|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 2 | Branched Fluorine/Adamantane Interfacial Compatibilizer for PBO Fibers/Cyanate Ester Wave-Transparent Laminated Composites显示文摘Comprehensive Summary Branched fluorine/adamantane PBO precursor(preFABPBO),synthesized via random co-condensation between 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoro propane,1,3-adamantanedicarbonyl dichloride,and trimesoyl chloride,is performed as interfacial compatibilizer,bisphenol A dicyanate ester(BADCy)resin as polymer matrix,and poly(p-phenylene-2,6-benzobisoxazole)(PBO)fibers as reinforcements to prepare PBO fibers/FABPBO-BADCy wave-transparent laminated composites by high temperature molding.The mechanical properties,wave-transparent performances,and heat resistances of PBO fibers/BADCy composites are simultaneously improved by the addition of preFABPBO.The interlaminar shear strength(ILSS)and flexural strength of PBO fibers/FABPBO-BADCy composites are 48.9 and 665.3 MPa,respectively,increased by 33.2%and 13.3%compared to those of PBO fibers/BADCy composites(36.7 and 587.4 MPa).The dielectric constant and dielectric loss values at 106 Hz are 2.53 and 0.003,respectively,lower than those of PBO fibers/BADCy composites(3.06 and 0.006),and the corresponding wave transmission efficiency is 94.8%,which also presents excellent stability over the wide temperature(25-200℃)and frequency range(103-107 Hz and 8.2-12.4 GHz).Meanwhile,the heat resistance index and glass transition temperature are 229.9℃and 247.5℃,also better than those of PBO fibers/BADCy composites(229.6℃and 247.1℃). | Zheng Liu Xiaoli Fan Muyi Han Hao Li Junliang Zhang Lixin Chen Qiju Zhu Junwei Gu | 2023 | Chinese Journal of Chemistry2023，41，8： | 2 |
| 3 | PBO fibers/fluorine-containing liquid crystal compound modified cyanate ester wave-transparent laminated composites with excellent mechanical and flame retardance properties显示文摘Bisphenol A dicyanate ester resins modified by fluorine-containing liquid crystal compound(LCFE)are applied as polymer matrix(LCFE-BADCy),poly(p-phenylene-2,6-benzobisoxazole)(PBO)fibers as rein-forcements,and fluorine/adamantane PBO precursor(pre FABPBO)as interfacial compatibilizer to prepare the corresponding PBO fibers/FABPBO/LCFE-BADCy wave-transparent laminated composites.LCFE could improve the order degree of BADCy cured network,in favor of enhancing the wave-transparent perfor-mance,mechanical properties,and intrinsic thermal conductivity.The dielectric constant and dielectric loss of PBO fibers/FABPBO/LCFE-BADCy composites are highly temperature(25–200℃)and frequency(10^(4)–10^(7) Hz and 8.2–12.4 GHz)stable with the value of 2.49 and 0.003 under 10^(6) Hz at 25℃,and the corresponding wave transmission efficiency is 95.0%,higher than that of 92.5%for PBO fibers/BADCy com-posites.The interlamellar shear strength and flexural strength are respectively 50.7 MPa and 682.5 MPa,38.1%and 16.2%higher than those of PBO fibers/BADCy composites.Besides,the volume resistivity,breakdown voltage,heat resistance index,glass transition temperature,flame retardant grade,and ul-timate oxygen index of PBO fibers/FABPBO/LCFE-BADCy composites are respectively 5.3×10^(15)Ωcm,29.75 kV/mm,217.2℃,245.7℃,V-1 grade,and 33.6%,expected to be performed as a new generation of“lightweight/loading/wave-transparent”electromagnetic window materials in advanced military weapons and civil communication base station. | Zheng Liu Xiaoli Fan Junliang Zhang Lixin Chen Yusheng Tang Jie Kong Junwei Gu | 2023 | Journal of Materials Science & Technology2023，，21： | 2 |
