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| 1 | Gastrointestinal radiation injury:Symptoms,risk factors and mechanisms显示文摘Ionising radiation therapy is a common treatment modality for different types of cancer and its use is expected to increase with advances in screening and early detection of cancer.Radiation injury to the gastrointestinal tract is important factor working against better utility of this important therapeutic modality.Cancer survivors can suffer a wide variety of acute and chronic symptoms following radiotherapy,which significantly reduces their quality of life as well as adding an extra burden to the cost of health care.The accurate diagnosis and treatment of intestinal radiation injury often represents a clinical challenge to practicing physicians in both gastroenterology and oncology.Despite the growing recognition of the problem and some advances in understanding the cellular and molecular mechanisms of radiation injury,relatively little is known about the pathophysiology of gastrointestinal radiation injury or any possible susceptibility factors that could aggravate its severity.The aims of this review are to examine the various clinical manifestations of post-radiation gastrointestinal symptoms,to discuss possible patient and treatment factors implicated in normal gastrointestinal tissue radiosensitivity and to outline different mechanisms of intestinal tissue injury. | Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan | 2013 | World Journal of Gastroenterology2013，19，2： | 35 |
| 2 | Gastrointestinal radiation injury:Prevention and treatment显示文摘With the recent advances in detection and treatment of cancer,there is an increasing emphasis on the efficacy and safety aspects of cancer therapy.Radiation therapy is a common treatment for a wide variety of cancers,either alone or in combination with other treatments.Ionising radiation injury to the gastrointestinal tract is a frequent side effect of radiation therapy and a considerable proportion of patients suffer acute or chronic gastrointestinal symptoms as a result.These side effects often cause morbidity and may in some cases lower the efficacy of radiotherapy treatment.Radiation injury to the gastrointestinal tract can be minimised by either of two strategies:technical strategies which aim to physically shift radiation dose away from the normal intestinal tissues,and biological strategies which aim to modulate the normal tissue response to ionising radiation or to increase its resistance to it.Although considerable improvement in the safety of radiotherapy treatment has been achieved through the use of modern optimised planning and delivery techniques,biological techniques may offer additional further promise.Different agents have been used to prevent or minimize the severity of gastrointestinal injury induced by ionising radiation exposure,including biological,chemical and pharmacological agents.In this review we aim to discuss various technical strategies to prevent gastrointestinal injury during cancer radiotherapy,examine the different therapeutic options for acute and chronic gastrointestinal radiation injury and outline some examples of research directions and considerations for prevention at a pre-clinical level. | Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan | 2013 | World Journal of Gastroenterology2013，19，2： | 32 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Regulation of Wnt/β-catenin signaling by herpesviruses显示文摘The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda. | Kevin J Zwezdaryk Joseph A Combs Cindy A Morris Deborah E Sullivan | 2016 | World Journal of Virology2016，5，4： | 2 |
| 5 | Use of CALPUFF for exposure assessment in a near-field, complex terrain setting显示文摘 | David L. MacIntosh James H. Stewart Theodore A. Myatt Joseph E. Sabato George C. Flowers Kirk W. Brown Dennis J. Hlinka David A. Sullivan | 2009 | Atmospheric Environment2009，，2： | 2 |
| 6 | Information-theoretic analysis of information hiding 显示文摘 | Moulin Pierre O' Sullivan Joseph A | 2003 | IEEE Transactions on Information Theory2003，49，3： | 1 |
| 7 | Incidence of Central Vein Stenosis and Occlusion Following Upper Extremity PICC and Port Placement显示文摘 | Carin F. Gonsalves David J. Eschelman Kevin L. Sullivan Nancy DuBois Joseph Bonn | 2003 | CardioVascular and Interventional Radiology2003，，2： | 1 |
| 8 | A Comparison of Two Sight Word Reading Fluency Drill Formats显示文摘 | Maureen Sullivan Moira Konrad LauriceM. Joseph KenC. T. Luu | 2013 | Preventing School Failure: Alternative Education for Children and Youth2013，，2： | 1 |
| 9 | Cloning of human androgen receptor complementary DNA and localization to the X chromosome显示文摘 | Lubahn DB Joseph DR Sullivan PM | 1988 | Science1988，240，4850： | 1 |
| 10 | Separation and identification of soybean leaf proteins by two-dimensional gel electrophoresis and mass spectrometry显示文摘 | Xu C P Wesley M Joseph Sullivan | 2006 | Phytochemistry2006，，67： | 1 |
| 11 | SAR ATR Performance Using a Conditionally Gaussian Model 显示文摘 | JOSEPH A O SULLIVAN | 2001 | IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS2001，37，1： | 1 |
| 12 | Correlation of NRAS mu- tations with clinical response to high-dose IL-2 in patients with advanced melanoma显示文摘 | Joseph R W Sullivan R J Harrell R | 2012 | J Immunother2012，35，1： | 1 |
| 13 | Cloning of human androgen receptor complementary DNA and localization to the X chromosome显示文摘 | Lubahn DB Joseph DR Sullivan PM | 1988 | Science1988，240，： | 1 |
| 14 | Cloning of human androgen receptor complementary DNA and localization to the X chromosome显示文摘 | JOSEPH D R SULLIVAN P M | 1988 | Science1988，240，： | 1 |
| 15 | Effect of (?)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis显示文摘 | Ann C. Sullivan Joseph Triscari James G. Hamilton O. Neal Miller Victor R. Wheatley | 1974 | Lipids1974，，2： | 1 |
| 16 | Cloning of human androgen receptor complementary DNA and localization to the X chromosome显示文摘 | Lubahn D B Joseph D R Sullivan P M | 1988 | Science1988，240，： | 1 |
| 17 | Information - theoretic analysis of information hiding显示文摘 | Pierre Moulin Joseph A O' Sullivan | 2003 | IEEE Transactions on Information Theory2003，49，2： | 1 |
| 18 | Characterization and expression of the complementary DNA encaoding rat histidine decar- boxylase显示文摘 | Joseph DR Sullivan PM Wang YM | 1990 | Proc Natl Acad Sci U S A1990，87，2： | 1 |
| 19 | Significance of Plk1 regulation by miR‐100 in human nasopharyngeal cancer显示文摘 | WeiShi Nehad M.Alajez CarloBastianutto Angela B.Y.Hui Joseph D.Mocanu EmmaIto PierreBusson Kwok‐WaiLo RaymondNg JohnWaldron BrianO’Sullivan Fei‐FeiLiu | 2010 | Int J Cancer2010，，9： | 1 |
| 20 | Information-Theoretic Analysis of Information Hiding显示文摘 | Joseph A O'Sullivan | 2003 | IEEE TRANSACTIONS ON INFORMATION THEORY2003，49，3： | 1 |
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