|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 2 | Real-time high-resolution mid-infrared optical coherence tomography显示文摘The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s.Nevertheless,the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region,resulting in slow acquisition,low sensitivity,and poor axial resolution.In this work,a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4μm and an axial resolution of 8.6μm is demonstrated.The system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9-to 4.7-μm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-μm bandwidth from 3.58–4.63μm to 820–865 nm,where a standard 800-nm spectrometer can be used for fast detection.The images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3μm,and the potential applications and samples suited for this technology are discussed.In doing so,the first practical mid-infrared optical coherence tomography system is demonstrated,with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths. | Niels M.Israelsen Christian R.Petersen Ajanta Barh Deepak Jain Mikkel Jensen Gunther Hannesschlager Peter Tidemand-Lichtenberg Christian Pedersen Adrian Podoleanu Ole Bang | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 3 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 4 | Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging显示文摘Magnetic resonance imaging(MRI)techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis(CP)patients.Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP.In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis.Thus,morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography(MRCP).Furthermore,secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas.These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP.Recently,spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas.Hence,the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP. | Tine Maria Hansen Matias Nilsson Mikkel Gram Jens Brφndum Frφkjr | 2013 | World Journal of Gastroenterology2013，19，42： | 7 |
| 5 | 堆积物古DNA揭示西藏廓雄遗址的食物构成显示文摘动物考古和植物考古是重建古代食谱的重要手段.对出土动植物遗存的种属鉴定是动植物考古研究的基础,但其鉴定效率严重依赖于动植物遗存的保存状态.沉积物古DNA(sedimentary ancient DNA)是一种新兴的技术手段,可以从数十万年以来的沉积物中提取出古代动植物和微生物的遗传信息,进而恢复当时生态环境中的物种组成.但目前将沉积物古DNA技术应用于旷野遗址的研究还鲜有报道.本文尝试将沉积物古DNA技术应用于西藏廓雄遗址(3160~2954cal a BP)的调查剖面,并与出土的动植物遗存进行对比.结果发现,在大麦(Hordeum vulgare)和绵羊(Ovis aries)等农作物与家养动物的鉴定上,两种方法可以互相印证,但遗址堆积物古DNA中还检测到大植物遗存中没有发现的粟(Setaria italica),以及多种与农作物伴生的微生物.本研究通过动植物常规鉴定方法与沉积物古DNA分析,揭示了廓雄遗址先民的部分食物组成,其中包括:粟类、麦类等谷物,绵羊、黄牛等家养动物,以及渔猎的野生动物等.本项研究表明,沉积物古DNA技术具有通过旷野遗址文化堆积物复原其中动植物种属信息的潜力,为其进一步应用于植物考古和动物考古研究奠定了基础. | 顾政权 高玉 王一如 杨继帅 冉景坤 杨晓燕 夏格旺堆 Mikkel Winther PEDERSEN 盛桂莲 王昱程 陈发虎 | 2023 | 中国科学:地球科学2023，53，4： | 4 |
| 6 | 生物公民的塑造:以北京的糖尿病人为例显示文摘文章介绍了'生物公民'的理论及发展趋势,讨论了本概念对阐释北京的糖尿病人的情况的作用。生物医学的糖尿病疗法主要取决于教育病人使用一套复杂的自我监督和自我管理方法,而文章描述了这样一套全球一致的疗法如何被地方化并认同及其社会组织的基础。生物公民理论描写的认同和社会组织进程在糖尿病人的领域显然也存在,但是教育并组织糖尿病人的主要驱动力来自药物公司和病人自己,而国家扮演的角色并不重要。因此文章建议用一个相关的概念——生物社会性,作为出发点去了解诸如糖尿病的生物差异在地方性的场合如何被赋予意义,如何成为社会实践。 | Mikkel Bunkenborg | 2007 | 中国农业大学学报(社会科学版)2007，24，3： | 2 |
| 7 | Epidemiology of dengue: past, present and future prospects显示文摘 | Annelies Wilder-Smith Mikkel Quam Murray | 2013 | 2013 (Issu)2013，，： | 2 |
| 8 | 通过晶相调控实现高性能十字形TTF分子场效应晶体管器件构筑显示文摘有机分子溶剂的选择对于调控不同晶相来说有着关键性作用.本文通过两种溶剂的调控,成功得到茚并芴四硫富瓦烯(IF-TTF)两种不同的晶相—α相带状晶体和β相片状晶体,并对两种晶相的内部分子排列堆积情况进行了一系列的对比分析.结果表明场效应电荷传输能力随着晶相的不同而有所差异,直接证明了分子堆积的合理调控对实现有机半导体材料高性能电荷传输性能的重要性. | 冯琳琳 董焕丽 李清源 朱伟刚 仇格格 丁尚 李旸 Mikkel A.Christensen Christian R.Parker 魏钟鸣 Mogens Brondsted Nielsen 胡文平 | 2017 | Science China Materials2017，60，1： | 2 |
