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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | Proteomic and genomic studies of non-alcoholic fatty liver disease-clues in the pathogenesis显示文摘Non-alcoholic fatty liver disease(NAFLD)is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology.NAFLD is strongly associated with liver inflammation,metabolic hyperlipidaemia and insulin resistance.Frequently,NAFLD has been considered as the hepatic manifestation of metabolic syndrome.The pathophysiology of NAFLD has not been fully elucidated.Some patients can remain in the stage of simple steatosis,which generally is a benign condition;whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis,fibrosis,cirrhosis and hepatocellular carcinoma.The mechanism behind the progression is still not fully understood.Much ongoing proteomic researches have focused on discovering the unbiased circulating biochemical markers to allow early detection and treatment of NAFLD.Comprehensive genomic studies have also begun to provide new insights into the gene polymorphism to understand patientdisease variations.Therefore,NAFLD is considered a complex and mutifactorial disease phenotype resulting from environmental exposures acting on a susceptible polygenic background.This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis.For proteomics section,this review highlighted functional proteins that involved in:(1)transportation;(2)metabolic pathway;(3)acute phase reaction;(4)antiinflammatory;(5)extracellular matrix;and(6)immune system.In the genomic studies,this review will discuss genes which involved in:(1)lipolysis;(2)adipokines;and(3)cytokines production. | Jun Wei Lim John Dillon Michael Miller | 2014 | World Journal of Gastroenterology2014，20，26： | 3 |
| 3 | Development of a corpus of Mandarin sentences in babble with homogeneity optimized via psychometric evaluation显示文摘 | Xin Xi Teresa Y.C. Ching Fei Ji Yang Zhao Jia-Nan Li John Seymour Meng-Di Hong Ai-Ting Chen Harvey Dillon | 2012 | International Journal of Audiology2012，，5： | 1 |
| 4 | Mechanism of apoptosis induction by inhibition of the anti-apoptotic Bcl-2 proteins 显示文摘 | Jerry E Chipuk John C Fisher Christopher P Dillon | 2008 | Nat Acad Sci USA2008，105，20： | 1 |
| 5 | An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer显示文摘 | Bríd M. Ryan Roger K. Wolff Nicola Valeri Mohammed Khan Dillon Robinson Alessio Paone Elise D. Bowman Abbie Lundgreen Bette Caan John Potter Derek Brown Carlo Croce Martha L. Slattery Curtis C. Harris | 2014 | Cancer Epidemiology2014，，5： | 1 |
| 6 | Clostridium used in mediaeval dyeing 显示文摘 | Padden A N Dillon V M John P Edmonds J Collins M D Alvarez N | 1998 | Nature1998，396，： | 1 |
| 7 | The Anatomic Pattern of Biliary Atresia Identified at Time of Kasai Hepatoportoenterostomy and Early Postoperative Clearance of Jaundice Are Significant Predictors of Transplant-Free Survival显示文摘 | Riccardo Superina John C. Magee Mary L. Brandt Patrick J. Healey Greg Tiao Fred Ryckman Frederick M. Karrer Kishore Iyer Annie Fecteau Karen West R. Cartland Burns Alan Flake Hanmin Lee Jeff A. Lowell Pat Dillon Paul Colombani Richard Ricketts Yun Li Jeff | 2011 | Annals of Surgery2011，，4： | 1 |
| 8 | Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis:An opinion review显示文摘There has long been a recognised association between non-alcoholic fatty liver disease(NAFLD)and the composite aspects of the metabolic syndrome.Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD.There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD.Given the increased economic and health burden associated with the NAFLD epidemic,improved methods of population-based,minimally-invasive methods and biomarkers are clearly highly sought and necessary.In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process. | Paul Brennan Kathleen Clare Jacob George John F Dillon | 2020 | World Journal of Gastroenterology2020，26，15： | 1 |
| 9 | Use of Raman Scattering to Investigate Disorder and Crystallite Formation in As-Deposited and Annealed Carbon Films显示文摘 | Dillon R O Woollam John A Katkanant V | 1984 | Physical Review1984，29，6： | 1 |
