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| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013，19，23： | 14 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | 3D打印碳纤维增强PLA试件的力学性能分析显示文摘以300目短切碳纤维(CF)和聚乳酸(PLA)为实验原料,分别配制CF质量分数为5%、10%、15%和20%的CF/PLA混合料,再经双螺杆挤出机挤出造粒后得到CF/PLA复合材料。分别以纯PLA和不同组分的CF/PLA复合材料为实验材料,在粒料3D打印机上制备抗拉伸、压缩、弯曲和冲击试样,并做力学性能测试。实验结果表明,随着CF含量的增加,材料最大拉伸强度呈先增大后减小的趋势,当CF含量为5%时,材料的平均拉伸强度最大,为48.45 MPa。材料的平均弯曲和压缩强度随CF含量的增加均呈先减小后增大再减小的趋势,且无CF填充时,二者的强度值最大,分别为114.77 MPa和103.94 MPa。材料的抗冲击强度随着CF含量的增大呈先增大后减小的趋势,当CF含量为5%时,材料的抗冲击强度最大,为14.49 kJ/m^2。 | 刘晓军 Liam Dillon Flynn Lachendro James 杨卫民 焦志伟 | 2017 | 塑料2017，46，3： | 12 |
| 4 | Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease显示文摘 | Sunder Mudaliar Robert R. Henry Arun J. Sanyal Linda Morrow Hanns-Ulrich Marschall Mark Kipnes Luciano Adorini Cathi I. Sciacca Paul Clopton Erin Castelloe Paul Dillon Mark Pruzanski David Shapiro | 2013 | Gastroenterology2013，，： | 7 |
| 5 | 内层视网膜从玻璃体腔摄取氧的初步研究显示文摘目的 研究内层视网膜从玻璃体腔摄取氧的可能性。方法 对兔眼行玻璃体切割术 ,使玻璃体腔被较富氧的灌注液填充 ,利用光纤测氧仪监测玻璃体腔内氧分压的改变。结果 对 6只兔进行实验 ,玻璃体中央的氧分压为( 15 9± 2 8)mmHg( 12眼 ) ;在 6只玻璃体切割眼中 ,玻璃体切割结束时玻璃体腔内灌注液的氧分压为 ( 119 3± 18 9)mmHg ,经过 ( 2 6 3± 11 8)min ,氧分压降低到 ( 2 8 9± 12 2 )mmHg并维持稳定。 结论 内层视网膜具有相当高的从玻璃体腔摄取氧的能力。 | 梁建宏 Irene Barbazetto James Dillon 黎晓新 | 2004 | 眼科研究2004，22，2： | 5 |
| 6 | 白蚁肠道二株链霉菌株所产纤维素酶的分离、纯化及其特性(英文)显示文摘通过硫酸铵沉析、依次过葡聚糖G100和阴离子交换树脂DEAE葡聚糖A50柱,从白蚁(Odontotermesformosanus)肠道2株放线菌株发酵液中获得了1种葡聚糖外切酶(C1)、2种葡聚糖内切酶(CX)和1种β-葡萄糖苷酶(β-glucosidase,βG)。该2株放线菌株在形态、生长、生理生化特性上显示属于链霉菌属种类。SDS-PAGA电泳分析表明上述4种酶的分子质量分别为76.9、22.3、66.2、31.9kD。外切酶在pH 5.6,内切酶和β-葡萄糖苷酶在pH 5.0;以及内切酶和外切酶在50℃,β-葡萄糖苷酶在40℃时,有最大酶活性,甚至温度高达70℃时,这些酶仍有50%以上的酶活性。二价阳离子如Fe2+、Ca2+在质量浓度100mg/L条件下对酶有激活作用,而Mn2+、Cu2+、Zn2+、Co2+对酶活起抑制作用。结果表明来自白蚁肠道2株链霉菌株所产的纤维素酶可能以Fe2+和Ca2+作为辅基,属于酸性、耐热性酶。这类酶具备用于工业上分解不溶性的纤维素的能力。 | 霍光华 黄小晖 Shannon DILLON 何刚强 陈明辉 龙昊知 | 2012 | 食品科学2012，33，17： | 4 |
| 7 | 铁岭市2015-2018年大气颗粒物PM2.5潜在源区分析显示文摘了解大气污染物的潜在源区分布对制定污染物减排措施至关重要.本文采用HYSPLIT模型,模拟出抵达铁岭市地区72 h的主要气流轨迹,结合铁岭市2015-2018年PM2.5逐小时浓度数据资料,采用CWT方法(concentration-weighted trajectory method)对铁岭市PM2.5潜在源区浓度进行了分析,在此基础上,提出了PCWT方法(percentage concentration-weighted trajectory method),对铁岭市地区PM2.5潜在源区浓度占比及传输过程进行了定量分析.研究表明,铁岭市PM2.5来源呈现出不同的季节特征:春季PM2.5主要来源于铁岭市西北和南部地区,夏季PM2.5主要来源于铁岭市南部地区,秋季PM2.5主要来源于铁岭市西北部及东北部地区,冬季PM2.5主要来源于铁岭市西北部及铁岭市周边地区.铁岭市PM2.5主要来源于3个方向,其中来自铁岭西北方向的源区贡献值4年平均占比27.36%、东北方向占18.51%、西南方向占15.73%;铁岭及周边城市、吉林省松嫩平原、科尔沁沙地以及辽宁中部城市群、环渤海湾地区是铁岭市PM2.5的主要国内源区;俄罗斯、蒙古、朝鲜是铁岭市PM2.5的主要国外源区,且近几年有增加趋势.研究成果对建立铁岭市生态环境管控分区,制定有效防治大气污染措施有重要的科学支撑作用. | 徐元畅 张慧 高吉喜 Dillon S.Dodson 秦思达 钱建平 史强 李庆义 | 2020 | 环境科学学报2020，40，8： | 4 |
| 8 | Complications and cost associated with parenteral nutrition delivered to hospitalized patients through either subclavian or peripherally-inserted central catheters显示文摘 | C.T. COWL J.V. WEINSTOCK A. AL-JURF K. EPHGRAVE J.A. MURRAY K. DILLON | 2000 | Clinical Nutrition2000，，4： | 3 |
| 9 | Proteomic and genomic studies of non-alcoholic fatty liver disease-clues in the pathogenesis显示文摘Non-alcoholic fatty liver disease(NAFLD)is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology.NAFLD is strongly associated with liver inflammation,metabolic hyperlipidaemia and insulin resistance.Frequently,NAFLD has been considered as the hepatic manifestation of metabolic syndrome.The pathophysiology of NAFLD has not been fully elucidated.Some patients can remain in the stage of simple steatosis,which generally is a benign condition;whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis,fibrosis,cirrhosis and hepatocellular carcinoma.The