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| 1 | Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages显示文摘OBJECTIVE: This study aimed to evaluate whether Hwangryunhaedoktang(HHT), a herbal compound, has an inhibitory effect on lipopolysaccharide(LPS)-induced inflammation in RAW264.7 macrophages.METHODS: The effects of HHT were evaluated by confirming nitric oxide(NO) production and expression of inducible NO synthase(iN OS) and mitogen-activated protein kinases(MAPKs) in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB(NF-κB). The secretion and expression of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were determined via enzyme-linked immunosorbent assay and Western blot analyses.RESULTS: HHT suppressed LPS-induced NO production and expression of iN OS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT.CONCLUSION: HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation. | Byung Hyuk Han Yun Jung Lee Jung Joo Yoon Eun Sik Choi Seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee | 2017 | Journal of Integrative Medicine2017，15，4： | 5 |
| 2 | Chest wall metastasis from unknown primary site of hepatocellular carcinoma显示文摘独居的变形肝细胞癌的以前的报告是稀罕的。因为这个肿瘤有一种不同处理形式和预后,精确鉴别诊断是必要的。这里,我们从肝细胞癌的未知主要地点报导独居的胸壁转移的一个稀罕案例。它包含因为一个摸得出的左上面的胸壁团,进入我们的医院的一个 51 岁的人。团是 resected,病理学的检查证实了变形肝细胞癌的诊断。尽管有我们的调查,没有证据被发现那显示肝细胞癌的主要起源。四个月以后,因为脊髓压缩,病人在第三和第四胸的椎骨,脊椎再被招收。突现的 decompressive 椎板切除术被执行,显微镜的特征 4 个月早揭示了象起始的胸壁团 resected 的一样的病理。在一年以后,后续腹的计算断层摄影术(CT ) 仍然没揭示主要肝细胞的证据癌。 | Yil Sik Hyun Ho Soon Choi Joong Ho Bae Dae Won Jun Hang Lak Lee Oh Young Lee Byung Chul Yoon Min Ho Lee Dong Hoo Lee Choon Shuk Kee Jung Ho Kang Moon Hyang Park | 2006 | World Journal of Gastroenterology2006，12，13： | 4 |
| 3 | Intestinal endometriosis:Diagnostic ambiguities and surgical outcomes显示文摘BACKGROUND Endometriosis is a common disease for women of reproductive age. However,when it involves intestines, it is difficult to diagnose preoperatively because its symptoms overlap with other diseases and the results of evaluations can be unspecific. Thus it is important to know the clinical characteristics of intestinal endometriosis and how to exactly diagnose.AIM To analyze patients in whom intestinal endometriosis was diagnosed after surgical treatments, and to evaluate the clinical characteristics of preoperatively misdiagnosed cases.METHODS We retrospectively reviewed the pathologic reports of 30 patients diagnosed as having intestinal endometriosis based on surgical specimens between January2000 and December 2017. We reviewed their clinical characteristics and surgical outcomes.RESULTS Twenty-three(76.6%) patients showed symptoms associated with endometriosis,with dysmenorrhea being the most common(n = 9, 30.0%). Thirteen patients(43.3%) had a history of pelvic surgeries. Ten patients(33.3%) had a history of treatment for endometriosis. Only 4 patients(13.3%) had a diagnosis of endometriosis based on endoscopic biopsy findings. According to preoperative evaluations, 13 patients(43.3%) had an initial diagnosis of pelvic endometriosis and 17 patients(56.6%) were misdiagnosed as having other diseases. The most common misdiagnosis was submucosal tumor in the large intestine(n = 8, 26.7%),followed by malignancies of the colon/rectum(n = 3, 10.0%) and ovary(n = 3,10.0%). According to the Clavien-Dindo classification, 5 complications were grade I or II and 2 complications were grade IIIa. The median follow-up period was 26.9(0.6-132.1) mo, and only 1 patient had a recurrence of endometriosis.CONCLUSION Intestinal endometriosis is difficult to diagnose preoperatively because it mimics various intestinal diseases. Thus, if women of reproductive age have ambiguous symptoms and signs with nonspecific radiologic and/or endoscopic findings,intestinal endometriosis should be included in the differential diagnosis. | Jun Woo Bong Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim | 2019 | World Journal of Clinical Cases2019，7，4： | 3 |
