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| 1 | Gallstone ileus,clinical presentation,diagnostic and treatment approach显示文摘Gallstone ileus is a mechanical intestinal obstruction due to gallstone impaction within the gastrointestinal tract. Less than 1% of cases of intestinal obstruction are derived from this etiology. The symptoms and signs of gallstone ileus are mostly nonspecific. This entity has been observed with a higher frequency among the elderly, the majority of which have concomitant medical illness. Cardiovascular, pulmonary, and metabolic diseases should be considered as they may affect the prognosis. Surgical relief of gastrointestinal obstruction remains the mainstay of operative treatment. The current surgical procedures are:(1) simple enterolithotomy;(2) enterolithotomy, cholecystectomy and fistula closure(one-stage procedure); and(3) enterolithotomy with cholecystectomy performed later(two-stage procedure). Bowel resection is necessary in certain cases after enterolithotomy is performed. Large prospective laparoscopic and endoscopic trials are expected. | carlos m nuno-guzmán maría eugenia marín-contreras mauricio figueroa-sánchez jorge l corona | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 11 |
| 2 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 3 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 4 | Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid显示文摘Hypocotyl formation during the epigeal germination of seedlings is under strict hormonal regulation. In a 3 d old Zinnia elegans seedling system, gibberellic acid (GA3) exerts an opposite effect to that exerted by light on hypocotyl photomorphogenesis because GA3 promotes an etiolated-like growth with an inhibition of radial (secondary) growth. For this reason, the effect of GA3 on the basic peroxidase isoenzyme from Z. elegans (ZePrx), an enzyme involved in hypocotyl lignin biosynthesis, was studied. The results showed that GA3 reduces ZePrx activity, similarly to the way in which it reduces seedling secondary growth. This hormonal response is supported by the analysis of the ZePrx promoter, which contains four types of GA3-responsive cis-elements: the W Box/O2S; the Pyr Box; the GARE; and the Amy Box. Taken together, these results suggest that ZePrx is directly regulated by GA3, with this effect matching the inhibitory effect of GA on the hypocotyl secondary growth. | María Josefa López Núez-Flores Jorge Gutirrez Laura V.Gómez-Ros Esther Novo Uzal Mariana Sottomayor Alfonso Ros Barceló | 2010 | Journal of Integrative Plant Biology2010，52，2： | 3 |
| 5 | Total phenolic content,in vitro antioxidant activity and chemical composition of plant extracts from semiarid Mexican region显示文摘Objective:To determine the extraction suitable conditions of total phenolic content(TPC) by heat-reflux system,antioxidant activities and HPLC characterization of the aqueous-ethanolic extracts of Jatropha dioica(J.dioica)(Dragon's blood).Flourensia cernua(F.cernua)(Tar bush).Eucalyptus camaldulensis(E.camaldulensis)(Eucalyptus) and Turnera diffusa(T.diffusa)(Damiana).Methods:TPC was evaluated by the well-known colorimetric assay using FolinCiocalteu reagent.The antioxidant activities were assayed by three methods based on scavenging of DPPH,ABTS and by lipid oxidation inhibition.The chemical composition of the extracts obtained was subject to HPLC analysis.Results:TPC in the plant extracts ranged from 2.3 to14.12 mg gallic acid equivalents/g for J.dioica and E.camaldulensis,respectively.The plant extracts of F.cernua,E.camaldulensis and T.diffusa showed similar strong antioxidant activities on scavenging of DPPH and lipid oxidation inhibition.In contrast,J.dioica extracts had lowest potential antioxidant in three assays used.HPLC assay showed the presence of several phenolic compounds in the extracts used.Conclusions:The results obtained suggest that F.cernua,E.camaldulensis and T.diffusa are potential sources to obtain bioactive phenolic compounds with high antioxidant properties which can be used in the factories as antioxidant agents or for treatments in diseases. | Jorge E.Wong-Paz Juan C.Contreras-Esquivel Raúl Rodríguez-Herrera María L.Carrillo-Inungaray Lluvia I.López Guadalupe V.Nevárez-Moorillón Cristóbal N.Aguilar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，2： | 3 |
| 6 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 7 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 8 | Transport stress in Southern chamois (Rupicapra pyrenaica) and its modulation by acepromazine显示文摘 | Jorge Ramo' n Lo' pez-Olvera l~lasi Marco Jordi Montane' | 2006 | The Veterinary Journal2006，172，： | 1 |
| 9 | Corneal aberrations after microincision cataract surgery显示文摘 | Bassam Elkady Jorge L. Alió Dolores Ortiz Raúl Montalbán | 2008 | Journal of Cataract & Refractive Surgery2008，，1： | 1 |
| 10 | Performance evaluation of an activated sludge system for removing petroleum hydrocarbons from oilfield produced water 显示文摘 | Tellez G T Nirmalakhandan N Jorge G L | 2002 | Advances in Environ- mental Research2002，，6： | 1 |
