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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Observation of atmospheric nitrous acid with DOAS in Beijing, China显示文摘Measurements of nitrous acid(HONO) and nitrogen dioxide(NO2) in Beijing City have been performed by means of a developed differential optical absorption spectroscopy(DOAS) system based on photodiode array(PDA), during the autumn of 2004. HONO and NO2 were simultaneously identified by their characteristic absorption bands in the spectral region between 337 nm and 372 nm with high sensibility and time resolution. The concentrations of HONO exhibit obviously diurnal variation with a nocturnal maximum and a daytime minimum. The highest HONO value up to 11.8 ?滋g/m3 was observed during the night of 2/3 September. Possible sources of the observed HONO were discussed. Good correlation to NO2 indicates that NO2 is a main source component. The measurement also shows direct emission of HONO is an important source in strongly polluted urban area. | QIN Min XIE Pin-hua LIU Wen-qing LI Ang DOU Ke FANG Wu LIU Jian-guo ZHANG Wei-jun | 2006 | Journal of Environmental Sciences2006，18，1： | 15 |
| 3 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 4 | A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk显示文摘Aim Eggs are one of the most nutritious foods in nature,but there is no unified conclusion about the association between egg intake and breast cancer risk.Methods The PubMed and Web of Science databases for the literature on egg intake and breast cancer risk were searched for papers published during the last 10 years.These were then filtered according to the inclusion and exclusion criteria.Stata16.0 software was applied to perform a meta-analysis,the generalized least squares method and constrained cubic spline model were used to assess the dose-response trends between egg intake and breast cancer risk.Results A total of 9 articles were included:6 case control studies and 3 cohort studies.The Newcastle-Ottawa scale(NOS)values of the included articles were all≥6 points.The pooled relative risks(RR)of egg intake and breast cancer risk was 0.91(95%CI:0.69-1.19).The dose-response analysis showed a linear trend for egg intake and breast cancer risk(P=0.689).With every 10 g/day increase in egg intake,the incidence of breast cancer increased by 2%(RR=1.02,95%CI:0.99-1.05).However,these results were not statistically significant.Conclusion This meta-analysis found no significant association between egg intake and breast cancer. | Peng Wei Ma Fei Fei Feng Zi Ang Shi Ke Di Xu Yuan Lin Zou Yan Li Wang Si Qi Ning Chun Hua Song | 2021 | Journal of Nutritional Oncology2021，6，2： | 3 |
| 5 | Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model显示文摘瞄准:Sildenafil, phosphodiesterase 5 (PDE5 ) 禁止者,被显示了在心失败施加有益的效果。这研究的目的是测试 sildenafil 是否压制了横向小管的(T 小管) 在左改变室(LV ) 失败并且从而提供治疗学的 benefits.Methods:一个压力导致超载的鼠科的心失败模型被胸的大动脉的 banding (标签) 在老鼠建立。在标签以后的一天,鼠标收到了 sildenafil (100 mg· kg −1·d−1, sc ) 或为 5 个星期盐。在处理的结束, echocardiography 被用来检验 LV 功能。然后,未经触动的心外面被把并且把房间放在 Langendorff 灌注为在 situ 从 epicardial myocytes.Results 的 T 小管超微结构的共焦的成像:标签外科导致了改变的显著 T 小管伴随的心失败。Sildenafil 处理显著地稀释了导致标签的心脏的肥大和充血的心失败,改进了 LV 可收缩的功能,并且保存了在 LV cardiomyocytes 的 T 小管正直。但是 sildenafil 处理显著地没影响房间膨胀。LV T 小管结构的完整与心脏的肥大被相关(R 2=0.74, P< 0.01 ) 并且全球 LV 功能(R 2=0.47, P< 0.01 ).Conclusion:Sildenafil 有效地改善在标签老鼠改变的 LV T 小管,揭示在心失败位于 sildenafil 的治疗学的好处下面的新奇机制。 | Chun-kai HUANG Bi-yi CHEN Ang GUO Rong CHEN Yan-qi ZHU William KUTSCH KE Jiang HONG Long-sheng SONG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 6 | Precise Rates in the Law of the Logarithm for the Moment Convergence in Hilbert Spaces显示文摘让 { X, X n ;n ≥
