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| 1 | The effects of land consolidation on the ecological connectivity based on ecosystem service value: A case study of Da'an land consolidation project in Jilin province显示文摘Land consolidation has a profound impact on landscape patterns and ecological functions at various scales through engineering and biological measures. In recent years, China invests more than 100 billion RMB yuan on land consolidation each year. To understand how land consolidation affects landscape patterns and ecosystems, we investigated the ecosystem service value and the ecological connectivity in a consolidated area of Da'an city from 2008 to 2014 using a revised ecological connectivity index. The results indicated that land consolidation has certain negative influences on the ecosystem services in this area. The total ecosystem service value will decrease by nearly 30% in the late stage of consolidation. This decrease is caused by the loss of ecosystem service of the wetland and grassland, despite a sensible increase of cultivated land. In addition, land consolidation could change the ecological connectivity as well as the land use structure. Up to 85% of the entire area will be in low connectivity in the late stage of consolidation, representing a 6.23% increase in the total coverage compared to pre-consolidation. Finally, the different connectivity landscape and their key areas can be identified by the revised ecological connectivity index effectively. This study is helpful to trace out the relationships between landscape pattern and ecological process, and provides insights for ecological planning and designing of land consolidation in this area. We suggest that more attentions should be paid to improve the quality and ecosystem service value per unit area of the landscape, to establish ecological compensation mechanism of wetland losses, and to create the ecological corridors along the least accumulated impendence surface in the key areas during land consolidation. | WANG Jun YAN Shenchun GUO Yiqiang LI Junran SUN Guoqing | 2015 | Journal of Geographical Sciences2015，25，5： | 26 |
| 2 | METTL3-mediated m^(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition显示文摘Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD. | Yuwei Wang Yuhong Chen Jian Liang Mei Jiang Ting Zhang Xiaoling Wan Jiahui Wu Xiaomeng Li Jieqiong Chen Junran Sun Yifan Hu Peirong Huang Jingyang Feng Te Liu Xiaodong Sun | 2023 | Journal of Molecular Cell Biology2023，15，3： | 1 |
| 3 | Toward a sustainable grassland ecosystem worldwide显示文摘Globally,grasslands,covering about 40%of the Earth’s land area,are vital for supporting important ecosystem functions,services,and livelihoods of millions of humans.Currently,grassland degradation is a major threat to the maintenance of ecological services,1 food security,and sustainable development,and directly hinders the global efforts with meeting goals and targets such as the The UN Decade on Ecosystem Restoration and Sustainable Development Goals(SDGs).Remote sensing approaches have the advantages of spanning large geographical areas withmultiple spatial,spectral,and temporal resolutions.In global scale,remote sensing methods used normalized difference vegetation index to determine net primary productivity(NPP),which still is the effectivemethod to indicate grassland conditions.To master the general situation of grassland,we analyzed the global spatial-temporal variation of NPP from 2001 to 2019 at the pixel level across the globe.As presented in Figure 1A,the NPP values of global grasslands showed an obvious variation trend,which indicated a considerable distribution pattern of spatial heterogeneity.The decreasing and increasing trend in grassland NPP covered approximately 25.3%and 74.5%of the total grassland area,respectively. | Jian Sun Yi Wang Shilong Piao Miao Liu Guodong Han Junran Li Eryuan Liang Tien Ming Lee Guohua Liu Andreas Wilkes Shiliang Liu Wenwu Zhao Huakun Zhou Mesenbet Yibeltal Mulatu Liyew Berihun Dawn Browning Ayele Almaw Fenta Atsushi Tsunekawa Joel Brown Walter Willms Mitsuru Tsubo | 2022 | The Innovation2022，3，4： | 0 |
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