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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Self-perceived burden and influencing factors in patients with cervical cancer administered with radiotherapy显示文摘BACKGROUND Cervical cancer is the fourth commonest malignancy in women around the world.It represents the second most commonly diagnosed cancer in South East Asian women,and an important cancer death cause in women of developing nations.Data collected in 2018 revealed 5690000 cervical cancer cases worldwide,85%of which occurred in developing countries.AIM To assess self-perceived burden(SPB)and related influencing factors in cervical cancer patients undergoing radiotherapy.METHODS Patients were prospectively included by convenient sampling at The Fifth Affiliated Hospital of Sun Yat-Sen University,China between March 2018 and March 2019.The survey was completed using a self-designed general information questionnaire,the SPB scale for cancer patients,and the self-care self-efficacy scale,Strategies Used by People to Promote Health,which were delivered to patients with cervical cancer undergoing radiotherapy.Measurement data are expressed as the mean±SD.Enumeration data are expressed as frequencies or percentages.Caregivers were the spouse,offspring,and other in 46.4,40.9,and 12.7%,respectively,and the majority were male(59.1%).As for pathological type,90 and 20 cases had squamous and adenocarcinoma/adenosquamous carcinomas,respectively.Stage IV disease was found in 12(10.9%)patients.RESULTS A total of 115 questionnaires were released,and five patients were excluded for too long evaluation time(n=2)and the inability to confirm the questionnaire contents(n=3).Finally,a total of 110 questionnaires were collected.They were aged 31-79 years,with the 40-59 age group being most represented(65.4%of all cases).Most patients were married(91.8%)and an overwhelming number had no religion(92.7%).Total SPB score was 43.13±16.65.SPB was associated with the place of residence,monthly family income,payment method,transfer status,the presence of radiotherapy complications,and the presence of pain(P<0.05).The SPB and self-care self-efficacy were negatively correlated(P<0.01).In multivariate analysis,self-care self-efficacy,place of residence,monthly family income,payment method,degree of radiation dermatitis,and radiation proctitis were influencing factors of SPB(P<0.05).CONCLUSION Patients with cervical cancer undergoing radiotherapy often have SPB.Self-care self-efficacy scale,place of residence,monthly family income,payment method,and radiation dermatitis and proctitis are factors independently influencing SPB. | Ting Luo Rong-Zhi Xie Yan-Xia Huang Xiao-Hua Gong Hui-Ying Qin Yi-Xiao Wu | 2021 | World Journal of Clinical Cases2021，9，17： | 19 |
| 3 | Evaluation of the effect of air pollution control during the Beijing 2008 Olympic Games using Lidar data显示文摘To examine the effect of pollution control measures on Beijing air quality during the 2008 Olympic Games, this paper analyzes the variation of aerosol extinction coefficient observed with a Dual-wavelength Polarized Lidar in Beijing during the Olympic Games. The results show that (1) during the Beijing Olympic Games, the aerosol extinction coefficient decreased to about 42.3% in the surface layer (below 250 m) compared with that in 2007 under almost the same meteorological conditions, indicating the effectiveness of local air pollution control measures in Beijing areas; (2) the analysis of the aerosol extinction coefficient obtained before (Jul. 20–Aug. 7, 2008) and during the Beijing Olympic Games (Aug. 8–Aug. 24, 2008) shows a maximum decrease of daily aerosol extinction coefficient in layer of 0.5-1.5 km. To elucidate such a phenomenon, the transport of PM10 from surrounding areas to Beijing was simulated by NAQPMS (the Nested Air Quality Prediction Modeling System) during Jul. 20 to Aug. 24, 2008. Analysis of PM10 transport from neighboring areas indicated a decrease of 36.6% during the Olympic Games. This demonstrated the efficiency of pollution control measures in surrounding areas in improving air quality in Beijing. | YANG Ting WANG ZiFa ZHANG Bai WANG XiQuan WANG Wei GBAUIDI Alex GONG YanBang | 2010 | Chinese Science Bulletin2010，55，13： | 9 |
