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| 1 | Long-term trend and abrupt events of the Holocene Asian monsoon inferred from a stalagmiteδ^(18)O record from Shennongjia in Central China显示文摘A high-resolution oxygen-isotope record from a thorium-uranium-dated stalagmite from Shanbao Cave at Shennongjia reflects variations in the amount of monsoon precipitation for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between 11.5 and 9.3 ka, a sharp decrease in δ18O indicates a rapid increase in monsoon precipitation. An interval of generally high monsoon precipitation is observed between 9.3 and 4.4 ka. An arid period has prevailed between 4.4 and 2.1 ka. The long-term trend of Shanbao record appears to follow summer insolation at 33°N latitude. An abrupt decrease in monsoon precipitation around 4.3 ka is synchronous with the collapse of Neolithic culture in central China. This abrupt change could have resulted from the amplifi- cation of the gradually decreased summer insolation by the positive vegetation-atmosphere-aerosol feed- back. The weakened Asian monsoon events were in concert with decreased Greenland temperature dur- ing the early Holocene, centered at 8.2, 8.6, 9.3, 10.2 and 11.0 ka. This correlation suggests that changes in low-latitude monsoon are connected with climate change in high-latitude polar region. | SHAO Xiaohua WANG Yongjin CHENG Hai KONG Xinggong WU Jiangying EDWARDS R. Lawrence | 2006 | Chinese Science Bulletin2006，51，2： | 64 |
| 2 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 3 | The Association of Overweight and Obesity with Blood Pressure among Chinese Children and Adolescents显示文摘Objective To examine the association between obesity and high blood pressure (BP) in Chinese children and adolescents. Methods Body mass index (BMI) and blood pressure measurements of 197 191 children aged 7-17 years were obtained from a Chinese national survey in 2010. Obesity and high BP were defined according to the reference values for Chinese children. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of different BMI categories for high BP, as well as the population attributable risk percent (PAR%), were also calculated. Results The prevalence of high BP was 16.1% for boys and 12.9% for girls in 2010. Overweight and obese children had a significantly higher prevalence of high BP than non-overweight children in both boys and girls in each age group. ORs (95% CI) for high BP were 4.1 (3.9, 4.4) in obese boys and 4.0 (3.7, 4.3) in obese girls. The overall PAR% for high BP due to overweight and obesity was 14.4%. Conclusion Overweight and obese children have a significantly higher risk of high BP than non-overweight children. Eliminating overweight and obesity could reduce 14.4% of high BP cases. | DONG Bin MA Jun WANG Hai Jun WANG Zhi Qiang | 2013 | Biomedical and Environmental Sciences2013，26，6： | 42 |
| 4 | Anti-tumor activities of active ingredients in Compound Kushen Injection显示文摘Kushen (根值 Sophorae Flavescentis ) 在繁体中文药为肿瘤,发炎和另外的疾病的治疗有使用的长历史。复合 Kushen 注射(CKI ) 是从 Kushen 和 Baituling (根茎 Smilacis Glabrae ) 提取的自然混合物的混合物。CKI 的主要原则是 matrine (MT ) 和展出许多药理学活动的 oxymatrine (OMT ) ,包括反煽动性,反过敏,抗病毒, anti-fibrotic 和心血管的保护的效果。最近的证据证明这些混合物也产生反癌症行动,例如禁止癌症房间增长,导致房间周期拘捕,加速 apoptosis ,制止 angiogenesis ,导致房间区别,禁止癌症转移和侵略,逆行的 multidrug 抵抗,并且阻止或减少化疗--或导致放射疗法的毒性当与化学疗法的药结合了时。在这评论,我们在学习 MT, OMT 和 CKI 和他们的潜在的分子的目标的反癌症活动总结最近的进步,它为进一步的学习提供线索和参考书。 | Wei WANG Rong-li YOU Wen-jie QIN Li-na HAI Ming-jing FANG Guo-hua HUANG Rui-xia KANG Ming-hua LI Yu-feng QIAO Jian-wei LI An-ping LI | 2015 | Acta Pharmacologica Sinica2015，36，6： | 41 |