1 } i.i.d 随机变量的一个序列在一个真实可分离的 Hilbert 空格正在拿值(H, ‖
· ‖
) 与协变性操作员 Σ
。集合 S n = X 1+ X 2+...+ X n , n ≥
1。我们证明为 b >
−1 ,如果,那成立前= 0 ,并且E‖X‖ 2(log ‖X‖)3b∨(b+4)<
∞
,在 Y 是拿的一个 Gaussian 随机的变量的地方,与平均数零在一个真实可分离的 Hilbert 空格珍视并且协变性操作符Σ
,并且σ
2表示Σ
的最大的特征值。 | Ke Ang FU Li Xin ZHANG | 2009 | Acta Mathematica Sinica,English Series2009，25，2： | 2 |
| 7 | Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary 显示文摘 | Friend KE Ang LW Shupnik MA | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 8 | Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietie lineages 显示文摘 | Schenke-Layland K Rhodes KE Angelis E | 2008 | Stem Cells2008，26，6： | 1 |
| 9 | Repro grammed mouse ifibroblasts differentiate into cells of the car diovascular and hematopoietic lineages显示文摘 | Schenke-Layland K Rhodes KE Angelis E | 2008 | Stem Cells2008，26，6： | 1 |
| 10 | Reprogrammed mousefibroblasts differentiate into cells of the cardiovascular andhematopoietic lineages显示文摘 | Schenke LK Rhodes KE Angelis E | 2008 | Stem Cells2008，26，6： | 1 |
| 11 | Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages显示文摘 | Schenke LK Rhodes KE Angelis E l | 2008 | Stem Cells2008，26，6： | 1 |
| 12 | The Role of Organ Failure and Infection in Necrotizing Pancreatitis: A Prospective Study显示文摘 | Qiang Guo Ang Li Qing Xia Xubao Liu Bole Tian Gang Mai Zongwen Huang Guangyuan Chen Wenfu Tang Xiaodong Jin Weixia Chen Huimin Lu Nengwen KE Zhaoda Zhang Weiming HU | 2014 | Annals of Surgery2014，，6： | 1 |
| 13 | Reprogrammed mouse fibroblasts differ- entiate into cells of the cardiovascular and hematopoietic lineages 显示文摘 | Schenke - Layland K Rhoder KE Angelis E | 2008 | Stem Cells2008，26，： | 1 |
| 14 | Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages 显示文摘 | Schenke-Layland K Rhodes KE Angelis E | 2008 | Stem Cells2008，26，6： | 1 |
| 15 | The effectiveness of simethicone in improving visibility during colonoscopy when given with a sodium phosphate solutron:a double-blind ran-domized study显示文摘 | SUDDUTH RH DE ANGELIS S SHERMAN KE | 1995 | Gastrointest Endosc1995，42，5： | 1 |
| 16 | Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages显示文摘 | Schenke-Layland K Rhodes KE Angelis E | | 0，，06： | 1 |
| 17 | Reprogrammed mouse fi-broblasts differentiate into cells of the cardiovascular and hematopoietic lineages显示文摘 | Schenke-Layland K Rhodes KE Angelis E | 2008 | Stem Cells2008，26，6： | 1 |
| 18 | Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary显示文摘 | Friend KE Ang LW Shupnik MA | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 19 | Audiological and ge-netic features of the mtDNA mutations显示文摘 | Liu XZ Angeli S Ouyang XM Liu W Ke XM Liu YH Liu SX Du LL Deng XW Yuan H Yan D | | 0，，07： | 1 |
| 20 | A Nonclassical LIL for Geometrically Weighted Series in Banach Space显示文摘Let {X, Xn ; n ≥ 0} be a sequence of independent and identically distributed random variables, taking values in a separable Banach space (B,||·||) with topological dual B* . Considering the geometrically weighted series ξ(β) =∑∞n=0βnXn for 0 < β < 1, and a sequence of positive constants {h(n), n ≥ 1}, which is monotonically approaching infinity and not asymptotically equivalent to log log n, a limit result for(1-β2)1/2||ξ(β)||/(2h(1/(1-β2)))1/2 is achieved. | Ke Ang FU Xiao Rong YANG Wei HUANG | 2013 | Acta Mathematica Sinica,English Series2013，29，7： | 1 |
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