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| 1 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 2 | 6-20 Importance of Flow Design in Water Cooling System显示文摘The Water Cooling System in Accelerator consists of three subsystems: CSR, SFC & SSC, and adopts the centralized supply mode for easy operation and convenient management. The whole system was built gradually more than 50 a and upgraded many times. So, all subsystems become very large and now in a status of overflow running. Now, the advantage of centralized supply mode doesn’t exist anymore. | Yu Haiyan Chen Wei Wang Lishi Wang Dingjiu Zhu Tieming Su Yalong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 3 | Pingxiao capsule(平消胶囊)inhibits lung metastasis of triple-negative breast cancer and sensitizes breast cancer to radiotherapy显示文摘OBJECTIVES: To investigate the anticancer effect of Pingxiao capsule(平消胶囊, PXC) on the treatment of breast cancer in vitro and in vivo. METHODS: The inhibition of PXC on cell viability and proliferation was determined by cell counting kit-8, EdU assay and colony formation assay, respectively. The effect of PXC on cell apoptosis was detected by using flow cytometry. The suppression of PXC on cell migration and invasion was investigated by chamber assay. To investigate the underlying molecular mechanisms, the expression of proteins related to epithelial to mesenchymal transition(EMT) was analyzed by Western blotting in breast cancer cells and by immunohistochemistry in tumor tissues. The anticancer effect of PXC in vivo was evaluated by using MDA-MB-231 xenograft model and 4T1 metastatic breast cancer model. RESULTS: Our results indicated that triple-negative breast cancer(TNBC) cell lines MDA-MB-231 and MDAMB-468 were sensitive to PXC. PXC potently inhibited the proliferation, colony formation, migration, and invasion of MDA-MB-231 and MDA-MB-468 cells in vitro. Then, in vivo MDA-MB-231 xenograft model depicted that PXC significantly reduced tumor size and weight compared with Control. 4T1 lung metastasis model showed that PXC significantly inhibited breast cancer cell spreading to lungs in mice. Mechanistically, PXC inhibited EMT process by reducing cadherin turnover in TNBC. Furthermore, PXC in combination with 8 Gy X-ray treatment obviously promoted the induction of apoptosis, and suppressed cell proliferation. CONCLUSION: PXC could inhibit the proliferation and invasion of TNBC both in vitro and in vivo, and exerted its anti-metastatic effect by regulating cadherin turnover, Furthermore, it sensitized the TNBC cells to radiotherapy. The data supported further development of PXC as an adjuvant-therapy agent for TNBC. | TANG Wenjuan HU Yu ZHU Man DONG Mingzhi LIU Tieming SARWAR Ammar ZHAN Yingzhuan ZHANG Yanmin | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 4 | Mechanism of Avastin in Treatment of Cancer: A Review显示文摘 | Ketao Jin Kaiyan Fu Yefei Zhang Ling Zheng Tieming Zhu Zhigang Jin | 2010 | Journal of US-China Medical Science2010，7，9： | 0 |
| 5 | Vascular Endothelial Growth Factor in Breast Cancer: A Systematic Review显示文摘 | Ketao Jin Yefei Zhang Ling Zheng Kaiyan Fu Tieming Zhu Zhigang Jin | 2011 | Journal of US-China Medical Science2011，8，3： | 0 |
| 6 | VEGF and Angiogenesis in Renal Cell Carcinoma: A Minireview显示文摘 | Ketao Jin Ling Zheng Kaiyan Fu Yefei Zhang Tieming Zhu Zhigang Jin | 2010 | Journal of US-China Medical Science2010，7，4： | 0 |
| 7 | 6-9 CW Beam Test of the Injector II RFQ for ADS Project显示文摘As one of the main components of the injector II of China ADS LINAC project, an RFQ working at 162.5 MHzis used to accelerate proton beams of 15 mA from 30 keV to 2.1 MeV. The four vane RFQ has been designed incollaboration with Lawrence Berkeley National Laboratory and built at the workshop of the Institute of ModernPhysics, Chinese Academy of Sciences (IMP, CAS). | Zhang Zhouli He Yuan Shi Aimin Sun Liepen Zhang Bin Jia Huan Wang Jing Pan Gang Shi Longbo Xu Xianbo Li Chenxing Wang Wenbin Wang Xianwu Wu Junxia Wu Qi Zhang Junhui Zhu Tieming Guo Yuhui Zhao Hongwei Liu Yong D. Li S. Virostek M. Hoff A. Lambert J. Staples | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 10 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 11 | 6-23 Design of Circulating Cooling Water System for LEAF显示文摘The Low Energy Accelerator Facility(LEAF)comprises a superconducting ion source,a LEBT,an RFQ,a MEBT and a test terminal.It comprises a lot of power electronics and consumes a large amount of electricity,which will eventually be converted into heat.The function of process circulating cooling water is to absorb and transfer the heat produced by these equipments,and realize the constant temperature regulating means of certain temperature sensitive parts,so as to ensure the long-term,reliable and stable operation of the LEAF equipment.The design requirement parameters are shown in Table 1.Primary water subsystem 1. | Zhu Tieming Zhang Bin Chen Wei Wang Lishi Wang Dingjiu | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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