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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Highly Coupon and Sales Prone Consumers : Benefits beyond Price Savings 显示文摘 | Judith A G Burton S | 2003 | Journal of Advertising Research''2003，43，2： | 1 |
| 3 | Using the Credit Spread as an Option-Risk Factor: Size and Value Effects in CAPM 显示文摘 | HWANG Y S MIN H G JUDITH A | 2010 | Journal of Banking and Finance2010，34，9： | 1 |
| 4 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 5 | Pathobiology of human cerebrovascular malformations:basic mechanisms and clinical relevance显示文摘 | Judith G Hemant S Nabil AA | 2004 | Neurosurgery2004，55，： | 1 |
| 6 | The next generation science standards: implications for preservice and inservice science teacher education 显示文摘 | NORMAN G L JUDITH S L | 2014 | Science Teacher Education2014，25，2： | 1 |
| 7 | The interferon antagonistic activities of the V proteins from two strains Newcastle disease vi- rus correlate with their known virulence properties 显示文摘 | Judith G A Subbiah E Siba K S | 2010 | Virus Research2010，147，： | 1 |
| 8 | Receptor and ligands implicated in hunman T cell costimulatory process显示文摘 | JUDITH L KATHARINA G P PETER S | | 0，，02： | 1 |
| 9 | From school to work:employer perceptions of nursing skills 显示文摘 | LOWRY JUDITH S JANET TIMMS DAVID G | 2000 | Journal for Nurses in Staff Development2000，16，2： | 1 |
| 10 | Pathobiology of human cerebrovascular malformation: basic mechanism and clinical relevance 显示文摘 | Judith G Hemant S Robert S | 2004 | Neurosurgery2004，55，： | 1 |
| 11 | In vivo detection of porcine reproductive and respiratory syndrome virus RNA by in situ hybridization at different times postinfection 显示文摘 | JUNG H S VICKIE L C JUDITH A G | 1996 | J Clin Microbio11996，34，9： | 1 |
| 12 | Receptor and ligands implicated in hunman T cell costimulatory process显示文摘 | Judith L Katharina G P Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 13 | Receptor and ligands implicated human T cell costimulatory process显示文摘 | Judith L Katharina G P Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 14 | Liquid-crystal templates for nanostruetured metals 显示文摘 | George S Attard Judith M Corker Christine G Goltner | 1997 | Angw Chem Int Engl1997，36，12： | 1 |
| 15 | Impairment of gallbladder emptying in diabetes mellitus显示文摘 | Bradford G S Judith S G Stenven H B | 1988 | Gastroenteroglogy1988，95，： | 1 |
| 16 | Consumer evaluation and quality measurement of fresh-cut slices of Fuji,'Golden Delicious,'GoldRush,and 'Granny Smith' apples显示文摘 | Judith A A Robert A S Kenneth C G | 2004 | Postharvest Biol Tec2004，33，2： | 1 |
| 17 | Consumer evaluation and quality measurement of fresh-cut slices of 'Fuji', 'Golden Delicious', 'GoldRush' and 'Granny Smith' apples显示文摘 | Judith A A Robert A S Kennth C G | 2004 | Postharvest Biology and Technology2004，33，： | 1 |
| 18 | The interferon anta- gonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known viru- lence properties显示文摘 | JUDITH G A SUBBIAH E SIBA K S | 2010 | VirusRes2010，147，1： | 1 |
| 19 | Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer显示文摘瞄准:屏蔽一个怀疑的匈牙利 HNPCC 家庭发现特定的变化并且在疾病的演讲上评估他们的效果。方法:家庭被使用阿姆斯特丹和 Bethesda 标准识别。Immunohistochemistry 被执行,并且从肿瘤织物孤立的 DNA 样品为微卫星不稳定性被评估。可能的变化的鉴定被定序 hMLH1 和 hMSH2 基因执行。结果:二个不同变化在索引病人并且在他的家庭成员被观察。第一个变化在 7 上位于前, 422 hMSH2 上的鳕鱼,并且上从 Glu 引起了一个变化到站鳕鱼。没有其它这报导一个变化被出版了,根据我们能在国际数据库发现。第二个变化在 127 hMSH2 基因上在 3 鳕鱼上在前被发现,导致毒蛇 -->Ser 替换。第二个变化已经被出版,作为一个非病原的突变而产生之遗传的变化。结论:家谱分析建议在 7 hMSH2 基因上的前的最新检测的胡说八道变化可能为结肠癌的发展负责。没在 7 变化上的前的家庭成员结合这个错误感觉变化,结肠癌出现在 40 岁以后。这二个变化的协会似乎是疾病的表明的年龄到减少进早三十。 | Miklós Tanyi Judith Olasz Géza Lukács Orsolya Csuka László Tóth Zoltán Szentirmay Zsuzsa Ress Zsolt Barta János L Tanyi László Damjanovich | 2006 | World Journal of Gastroenterology2006，12，8： | 0 |
| 20 | Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting显示文摘AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized. | Huascar Ramos Pedro Linares Ester Badia Isabel Martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García Pilar Conde Begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo Mónica Vásquez Diana Joao Marina de Benito Lourdes Ruiz Felipe Jiménez Federico Sáez-Royuela 无 | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，2： | 0 |
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