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| 1 | Application of the sodium hyaluronate-CNTF scaffolds in repairing adult rat spinal cord injury and facilitating neural network formation显示文摘The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI. A planar multielectrode dish system (MED64) was used to test the electrophysiological characteristics of the regenerated neural network in the lesioned area. Electrophysiology and behavior evaluation were used to evaluate functional recovery of paraplegic rat hindlimbs. The Dil tracing and immunofluorescence results suggest that the sodium hyaluronate-CNTF scaffold could activate the NSCs originating from the spinal cord ependymal, and facilitate their migration to the lesion area and differentiation into mature neurons, which were capable of forming synaptic contact and receiving glutamatergic excitatory synaptic input. The MED64 results suggest that functional synapsis could be established among regenerated neurons as well as between regenerated neurons and the host tissue, which has been evidenced to be glutamatergic excitatory synapsis. The electrophysiology and behavior evaluation results indicate that the paraplegic rats’ sensory and motor functions were recovered in some degree. Collectively, this study may shed light on paraplegia treatment in clinics. | Yabin Xie Wei Song Wen Zhao Yudan Gao Junkui Shang Peng Hao Zhaoyang Yang Hongmei Duan Xiaoguang Li | 2018 | Science China(Life Sciences)2018，61，5： | 6 |
| 2 | Effect of Particle Size Distribution on Radiative Heat Transfer in High-Temperature Homogeneous Gas-Particle Mixtures显示文摘The weighted-sum-of-gray-gas(WSGG)model and Mie theory are applied to study the influents of particle size on the radiative transfer in high temperature homogeneous gas-particle mixtures,such as the flame in aero-engine combustor.The radiative transfer equation is solved by the finite volume method.The particle size is assumed to obey uniform distribution and logarithmic normal(L-N)distribution,respectively.Results reveal that when particle size obeys uniform distribution,increasing particle size with total particle volume fraction fvunchanged will result in the decreasing of the absolute value of radiative heat transfer properties,and the effect of ignoring particle scattering will also be weakened.Opposite conclusions can be obtained when total particle number concentration N0 is unchanged.Moreover,if particle size obeys L-N distribution,increasing the narrowness indexσor decreasing the characteristic diameter Dˉwith the total particle volume fraction fvunchanged will increase the absolute value of radiative heat transfer properties.With total particle number concentration N0 unchanged,opposite conclusions for radiative heat source and incident radiation terms can be obtained except for radiative heat flux term.As a whole,the effects of particle size on the radiative heat transfer in the high-temperature homogeneous gas-particle mixtures are complicated,and the particle scattering cannot be ignoring just according to the particle size. | LIANG Dong HE Zhenzong XU Liang MAO Junkui | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，5： | 3 |
| 3 | Rapid qualitative and quantitative analysis of strong aroma base liquor based on SPME-MS combined with chemometrics显示文摘To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were used.Results showed that SPME-MS combined with a back-propagation artificial neural network(BPANN)method yielded almost the same recognition performance compared to linear discriminant analysis(LDA)in distinguishing different grades of SABL,with 84%recognition rate for the test set.Partial least squares(PLS),successive projection algorithm partial least squares(SPA-PLS)model,and competitive adaptive reweighed samplingpartial least squares(CARS-PLS)were established for the prediction of the four esters in the SABL.CARS-PLS model showed a greater advantage in the quantitative analysis of ethyl acetate,ethyl butyrate,ethyl caproate,and ethyl lactate.These results corroborated the hypothesis that SPME-MS combined with chemometrics can effectively achieve an accurate determination of different grades of SABL and prediction performance of esters. | Zongbao Sun Junkui Li Jianfeng Wu Xiaobo Zou Chi-Tang Ho Liming Liang Xiaojing Yan Xuan Zhou | 2021 | Food Science and Human Wellness2021，10，3： | 3 |
