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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Dynamic capabilities-What are they?显示文摘 | Kathleen M E Jeffrey A M | 2000 | Strategic Management Journal2000，21，： | 1 |
| 3 | Comparison of methods to detect biosurfactant production by diverse microorganisms 显示文摘 | NOHA H Y KATHLEEN E | 2004 | Microbiological Methods2004，56，： | 1 |
| 4 | Infections in Patients with Inherited Defects in Phagocytic Function 显示文摘 | ANDREWS T KATHLEEN E SULLIVAN | 2003 | Clin Microbiol Rev2003，16，10： | 1 |
| 5 | Strategy as Simple Rules 显示文摘 | KATHLEEN M E DONALD N S | 2001 | Harvard Business Review2001，，1： | 1 |
| 6 | Optimal struc- ture, market dynamism, and the strategy of simple rules显示文摘 | Jason P D Kathleen M E Bingham C B | 2009 | Administrative Science Quarterly2009，54，3： | 1 |
| 7 | ^1H NMR studies of chloroform@- cryptophane-A and chloroform@bis-cryptophane inclusion complexes oriented in thermotropic liquid crystals显示文摘 | KATHLEEN E CHAFFEE MALGORZATA MARJANSKA BOYD M GOODSON | 2006 | Solid State Nuclear Magnetic Rcsonance2006，29，： | 1 |
| 8 | Comparison of methods to detect biosurfactant production by diverse microorganisms显示文摘 | Noha H Y Kathleen E D David P N | 2004 | Journal of Microbiological Methods2004，56，： | 1 |
| 9 | Long-term safety and once-daily niacin/lovastatin formulation for patients with dyslipidemia 显示文摘 | Moti L K Mark E M Kathleen B | 2002 | Am J Cardiol2002，89，6： | 1 |
| 10 | Self-esteem, appraisal and coping: a comparison of unemployed and reemployed people显示文摘 | Lea E W Kathleen A M | 2002 | Journal of Organizational Behavior2002，，5： | 1 |
| 11 | Reduction of Epidural Fibrosis in Lumbar Surgery with Oxiplex Adhesion Bar-riers of Carboxymethylcellulose and Polyethylene Oxide显示文摘 | Rodgers K E Kathleen E Robertson J T | 2003 | The Spine Journal2003，3，4： | 1 |
| 12 | Optima/ structure, market dynamism, and the strategy of simple rules 显示文摘 | JASON P D KATHLEEN M E CHRISTOPHER B B | 2009 | Administrative Science Quarterly2009，，9： | 1 |
| 13 | See- king self evaluative feedback The interactive role of global self- esteam and specific self views显示文摘 | Bemichon Tiffing Cook Kathleen E Brown Jonathon D | 2003 | Journal of Personality Social Psychology2003，84，1： | 1 |
| 14 | Linear probe endobronchial ultrasound bronchoscopy with guided transbronchial needle aspiration (EBUS-TBNA) in the evaluation of mediastinal and hilar pathology: introducing the procedure to a teaching institution显示文摘 | MUHANNED A H YASER E S KATHLEEN E | 2013 | Lung2013，191，1： | 1 |
| 15 | Expression of Distinct Self-Incompatibility Specificities in Arabidopsis thaliana显示文摘 | Boggs Nathan A Dwyer Kathleen G Shah Paurush McCulloch Amanda A Bechsgaard Jesper Schierup Mikkel H Nasrallah Mikhail E Nasrallah June B | 2009 | Genetics2009，，4： | 1 |
| 16 | GABA receptor antagonists and insecticides:common structural features of 4-alkyl-1-phenyIpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes显示文摘 | Robert E S Pierluigi C Kathleen A D | 2004 | Casida Bioorganic & Medicinal Chemistry2004，12，： | 1 |
| 17 | Structure robustness in the light of risk and consequence analysis显示文摘 | Marc A Maes Kathleen E Fritzsons Simon Glowienka | 2006 | IABSE Structural Engineering International2006，16，2： | 1 |
| 18 | The national spina bifida patient registry:Profile of a large cohort of participants from the first 10 clinics显示文摘 | Kathleen J Sawin T Liu E | 2015 | The Journal of Pediatrics2015，166，2： | 1 |
| 19 | The Florida manatee and eco-tourism:toward a safe minimum standard显示文摘 | BARRY D S CRISTI M C KATHLEEN E H | 2004 | Ecological Economics2004，50，： | 1 |
| 20 | In their own words:Patients and families define high-quality palliative care in intensive care unit显示文摘 | Nelson-Judith E Kathleen A Puntillo JD | 2010 | Crit Care Med2010，38，3： | 1 |
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