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| 1 | cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment显示文摘为模仿减少的严肃环境的一个新奇基于地面的模型广泛地在许多地里被使用了的抗磁的悬浮。在这研究,一个专辑设计了超导的磁铁,它能生产三个明显的严肃层次(0, 1,和 2 g ) ,也就是高的磁电机重力的环境(HMGE ) ,被用来模仿空间严肃环境。造骨细胞基因表示侧面上的 HMGE 的效果被 microarray 调查。对抗磁的悬浮环境(0 g ) 敏感的基因,严肃变化,和高磁场变化根据典型房间功能被排序。作为细胞内部的忍受负担的结构,细胞骨架在严肃感觉起一个重要作用。因此, 13 细胞骨架相关的基因根据 microarray 分析的结果被选择,并且这些基因的表情被发现被即时 PCR 在 HMGE 下面改变。基于 PCR 结果, WASF2 的表情(是蛋白质家庭,成员 2 ) , WIPF1 (WAS/WASL 交往蛋白质家庭,成员 1 ) , paxillin,和 talin 1 被西方的污点试金进一步识别。结果显示了那 WASF2, WIPF1 对改变的严肃层次,和 talin 更敏感 1 并且 paxillin 对磁场和严肃变化敏感。我们的调查结果证明 HMGE 能影响造骨细胞基因表示侧面和细胞骨架相关的基因表示。mechanosensitive 基因的鉴定可以提高我们的理解到 microgravity 导致的骨头损失的机制并且可以为阻止并且对待骨头损失或骨质疏松症提供一些潜在的目标。 | Airong Qian Shengmeng Di Xiang Gao Wei Zhang Zongcheng Tian Jingbao Li Lifang Hu Pengfei Yang Dachuan Yin Peng Shang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 8 |
| 2 | NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves显示文摘Blast lung injury(BLI)is the major cause of death in explosion-derived shock waves;however,the mechanisms of BLI are not well understood.To identify the time-dependent manner of BLI,a model of lung injury of rats induced by shock waves was established by a fuel air explosive.The model was evaluated by hematoxylin and eosin staining and pathological score.The inflammation and oxidative stress of lung injury were also investigated.The pathological scores of rats’lung injury at 2 h,24 h,3 days,and 7 days post-blast were 9.75±2.96,13.00±1.85,8.50±1.51,and 4.00±1.41,respectively,which were significantly increased compared with those in the control group(1.13±0.64;P<0.05).The respiratory frequency and pause were increased significantly,while minute expiratory volume,inspiratory time,and inspiratory peak flow rate were decreased in a time-dependent manner at 2 and 24 h post-blast compared with those in the control group.In addition,the expressions of inflammatory factors such as interleukin(IL)-6,IL-8,FosB,and NF-κB were increased significantly at 2 h and peaked at 24 h,which gradually decreased after 3 days and returned to normal in 2 weeks.The levels of total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase were significantly decreased 24 h after the shock wave blast.Conversely,the malondialdehyde level reached the peak at 24 h.These results indicated that inflammatory and oxidative stress induced by shock waves changed significantly in a time-dependent manner,which may be the important factors and novel therapeutic targets for the treatment of BLI. | Hong Wang Wenjuan Zhang Jinren Liu Junhong Gao Le Fang Zhiyong Liu Baoqing Xia Xiaolin Fan Cunzhi Li Qing Lu Airong Qian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 4 |
| 3 | Clinical profile of autosomal dominant polycystic liver disease显示文摘 | Qian Q Airong L King BF | 2003 | Hepatology2003，37，1： | 1 |
| 4 | Large gradient high magnetic fields affect osteoblast ultrastructure and function by disrupting collagen I or fibronectin / αβ1 integrin显示文摘 | Qian Airong Gao Xiang Zhang Wei | 2013 | PLoS ONE2013，8，51： | 1 |
| 5 | Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4‐week hindlimb unloading显示文摘 | Jing Liu Yunhua Peng Zhiwei Cui Zhiming Wu Airong Qian Peng Shang Lina Qu Yinghui Li Jiankang Liu Jiangang Long | 2012 | IUBMB Life2012，，11： | 1 |
| 6 | Clinical profile of autosomal dominant polycystic liver disease显示文摘 | Qi Qian Airong Li Bernard F. King Patrick S. Kamath Donna J. Lager John Huston Clarence Shub Sonia Davila Stefan Somlo Vicente E. Torres | 2003 | Hepatology2003，，1： | 1 |
| 7 | Mutations in PRKCSH Cause Isolated Autosomal Dominant Polycystic Liver Disease显示文摘 | Airong Li Sonia Davila Laszlo Furu Qi Qian Xin Tian Patrick S. Kamath Bernard F. King Vicente E. Torres Stefan Somlo | 2003 | The American Journal of Human Genetics2003，，3： | 1 |
| 8 | Mutations in PRKCSH Cause Isolated Autosomal Dominant Polycystic Liver Disease显示文摘 | Airong Li Sonia Davila Laszlo Furu Qi Qian Xin Tian Patrick S. Kamath Bernard F. King Vicente E. Torres Stefan Somlo | 2003 | The American Journal of Human Genetics2003，，3： | 1 |