| 4 | Retrieval of aerosol optical constants from angular light-scattering measurement signals using principal component analysis approach显示文摘An angular light-scattering measurement (ALSM) method combined with the probability density function-bmsed ant colony optimization algorithm (PDF-ACO) is proposed for retrieval of aerosol optical constants. An optimal measurement angle selection method using a principal component analysis (PCA) approach is developed to improve retrieval accuracy. Results indicate that optimized angle selection can ensure retrieval accuracy. The aerosol optical constants over Beijing, China, which are available from the Aerosol Robotic Network (AERONET), are then rec on structed. The ALSM method's con vergence properties are also studied via comparison w让h those of the light reflection-transmittance measurement (LRTM) method. Results retrieved using the ALSM method show better convergence speed and accuracy than those retrieved using the LRTM method because the ALSM method does not require solution of the radiative transfer equation and allows more useful signals to be obtained. Additionally, the inverse accuracy of the refractive index results is better than that of the absorption index results;this is attributed to differences between the monodromic characteristics of the refractive index and absorption index retrieval results. All results confirm that the combination of the ALSM method w让h the PDF-ACO algorithm and the optimal measurement angle selection method provides effective and reliable aerosol optical constant reconstructio n. | Zhenzong He Junkui Mao Xingsi Han Hao Wang | 2019 | Particuology2019，17，2： | 2 |
| 5 | Disinfection byproduct formation from algal organic matters after ozonation or ozone combined with activated carbon treatment with subsequent chlorination显示文摘Algal organic matter(AOM),including extracellular organic matter(EOM)and intracellular organic matter(IOM)from algal blooms,is widely accepted as essential precursors of disinfection byproducts(DBPs).This study evaluated the effect of ozonation or ozone combined with activated carbon(O_(3)-AC)treatment on characteristic alternation and DBP formation with subsequent chlorination of Chlorella sp..The effects of p H and bromide concentration on DBP formation by ozonation or O_(3)-AC treatment were also investigated.Results showed that the potential formation of DBPs might be attributed to ozonation,but these DBP precursors could be further removed by activated carbon(AC)treatment.Moreover,the formation of target DBPs was controlled at acidic pH by alleviating the reactions between chlorine and AOM.Besides,the bromide substitution factor(BSF)value of trihalomethanes(THMs)from EOM and IOM remained constant after AC treatment.However,THM precursors could be significantly decreased by AC treatment.The above results indicated that O_(3)-AC was a feasible treatment method for algal-impacted water. | Qiufeng Lin Feilong Dong Cong Li Junkui Cui | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 6 | Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages显示文摘OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. | Yin Chengle Muhammad Jahangir Hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 7 | Cost-effective reduced gra- phene oxide-coated polyurethane sponge as a highly efficient and reusable oil-absorbent显示文摘 | Liu Yue Ma Junkui Wu Tao | 2013 | ACS Appl Mater Interfaces2013，5，10： | 1 |
| 8 | Experimental Study on Impingement and Film Overall Cooling Characteristics of Turbine Shroud显示文摘Based on the variable characteristics of the actual operating conditions of the turbine shroud and the purpose of improving the cooling effect of the turbine shroud,this paper builds a test system of the impingement-film cooling shroud with two gas inlet angles(90°,167°).The effects of film cooling hole arrangement,gas inlet angle,blowing ratio(0.7,1.0,1.5,2.0,2.5,3.0)and temperature ratio(1.2,1.3,1.4,1.5,1.6)on the cooling characteristics of the impingement-film cooling shroud were experimentally studied by infrared temperature measurement technology,especially the effects of gas inlet angle and temperature ratio.The results showed that the film covering effect of the film cooling hole vertical or the same direction of the high-temperature gas incoming flow is better than the film covering effect of the reverse direction with the incoming flow,and the optimal arrangement of film cooling holes can improve the cooling effectiveness of the shroud.Compared with 90°intake gas,the film coverage area on the shroud surface of the 167°intake gas is expanded,and the surface average overall cooling effectiveness is increased by 1.03%to 12.6%.The overall cooling effectiveness of turbine shroud increases with the increase of blowing ratio,which increases the flow rate and pressure of cooling gas,and the corresponding increase rate is between 1.04%and 9.96%.However,the increase in the temperature ratio increases the mainstream heating capacity,resulting in a decrease in the cooling effectiveness of the shroud,with a maximum reduction rate of 11.04%. | LI Ziqiang WANG Longfei MAO Junkui BI Shuai WANG Feilong | 2022 | Journal of Thermal Science2022，31，1： | 1 |