| 4 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 5 | Controlled attenuation parameter ( CAP ) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population显示文摘 | Young Eun Chon Kyu Sik Jung Seung Up Kim Jun Yong Park Young Nyun Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Hye Won Lee Yehyun Park Kwang‐Hyub Han | 2014 | Liver Int2014，，1： | 2 |
| 6 | Expression of survivin and clinical correlation in patients with breast cancer显示文摘 | Doo Min Sohn Sung Yong Kim Moo Jun Baek Cheol Wan Lim Min Hyuk Lee Moo Sik Cho Tae Yoon Kim | 2006 | Biomedicine & Pharmacotherapy2006，，6： | 2 |
| 7 | Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study显示文摘Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment completion.Thus,extending the period of remission in MZL patients remains an essential goal.This multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further investigation.Methods:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV MZL.Rituximab(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week cycle.The patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 cycles.The primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment safety.Results:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance treatment.Fifteen(33%)patients had nodal MZL.Following R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,respectively.After a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of R-CVP.Elevated LDH and the presence of B symptoms were found to be significant prognostic factors for PFS(P=0.003)and demonstrated a 3-year OS rate of 90%.Rituximab-maintenance therapy was well tolerated,and the common treatment-emergent adverse events were sensory neuropathy(18%),myalgia(13%),fatigue(9%),and neutropenia(9%).Conclusion: Rituximab-maintenance therapy following first-line R-CVP demonstrated good PFS in patients with stage III-IV MZL, in addition to a favorable toxicity profile. | Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun Yoon Deok-Hwan Yang Won Sik Lee Hyo Jung Kim Ho-Young Yhim Seong Hyun Jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung-Nam Lim Jun Ho Ji Kyung A.Kwon Gyeong-Won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin Shin Cheolwon Suh | 2019 | Cancer Communications2019，39，1： | 2 |
| 8 | The Accuracy of Noninvasive Methods in Predicting the Development of Hepatocellular Carcinoma and Hepatic Decompensation in Patients With Chronic Hepatitis B显示文摘 | Young Eun Chon Eun Suk Jung Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Kyu Sik Jung Seung Up Kim | 2012 | Journal of Clinical Gastroenterology2012，，6： | 2 |
| 9 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 2 |
| 10 | Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than 6 Months Compared With More Than 6 Months: A 15-Year Prospective Study显示文摘 | Kwang-Hyub Han Do Young Kim Jun Yong Park Sang Hoon Ahn Jieun Kim Seung Up Kim Ja Kyung Kim Kwan Sik Lee Chae Yoon Chon | 2013 | Journal of Clinical Gastroenterology2013，，6： | 1 |
| 11 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 12 | Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan?) before curative resection of hepatocellular carcinoma: a pilot study显示文摘 | Seung Up Kim Sang Hoon Ahn Jun Yong Park Do Young Kim Chae Yoon Chon Jin Sub Choi Kyung Sik Kim Kwang-Hyub Han | 2008 | Hepatology International2008，，4： | 1 |
| 13 | A randomised clinical trial of 10-day concomitant therapy and standard triple therapy for Helicobacter pylori eradication显示文摘 | Jun Heo Seong Woo Jeon Jin Tae Jung Joong Goo Kwon Eun Young Kim Dong Wook Lee Hyang Eun Seo Chang Yoon Ha Hyun Jin Kim Eun Soo Kim Kyung Sik Park Kwang Bum Cho Si Hyung Lee Byung Ik Jang | 2014 | Digestive and Liver Disease2014，，11： | 1 |
| 14 | Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B显示文摘 | Do Young Kim Seung Up Kim Sang Hoon Ahn Jun Yong Park Jung Min Lee Young Nyun Park Ki Tae Yoon Yong Han Paik Kwan Sik Lee Chae Yoon Chon Kwang-Hyub Han | 2009 | Digestive Diseases and Sciences2009，，8： | 1 |