| 4 | Hybrid Polymer Membrane Functionalized PBO Fibers/Cyanate Esters Wave‑Transparent Laminated Composites显示文摘Hybrid polymer membrane(TA-APTES),synthesized by tannic acid(TA)and aminopropyl trethoxysilane(APTES)based on the Schif’s base and Michael addition reaction,is deposited on the surface of poly(p-phenylene-2,6-benzobisoxazole)(PBO)fbers,and then grafted with epoxy-terminated polysesquisiloxane(POSS)to obtain POSS-g-PBO@TA-APTES fbers.The POSS-g-PBO@TA-APTES fbers reinforced bisphenol A dicyanate ester(BADCy)resins(POSS-g-PBO@TAAPTES fbers/BADCy)wave-transparent laminated composites are prepared.The interlaminar shear strength and fexural strength of POSS-g-PBO@TA-APTES fbers/BADCy composites are respectively enhanced from 36.7 and 587.4 MPa to 42.8 and 645.8 MPa,increased by 16.6%and 9.9%compared with those of PBO fbers/BADCy composites.At 1 MHz,the corresponding dielectric constant and dielectric loss are reduced to 2.85 and 0.0047,respectively,lower than those of PBO fbers/BADCy(3.06 and 0.006)composites.Meanwhile,the simulated wave transmittance rate of POSS-g-PBO@TA-APTES fbers/BADCy composites with the thicknesses of 1.5–3.5 mm is higher than 86.2%at 0.3–40 GHz.The volume resistivity and breakdown strength of POSS-g-PBO@TA-APTES fbers/BADCy composites are 2.8×10^(15)Ω·cm and 19.80 kV/mm,higher than PBO fbers/BADCy composites(2.2×10^(15)Ω·cm and 17.69 kV/mm),respectively.And the corresponding heat resistant index is 221.5℃,lower than PBO fbers/BADCy composites(229.6℃). | Zheng Liu Xiaoli Fan Lei Cheng Junliang Zhang Lin Tang Yusheng Tang Jie Kong Junwei Gu | 2022 | Advanced Fiber Materials2022，4，3： | 2 |
| 5 | Two-episode Tectono-thermal Events of the Heyuan Fault in Late Cretaceous and Oligocene and their Tectonic Implications, Southernmost South China Block显示文摘The Heyuan Fault, is one of the main NE-trending faults in the southernmost South China Block and is close to the northernmost South China Sea to the south. The fault features multi-stage deformation and controlled the formation of late Cretaceous to Cenozoic basins. Based on detailed field investigations and comprehensive geochronological research, including zircon U-Pb, Rb-Sr isochron, zircon U-Th-He dating, two episodic tectono-thermal events are recognized. The first occurred during ~79 Ma to 66 Ma, which is characterized by large-scale quartz-fluid emplacement. The other occurred at ~34 Ma, which features the eruption of a set of basalts. The two events show a changing on material source from siliceous hydrotherm to basalt magma, supporting obvious lithospheric thinning of the southernmost South China Block, which shed light on the geological evolution and the interaction mechanisms between the SCB and the northern South China Sea since the Late Cretaceous. | WANG Qiangmao LI Hailong LI Tingdong DING Xiaozhong ZHEN Junwei ZHANG Min FAN Yanxia | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 2 |
| 6 | Sensitivity analysis of the 3-PRS parallel kinematic spindle platform of a serial-parallel machine tool显示文摘 | Fan Kuangchao Wang Hai Zhao Junwei | 2003 | International Journal of Machine Tools&Manufacture2003，43，15： | 1 |
| 7 | Sensitivity analysis of the 3-PRS parallel kinematic spindle platform of a serial-parallel machine tool显示文摘 | FAN Kuangchao WANG Hai ZHAO Junwei | 2003 | International Journal of Machine Tools and Manufacture2003，43，15： | 1 |
| 8 | Vehicle detection using normalized color and edge map 显示文摘 | Tsai Luowei Hsieh Junwei Fan Kuochin | 2007 | IEEE Transactions on Image Processing2007，16，3： | 1 |
| 9 | Sensitivity Analy- sis of the 3-PRS Parallel Kinematic Spindle Platform of a Se- rial-parallel Machine Tool显示文摘 | Fan Kuangchao Wang Hai Zhao Junwei | 2003 | International Journal of Ma- chine Tools and Manufacture2003，43，15： | 1 |
| 10 | Biotemplated preparation of CdS nanoparticles/bacterial cellulose hybrid nanofibers for photocatalysis application显示文摘 | Jiazhi Yang Junwei Yu Jun Fan Dongping Sun Weihua Tang Xuejie Yang | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 11 | Sensitivity A- nalysis of the 3-PRS Parallel Kinematic Spindle Platform of a Serial-parallel Machine Tool 显示文摘 | FAN Kuangchao WANG Hai ZHAO Junwei | 2003 | International Journal of Machine Tools and Manufacture2003，43，15： | 1 |
| 12 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 13 | Novel Single Nucleotide Poly- morphisms in Interleukin 6 Affect Tacroliraus Metabolism in Liver Transplant Patients显示文摘 | Dawel Chen Junwei Fan Feng Guo | 2013 | PLoS ONE2013，8，73： | 1 |
| 14 | Effect of catalysts supporting on tandem polymerization of ethylene stock in synthesis of ethylene-l-hexene eopolymer显示文摘 | Zhang Junwei Fan Hong Li Bogeng eta | 2008 | Ind Eng Chem Res2008，47，15： | 1 |