| 9 | Mechanoresponsive MiR-138-5p Targets MACF1 to Inhibit Bone Formation显示文摘Mechanical stimuli play an essential role in maintaining bone remodeling and skeletal integrity.Meanwhile,bone can respond to the changes of mechanical condition to adjust its mass and architecture.Clinical studies discover that bedridden patients showed osteoporotic T-scores and low bone mineral density,and long-term immobilized patients presented reduced markers of bone formation.However,as bone formation mediated by osteoblast differentiation is a complex process,the underlying molecular mechanism of mechanical stimuli regulating bone formation is still unclear.Recent evidences show that microRNAs(miRNAs)are involved in mechanical stimuli regulating bone formation or osteoblast differentiation.Nevertheless,no direct evidence identifies mechanoresponsive miRNA in both human and animal bones,and clarifies its mechanoresponsive role under different mechanical conditions(e.g.mechanical unloading,reloading,loading).In the current study,we screened for differentially expressed miRNAs in bone specimens of bedridden patients with fractures,then identified that the expression of miR-138-5p,but not the other miRNAs,altered withbedridden time and was negatively correlated with the expression of the bone formation marker genes Alp(alkaline phosphatase).Moreover,miR-138-5p was up-regulated with reduced bone formation during unloading and down-regulated with increased bone formation during reloading in hind4imb unloaded mice.In addition,miR-138-5p was verified to be responsive to different mechanical unloading condition and cyclic mechanical stretch condition in primary osteogenic cells,respectively.Further in vitro data suggested that mechanoresponsive miR-138-5p directly targeted microtubule actin crosslinking factor 1(MACF1)to inhibit osteoblast differentiation.In vivo,we constructed an osteoblastic miR-138-5p transgenic mice model(TG138)with the Runx2promoter,and found that overexpression miR-138-5p supressed bone formation.Moreover,osteoblast-targeted inhibition of miR-138-5p sensitized bone anabolic response to mechanical loading in TG138 mice.Predominantly,the osteoblast-targeted inhibition of miR-138-5p could counteract bone formation reduction induced by hind limb unloading.Taken together,the mechanoresponsive miR-138-5p inhibited bone anabolic response for developing a novel bone anabolic sensitization strategy. | Zhihao Chen Zhao Fan Liang Chao Lifang Hu Chen Lei Zhang Yan Yin Chong Dijie Li Tian Ye Wuxia Qiu Kewen Zhang Chaofei Yang Xiaona Li Li Yu Weiyi Chen Zhang Ge Qian Airong | 2019 | 医用生物力学2019，34，A01： | 1 |
| 10 | Clinical profile of autosomal dominant polycystic liver disease 显示文摘 | Qian Q Airong L King BF | 2003 | Hepatology2003，37，1： | 1 |
| 11 | Mechanical Sensitive Molecule MACF1 Promotes Osteoblast Differentiation显示文摘The decreased osteoblast differentiation associated with reduced bone formation is one main cause of microgravityinduced bone loss.Our previous studies have demonstrated that microtubule actin crosslinking factor 1(MACF1)is downregulated in association with the decreased osteoblast differentiation and bone formation under simulated microgravity conditions.These findings suggest that MACF1 is sensitive to mechanical condition and may be critical for osteoblast differentiation and bone formation.To verify this hypothesis,current study investigates the role and mechanism of MACF1 in regulatingosteoblast differentiation by adopting MACF1 knockdown(MACF1-KD)osteoblasts.The results showed that MACF1 knockdown suppressed mineralized nodules formation,alkaline phosphatase(ALP)activity,osteogenic gene expression andβ-catenin signaling transduction.Moreover,we used RNA sequencing(RNA-seq)and chromatin immunoprecipitation sequencing(ChIP-seq)to investigate further mechanism.Interestingly,we found that MACF1 sequesterd repressors of osteoblast differentiation in cytoplasm.In conclusion,MACF1 is sensitive to mechanical condition and plays key role in activatingβ-catenin signaling transduction and sequestering repressors of osteoblast differentiation,which further promotes osteoblast differentiation. | Lifang Hu Chong Yin Zixiang Wu Zizhang Huang Peihong Su Yan Zhang Zhihao Chen Airong Qian | 2019 | 医用生物力学2019，34，A01： | 0 |
| 12 | Effects of Microgravity on Human Physiology and Ground-Based Models for Space Physiological Studies显示文摘With the development of manned spaceflight, more and more researches are involved in the area of gravitation physiology. When astronauts are exposed to microgravity, a series of special physiological or pathological changes will occur, which will start self-regulation mechanisms to reduce abnormalities and help the organism to better adapt to microgravity. However, these adaptive changes may also induce degradation or damage to physiological functions. This paper summarizes the physiological effects of microgravity on the human body from the aspects of skeletal and mineral metabolism, muscle structure and function, vestibular functions, cardiovascular function and pulmonary function, as well as expounds some commonly used ground-based space analogies. The paper will provide a reference for further study on the physiological effects of microgravity. | QIU Wuxia LIN Xiao MIAO Zhiping QIAN Airong | 2017 | Aerospace China2017，18，4： | 0 |