| 4 | Two new prenylflavonoids from Morus nigra L.显示文摘二新 prenylflavonoids, mornigrol E (1 ) 和 mornigrol F (2 ) 从桑属 nigra L 被孤立。他们的结构根据分光镜的方法被阐明,特别 2D-NMR 技术。 | Lei Wang Ting Gong Ruo Yun Chen | 2009 | Chinese Chemical Letters2009，20，12： | 8 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Structural Evolution and Hydrocarbon Potential of the Upper Paleozoic Northern Ordos Basin, North China显示文摘在北 Ordos 盆的 Hangjinqi 区域的烃潜力不是众所周知的,与盆的另外的区域相比,尽管有它的实质的石油系统。越过在东方 Hangjinqi 区域的 Hangjinqi 差错地区( HFZ )的变换深度的地震侧面的恢复显示出创造了背斜的结构在的一压缩晚三叠纪,并且在 ∼Middle 侏罗记的二延期和晚早的白垩纪,它被倒置分别地在晚侏罗记早的早白垩纪和迟了的白垩纪打断。在在中央 Ordos 盆(圆块) 的井地点的烃产生开始了在晚三叠纪。盆当模特儿井 Zhao-4 从北 Shanbei 斜坡的迟了的含碳早二叠的煤措施建议那烃代在早白垩纪达到顶点,在迟了的白垩纪早于倒置。在 Shanbei 斜坡的大多数来源岩石除了 Hangjinqi 区域来源岩石(井 Jin-48 ) 传递了主要煤气迁居的阶段。因为盆充满阶层向南正在蘸,从 COB 产生的烃是可能的沿着 HFZ 向背斜的结构和陷井向北方移植了。指责在 Hangjinqi 区域的 extensional 阶段(晚早的白垩纪) 期间继续那可能为烃的迁居充当了水管。因此,到 HFZ 的北方的背斜的结构和联系陷井可能套住自从中间的侏罗记,在 COB 从迟了的含碳早二叠的煤措施被控告的烃。 | YANG Minghui LI Liang ZHOU Jin JIA Huichong SUN Xiao GONG Ting DING Chao | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 7 |
| 7 | Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China显示文摘Objective To investigate the association between birth defects and dietary nutrient intake in a high risk area of China. Methods A dietary survey was performed and serum folic acid was measured in women whose pregnancy was affected by neural tube defects (NTDs) or unaffected by any birth defects (BDs) in Zhongyang and Jiaokou Counties in Shanxi Province of China. Results The local average consumption of foods including dark green vegetables, fruits, fat and meat, and nutrient intake (e.g. energy, protein, retinol, riboflavin, vitamin E, and selenium) were lower than the national average level. In women of childbearing age, these regions, the intake of nutrients was much lower than the recommended nutrient intake (9%-77%). The case-control dietary nutrition study of women whose pregnancy was affected by BDs (including NTDs and congenital heart defects) demonstrated that, in early pregnancy, adequate nutrition (i.e. eating meat, fresh vegetables, fruit more than once a week) was a protective factor, while eating germinated potatoes was a risk factor. The geometrical mean (p5-p95) of serum folic acid in women with NTD birth defects was 9.6 nmol/L (3.6, 23.03), which was significantly lower than that in normal women (14.03 nmol/L). Conclusion Women of childbearing age in the two counties of Shanxi Province, China, have a marked insufficient intake of some nutrients, especially folic acid, zinc, vitamins A and B12. This nutrient deficiency may be an important risk factor for the high prevalence of birth defects in these regions. Therefore, adequate dietary nutrition in early pregnancy can prevent BDs. | BAO-YUAN ZHANG TING ZHANG LIANG-MING LIN FANG WANG RUO-LEI XIN XUE GU YU-NA HE DONG-MEI YU PEI-ZHEN LI QING-SHAN ZHANG JIN ZHAO Yu-Fu QIN XIU-FENG YANG GONG CHEN JU-FEN LIU XIN-MING SONG XIAO-YING ZHENG | 2008 | Biomedical and Environmental Sciences2008，21，1： | 7 |
| 8 | Clinical Analysis of Early Noninvasive Mechanical Ventilation in the Treatment of Acute Left Heart Failure Complicated with Respiratory Failure显示文摘Objective To evaluate the efficacy of early and non-early non-invasive mechanical ventilation(NIV) for acute left heart failure and respiratory failure. Methods 29 cases of patients with acute left heart failure and respiratory failure treated by NIV were selected from our department from August 2016 to March 2019. According to the time of initiation of noninvasive mechanical ventilation, the patients were divided into the early treatment group(group A, treatment with NIV immediately after admission, n=15) and the non-early treatment group(group B, treatment with NIV for 2 h after admission, n=14), the improvement time, mechanical ventilation time, effective rate, intubation rate and fatality rate were compared between the two groups. Results The improvement time of patients in group A was(4.8±2.5) hours, the time of mechanical ventilation was(9.6±3.2) hours, the improvement time of group B was(6.8±2.6) hours, and the time of mechanical ventilation(12.8±4.4) hours. There were significant differences between the two groups(P<0.05). In group A, 13 patients were cured, 2 patients were intubated, 1 patient died, 10 patients in group B were cured, 4 patients were intubated, and 2 patients died. The difference in cure rate, intubation rate and mortality was statistically significant(P<0.05). Conclusion The treatment of acute left heart failure and respiratory failure is effective, and early application can improve the cure rate, reduce intubation and mortality. | Ting SUN Tianfu GONG Qianhui SUN Jian ZHANG Jiaming CAO | 2019 | 国际感染病学(电子版)2019，8，2： | 4 |
