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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Pharmacological approach to acute pancreatitis显示文摘The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis (AP) based on experimental animal models and clinical trials. Somatostatin (SS) and octreotide inhibit the exocrine production of pancreatic enzymes and may be useful as prophylaxis against Post Endoscopic retrograde cholangiopancreatography Pancreatitis (PEP). The protease inhibitor Gabexate mesilate (GM) is used routinely as treatment to AP in some countries, but randomized clinical trials and a meta-analysis do not support this practice. Nitroglycerin (NGL) is a nitrogen oxide (NO) donor, which relaxes the sphincter of Oddi. Studies show conflicting results when applied prior to ERCP and a large multicenter randomized study is warranted. Steroids administered as prophylaxis against PEP has been validated without effect in several randomized trials. The non-steroidal anti-inflammatory drugs (NSAID) indomethacin and diclofenac have in randomized studies showed potential as prophylaxis against PEP. Interleukin 10 (IL-10) is a cytokine with anti-inflammatory properties but two trials testing IL-10 as prophylaxis to PEP have returned conflicting results. Antibodies against tumor necrosis factor-alpha (TNF-α) have a potential as rescue therapy but no clinical trials are currently being conducted. The antibiotics beta- lactams and quinolones reduce mortality when necrosis is present in pancreas and may also reduce incidence of infected necrosis. Evidence based pharmacological treatment of AP is limited and studies on the effect of potent anti-inflammatory drugs are warranted. | Ulrich Christian Bang Synne Semb Camilla Nφjgaard Flemming Bendtsen | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 3 | 采用椭圆形非骨水泥压配固定髋臼杯行全髋关节置换术治疗髋关节发育不良显示文摘对继发于髋关节发育不良的晚期骨性关节炎患者来说,全髋关节置换术是较好的治疗选择,但由于此类患者存在的解剖结构异常,手术变得较为复杂。在分型为HartofilakidisⅡ型的患者中,股骨头的半脱位造成髋臼顶部外上方的骨缺损,往往需要某种形式的支撑来使髋臼杯获得稳定的固定。处理这种类型的骨缺损可以采用多种不同的方法,孰优孰劣尚有争议。本文的目的是通过回顾性分析比较两种不同的骨缺损处理方法,来探讨椭圆形非骨水泥髋臼杯是否可以作为传统处理方法的替代方法。 | 王俏杰 张先龙 Boris M.Holzapfel Felix Greimel Peter M.Prodinger Hakan Pilge Ulrich Nth Hans Gollwitzer Maximilian Rudert | 2012 | 中国矫形外科杂志2012，20，17： | 3 |
| 4 | Prognostic relevance of minimal residual disease in colorectal cancer显示文摘Presence of occult minimal residual disease in patients with colorectal cancer(CRC)has a strong prognostic impact on survival.Minimal residual disease plays a major role in disease relapse and formation of metastases in CRC.Analysis of circulating tumor cells(CTC)in the blood is increasingly used in clinical practice for disease monitoring of CRC patients.In this review article the role of CTC,disseminated tumor cells(DTC)in the bone marrow and micrometastases and isolated tumor cells(ITC)in the lymph nodes will be discussed,including literature published until September 2013.Occult disease is a strong prognostic marker for patient survival in CRC and defined by the presence of CTC in the blood,DTC in the bone marrow and/or micrometastases and ITC in the lymph nodes.Minimal residual disease could be used in the future to identify patient groups at risk,who might benefit from individualized treatment options. | Ulrich Bork Robert Grützmann Nuh N Rahbari Sebastian Schlch Marius Distler Christoph Reissfelder Moritz Koch Jürgen Weitz | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
| 5 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 6 | Fighting restenosis after coronary angioplasty: contemporary and future treatment options显示文摘 | MARC H ULRICH S JOSEF N | 2002 | Int J Cardiol2002，83，3： | 1 |
| 7 | Effects of magnesium deficiency on the photosynthesis and respiration of leaves of sugar beet显示文摘 | TERRY N ULRICH A | 1974 | Plant Physiology1974，54，： | 1 |
| 8 | Status and prospects of digital detector technology for CR and DR显示文摘 | Ulrich N | 2005 | Radiation Protection Dosimetry2005，114，13： | 1 |
| 9 | High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells显示文摘 | Verena KL Ulrich S Andreas N | 1998 | J Clin Invest1998，101，1： | 1 |
| 10 | Status and prospects of digital detector technology for CR and DR显示文摘 | Ulrich N | 2005 | Radiation Protection Dosimetry2005，114，13： | 1 |
| 11 | Aberrant lymphocyte enhancere binding factor 1 expression is characteristic for sporadic Burkitt' s lymphoma显示文摘 | Walther N Ulrich A Voekerodt M | 2013 | Am J Pathol2013，182，4： | 1 |
| 12 | Alcohol - related seizures显示文摘 | Rathlev NK Ulrich AS Delanty N et el | 2006 | J Emerg Med2006，31，2： | 1 |
| 13 | Diverting stoma after low anterior resection:more arguments in favor显示文摘 | Ulrich A Seiler C Rahbari N Weitz J | 2009 | Dis Colon Rectum2009，52，3： | 1 |
| 14 | MUC4 mucin ex- pression in human pancreatic tumours is affected by organenvir- onment the possible role of TGF beta2显示文摘 | Choudhury A Moniaux N Ulrich AB | 2004 | Br J Cancer2004，90，3： | 1 |
| 15 | The epidemiology of myelodysplastic syndromes显示文摘 | Ulrich G Judith N Rainer H | 2008 | Clinical Leukemia2008，2，1： | 1 |
| 16 | Low back pain and lumbago–sciatica in nurses and a reference group of clerks: results of a comparative prevalence study in Germany显示文摘 | Friedrich Hofmann Ulrich St?ssel Martina Michaelis Matthias Nübling Achim Siegel | 2002 | International Archives of Occupational and Environmental Health2002，，7： | 1 |
| 17 | Adaptive heamforming algorithms with robustness against jammer motion 显示文摘 | Alex B Ulrich N Johann F B | 1997 | IEEE Transactions on Signal Processing1997，45，7： | 1 |
| 18 | Reversible color switchingand unusual solution polymerization of hydrazide-modifieddiacetylene lipids显示文摘 | Ulrich J Koonj S Sophie N | 1999 | Journal of the American Chemical Society1999，121，： | 1 |
| 19 | Tracking in multistatic passive radar systems using DAB/DVB-T illumination显示文摘 | Martina D Ulrich N and Wolfgang K | 2012 | Signal Processing2012，92，6： | 1 |
| 20 | Prevalence of Perkinsusmarinus(dermo),Haplosporidium nelsoni(MSX),and QPX in bi-valves of Delaware's inland bays and quantitative,high-throughput diagnosis of dermo by QPCR显示文摘 | Ulrich P N Ewart J W Marsh A G | 2007 | J Eukaryot Micro-biol2007，54，6： | 1 |
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