| 9 | Shot-noise limited, supercontinuum-based optical coherence tomography显示文摘We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography(SD-OCT)with an axial resolution of 5.9μm at a center wavelength of 1370 nm.Current supercontinuumbased SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-topulse relative intensity noise of the supercontinuum source.To overcome this disadvantage,we have developed a low-noise supercontinuum source based on an all-normal dispersion(ANDi)fiber,pumped by a femtosecond laser.The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate.We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast,better sensitivity,and improved penetration.From SD-OCT imaging of skin,retina,and multilayer stacks we conclude that supercontinuumbased SD-OCT can enter the domain of shot-noise limited detection. | Shreesha Rao D.S. Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Björn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels Møller Israelsen Ole Bang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 10 | Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-IR chalcogenide fibers [Invited]显示文摘Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(IR) supercontinuum laser. | Christian R.Petersen Mikkel B.Lotz Christos Markos Getinet Woyessa David Furniss Angela B.Seddon Rafael J.Taboryski O.Bang | 2021 | Chinese Optics Letters2021，19，3： | 2 |
| 11 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 12 | 一把椅子抵住这时间的洪流显示文摘关于人与物是如何互相影响的,我想一把汉斯·瓦格纳(HANS J.WEGNER)的椅子便能说明这两者间全部的关系。 | msright PP M?bler Mikkel Adsb?l Jens Mourits S?rensen Erik Brahl Rasmus Koch Studio Katja Kejser Kasper Holst Pedersen | 2015 | 设计2015，28，22： | 2 |
| 13 | Epidemiology of dengue: past, present and future prospects显示文摘 | Annelies Wilder-Smith Mikkel Quam Murray | 2013 | Clinical Epidemiology . 2013 (Issu)2013，，： | 2 |
| 14 | Cardiac function in growth hormone deficient patients before and after 1 year with replacement therapy:a magnetic resonance imaging study显示文摘 | Mikkel Andreassen Jens Faber Andreas Kjr | 2011 | Pituitary2011，14，： | 1 |
| 15 | Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis显示文摘BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.Data were sparse for the other natriuretic peptides;B-type natriuretic peptide and urodilatin.CONCLUSION Intravenous ANP infusions increase sodium excretion in patients with cirrhotic ascites.Continuous infusion rates>30 ng/kg/min are the most effective.However,safety increases with infusion rates≤30 ng/kg/min. | Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 16 | Floats,integers,and single source shortest paths显示文摘 | Mikkel Thorup | 2000 | Journal of algorithms (S0196-6774)2000，35，2： | 1 |
| 17 | Undirected Single-Source Shortest Paths with Positive Integer Weights in Linear Time显示文摘 | Mikkel Trorup | 1999 | Journal of the ACM (S0004-5411)1999，46，3： | 1 |
| 18 | National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications显示文摘 | Hannah Blencowe Simon Cousens Mikkel Z Oestergaard Doris Chou Ann-Beth Moller Rajesh Narwal Alma Adler Claudia Vera Garcia Sarah Rohde Lale Say Joy E Lawn | 2012 | The Lancet2012，，9832： | 1 |
| 19 | Expression of Distinct Self-Incompatibility Specificities in Arabidopsis thaliana显示文摘 | Boggs Nathan A Dwyer Kathleen G Shah Paurush McCulloch Amanda A Bechsgaard Jesper Schierup Mikkel H Nasrallah Mikhail E Nasrallah June B | 2009 | Genetics2009，，4： | 1 |
| 20 | Stability/degradation of poly- mer solar cells显示文摘 | Mikkel J Kion N Frederik C K | 2008 | Solar Energy Materials & Solar Cells2008，，92： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员