| 15 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 16 | Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than 6 Months Compared With More Than 6 Months: A 15-Year Prospective Study显示文摘 | Kwang-Hyub Han Do Young Kim Jun Yong Park Sang Hoon Ahn Jieun Kim Seung Up Kim Ja Kyung Kim Kwan Sik Lee Chae Yoon Chon | 2013 | Journal of Clinical Gastroenterology2013，，6： | 1 |
| 17 | Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B显示文摘 | Do Young Kim Seung Up Kim Sang Hoon Ahn Jun Yong Park Jung Min Lee Young Nyun Park Ki Tae Yoon Yong Han Paik Kwan Sik Lee Chae Yoon Chon Kwang-Hyub Han | 2009 | Digestive Diseases and Sciences2009，，8： | 1 |
| 18 | 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses显示文摘 | Mi Eun Kim Hyung Keun Kim Dong Hwan Kim Ju Hwa Yoon Jun Sik Lee | 2013 | Immunopharmacology and Immunotoxicology2013，，3： | 1 |
| 19 | Effect of music on colonoscopy performance: A propensity scorematched analysis显示文摘BACKGROUND Music has been used to reduce stress and improve task performance during medical therapy.AIM To assess the effects of music on colonoscopy performance outcomes.METHODS We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular music.Colonoscopy performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music groups.To reduce selection bias,propensity score matching was used.RESULTS After one-to-one propensity score matching,169 colonoscopies were selected from each group.No significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two groups.Subgroup analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in experts.However,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic group.CONCLUSION The current study found that listening to music during colonoscopy did not affect procedure performance.Moreover,it suggested that music may distract trainees from appropriately detecting adenomas and polyps. | Eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon Seung Jung Yu Jong Hyun Lee Han Byul Lee Sang Wook Yi Myeong Pyo Kim Byung Cheol Chung Hong Sub Lee | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 0 |
| 20 | Randomized clinical trial comparing fixed-time split dosing and split dosing of oral Picosulfate regimen for bowel preparation显示文摘AIM To compare the efficacy of fixed-time split dose and split dose of an oral sodium picosulfate for bowel preparation.METHODS This is study was prospective, randomized controlled study performed at a single Institution(2013-058). A total of 204 subjects were assigned to receive one of two sodium picosulfate regimens(i.e., fixed-time split or split) prior to colonoscopy. Main outcome measurements were bowel preparation quality and subject tolerability.RESULTS There was no statistical difference between the fixedtime split dose regimen group and the split dose regimen group(Ottawa score mean 2.57 ± 1.91 vs 2.80 ± 2.51, P = 0.457). Cecal intubation time and physician's satisfaction of inspection were not significantly different between the two groups(P = 0.428, P = 0.489). On subgroup analysis, for afternoon procedures, the fixed-time split dose regimen was equally effective as compared with the split dose regimen(Ottawa score mean 2.56 ± 1.78 vs 2.59 ± 2.27, P = 0.932). There was no difference in tolerability or compliance between the two groups. Nausea was 21.2% in the fixed-time split dose group and 14.3% in the split dose group(P = 0.136). Vomiting was 7.1% and 2.9%(P = 0.164), abdominal discomfort 7.1% and 4.8%(P = 0.484), dizziness 1% and 4.8%(P = 0.113), cold sweating 1% and 0%(P = 0.302) and palpitation 0% and 1%(P = 0.330), respectively. Sleep disturbance was two(2%) patients in the fixed-time split dose group and zero(0%) patient in the split dose preparation(P = 0.143) group.CONCLUSION A fixed-time split dose regimen with sodium picosulfate is not inferior to a split dose regimen for bowel preparation and equally effective for afternoon colonoscopy. | Jae Hyuck Jun Koon Hee Han Jong Kyu Park Hyun Il Seo Young Don Kim Sang Jin Lee Baek Gyu Jun Min Sik Hwang Yoon Kyoo Park Myeong Jong Kim Gab Jin Cheon | 2017 | World Journal of Gastroenterology2017，23，32： | 0 |
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