| 5 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 6 | L_(1/2) regularization显示文摘In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasedness, sparsity and oracle properties.A reweighed iterative algorithm is proposed so that the solution of the L 1/2 regularizer can be solved through transforming it into the solution of a series of L 1 regularizers.The solution of the L 1/2 regularizer is more sparse than that of the L 1 regularizer, while solving the L 1/2 regularizer is much simpler than solving the L 0 regularizer.The experiments show that the L 1/2 regularizer is very useful and efficient, and can be taken as a representative of the Lp(0 < p < 1) regularizer. | XU ZongBen ZHANG Hai WANG Yao CHANG XiangYu LIANG Yong | 2010 | Science China(Information Sciences)2010，53，6： | 32 |
| 7 | Representative of L1/2 Regularization among Lq (0 〈 q ≤ 1) Regularizations: an Experimental Study Based on Phase Diagram显示文摘 | XU Zong-Ben GUO Hai-Liang WANG Yao ZHANG Hai | 2012 | 自动化学报2012，38，7： | 34 |
| 8 | Diver CE versus Guardwire Plus for thrombectomy in patients with inferior myocardial infarction:a trial of aspiration of thrombus during primary angioplasty for inferior myocardial infarction显示文摘背景不同可行、安全的 thrombectomy 和远侧的保护设备用 Diver CE 设备在临床的 practice.The 效率和附属物 thrombectomy 的安全被使用了( Invatec ,意大利 )对 Guardwire 正设备( Medtronic ,美国)在经皮的冠的干预(一种总线标准)与尖锐劣等的 ST-segment-elevation 心肌的梗塞( STEMI )在病人被作比较不到 12 个小时以前,在心肌的梗塞( TIMI )的 thrombolysis 流动分级 0~1 ,并且总计吸藏第二等的结束点被让结束心脏舒张的体积( LVEDV )室,左室喷射部分( LVEF )和包括死亡的主要不利心脏的事件(权标),心肌的梗塞,在 122 个病人的 30 days.Results A 总数的目标容器 revascularization 和击同等地被划分成 Diver CE 组和 Guardwire 正组,它到年龄是可比较的(( 60 ?????????汣灯摩杯敲????朠潲灵?潃据畬楳湯??湡獵? | YAN Hong-bing WANG Jian LI Nan ZHU Xiao-ling GAO Hai AI Hui LI Xiang YE Ming CHI Yun-peng ZHANG Hong | 2007 | Chinese Medical Journal2007，，7： | 29 |
| 9 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 10 | The miR156/SPL Module, a Regulatory Hub and Versatile Toolbox, Gears up Crops for Enhanced Agronomic Traits显示文摘在过去的二十年,SQUAMOSA倡导者绑定的成员像蛋白质(系统程序设计语言)抄写因素的家庭,首先在金鱼草 majus 识别了,在植物作为多样的生物进程的枢轴的管理者出现了包括预定植物、繁殖的阶段变化,长叶开发, tillering/branching , plastochron ,圆锥花序/缨建筑学,成熟的水果,富饶,和对压力的反应。系统程序设计语言的一个子集的抄本被 microRNA156s (miR156s ) 为劈开或翻译压抑指向。miR156s 的层次被内长的发展暗示和各种各样的外部刺激调整。积累的证据证明在 miR156/SPL 模块附近的规章的电路高度在种系发生地不同的植物种类之中被保存,并且在调整植物健康,生物资源,和产量起重要作用。与膨胀知识和他们的角色和规章的关系的机械学的理解,我们现在能作为工具的过多利用 miR156/SPL 模块遗传上在生长和开发为最佳的参数操作庄稼,并且最终由庄稼的聪明的设计让步最大化。 | Hai Wang Haiyang Wang | 2015 | Molecular Plant2015，8，5： | 28 |
| 11 | Shenfu Injection(参附注射液) Inhibits Inflammation in Patients with Acute Myocardial Infarction Complicated by Cardiac Shock显示文摘Objectives: To investigate the effect of Shenfu Injection(参附注射液, SFI) on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock(CS) treated with and intra-aortic balloon pump(IABP). Methods: This study enrolled 60 patients with ST-segment elevation myocardial infarction(STEMI) complicated by CS. Patients underwent IABP and emergency percutaneous coronary intervention(PCI) were randomly divided into two groups by random number table with 30 cases in each group, one given SFI treatment(100 m L/24 h), one not. The two groups were then compared in a clinical setting for left ventricular function, biochemical indicators and Inflammatory factors, including C-reactive proteins(CRP), interleukin-1(IL-1) and tumor necrosis factor alpha(TNF-α). Major adverse cardiac and cerebrovascular