| 11 | The effect of different training programs on antioxidant status,oxidative stress,and metabolic control in type 2diabetes显示文摘 | De Oliveira V N Bessa A Jorge M L | 2012 | Appl Physiol Nutr Metab2012，37，2： | 1 |
| 12 | Pseudo-accoramodation with intraocular lenses im- planted in the bag显示文摘 | Altan-Yaycioglu R Gozum N Gucukoglu A Jorge L Tetsuro O Tatsuya M | 2002 | JRefrat Surg2002，18，3： | 1 |
| 13 | Effect of rosemary (Rosmarinus o~cinalis) extracts on the oxidative stability and sensory acceptability of soybean oil 显示文摘 | DIAS L S MENIS M E C JORGE N | 2015 | Journal of Science of Food and Agriculture2015，95，： | 1 |
| 14 | No association between ApoE and schizophrenia: Evidence of systematic review and updated meta-analysis显示文摘 | Thelma Beatriz González-Castro Carlos Alfonso Tovilla-Zárate Yazmín Hernández-Díaz Ana Fresán Isela E. Juárez-Rojop Jorge L. Ble-Castillo Lilia López-Narváez Alma Genis Mervyn Manuel Hernández-Alvarado | 2015 | Schizophrenia Research2015，，： | 1 |
| 15 | Corn posite materials in flexible multibody systems 显示文摘 | MARIA A N JORGE A C ROGERIO P L | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，： | 1 |
| 16 | New Applications of Zirconium Phosphate Nanomaterials显示文摘CONSPECTUS:The 2-D layers of the inorganic ion exchangerα-zirconium phosphate(Zr(HPO_(4))2·H_(2)O,α-ZrP)make this compound particularly stable to low pH,high temperature,and ionizing radiation.Initially studied for its ion exchange properties,once the conditions for its synthesis in crystalline form was accomplished by James Stynes and Abraham Clearfield in 1964,numerous other types of studies and applications followed.Extensive studies in the 1960s and 1970s on the thermodynamics of ion exchange led to insights into the intercalation mechanism of this material.The Clearfield group solved the crystal structure in 1968 and refined it in 1977.Powder methods were pioneered by the Clearfield group to solve the structure of this type of materials.In 1968 Giulio Alberti reported means to prepare zirconium phosphonates expanding the chemistry of these layered compounds.New phases of ZrP were also discovered(e.g.,γ,θ,λ,τ)and the applications ranged from heterogeneous catalysis to intercalation chemistry and solid-state proton conductors.Methods to exfoliate the layers of ZrP were developed in the 1990s as interest grew in new applications of these types of materials.For example,protein and enzyme intercalation was accomplished starting in the 1990s by the McLendon,Mallouk,and Kumar groups.In the early 2000s,the Colon group pioneered the use of théθphase of ZrP for the direct intercalation of large inorganic metal complexes that could not be directly intercalated into theαphase.Initial studies in the Colon group ranged from applications of these directly intercalated ZrP derivatives in photophysics and photochemistry,́amperometric biosensors,vapochromism,and vapoluminescence.Over the past decade,new applications of these materials have been developed in anticancer drug delivery and electrocatalysis of the oxygen evolution reaction(OER).ZrP has now proven to be a promising drug nanocarrier and its unique chemical microenvironment provided by theα-type layers and the interlayer space enhances catalytic activity for numerous types of reactions.Further elucidation of the catalytic active species under operando conditions as well as the chemical structure of drug-intercalated derivatives should provide new insights that will advance the design and development of new compounds with desired properties.The initial pioneering efforts of Clearfield and Alberti are being continued by numerous research groups providing new exciting areas of development on the chemistry of layered M(IV)phosphate and phosphonate compounds.In this Account we present the efforts of the Colon group during the past decade on studies of théapplications of ZrP for anticancer drug delivery and electrocatalysis of the OER. | Mario V.Ramos-Garcés Julissa González-Villegas Aleannette López-Cubero Jorge L.Colón | 2021 | Accounts of Materials Research2021，2，9： | 1 |
| 17 | Evaluation of biokinetic coefficient in degradation of oilfield produced water under varying salt concentrations显示文摘 | Tellez G T Nirmalakhandan N Jorge G L | 1995 | Water Research1995，29，7： | 1 |
| 18 | Performance evaluation of an activated sludge system for removing petroleum hydrocarbons from oilfield produced water显示文摘 | Tellez G T Nirmalakhandan N Jorge G L | 2002 | Advances in Environmental Research2002，6，： | 1 |
| 19 | Comparative evaluation of effort, capture and handling effects of drive nets to capture roe deer (Capreolus capreolus), Southern chamois (Rupicapra pyrenaica) and Spanish ibex (Capra pyrenaica)显示文摘 | Jorge R. López-Olvera Ignasi Marco Jordi Montané Encarna Casas-Díaz Gregorio Mentaberre Santiago Lavín | 2009 | European Journal of Wildlife Research2009，，3： | 1 |
| 20 | Performance evaluation of an activated sludge sys-tem for removing petroleum hydrocarbons from oilfield pro- duced water 显示文摘 | Gilbert T TeIlez N Nirmalakhandan Jorge L GardemTor resdey | 2002 | Advances in Environmental Research2002，6，45： | 1 |
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