| 9 | Prospect of concentrating solar power in China—the sustainable future显示文摘 | Qu Hang Zhao Jun Yu Xiao Cui Junkui | 2007 | Renewable and Sustainable Energy Reviews2007，，9： | 1 |
| 10 | Early Abandon to Accelerate Exact Dynamic Time Warping 显示文摘 | LI Junkui WANG Yuanzhen | 2009 | The International ArabJournal of Information Technology2009，6，2： | 1 |
| 11 | Mechanisms regulating cerebral hypoperfusion in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy显示文摘Cerebral small vessel disease (CSVD) is a leading cause of stroke and dementia. As the most common type of inherited CSVD, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by the NOTCH3 gene mutation which leads to Notch3 ectodomain deposition and extracellular matrix aggregation around the small vessels. It further causes smooth muscle cell degeneration and small vessel arteriopathy in the central nervous system. Compromised cerebral blood flow occurs in the early stage of CADASIL and is associated with white matter hyperintensity, the typical neuroimaging pathology of CADASIL. This suggests that cerebral hypoperfusion may play an important role in the pathogenesis of CADASIL. However, the mechanistic linkage between NOTCH3 mutation and cerebral hypoperfusion remains unknown. Therefore, in this mini-review, it examines the cellular and molecular mechanisms contributing to cerebral hypoperfusion in CADASIL. | Xi Yan Junkui Shang Runrun Wang Fengyu Wang Jiewen Zhang | 2022 | The Journal of Biomedical Research2022，36，5： | 1 |
| 12 | Effects of different regional cerebral blood flow on white matter hyperintensity in CADASIL patients显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is an early-onset inherited small vessel disease.Decreased cerebral blood flow(CBF)may contribute to white matter hyperintensity(WMH)severity in CADASIL,but more evidence is needed to support this hypothesis.This study comprised six patients with CADASIL who harbored mutations in the coding sequence of NOTCH3 and twelve age-matched neurologically healthy controls.We collected clinical and imaging data from patients with CADASIL and divided the brain into four regions:WMH,normal-appearing white matter(NAWM),gray matter(GM),and global brain.We analyzed the relationship between CBF of each region and the WMH volume.Compared with the control group,CBF was significantly decreased in all four regions in the CADASIL group.Lower CBF in these regions was correlated with higher WMH volume in CADASIL.CBF in the NAWM,GM and global regions was positively correlated with that in WMH region.However,after correction tests,only CBF in the WMH region but not in NAWM,GM and global regions was associated with WMH volume.Our findings suggest that CBF in the WMH region is an influencing factor of the WMH severity in CADASIL. | Runrun Wang Jiewen Zhang Junkui Shang Fengyu Wang Xi Yan | 2022 | The Journal of Biomedical Research2022，36，5： | 1 |
| 13 | Radiation Safety Report of HIRFL in 2011显示文摘 | Su Youwu Li Zongqiang Li Wuyuan Xu Junkui Mao Wang Yan Weiwei Xu Chong | 2011 | IMP & HIRFL Annual Report2011，，1： | 1 |
| 14 | Enhancement of oxygen evolution reaction activity and durability of Ba0.5Sr0.5Co0.8Fe0.2O3-δ by CO2 thermal treatment显示文摘This work demonstrates that in situ formation of carbonate layer on the surface of Ba0.5Sr0.5Co0.8Fe0.2O3-δ(BSCF)obtained by exposure to CO2 during heating between 500℃ and 700℃ can provide enhanced oxygen evolution reaction(OER)performance and durability in an alkaline solution relative to the original BSCF.Three temperatures,i.e., 500℃,600℃,and 700℃ were chosen to perform the CO2 thermal treatment,resulting into BSCF-500,BSCF-600,and BSCF-700 samples.The OER was enhanced in the order of BSCF-500< BSCF-700 < BSCF-600. BSCF-600 showed the best OER performance, i.e., a low overpotential of 0.36 V required to attain 10 mA cm^-2 current density as well as a mass