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| 1 | Achalasia: will genetic studies provide insights?显示文摘 | Henning R. Gockel Johannes Schumacher Ines Gockel Hauke Lang Thomas Haaf Markus M. N?then | 2010 | Human Genetics2010，，4： | 3 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | A polyketide synthase in glycopeptide biosynthesis 显示文摘 | Volker Pfeifer Graeme J N Johannes R | 2001 | J Biol Chem2001，276，38： | 1 |
| 4 | Adiponectin gene expresion is inhibited by B-adrenergic stimulation via pro- tein Kinase A in 3T3-L1 adipocyte显示文摘 | Mathias F Johannes K Susanne N | 2001 | FEBS Letters2001，507，： | 1 |
| 5 | The impact of jumps in volatility and returns显示文摘 | Eraker B Johannes M S Polson N G | | 0，，： | 1 |
| 6 | Stock Market Liquidity and the Business Cycle 显示文摘 | Randi N S Johannes A Skjehorp Bernt Ame Degaard | 2011 | The Journal of Finance2011，，1： | 1 |
| 7 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 8 | The impact of jumps in volatility and returns显示文摘 | ERAKER B JOHANNES M POLSON N | 2003 | Journal of Finance2003，58，3： | 1 |
| 9 | Receptor-mediated lipoprotein transport in laying hens显示文摘 | JOHANNES N WOLF G J S | 1991 | J Nutr1991，121，9： | 1 |
| 10 | Modeling the adsorption of metal-EDTA complexes onto oxides 显示文摘 | BERND N JOHANNES L PHILIPPE B | 1996 | Environmental Science & Technology1996，30，： | 1 |
| 11 | Characterrization of the mouse bile salt export pump over expressed in the baculovirus system显示文摘 | Bruno H Perter J | 2001 | Hepatology2001，33，： | 1 |
| 12 | Adaptive heamforming algorithms with robustness against jammer motion 显示文摘 | Alex B Ulrich N Johann F B | 1997 | IEEE Transactions on Signal Processing1997，45，7： | 1 |
| 13 | The Sulfomethylation of Lignin显示文摘 | Robert A M C Miguel G N Johannes R L | 1987 | Tappi Journal1987，，3： | 1 |
| 14 | Eme-rgence of Enterobacterlaceae producing extended-spectrum β-lactamases(ESBL) in the community显示文摘 | Johann D D Patrice N Kevin B L | 2005 | J Antimicrb Chemother2005，56，2： | 1 |
| 15 | The Impact of Jumps in Volatility and Returns 显示文摘 | Eraker B Johannes MS Poison N | 2003 | Journal of Finance2003，58，： | 1 |
| 16 | Calibration methodolo- gy for the airborne dispersive pushbroom imaging spectrometer (APEX) 显示文摘 | Jens N Johannes W K Daniel S | 2004 | Proceedings of SPIE2004，5570，： | 1 |
| 17 | The impact of jumps in volatility and returns显示文摘 | Eraker B Johannes M Polson N | | 0，，03： | 1 |
| 18 | Indexed Induction and Coinduc- tion,Fibrationally显示文摘 | Ghani N Johann P Fumex C | 2013 | Logical Methods in Computer Science2013，9，36： | 1 |
| 19 | An improved solid phosphoric acid catalyst for alkene oligomerization in a Fischer-Tropsh refinery 显示文摘 | Johannes H C Thomas N M Nicolaas M P | 2006 | Applied Catalysis A : General2006，308，： | 1 |
| 20 | Generic Fibrational Induction显示文摘 | Ghani N Johann P Fumex (2 | 2012 | Logical Methods in Computer Science2012，8，2： | 1 |
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