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| 1 | Studies on Fixed-depth Control of Supercavitating Vehicles显示文摘 | LI Dai-Jin LUO Kai ZHANG Yu-Wen DANG Jian-Jun | 2010 | 自动化学报2010，36，3： | 15 |
| 2 | Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis显示文摘BACKGROUND: Severe acute pancreatitis (SAP) can result in intestinal mucosal injury. This study aimed to demonstrate the protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with SAP. METHODS: Liposomes containing clodronate or phosphate buffered saline (PBS) were prepared by the thin-film method SAP models were prepared by a uniform injection of sodium taurocholate (2 mL/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group (C group), a SAP plus PBS-containing liposomes group (P group) and a SAP plus clodronate-containing liposomes group (T group). At 2 and 6 hours after the establishment of SAP models, 2 mL blood samples were taken from the superior mesenteric vein to measure the contents of serum TNF-α and IL-12. Pathological changes in the intestine and pancreas were observed using hematoxylin and eosin staining, while apoptosis was detected using TUNEL staining. In addition, the macrophage markers cluster of differentiation 68 (CD68) in the intestinal tissue was assessed with immunohistochemistry. RESULTS: At the two time points, the levels of TNF-α and IL-12 in the P group were higher than those in the C group (P<0.05) Compared with the P group, the levels of TNF-α and IL-12 decreased in the T group (P<0.05). The pathological scores of the intestinal mucosa and pancreas in the T group were lower than those of the P group. In the T group, large numbers of TUNEL-positive cells were observed, but none or few in the C and P groups. The number of CD68-positive macrophages decreased in the T group.CONCLUSIONS: Clodronate-containing liposomes have prote- ctive effects against intestinal mucosal injury in rats with SAP. The blockade of macrophages may provide a novel therapeutic strategy in SAP. | Jian-Xin Zhang, Sheng-Chun Dang, Kai Yin and De-Li Jiang Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China School of Chemistry and Chemical Engineering of Jiangsu University, Zhenjiang 212013, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 10 |
| 3 | Insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma EC9706 cells related to inhibition of autophagy显示文摘 | Yang Yang Wen Fengbiao Dang Lifeng Fan Yuxia Liu Donglei Wu Kai Zhao Song | 2014 | Chinese Medical Journal2014，，2： | 6 |
| 4 | High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads显示文摘Arabidopsis thaliana is an important and long-established model species for plant molecular biology,genetics,epigenetics,and genomics.However,the latest version of reference genome still contains a significant number of missing segments.Here,we reported a high-quality and almost complete Col-0 genome assembly with two gaps(named Col-XJTU)by combining the Oxford Nanopore Technologies ultra-long reads,Pacific Biosciences high-fidelity long reads,and Hi-C data.The total genome assembly size is 133,725,193 bp,introducing 14.6 Mb of novel sequences compared to the TAIR10.1 reference genome.All five chromosomes of the Col-XJTU assembly are highly accurate with consensus quality(QV)scores>60(ranging from 62 to 68),which are higher than those of the TAIR10.1 reference(ranging from 45 to 52).We completely resolved chromosome(Chr)3 and Chr5 in a telomere-to-telomere manner.Chr4 was completely resolved except the nucleolar organizing regions,which comprise long repetitive DNA fragments.The Chrl centromere(CEN1),reportedly around 9 Mb in length,is particularly challenging to assemble due to the presence of tens of thousands of CEN180 satellite repeats.Using the cutting-edge sequencing data and novel computational approaches,we assembled a 3.8-Mb-long CEN1 and a 3.5-Mb-long CEN2.We also investigated the structure and epigenetics of centromeres.Four clusters of CEN180 monomers were detected,and the centromere-specific histone H3-like protein(CENH3)exhibited a strong preference for CEN180 Cluster 3.Moreover,we observed hypomethylation patterns in CENH3-enriched regions.We believe that this high-quality genome assembly,Col-XJTU,would serve as a valuable reference to better understand the global pattern of centromeric polymorphisms,as well as the genetic and epigenetic features in plants. | Bo Wang Xiaofei Yang Yanyan Jia Yu Xu Peng Jia Ningxin Dang Songbo Wang Tun Xu Xixi Zhao Shenghan Gao Quanbin Dong Kai Ye | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 6 |