events(MACCE) events were compared between patients of the two groups both in-hospital and in follow-ups. Results: The IABP support treatment times of patients in the IABP+SFI group were significantly shorter than the IABP group(52.87±28.84 vs. 87.45±87.31, P=0.047). In the patients of the IABP+SFI group, the CRP peak appeared in 24 h after PCI operation. The CRP peak in the patients of the IABP+SFI group was significantly lower than that in the IABP group(31.27±3.93 vs. 34.62±3.47, P=0.001). The increases in range of TNF-α in the patients of the IABP+SFI group were significantly lower than those of the IABP group(182.29±22.79 vs. 195.54±12.02, P=0.007). The increases in range of IL-1 in the patients of the IABP+SFI group were significantly lower than those of the IABP group(214.98±29.22 vs. 228.60±7.03, P=0.019). The amplitude elevated TNF-α 72 h after admission was an independent risk factor of in-hospital MACCE events(OR 0.973, 95% CI 0.890–0.987, P=0.014) in patients with STEMI and CS. Conclusion: Patients with STEMI complicated by CS treated by IABP and SFI had a reduced inflammatory reaction, a reduced dependence of CS on IABP and shortened the course of disease. | JIN Yan-yan GAO Hai ZHANG Xin-yong AI Hui ZHU Xiao-lin WANG Jing | 2017 | Chinese Journal of Integrative Medicine2017，23，3： | 27 |
| 12 | 南京葫芦洞石笋δ^(13)C对冰期气候的复杂响应与诊断显示文摘文中重建了南京葫芦洞内距今75~10ka期间7支石笋δ13C的时间变化序列,δ13C曲线在重叠时段均具有一致性波动形式.在最后一个冰期/间冰期旋回,δ13C值变化幅度达6‰,反映了C3/C4植被类型变化对δ13C的主控作用.然而,在末次冰期格陵兰冰心记录的DO暖事件时(千年尺度),δ13C与指示降水变化的δ18O呈反相关,主要反映了快速渗水条件下洞穴岩溶水对土壤CO2溶解量的降低.据同期生长石笋δ13C和δ18O对比分析,石笋碳同位素动力分馏程度与生长速率有关.进一步研究发现,本区末次冰消期植被类型变化滞后于降水变化约700年. | 孔兴功 汪永进 吴江滢 Cheng Hai L R Edwards Wang Xianfeng | 2005 | 中国科学(D辑)2005，35，11： | 24 |
| 13 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 14 | Bt Cotton in China:Are Secondary Insect Infestations Offsetting the Benefits in Farmer Fields?显示文摘The area sown to Bt cotton has expanded rapidly in China since 1997.It has effectively controlled the bollworm.However,in recent years,concern has surfaced about the emergence of secondary insect pests,particular mirids,in Bt cotton fields.This study measures the patterns of insecticide use based on farm-level from 1999 to 2006,the analysis demonstrates a rise in insecticide use to control mirids between 2001 and 2004,secondary insect infestations is largely related to the rise of mirids,but this rising did not continue in more than half of sample villages studied in 2004-2006.Moreover,the increase in insecticide use for the control of secondary insects is far smaller than the reduction in total insecticide use due to Bt cotton adoption.Further econometric analyses show that rise and fall of mirids is largely related to local temperature and rainfall. | WANG Zi-jun LIN Hai HUANG Ji-kun HU Rui-fa Scott Rozelle Carl Pray | 2009 | Agricultural Sciences in China2009，8，1： | 21 |
| 15 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 16 | An H^1-Galerkin Nonconforming Mixed Finite Element Method for Integro-Differential Equation of Parabolic Type显示文摘H1-Galerkin nonconforming mixed finite element methods are analyzed for integro-differential equation of parabolic type.By use of the typical characteristic of the elements,we obtain that the Galerkin mixed approximations have the same rates of convergence as in the classical mixed method,but without LBB stability condition. | SHI Dong Yang WANG Hai Hong | 2009 | Journal of Mathematical Research and Exposition2009，29，5： | 20 |