| 10 | 显示文摘 | Dillon R O Woollam John A Katkanant V | 1984 | Phys Rev B1984，29，6： | 1 |
| 11 | Use of Raman scattering to investigate disorder and crystallite formation in as-deposited and annealed carbon films显示文摘 | Dillon R O Woollam John A Katkanant V | 1984 | Physical Review B1984，29，6： | 1 |
| 12 | Assessment of cost uncertainties for large technology projects: A methodology and an application显示文摘 | Dillon R L John R Winterfeldt D | 2002 | Interface2002，32，4： | 1 |
| 13 | The Albumin in Subarachnoid Hemorrhage (ALISAH) Multicenter Pilot Clinical Trial: Safety and Neurologic Outcomes显示文摘 | Jose I. Suarez Renee H. Martin Eusebia Calvillo Catherine Dillon Eric M. Bershad R. Loch MacDonald John Wong Robert Harbaugh | 2012 | Stroke2012，，3： | 1 |
| 14 | Uptake of hepatitis C specialist services and treatment following diagnosis by dried blood spot in Scotland显示文摘 | Georgina McAllister Hamish Innes Allan Mcleod John F. Dillon Peter C. Hayes Ray Fox Stephen T. Barclay Kate Templeton Celia Aitken Rory Gunson David Goldberg Sharon J. Hutchinson | 2014 | Journal of Clinical Virology2014，，： | 1 |
| 15 | 利用应用使能机制挖掘多媒体网络宝藏显示文摘潜在的获利机会
以前业务提供商通过通信设施和业务扩展方而的投资来获取利润,现在通过这种方式获取的利润正在锐减。山多媒体业务和面向消费者的应用业务导致的流量增长正在蚕食业务提供商的利润。要想在市场中具备持续高效的竞争力,业务提供商必须以特有的方式为内容传递价值链提供附加值,从而增加他们在价值链上的影响力。融入这个生态系统可以存以下几个方面获得新的市场机会。 | John Dillon | 2010 | 网络电信2010，12，8： | 0 |
| 16 | 需要新的会话体验显示文摘体验将驱动技术现在是时候去提供一种新的会话体验,这种体验给予人类互动而不是技术。谈话不再局限于语音和文本。 | John Dillon | 2011 | 网络电信2011，13，12： | 0 |
| 17 | Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia显示文摘 | John C. Radcliffe Declan Page Bruce Naumann Peter Dillon | 2017 | Frontiers of Environmental Science & Engineering2017，11，4： | 0 |
| 18 | Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue?显示文摘AIM: To the look at the current strength of evidence and the potential application of anti-oxidants in this setting.METHODS: Two electronic databases(Pub Med and Web of Knowledge) were searched to January 2013 to find studies addressing serum bilirubin levels in nonalcoholic fatty liver disease(NAFLD). The search used key word combinations in relation to NAFLD and serum bilirubin specific to human adults only. After screening selected studies were reviewed in depth by two independent reviewers. Data synthesis with further metaanalysis was planned but not possible due to the heterogeneity of the outcome measures in these studies.RESULTS: Out of 416 studies screened only seven studies were considered suitable for inclusion. All seven studies consistently reported an inverse association of bilirubin with NAFLD despite the heterogeneous sample of studies. Only two studies were prospective. No negative studies were found. CONCLUSION: Most studies suggest a correlationbetween high bilirubin levels of any type are inversely correlated with NAFLD. But to date most of these studies have been poorly designed to allow meaningful conclusions, except one cohort study. There is a need for a large prospective cohort study in multiple populations to test this hypothesis fully before mechanistic associations can be established and therapeutic options of the apparent anti-oxidant effect of bilirubin be explored in NAFLD. Furthermore these studies should include analysis of UGT1A1 gene to expound upon underlying cause of unconjugated hyperbilirubinaemia. | Mohamed S Anwar John F Dillon Michael H Miller | 2014 | World Journal of Pharmacology2014，3，4： | 0 |
| 19 | Nature:研究首次证实帕金森病部分上是一种自身免疫疾病显示文摘帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白(alpha-synuclein)在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中,来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免疫学研究所等研究机构的研究人员发现首个直接的证据证实自身免疫反应在帕金森病中发挥着作用。 | David Sulzer, Francesca Garretti, Ellen Kanter, Julian Agin-Liebes, Elizabeth Phillips, Simon Mallal David Sulzer, Roy N. Alcalay, Lucien Cote, Christopher Liong, Elizabeth Phillips, Simon Mallal David Sulzer Curtis McMurtrey, William H. Hildebrand Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Valina L. Dawson Valina L. Dawson, Ted M. Dawson Ted M. Dawson Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette Elizabeth Phillips, Simon Mallal | 2017 | 现代生物医学进展2017，17，27： | 0 |
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