CLIF-Consortiumacute-on-chronic liver failure score(CLIF-C-ACLFs)models,we assessed the predictive accuracy of the nomogram using the concordance index(C-index),and its discriminative ability using time-dependent receiver operating characteristics(td-ROC)analysis,respectively.Results:Multivariate logistic regression analysis of the development set carried out to predict mortality revealed that γ-glutamyl transpeptidase,albumin,total bilirubin,urea nitrogen,creatinine,international normalized ratio,and neutrophil-to-lymphocyte ratio were independent factors,all of which were incorporated into the new nomogram to predict the mortality of HEV-ALF patients.The area under the curve of this nomogram for mortality prediction was 0.671(95%confidence interval:0.602-0.740),which was higher than that of the MELD and CLIF-C-ACLFs models.Moreover,the td-ROC and decision curves analysis showed that both discriminative ability and threshold probabilities of the nomogram were superior to those of the MELD and CLIF-C-ACLFs models.A similar trend was observed in the validation set.Conclusions:The novel nomogram is an accurate and efficient mortality prediction method for HEV-ALF patients. | Jian Wu Cuifen Shi Xinyu Sheng Yanping Xu Jinrong Zhang Xinguo Zhao Jiong Yu Xinhui Shi Gongqi Li Hongcui Cao Lanjuan Li | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 17 | One-stage dorsal lingual mucosal graft urethroplasty for the treatment of failed hypospadias repair显示文摘这研究的目的是回顾地调查经历了一个阶段 onlay 的病人的结果或在没有通过的 hypospadias 修理以后用语言的 mucosal 接枝(LMG ) 镶嵌 urethroplasty。包括标准包括了没有通过的 hypospadias 修理的历史,与皮肤拍动做了操作的本地皮肤的不足困难,并且口头的 mucosal 接枝 urethroplasty 的必要性。如果他们用包皮或多级式的修理 urethroplasty 经历了一个没有通过的 hypospadias 修理,病人们被排除。在 2008 年 1 月和 2012 年 12 月之间,有没有通过的 hypospadias 修理的 110 个病人在我们的中心被对待。这些病人, 56 经历了一个阶段 onlay 或用 LMG 镶嵌 urethroplasty。中部的年龄是 21.8 年(范围:4-45 年) 。56 个病人,一个阶段 onlay LMG urethroplasty 在 42 被执行病人(组 1 ) ,和用一个阶段的一种修改 Snodgrass 技术镶嵌 LMG urethroplasty 在 14 被执行(组 2 ) 。中部的 LMG urethroplasty 长度是 5.6 ±1.6 厘米(变化:4-13 厘米) 。吝啬的后续是 34.7 个月(范围:10-58 月) ,并且复杂并发症在 56 个病人(21.4%) 中的 12 个发展了,包括在 7 的 urethrocutaneous 管(6 在组 1, 1 在组 2 ) 并且在 5 的 neourethral 苛评(4 在组 1, 1 在组 2 ) 。全部的成功率是 78.6% 。我们的调查建议那一个阶段 onlay 或与 LMG 镶嵌 urethroplasty 可以是一种有效选择在没有通过的 hypospadias 修理以后与更少的可得到的皮肤对待病人;收获的 LMG 容易、安全,不管病人年龄。 | Hong-Bin Li Yue-Min Xu Qiang Fu Ying-Long Sa Jiong Zhang Hong Xie | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 18 | XAFS study of Cu^(2+) in aqueous solution of CuBr_2显示文摘Copper ion is the essential microelement to many organisms. In this paper, the local structure of Cu2+ in CuBr2 aqueous solutions with different concentrations are investigated by using X-ray absorption fine structure (XAFS) technique. XANES (X-ray Absorption Near Edge Structure) spectra indicate that charge transfer from Br- to Cu2+ decreases with the solution concentration, which lead to a shift of the absorption edge. The shoulder appearing at the rising edge proves to be characteristic of a tetragonal distortion. The Fourier transform magnitudes of EXAFS (Extended X-ray absorption fine structure) data of Cu species suggest that more Cu-Br bonds may exist in high concentrations. A fivefold coordination configuration like a pyramid is used as the fitting parameters. From the analysis of the coordination numbers, the proportion of Cu-O and Cu-Br is 4:1 in the saturated solution. The Br atom is on the equatorial plane of the model. The fitting results agree well with the experiment data. | DAI Binbin WANG Qian MA Jingyuan LI Jiong ZHANG Shuo HUANG Yuying HUANG Wei WU Guozhong ZOU Yang JIANG Zheng XU Hongjie | 2012 | Nuclear Science and Techniques2012，23，3： | 2 |
| 19 | Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats显示文摘Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes, hepatic mitochondrial, and microsomal systems. A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to rats. The ?tted total in vivo clearance values were further compared with the in vitro values predicted by the well-stirred model. We showed that hepatic microsomal CYP450s did not catalyze β-oxidative or reductive metabolism of the three compounds. Similar to β-oxidation of fatty acids,β-oxidative metabolism on their acyl side chain occurred mainly in mitochondria, which was highly dependent on ATP, CoA and NAD+. Fatty acids and NADH inhibited the β-oxidative metabolism. Reductive metabolism occurred in both mitochondria and microsomes. Reduction in mitochondria was ATP-, CoA-, and NAD(P)H-dependent and reversible, which was suppressed by enoyl reductase inhibitor triclosan. Reduction in microsomes was ATP-, CoA-, and NADPH-dependent but little affected by triclosan. Both plasma concentrations of β-oxidative metabolites and reductive metabolites were successfully ?tted using the compartmental model. The estimated total in vivo clearance values were consistent with those predicted from hepatocytes and organelles, implicating signi?cance of in vitro kinetics. These ?ndings demonstrate the roles of hepatic mitochondria and microsomes in β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues along with their metabolic characteristics. | Kai-jing Zhao Yang Chen Shi-jin Hong Yi-ting Yang Jiong Xu Han-yu Yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang Ting-ting Yang Ya-qian Zhou Li Liu Xiao-dong Liu | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 20 | Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers显示文摘Background:Individuals with subjective memory complaints(SMC)feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease(AD).However,the pathological mechanism underlying SMC remains unclear.We aimed to assess the intrinsic connectivity network and its relationship with AD-related pathologies in SMC individuals.Methods:We included 44 SMC individuals and 40 normal controls who underwent both resting-state functional MRI and positron emission tomography(PET).Based on graph theory approaches,we detected local and global functional connectivity across the whole brain by using degree centrality(DC)and eigenvector centrality(EC)respectively.Additionally,we analyzed amyloid deposition and tauopathy via florbetapir-PET imaging and cerebrospinal fluid(CSF)data.The voxel-wise two-sample T-test analysis was used to examine between-group differences in the intrinsic functional network and cerebral amyloid deposition.Then,we correlated these network metrics with pathological results.Results:The SMC individuals showed higher DC in the bilateral hippocampus(HP)and left fusiform gyrus and lower DC in the inferior parietal region than controls.Across all subjects,the DC of the bilateral HP and left fusiform gyrus was positively associated with total tau and phosphorylated tau181.However,no significant between-group difference existed in EC and cerebral amyloid deposition.Conclusion:We found impaired local,but not global,intrinsic connectivity networks in SMC individuals.Given the relationships between DC value and tau level,we hypothesized that functional changes in SMC individuals might relate to pathological biomarkers. | Kaicheng Li Xiao Luo Qingze Zeng Yeerfan Jiaerken Xiaojun Xu Peiyu Huang Zhujing Shen Jingjing Xu Chao Wang Jiong Zhou Min-Ming Zhang the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
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