mechanism behind the progression is still not fully understood.Much ongoing proteomic researches have focused on discovering the unbiased circulating biochemical markers to allow early detection and treatment of NAFLD.Comprehensive genomic studies have also begun to provide new insights into the gene polymorphism to understand patientdisease variations.Therefore,NAFLD is considered a complex and mutifactorial disease phenotype resulting from environmental exposures acting on a susceptible polygenic background.This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis.For proteomics section,this review highlighted functional proteins that involved in:(1)transportation;(2)metabolic pathway;(3)acute phase reaction;(4)antiinflammatory;(5)extracellular matrix;and(6)immune system.In the genomic studies,this review will discuss genes which involved in:(1)lipolysis;(2)adipokines;and(3)cytokines production. | Jun Wei Lim John Dillon Michael Miller | 2014 | World Journal of Gastroenterology2014，20，26： | 3 |
| 10 | A new international classification of childhood vasculitis显示文摘 | Michael J. Dillon Seza Ozen | 2006 | Pediatric Nephrology2006，，9： | 2 |
| 11 | The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Treatment of Adult Acute Lymphoblastic Leukemia: Update of the 2006 Evidence-Based Review显示文摘 | Denise M. Oliansky Richard A. Larson Daniel Weisdorf Hildy Dillon Thomas A. Ratko Donna Wall Philip L. McCarthy Theresa Hahn | 2012 | Biology of Blood and Marrow Transplantation2012，，1： | 2 |
| 12 | Electricity price short-term forecasting using artificial neural networks显示文摘 | Szkuta B R Sanabria L A Dillon T S | 1999 | IEEE Trans on PS1999，14，3： | 2 |
| 13 | 温度测量系统对ADC的要求显示文摘引言
适用于温度测量的温度传感器有好几种。为具体应用选择适当的温度传感器取决于待测温度范围以及所需要的精度。系统精度取决于温度传感器的精度以及用于将传感器输出数字化的模数转换器(ADC)的性能。多数情况下,传感器的信号幅度相当小,需要一种高分辨率的ADC。∑-△ADC分辨率高,通常包含温度测量系统所需的内置电路,如激励电流源。本文讨论不同类型的温度传感器(热电偶、电阻式温度检测器(RTD)、热敏电阻以及热敏二极管)以及连接传感器和ADC所需要的电路,还介绍对ADC的性能要求。 | Mary Mc Carthy Eamonn Dillon | 2006 | 世界电子元器件2006，，8： | 2 |
| 14 | Storage of hydrogen in single-walled carbon nanotubes显示文摘 | Dillon A C Jones K M Bekkedahl T A | 1997 | Nature1997，386，6623： | 2 |
| 15 | Outcomes of Early- and Late-Identified Children at 3 Years of Age: Findings From a Prospective Population-Based Study显示文摘 | Teresa Y. C. Ching Harvey Dillon Vivienne Marnane Sanna Hou Julia Day Mark Seeto Kathryn Crowe Laura Street Jessica Thomson Patricia Van Buynder Vicky Zhang Angela Wong Lauren Burns Christopher Flynn Linda Cupples Robert S. C. Cowan Greg Leigh Jessica Sja | 2013 | Ear and Hearing2013，，5： | 2 |
| 16 | New cyclic difference sets with Singer parameters显示文摘 | J.F Dillon Hans Dobbertin | 2003 | Finite Fields and Their Applications2003，，3： | 2 |
| 17 | Transcriptional complementarity in breast cancer:application to detection of circulating tumor cells显示文摘 | Houghton R L Dillon D C Molesh D A | 2001 | Mol Diagn2001，6，2： | 1 |
| 18 | Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium boris BCG显示文摘 | Dillon DC Alderson MR Day CH Bement T Campos Neto A Skeiky YA Vedvick T Badaro R Reed SG Houghton R | 2000 | J Clin Microbiol2000，38，9： | 1 |
| 19 | Genres and the Web:Is the personal home page the first uniquely digital genre?显示文摘 | GUSHROWSKI B | 2000 | Journal of the American Society for Information Science2000，5，12： | 1 |
| 20 | The actin cytoskeleton: integrating form and function at the synapse 显示文摘 | DILLON C GODA Y | 2005 | Annual review of neuroscience2005，28，： | 1 |
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