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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 3 | Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches显示文摘 | Robert Machold Shigemi Hayashi Michael Rutlin Mandar D Muzumdar Susana Nery Joshua G Corbin Amel Gritli-Linde Tammy Dellovade Jeffery A Porter Lee L Rubin Henryk Dudek Andrew P McMahon Gord Fishell | 2003 | Neuron2003，，1： | 1 |
| 4 | 显示文摘 | Zoran D P Stephen J A Joshua L G | 1998 | Phys Chem B1998，102，： | 1 |
| 5 | Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy显示文摘Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous thrombolysis.Outstanding questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical outcomes.Objective Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October 2018.We reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical outcomes.Results Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(p<0.001).Seven MSU patients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS care.Endovascular thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal variable.Conclusions Mobile stroke care expedited both intravenous thrombolysis and endovascular thrombectomy.There is an ongoing need to show improved functional outcomes with MSU care. | Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman Webster H Pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 6 | Model-Based Feedback Control of AutonomousUnderwater Gliders显示文摘 | Naomi E L Joshua G G | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 7 | Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity显示文摘 | KIMBERLY A G JOSHUA D L | 2010 | J Null''2010，140，： | 1 |
| 8 | Fibular lengthening using distraction osteogenesis for the treat- ment of fibular malunion: A case report显示文摘 | Paul G Talusan David Essig Joshua L Perez | 2013 | Foot&Ankle In- ternational2013，34，7： | 1 |
| 9 | Model-based control of fuel cells 显示文摘 | Joshua G Daniel R L | 2004 | Journal of Power Sources2004，135，： | 1 |
| 10 | Synthetic and structural studies on Fe2 ( SR ) 2 (CN), ( CO ) -, as active site models for Fe-only hydrogenases 显示文摘 | Frederic G Joshua D L Michael S | 2001 | J Am Chem Soc2001，123，12： | 1 |
| 11 | Academic institutions in the United States and Canada ranked according to research productivity in the field of conservation biology显示文摘 | Jacqualine B G Julian D O Joshua J L | 2007 | Conservation Biology2007，21，5： | 1 |
| 12 | Academic Institu- tions in The United States and Canada Ranked According to Re- search Productivity in The Field of Conservation Biology 显示文摘 | Jacqualine B G Julian D O Joshua J L | 2007 | Conservation Biology2007，21，5： | 1 |
| 13 | Model-Based Feedback Control of Autonomous Underwater Gliders 显示文摘 | Naomi E L Joshua G G | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 14 | Experi- mentation of TCP schemes over GPRS gWLAN显示文摘 | LEANG T Y JOSHUA L WINSTON K G | 2002 | IEEE Communications2002，29，11： | 1 |
| 15 | Model - Based Feedback Control of Autonomous Underwater Gliders 显示文摘 | Naomi E L Joshua G G | 2001 | IEEE Journal of O- ceanic Engineering2001，26，4： | 1 |
| 16 | Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity显示文摘 | Kimberly G Joshua L | 2010 | J Nutr2010，140，3： | 1 |
| 17 | Candida albicans and Candida parapsilosis Induce Different T-Cell Responses in Human Peripheral Blood Mononuclear Cells显示文摘 | Adél Tóth Katalin Csonka Cor Jacobs Csaba Vágv?lgyi Joshua D. Nosanchuk Mihai G. Netea Attila Gácser | 2013 | Journal of Infectious Diseases2013，，4： | 1 |
| 18 | Enterobacter sakazakii:AColiform of Increased Concern to Infant Health显示文摘 | JOSHUA B G JEFFREY L K LARRY R B | 2005 | Intemational Journal of Food Microbiology2005，104，1： | 1 |
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