| 9 | Synergetic effect of FeVO_4 andα-Fe_2O_3 in Fe-V-O catalysts for liquid phase oxidation of toluene to benzaldehyde显示文摘Synergistic effect of FeVO_4 withα-Fe_2O_3 was found in Fe-V-O catalyst,which was responsible for the high apparent formation rate(A.F.R.) of benzaldehyde in liquid phase oxidation of toluene by hydrogen peroxide.The synergistic effect might create VO_πspecies as active sites;moreover,it improved the reducibility and the reactivity of Fe-V-O catalyst.In order to gain the high A.F.R. of benzaldehyde,the catalyst should have the moderate reducibihty. | Gui Quan Zhang Xin Zhang Tao Lin Ting Gong Min Qi | 2012 | Chinese Chemical Letters2012，23，2： | 4 |
| 10 | Shape-Controlled CuCl Crystallite Catalysts for Aniline Coupling显示文摘The catalytic activity of crystallites depends mainly upon the arrangement of surface atoms,the number of dangling bonds,and defect site distribution on different crystal planes.Here,we report the shape-controlled synthesis of CuCl crystallites,including tetrahedra,face-centered-etched tetrahedra,tripod dendrites,and tetrapods.These different morphologies of CuCl crystallites expose different proportions of{111}and{110}crystal planes,and materials with a preponderance of{111}crystal planes have better catalytic activity in aniline coupling than those with more{110}planes. | Ting Xie Ming Gong Zhiqiang Niu Shuai Li Xiaoyu Yan Yadong Li | 2010 | Nano Research2010，3，3： | 4 |
| 11 | Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China显示文摘Objective To study the prevalence of different types of neural tube defects (NTDs) in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns. | GONG CHEN LI-JUN PEI JIAN HUANG XIN-MING SONG LIANG-MING LIN XUE GU JIAN-XIN WU FANG WANG JI-LEI WU JIA-PENG CHEN JU-FEN LIU RUO-LEI XIN TING ZHANG XIAO-YING ZHENG | 2009 | Biomedical and Environmental Sciences2009，22，4： | 4 |
| 12 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 13 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 14 | A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance显示文摘When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses. | Caixia Gong Zhenhuan Ouyang Weiqiao Zhao Jie Wang Kun Li Peipei Zhou Ting Zhao Nenggan Zheng Zhefeng Gong | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 15 | Evaluation of the fishbone model in simulating the seismic response of multistory reinforced concrete moment-resisting frames显示文摘The fishbone model is a simplified numerical model for moment-resisting frames that is capable of modelling the effects of column-beam strength and stiffness ratios. The applicability of the fishbone model in simulating the seismic responses of reinforced concrete moment-resisting frames of different sets of column-beam strength and stiffness ratios are evaluated through nonlinear static, dynamic and incremental dynamic analysis on six prototype buildings of 4-, 8-and 12-stories. The results show that the fishbone model is practically accurate enough for reinforced concrete frames, although the assumption of equal joint rotation does not hold in all cases. In addition to the ground motion characteristics and the number of stories in the structures, the accuracy of the model also varies with the column-beam stiffness and strength ratios. The model performs better for strong column-weak beam frames, in which the lateral drift patterns are better controlled by the continuous stiffness provided by the strong columns. When the inelastic deformation is large, the accuracy of the model may be subjected to large record-to-record variability. This is especially the case for frames of weak columns. | Qu Zhe Gong Ting Li Qiqi Wang Tao | 2019 | Earthquake Engineering and Engineering Vibration2019，18，2： | 3 |