| 5 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 6 | van der Waals epitaxial growth of ultrathin metallic NiSe nanosheets on WSe2 as high performance contacts for WSe2 transistors显示文摘A prerequisite for widespread applications of atomically thin transition metal dichalcogenides in future electronics is to achieve reliable electrical contacts,which is of considerable challenge due to the difficulties in selectively doping and inevitable physical damages of these atomically thin materials during typical metal integration process.Here,we report the in situ growth of ultrathin metallic NiSe single crystals on WSe2 in which the metallic NiSe nanosheets function as the contact electrodes to WSe2,creating an interface that is essentially free from chemical disorder.The NiSe/WSe2 heterostructures also exhibit well-aligned lattice orientation between the two layers,forming a periodic Moire pattern.Electrical transport studies demonstrate that the NiSe nanosheets exhibit an excellent metallic feature,as evidenced by the extra-high electrical conductivity of up to 1.6×10^6 S-nf1.The WSe2 transistors with the NiSe contact show field-effect mobilities (/vFe) more than double that with Cr/Au electrodes.This study demonstrates an effective pathway to achieve reliable electrical contacts to the atomically thin 2D materials,and maybe readily extended for fabricating 2D/2D low-resistance contacts for a variety of transition metal dichalcogenides. | Bei Zhao Weiqi Dang Xiangdong Yang Jia Li Haihong Bao Kai Wang Jun Luo Zhengwei Zhang Bo Li Haipeng Xie Yuan Liu Xidong Duan | 2019 | Nano Research2019，12，7： | 4 |
| 7 | Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment显示文摘Objective:Osteoporosis has become the biggest cause of non-fatal health issue.Currently,the limitations of traditional anti-osteoporosis drugs such as long-term ill-effects and drug resistance,have raised concerns toward complementary and alternative therapies,particularly herbal medicines and their natural active compounds.Thus,this study aimed to provide an integrative analysis of active chemicals,drug targets and interacting pathways of the herbs for osteoporosis treatment.Methods:Here,we introduced a systematic pharmacology model,combining the absorption,distribution,metabolism,and excretion(ADME)screening model,drug targeting and network pharmacology,to probe into the therapeutic mechanisms of herbs in osteoporosis.Results:We obtained 86 natural compounds with favorable pharmacokinetic profiles and their 58 targets from seven osteoporosis-related herbs.Network analysis revealed that they probably synergistically work through multiple mechanisms,such as suppressing inflammatory response,maintaining bone metabolism or improving organism immunity,to benefit patients with osteoporosis.Furthermore,experimental results showed that all the five compounds(calycosin,asperosaponin VI,hederagenin,betulinic acid and luteolin)enhanced osteoblast proliferation and differentiation in vitro,which corroborated the validity of this system pharmacology approach.Notably,gentisin and aureusidin among the identified compounds were first predicted to be associated with osteoporosis.Conclusion:Herbs and their natural compounds,being characterized as the classical combination therapies,might be engaged in multiple mechanisms to coordinately improve the osteoporosis symptoms.This work may contribute to offer novel strategies and clues for the therapy and drug discovery of osteoporosis and other complex diseases. | Ying Huai Wen-juan Zhang Wei Wang Kai Dang Shan-feng Jiang Dan-ming Li Meng Li Qiang Hao Zhi-ping Miao Yu Li Ai-rong Qian | 2021 | Chinese Herbal Medicines2021，13，3： | 3 |
| 8 | A novel CD4+CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’orbitopathy显示文摘Graves*orbitopathy(GO),the most severe manifestation of Graves'hyperthyroidism(GH),is an autoimmune-mediated inflammatory disorder,and treatments often exhibit a low efficacy.CD4+T cells have been reported to play vital roles in GO progression.To explore the pathogenic CD4-f T cell types that drive GO progression,we applied single-cell RNA sequencing(scRNA-Seq),T cell receptor sequencing(TCR-Seq),flow cytometry,immunofluorescence and mixed lymphocyte reaction(MLR)assays to evaluate CD4+T cells from GO and GH patients.scRNA-Seq revealed the novel GO-spedfic cell type CD4+cytotoxic T lymphocytes(CTLs),which are characterized by chemotactic and inflammatory features.The clonal expansion of this CD4+CTL population,as demonstrated by TCR-Seq,along with their strong cytotoxic response to autoantigens,localization in orbital sites,and potential relationship with disease relapse provide strong evidence for the pathogenic roles of GZMB and IFN-y-secreting CD4+CTLs in GO.Therefore,cytotoxic pathways may become potential therapeutic targets for GO. | Yue Wang Ziyi Chen Tingjie Wang Hui Guo Yufeng Liu Ningxin Dang