| 13 | The Study of Tactical Missile's Airframe Digital Optimization Design显示文摘Digital design and optimal are very important in modern design.The traditional design methods and procedure are not fit for the modern missile weapons research and development.Digital design methods and optimal ideas were employed to deal with this problem.The disadvantages of the traditional missile’s airframe design procedure and the advantages of the digital design methods were discussed.A new concept of design process reengineering(DPR)was put forward.An integrated missile air- frame digital design platform and the digital design procedure,which integrated the optimization ideas and methods,were devel- oped.Case study showed that the design platform and the design procedure could improve the efficiency and quality of missile’s airframe design,and get the more reasonable and optimal results. | LUO Zhiqing~(1,2) QIAN Airong~1 LI Xuefeng~2 GAO Lin~2 LEI Jian~1 (1.College of Mechanical Engineering,Northwestern Polytechnical University,Xi’an 710072,China, 2.NO.203 Research Institute of China Ordnance Industries,Xi’an 710065,China) | 2006 | 武汉理工大学学报2006，28，S3： | 0 |
| 14 | The role of 5′-adenosine monophosphate-activated protein kinase(AMPK)in skeletal muscle atrophy显示文摘As a key coordinator of metabolism,AMP-activated protein kinase(AMPK)is vitally involved in skeletal muscle maintenance.AMPK exerts its cellular effects through its function as a serine/threonine protein kinase by regulating many downstream targets and plays important roles in the development and growth of skeletal muscle.AMPK is activated by phosphorylation and exerts its function as a kinase in many processes,including synthesis and degradation of proteins,mitochondrial biogenesis,glucose uptake,and fatty acid and cholesterol metabolism.Skeletal muscle atrophy is a result of various diseases or disorders and is characterized by a decrease in muscle mass.The pathogenesis and therapeutic strategies of skeletal muscle atrophy are still under investigation.In this review,we discuss the role of AMPK in skeletal muscle metabolism and atrophy.We also discuss targeting AMPK for skeletal muscle treatment,including exercise,AMPK activators including 5-amino-4-imidazolecarboxamide ribonucleoside and metformin,and low-level lasers.These studies show the important roles of AMPK in regulating muscle metabolism and function;thus,the treatment of skeletal muscle atrophy needs to take into account the roles of AMPK. | KAI DANG HAFIZ MUHAMMAD UMER FAROOQ YUAN GAO XIAONI DENG AIRONG QIAN | 2023 | BIOCELL2023，47，2： | 0 |
| 15 | Microtubule actin crosslinking factor 1 functions as a novel therapeutic target in lung metastasis of osteosarcoma显示文摘Lung metastasis is the primary cause of death in osteosarcoma(OS)patients.1 A better understanding of the molecular mechanisms underlying OS tumorigenesis and metastasis is urgently needed to identify therapeutic targets.Microtubule actin crosslinking factor 1(MACF1),which belongs to the spectraplakin family of cytoskeletal crosslinking proteins,2 is critical for cell migration and polarization due to its regulation of the cytoskeleton.Recently,MACF1 was indicated to be involved in the metastatic invasion of some human cancers,3 but the function of MACF1 in OS is still unclear. | Chaofei Yang Ye Tian Fan Zhao Qian Huang Zhiyong Liu Chenyang He Hui Li Yu li Zhiping Miao Airong Qian | 2023 | Genes & Diseases2023，10，2： | 0 |
| 16 | An integrated genome-wide analysis identifies HUR/ELAVL1 as a positive regulator of osteogenesis through enhancing theβ-catenin signaling activity显示文摘Osteoporosis is a prevalent multifactorial bone disease with a strong genetic contribution.The heritability of traits that contribute to osteoporosis(bone mass,bone mineral density(BMD),bone size,bone loss and fractures)ranges from 50 to 85%,suggesting that a comprehensive understanding of the genetic basis may help identify new therapeutic targets.1 However,the genetic characteristics remain obscure,and the existing drug targets are associated with various challenges.Numerous studies have demonstrated that high-throughput sequencing data analysis is fruitful for identifying novel targets of human diseases.2 We therefore integrated GWAS and transcriptome analyses through Multi-marker Analysis of GenoMic Annotation(MAGMA)and weighted gene co-expression network analysis3(WGCNA)to identify new network modules and potential therapeutic genes for osteoporosis.As an illustration,the flow chart presenting the process of the present study was shown in Figure S1. | Ying Huai Zhihao Chen Xiaoni Deng Xue Wang Wenjing Mao Zhiping Miao Yu Li Hui Li Xiao Lin Airong Qian | 2023 | Genes & Diseases2023，10，2： | 0 |
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