activity of 74.14 Agcmcat-1 and a specific activity of 5.04 mA cmcat-2 at an overpotential of 0.4 V. The OER performance durability of BSCF-600 was highlighted by its ability to maintain a stable potential of around 1.61 V vs. RHE (RHE: reversible hydrogen electrode) when charged at a constant current density of 10 mA cm^-2 throughout the 800 min continuous chronopotentiometry test. The enhanced OER performance for BSCF-600 relative to the original BSCF is attributed to three factors:(i) higher electrochemically active surface area;(ii) faster charge transfer rate and higher electrical conductivity;and (iii) modified oxidation state of cobalt ions. The formation of thin carbonate layer in BSCF-600 appears to suppress the durability issue observed in BSCF. | Fengli Liang Ziqiong Yang Haipeng Deng Jaka Sunarso Lili Yang Junkui Mao | 2019 | Journal of Materials Science & Technology2019，35，6： | 1 |
| 15 | 6 - 35 Measurement Results of Soil Radiation Level around HIRFL in 2012显示文摘 | Xu Chong Xu Junkui Su Youwu Pang Chengguo Mao Wang | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 16 | 6-43 Radiation Safety Report of HIRFL in 2016显示文摘The total operation time of HIRFL is 7 488 h in 2016,the user beam time is about 5 547.5 h(from 21 Dec.2015 to 21 Dec.2016).3 178 h for physics experiment,238.5 h for biological physics science research,2 023 h for irradiation effect research,and 108 h for machine research.There are 26 heavy ions beams were provided by HIRFL in 2016.The highest ions energy provided is 7.9 MeV/u,the maximum accumulated ion intensity is 1μA.Environment radiation level was measured with TLDs which were placed in the yard of the institute around HIRFL,15 sites of radiation level show no difference with environment background level of Gansu province[1]. | Su Youwu Xu Junkui Li Zongqiang Li Wuyuan Mao Wang Wang Lijun Xu Chong Yan Weiwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 17 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 18 | Cloning and functional research of renal cell carcinoma related novel gene——GYLZ-RCC18显示文摘After the renal cell carcinoma related novel gene fragment GYLZ-RCC18 was cloned by using suppression subtractive hybridization (SSH), we used the SMART RACE technology to clone the full length of GYLZ-RCC18 and performed chromosome location by the FISH method. RT-PCR was used to detect the expression of the first reading frame of GYLZ-RCC18 in different stages and grades of renal cell carcinoma tissue and other tissues. Also we trans-fected the antisense oligonucleotide of GYLZ-RCC18 to renal cell carcinoma cell line GRC-1, and analyzed the proliferation activity, growth speed, apoptosis and mortality changes in GRC-1. The results show that the full length of GYLZ-RCC18 (GenBank accession No.: BE825133) cDNA is about 3.5 kb long which is located at No. 14 chromosome. GYLZ-RCC18 has a higher expression in higher grades and stages of renal cell carcinoma than in the lower ones. The expression of GYLZ-RCC18 in renal cell carcinoma was much higher than that in normal kidney and other tissues. After | ZHANG Qiang CHEN Lin AI Junkui Chung Lee LIANG Lili TONG Ming ZHANG Zhiwen NA Yanqun QUO Yinglu | 2001 | Chinese Science Bulletin2001，46，19： | 0 |
| 19 | 6-42 Radiation Safety Report of HIRFL in 2015显示文摘The total operation time of HIRFL is 7 536 h in 2015; the user beam time is about 5 451.5 (from 21 Dec.2014 to 21 Dec. 2015); 4 836 h were used for experiments; 615.5 h were used for accelerator research. There are 26 heavy ions beams were provided by HIRFL in 2015. The highest ions energy provided is 464 MeV/u, the maximum accumulated ion intensity is 1 400 A for carbon ion. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 20 | 6-43 Radiation Monitoring System for Wuwei Heavy Ion Medical Accelerator显示文摘To ensure the radiation safety of the accelerator staff, medical personnel, patients and surrounding residents,radiation monitoring system in the workplace was established at HIMM WuWei.The Radiation monitoring system is composed of monitoring, data acquisition unit and central control computer,the structure shown in Fig. 1. Inside and outside the accelerator radiation area 14 monitoring points were arranged(Fig. 2). A neutron detector and a -ray detector was installed at each monitoring point. | Li Zongqiang Mao Wang Li Wuyuan Xu Junkui Fu Xin Xu Chon Yan Weiwei Su Youwu | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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