Shiqian Hu Liping Wu Chengsheng Zhang Kai Ye Bingyin Shi | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 9 | Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration显示文摘Stem cells play a key role in tissue regeneration due to their self-renewal and multidirectional differentiation,which are continuously regulated by signals from the extracellular matrix(ECM)microenvironment.Therefore,the unique biological and physical characteristics of the ECM are important determinants of stem cell behavior.Although the acellular ECM of specific tissues and organs(such as the skin,heart,cartilage,and lung)can mimic the natural microenvironment required for stem cell differentiation,the lack of donor sources restricts their development.With the rapid development of adipose tissue engineering,decellularized adipose matrix(DAM)has attracted much attention due to its wide range of sources and good regeneration capacity.Protocols for DAM preparation involve various physical,chemical,and biological methods.Different combinations of these methods may have different impacts on the structure and composition of DAM,which in turn interfere with the growth and differentiation of stem cells.This is a narrative review about DAM.We summarize the methods for decellularizing and sterilizing adipose tissue,and the impact of these methods on the biological and physical properties of DAM.In addition,we also analyze the application of different forms of DAM with or without stem cells in tissue regeneration(such as adipose tissue),repair(such as wounds,cartilage,bone,and nerves),in vitro bionic systems,clinical trials,and other disease research. | Ji-Zhong Yang Li-Hong Qiu Shao-Heng Xiong Juan-Li Dang Xiang-Ke Rong Meng-Meng Hou Kai Wang Zhou Yu Cheng-Gang Yi | 2020 | World Journal of Stem Cells2020，12，7： | 2 |
| 10 | Diabolical points in coupled active cavities with quantum emitters显示文摘In single microdisks,embedded active emitters intrinsically affect the cavity modes of the microdisks,resulting in trivial symmetric backscattering and low controllability.Here we demonstrate macroscopic control of the backscattering direction by optimizing the cavity size.The signature of the positive and negative backscattering directions in each single microdisk is confirmed with two strongly coupled microdisks.Furthermore,diabolical points are achieved at the resonance of the two microdisks,which agrees well with theoretical calculations considering the backscattering directions.Diabolical points in active optical structures pave the way for an implementation of quantum information processing with geometric phase in quantum photonic networks. | Jingnan Yang Chenjiang Qian Xin Xie Kai Peng Shiyao Wu Feilong Song Sibai Sun Jianchen Dang Yang Yu Shushu Shi Jiongji He Matthew JSteer Iain GThayne Bei-Bei Li Fang Bo Yun-Feng Xiao Zhanchun Zuo Kuijuan Jin Changzhi Gu Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 11 | Radial Clearance Control and Internal Leakage Analysis of a Tri-Proportion Controller显示文摘The tri-propellant thermal propulsion system is one of the hottest subjects in the field of underwater vehicles recently.To improve efficiency of underwater vehicles,a method of radial clearance control of the tri-proportion has been proposed.Based on analyzing the factors which influence the pressure decrease and leakage of the tri-proportion controller,a method is used for precision analysis and proportion adjustment by using the median optimizing theory.Analysis results show that accuracy of the proportion controller is dependent on all the leakage,while the leakage is decided by radial clearance and pressure;the leakage can be controlled effectively and the accuracy of the proportion can be improved with the radial clearance control method.The method of accuracy analysis and clearance control has value on the design of various hydraulic motors. | LI Dai-jin ZHANG Yu-wen TANG Hao DANG Jian-jun LUO Kai | 2009 | International Journal of Plant Engineering and Management2009，14，2： | 1 |
| 12 | Flexible Nanodielectric Materials with High Permittivity for Power Energy Storage显示文摘 | Zhi‐Min Dang Jin‐Kai Yuan Sheng‐Hong Yao Rui‐Jin Liao | 2013 | Adv Mater2013，，44： | 1 |