| 16 | PINPOINT SOURCE LOCALIZATION FOR OCULAR NONSELECTIVE ATTENTION WITH COMBINATION OF ERP AND fNIRI MEASUREMENTS显示文摘Compared with event-related potential(ERP)which is widely used in psychology research,functional near-infrared imaging(fNIRI)is a new technique providing hemodynamic information related to brain activity,except for electrophysiological signals.Here,we use both these techniques to study ocular attention.We conducted a series of experiments with a classic paradigm of ocular nonselective attention,and monitored responses with fNIRI and ERP respectively.The results showed that fNIRI measured brain activations in the left prefrontal lobe,while ERPs showed activation in frontal lobe.More importantly,only with the combination measurements of fNIRI and ERP,we were then able to find the pinpoint source of ocular nonselective attention,which is in the left and upper corner in Brodmann area 10.These results demonstrated that fNIRI is a reliable technique in psychology,and the combination of fNIRI and ERP can be promising to reveal more information in the research of brain mechanism. | TING LI LI LI PENG DU QINGMING LUO HUI GONG | 2008 | Journal of Innovative Optical Health Sciences2008，1，2： | 3 |
| 17 | Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peripheral inflammatory pain: multi-electrode array recordings in rats显示文摘To explore whether experiencing inflammatory pain has an impact upon intracortical synaptic organization,the planar multi-electrode array(MEA)technique and 2-dimensional current source density(2D-CSD)imaging were used in slice preparations of the anterior cingulate cortex(ACC)from rats.Synaptic activity across different layers of the ACC was evoked by deep layer stimulation through one electrode.The layer-localization of both local field potentials(LFPs)and the spread of current sink calculated by 2D-CSD analysis was characterized pharmacologically.Moreover,the induction of long-term potentiation(LTP)and changes in LTP magnitude were also evaluated.We found that under na ve conditions,the current sink was initially generated in layer VI,then spread to layer V and finally confined to layers II–III.This spatial pattern of current sink movement typically reflected changes in depolarized sites from deep layers(V–VI)to superficial layers(II–III)where intra-and extracortical inputs terminate.In the ACC slices from rats in an inflamed state(for 2 h)caused by intraplantar bee-venom injection,the spatial profile of intra-ACC synaptic organization was significantly changed,showing an enlarged current sink distribution and a leftward shift of the stimulus-response curves relative to the na ve and saline controls.The change was more distinct in the superficial layers(II–III)than in the deep site.In terms of temporal properties,the rate of LTP induction was significantly increased in layers II–III by inflammatory pain.However,the magnitude of LTP was not significantly enhanced by this treatment.Taken together,these results show that inflammatory pain results in distinct spatial and temporal plasticity of synaptic organization in the ACC,which may lead to altered synaptic transmission and modulation. | Yun-Fei Lu Yan Wang Ying He Fu-Kang Zhang Ting He Rui-Rui Wang Xue-Feng Chen Fei Yang Ke-Rui Gong Jun Chen | 2014 | Neuroscience Bulletin2014，30，1： | 3 |
| 18 | Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study显示文摘Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma. | Siyi Li Peilin Lv Min He Wenjing Zhang Jieke Liu Yao Gong Ting Wang Qiyong Gong Yulin Ji Su Lui | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 19 | Gene expression profiles of the Southern house mosquito Culex quinquefasciatus during exposure to permethrin显示文摘 | William R. Reid Lee Zhang Youhui Gong Ting Li Nannan Liu | 2018 | Insect Science2018，25，3： | 3 |
| 20 | Rock burst and slabbing failure and its influence on TBM excavation at headrace tunnels in Jinping II hydropower station显示文摘 | Q.M. Gong L.J. Yin S.Y. Wu J. Zhao Y. Ting | 2011 | Engineering Geology2011，，： | 3 |
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