| 15 | Vehicle detec- tion using normalized color and edge map 显示文摘 | TSAI LUOWEI HSIEH JUNWEI FAN KUOCHIN | 2007 | IEEE Transactions on Image Processing2007，16，3： | 1 |
| 16 | Sensitivity Analysis of the 3- PRS Parallel Kinematic Spindle Platform of a Serial--parallel Machine Tool 显示文摘 | Fan Kuangchao Wang Hai Zhao Junwei | 2003 | Inter- national Journal of Machine Tools and Manufacture2003，43，15： | 1 |
| 17 | Vehicle de-tection using normalized color and edge map显示文摘 | TSAI Luowei HSIEH Junwei FAN Kuochin | 2007 | IEEE Trans-actions on Image Processing2007，16，3： | 1 |
| 18 | Applying deep neural networks to the detection and space parameter estimation of compact binary coalescence with a network of gravitational wave detectors显示文摘In this paper, we study an application of deep learning to the advanced laser interferometer gravitational wave observatory(LIGO)and advanced Virgo coincident detection of gravitational waves(GWs) from compact binary star mergers. This deep learning method is an extension of the Deep Filtering method used by George and Huerta(2017) for multi-inputs of network detectors.Simulated coincident time series data sets in advanced LIGO and advanced Virgo detectors are analyzed for estimating source luminosity distance and sky location. As a classifier, our deep neural network(DNN) can effectively recognize the presence of GW signals when the optimal signal-to-noise ratio(SNR) of network detectors ≥ 9. As a predictor, it can also effectively estimate the corresponding source space parameters, including the luminosity distance D, right ascension α, and declination δ of the compact binary star mergers. When the SNR of the network detectors is greater than 8, their relative errors are all less than 23%.Our results demonstrate that Deep Filtering can process coincident GW time series inputs and perform effective classification and multiple space parameter estimation. Furthermore, we compare the results obtained from one, two, and three network detectors;these results reveal that a larger number of network detectors results in a better source location. | XiLong Fan Jin Li Xin Li YuanHong Zhong JunWei Cao | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，6： | 1 |
| 19 | FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria显示文摘 | Hongcheng Sun Mujian Teng Jie Liu Dong Jin Junyi Wu Dongwang Yan Junwei Fan Xuebin Qin Huamei Tang Zhihai Peng | 2011 | Cancer Letters2011，，2： | 1 |
| 20 | Highly Soluble Phenylethynyl-terminated Imide Oligomers and Thermosetting Polyimides Based on 2,2′3,3′-Biphenyltetracarboxylic Dianhydride显示文摘The properties of a series of imide oligomers were characterized according to their molecular weights, solubility, and thermal and rheological properties. This series of imide oligomers was synthesized via a two-step method using 2,2′,3,3′-biphenyltetracarboxylic dianhydride(3,3′-BPDA) and aromatic diamines as the monomers, and 4-phenylethynyl phtlialic anhydride(PEPA) as the end-capping agent. The imide oligomers based on 3,3′-BPDA showed excellent solubility in low boiling point solvents and low melt viscosity, which were attributed to their unique bent architectures. High-performance thermosetting polyimides were produced from these oligomers via thermal crosslinking of the phenylethynyl groups. The mechanical and thermal properties of the thermosets were studied using tensile testing, dynamic mechanical thermal analysis(DMTA), and thermogravimetric analysis(TGA). The 3,3′EPDA-based thermosets exhibited excellent thermal properties, with glass transition temperatures of up to 455℃, and 5% mass loss temperatures of up to 569℃ in air. The thermosets based on 3,3-BPDA showed superior thermal properties compared to those derived from TriA-X series oligomers. | MENG Xiangsheng LU Gewu LIU Xiuju MENG Qingjie SHI Junwei YUAN Hang KE Hongjun WANG Xianwei FAN Weifeng LIU Jingfeng YAN Jingling WANG Zhen | 2019 | Chemical Research in Chinese Universities2019，35，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员