| 13 | Influence of Ramjets’ Water Inflow on Supercavity Shape and Cavitator Drag Characteristics显示文摘Water ramjets using outer water as an oxidizer have been demonstrated as a potential propulsion mode for underwater High Speed Supercavitating Vehicles (HSSVs) because of their higher energy density, power density, and specific impulse, but water flux changes the shapes of supercavity. To uncover the cavitator drag characteristics and the supercavity shape of HSSVs with water inflow for ramjets, supercavitation flows around a disk cavitator with inlet hole are studied using the homogenous model. By changing the water inflow in the range of 0-10 L/s through cavitators having different water inlet areas, a series of numerical simulations of supercavitation flows was performed. The water inflow flux of ramjets significantly influences the drag features of disk cavitators and the supercavity shape, but it has little influence on the slender ratio of supercavitaty. Furthermore, as the water inlet area increases, the drag coefficient of the cavitators' front face decreases, but this increase does not influence the diameter of the supercavity's maximum cross section and the drag coefficient of the entire cavitator significantly. In addition, with increasing waterflux of the ramjet, both the drag coefficient of cavitators and the maximum diameter of supercavities decrease stably. This research will be helpful for layout optimization and supercavitaty scheme design of HSSVs with water inflow for ramjets. | Chuang Huang Jianjun Dang Kai Luo Daijin Li Zhiqiang Wang | 2017 | Journal of Marine Science and Application2017，16，2： | 1 |
| 14 | Anisotropies of the g-factor tensor and diamagnetic coefficient in crystal-phase quantum dots in InP nanowires显示文摘Crystal-phase low-dimensional structures offer great potential for the implementation of photonic devices of interest for quantum information processing.In this context,unveiling the fundamental parameters of the crystal phase structure is of much relevance for several applications.Here,we report on the anisotropy of the g-factor tensor and diamagnetic coefficient in wurtzite/zincblende(WZ/ZB)crystal-phase quantum dots(QDs)realized in single InP nanowires.The WZ and ZB alternating axial sections in the NWs are identified by high-angle annular dark-field scanning transmission electron microscopy.The electron(hole)g-factor tensor and the exciton diamagnetic coefficients in WZ/ZB crystal-phase QDs are determined through micro-photoluminescence measurements at low temperature(4.2 K)with different magnetic field configurations,and rationalized by invoking the spin-correlated orbital current model.Our work provides key parameters for band gap engineering and spin states control in crystal-phase low-dimensional structures in nanowires. | Shiyao Wu Kai Peng Sergio Battiato Valentina Zannier Andrea Bertoni Guido Goldoni Xin Xie Jingnan Yang Shan Xiao Chenjiang Qian Feilong Song Sibai Sun Jianchen Dang Yang Yu Fabio Beltram Lucia Sorba Ang Li Bei-bei Li Francesco Rossella Xiulai Xu | 2019 | Nano Research2019，12，11： | 1 |
| 15 | Enhanced tensile ductility of tungsten microwires via high-density dislocations and reduced grain boundaries显示文摘Despite being strong with many outstanding physical properties,tungsten is inherently brittle at room temperature,restricting its structural and functional applications at small scales.Here,a facile strategy has been adopted,to introduce high-density dislocations while reducing grain boundaries,through electron backscatter diffraction(EBSD)-guided microfabrication of cold-drawn bulk tungsten wires.The designed tungsten microwire attains an ultralarge uniform tensile elongation of~10.6%,while retains a high yield strength of~2.4 GPa.in situ TEM tensile testing reveals that the large uniform elongation of tungsten microwires originates from the motion of pre-existing high-density dislocations,while the subsequent ductile fracture is attributed to crack-tip plasticity and the inhibition of grain boundary cracking.This work demonstrates the application potential of tungsten microcomponents with superior ductility and workability for micro/nanoscale mechanical,electronic,and energy systems. | Chaoqun Dang Weitong Lin Fanling Meng Hongti Zhang Sufeng Fan Xiaocui Li Ke Cao Haokun Yang Wenzhao Zhou Zhengjie Fan Ji-jung Kai Yang Lu | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 16 | Homogenous lithium plating/stripping regulation by a mass-producible Zn particles modified Li-metal composite anode显示文摘A stable lithium-metal anode is critical for high performance lithium-metal batteries. However, heterogeneous Li plating/stripping may induce lithium dendrites formation on bare lithium-metal anode, which lowers the cell Coulombic efficiency and weakens battery safety. We found that bare Li metal surface becomes bumpy and cratered with numerous pits formation during Li stripping. These pits enhance electric field distortion and heterogeneous ion distribution during plating. Li plating preferentially happens on the edge of the pits, intensifying the voltage variation and Li dendrites growth, which leads to the cell rapid death or separator piercing. Herein, we propose a facile and mass-producible method to