| 17 | Experimental study on the angle of repose of pulverized coal显示文摘An experimental study on the angle of repose(AoR)of pulverized coal with different particle sizes and different moisture contents(MC)was conducted.Three different measurement methods,free-base piling,fixed-base piling and sliding,were used.The data were analyzed by one-way and two-way analysis of variance.The results showed that the AoRs of pulverized coal with particle sizes smaller than 150 m were in the range of 30-50°.The characterization of the flowability of pulverized coal was some cohesiveness or true cohesiveness.The increase of MC will increase AoR and thus decrease the flowability of the powder.However,the particle size effect is bifurcated.Below a critical size,the decrease of particle size decreases the flowability;while above the critical size,the decrease of particle size increases the flowability.It was found that the value of the critical size strongly depends on the powder density.Moreover,the AoR dependence on particle size could be linked with the Geldart's particle classification.The critical size at the turning point is on the boundary between Group A and Group B in Geldart's classification diagram.Based on the experimental results,there is no significant cross interaction between particle size and MC.The AoRs measured by free-base method and fixed-base method are close,but both remarkably smaller than that measured by the sliding method. | Wei Wang Jiansheng Zhang Shi Yang Hai Zhang Hairui Yang Guangxi Yue | 2010 | Particuology2010，8，5： | 20 |
| 18 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 19 | Numerical simulation of gas transport mechanisms in tight shale gas reservoirs显示文摘Due to the nanometer scale pore size and extremely low permeability of a shale matrix,traditional Darcy's law can not exactly describe the combined gas transport mechanisms of viscous flow and Knudsen diffusion.Three transport models modified by the Darcy equation with apparent permeability are used to describe the combined gas transport mechanisms in ultra-tight porous media,the result shows that Knudsen diffusion has a great impact on the gas transport and Darcy's law cannot be used in a shale matrix with a pore diameter less than 1 μm.A single porosity model and a double porosity model with consideration of the combined gas transport mechanisms are developed to evaluate the influence of gas transport mechanisms and fracture parameters respectively on shale gas production.The numerical results show that the gas production predicted by Darcy's law is lower than that predicted with consideration of Knudsen diffusion and the tighter the shale matrix,the greater difference of the gas production estimates.In addition,the numerical simulation results indicate that shale fractures have a great impact on shale gas production.Shale gas cannot be produced economically without fractures. | Yao Jun Sun Hai Fan Dong-yan Wang Chen-chen Sun Zhi-xue | 2013 | Petroleum Science2013，10，4： | 20 |
| 20 | The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data显示文摘目的: 当每周,每天管理了时,口头的 risedronate 在绝经后的骨质疏松症的处理是有效的。在这 1 年,使随机化,双窗帘,我们比较了的 multicenter 学习在有骨质疏松症或 osteopenia 的中国绝经后的女人的处理的每周的 35-mg 和每日的 5-mg risedronate dosing 政体。 | Jie-mei GU Li WANG Hua LIN De-cai CHEN Hai TANG Xiao-lan JIN Wei-bo XIA Yun-qiu HU Wen-zhen FU Jin-wei HE Hao ZHANG Chun WANG Hua YUE Wei-wei HU Yu-juan LIU Zhen-lin ZHANG | 2015 | Acta Pharmacologica Sinica2015，36，7： | 19 |
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