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| 1 | Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms显示文摘Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.Here,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.We validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin expression.Interestingly,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s effects.In addition,AUR induces IL-6 via the NF-κB pathway.In C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin saturation.Whereas chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in females.Further analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)mice.Notably,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)activity.We demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron metabolism.In conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders. | Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Transfer function based equivalent modeling method for wind farm显示文摘To effectively study the dynamics of power systems with large-scale wind farms(WFs), an equivalent model needs to be developed. It is well known that back-toback converters and their controllers are important for the dynamic responses of the wind turbine(WT) under disturbances. However, the detailed structure and parameters of the back-to-back converters and their controllers are usually unknown to power grid operators. Hence, it is difficult to build an accurate equivalent model for the WF using the component model-based equivalent modeling method. In this paper, a transfer function based equivalent modeling method for the WF is proposed. During modeling, the detailed structure and parameters of the WF are not required. The objective of the method is reproducing the output dynamics of the WF under the variation of the wind speed and power grid faults. A decoupled parameter-estimation strategy is also developed to estimate the parameters of the equivalent model. A WF that consists of 16 WTs is used to test the proposed equivalent model. Additionally,the proposed equivalent modeling method is applied to build the equivalent model for a real WF in Northwest China. The effectiveness of the proposed method is validated by the real measurement data. | Feng WU Junxia QIAN Ping JU Xiaoping ZHANG Yuqing JIN Dan XU Michael STERLING | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 2 |
| 3 | ACIMMYR2, an Inhib- itor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial- Mesenchymal Transition and Suppresses Tumor Growth and Progression显示文摘 | Zhendong Shi Junxia Zhang Xiaomin Qian | 2013 | Cancer Res2013，73，17： | 1 |
| 4 | Monitoring and Modeling the Effects of Groundwater Flow on Arsenic Transport in Datong Basin显示文摘Although arsenic-contaminated groundwater in the Datong Basin has been studied for more than 10 years, little has been known about the complex patterns of solute transport in the aquifer systems. Field monitoring and transient 3D unsaturated groundwater flow modeling studies were carried out on the riparian zone of the Sanggan River at the Datong Basin, northern China, to better understand the effects of groundwater flow on As mobilization and transport. The results indicate that irrigation is the primary factor in determining the groundwater flow paths. Irrigation can not only increase groundwater level and reduce horizontal groundwater velocity and thereby accelerate vertical and horizontal groundwater exchange among sand, silt and clay formations, but also change the HSconcentration, redox conditions of the shallow groundwater. Results of net groundwater flux estimation suggest that vertical infiltration is likely the primary control of As transport in the vadose zone, while horizontal water exchange is dominant in controlling As migration within the sand aquifers. Recharge water, including irrigation return water and flushed saltwater, travels downward from the ground surface to the aquifer and then nearly horizontally across the sand aquifer. The maximum value of As enriched in the riparian zone is roughly estimated to be 1 706.2 mg·d-1 for a horizontal water exchange of 8.98 m3·d-1 close to the river and an As concentration of 190 μg·L-1. | Qian Yu Yanxin Wang Rui Ma Chunli Su Ya Wu Junxia Li | 2014 | Journal of Earth Science2014，25，2： | 1 |
| 5 | Fbxl4作为节律输出分子通过周期性降解GABAA受体调控睡眠行为显示文摘文章简介睡眠是一种保守、可逆的行为状态,该过程受到生物节律和睡醒稳态的调控。然而生物节律到底是以何种输出形式调控睡眠的一直不清楚。 | Qian Li Yi Li Xiao Wang Junxia Qi Xi Jin Huawei Tong Zikai Zhou Zi Chao Zhang 韩俊海 | 2018 | 科学新闻2018，0，4： | 0 |
| 6 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 7 | Allele frequency of somatic mutations in individuals reveals signatures of cancer-related genes显示文摘在过去的十年,全面定序努力揭示了癌症相关的基因的签名,例如司机和旅客基因, oncogenes,和肿瘤 suppressor 基因(TSG )[1 ] 。这些签名提供在分子的水平定义癌症的一个工具并且增加我们癌症的理解。然而,揭示这些签名的当前的方法总是在一张大癌症人口探索变异的基因的复发,消费样品收集上的很多时间和钱,定序并且确认,进一步产生大量数据分析[2 ] 。我们想知道这些签名是否能从另外的方面被恢复。由于一系列变化从对恶意的损害良性,广泛的基因变化在单个肿瘤以内存在。在这个过程期间,司机基因提供一个选择生长优点给他们居住在的房间。因此,在一个个人的体的变化的等位基因频率,测量变化居住在的细胞的比例,能反映两个选择生长优点和变化的按年代先后的顺序。这里,我们作了一个努力在个人用体的变化的等位基因频率揭示癌症相关的基因的签名。 | Xingyu Lu Qian Xu Junxia Wang Jie Bi Zhen Wang Yixue Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 0 |
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