homogenize Li plating/stripping via adding lithiophilic particles into Li metal. Zinc particles were uniformly pressed in Li metal by a facile and scalable physical strategy of “rolling”, and transformed into LiZn alloy in situ through Li-Zn alloying at room temperature in a few minutes. The critical role of modified LiZn/Li composite anode in stabilizing electrode surface was revealed by both electrochemical test and simulation. Compared with bare Li anode, the evenly dispersed LiZn alloy particles in Li metal can effectively regulate the Li plating/stripping on electrode surface, reducing deepness of pits during stripping and directionally inducing Li plating to maintain electrode surface stability. On this basis, the pits depth of LiZn/Li composite during Li stripping is reduced to ∼ 15 μm, which is much shallower than that of bare Li metal of ∼ 40 μm. The LiZn/Li composite electrode can stably cycle for 600 h under Li plating/stripping capacity of 1 mAh·cm−2 and current density of 1 mA·cm−2 without any short circuit. Furthermore, assembled LiZn/Li||LiFePO4 full cell presents better cycling stability and rate performances than that of based on bare Li anode. | ZiLi Zhang Yang Jin Yu Zhao Jing Xu Bin Sun Kai Liu Hongfei Lu Nawei Lv Zhimin Dang Hui Wu | 2021 | Nano Research2021，14，11： | 0 |
| 17 | Particle packing theory guided multiscale alumina filled epoxy resin with excellent thermal and dielectric performances显示文摘Polymers and composites with high thermal conductivity are promising yet challenging for the growing demand of thermal management in electrical and electronic equipment.Guided by the closest packing model,a multiscale filling Al_(2)O_(3) strategy was designed and incorporated with epoxy resin(EP)to form high thermal conductive composites in this work.Epoxy composites with single filler loading were also prepared.The microstructures,thermal,rheological,and dielectric characteristics of the multiscale filling Al_(2)O_(3)/EP composites have been investigated.Compared with single-scale Al_(2)O_(3) filled epoxy based composites,it is found that the multiscale filling Al_(2)O_(3)/EP composites exhibit higher thermal conductivity under the same filler loading of 50 vol%,which is attributed to the efficient heat conduction paths formed by appropriate multiscale fillers.Particularly,a remarkably improved thermal conductivity of 2.707 W m^(-1) K^(-1) was acquired in Al_(2)O_(3)/EP composites at filler loading of 50 vol%(5 mm Al_(2)O_(3)(26.67 vol%),30 mm Al_(2)O_(3)(27.41 vol%)and 70 mm Al_(2)O_(3)(45.92 vol%)),which is about 1300%higher than that of the pure epoxy resin.In addition,the dielectric constant of the Al_(2)O_(3)/EP composites were significantly improved while keeping the dielectric loss almost unchanged.The finite element simulation further verified the effectiveness of improving the thermal conductivity of materials in the heat dissipation of electrical equipment.Therefore,this research provides a simple strategy for manufacturing high thermal conductive composite materials with a wide range of potential applications as packaging materials. | Qi-Kun Feng Chang Liu Dong-Li Zhang Yan-Hui Song Kai Sun Hai-Ping Xu Zhi-Min Dang | 2022 | Journal of Materiomics2022，8，5： | 0 |
| 18 | The role of 5′-adenosine monophosphate-activated protein kinase(AMPK)in skeletal muscle atrophy显示文摘As a key coordinator of metabolism,AMP-activated protein kinase(AMPK)is vitally involved in skeletal muscle maintenance.AMPK exerts its cellular effects through its function as a serine/threonine protein kinase by regulating many downstream targets and plays important roles in the development and growth of skeletal muscle.AMPK is activated by phosphorylation and exerts its function as a kinase in many processes,including synthesis and degradation of proteins,mitochondrial biogenesis,glucose uptake,and fatty acid and cholesterol metabolism.Skeletal muscle atrophy is a result of various diseases or disorders and is characterized by a decrease in muscle mass.The pathogenesis and therapeutic strategies of skeletal muscle atrophy are still under investigation.In this review,we discuss the role of AMPK in skeletal muscle metabolism and atrophy.We also discuss targeting AMPK for skeletal muscle treatment,including exercise,AMPK activators including 5-amino-4-imidazolecarboxamide ribonucleoside and metformin,and low-level lasers.These studies show the important roles of AMPK in regulating muscle metabolism and function;thus,the treatment of skeletal muscle atrophy needs to take into account the roles of AMPK. | KAI DANG HAFIZ MUHAMMAD UMER FAROOQ YUAN GAO XIAONI DENG AIRONG QIAN | 2023 | BIOCELL2023，47，2： | 0 |
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