|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 4 | Seasonal Variations of Net-Phytoplankton Community Structure in the Southern Yellow Sea显示文摘Based on the field survey data of four cruises in 2011,all phytoplankton communities in the southern Yellow Sea (SYS) were investigated for the species composition,dominant species,abundance and diversity indices.A total of 379 species belonging to9 phyla were identified,of which the most abundant group was Bacillariophyta (60.9%) ,followed by Pyrrophyta (23.7%) and Haptophyta (6.9%) .The seasonal distribution of abundance was:summer (4137.1×103ind m 3) >spring (3940.4×103ind m 3) >winter (3010.6×103ind m 3) >autumn (340.8×103ind m 3) ,while the horizontal distribution showed a decreasing tendency from inshore to offshore regions.The dominant species of phytoplankton varied in different seasons.The dominant species were Thalassiosira pacifica,Skeletoema spp.and Chaetoceros cinctus in spring,Chaetoceros debbilis,Chaetoceros pseudocurvisetus and Chaetoceros curvisetus in summer,Thalassiosira curviseriata,Alexandrium catenella and Ceratium fusus in autumn,Paralia sulcata,Phaeocystis sp.and Bacillaria paradoxa in winter,respectively.In SYS,the group of temperate coastal species was the major ecotype,and the groups of the central SYS species and oceanic species were also important constituents.The average values of Shannon-Weaver diversity index (H’) and Pielou evenness index (J) were 2.37 and 0.65 respectively.The indices H’and J in the open sea were higher than those in coastal waters.Obvious co-variation tendencies between H’and J were observed in all but the summer cruise of this survey. | GAO Yu JIANG Zhibing LIU Jingjing CHEN Quanzhen ZENG Jiangning HUANG Wei | 2013 | Journal of Ocean University of China2013，12，4： | 10 |
| 5 | The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury显示文摘充分位于调停房间的暴发性的肝炎不是的 T 下面的机制理解。在这研究,我们调查了 myeloid 是否导出房间(MDSC ) 能阻止的 suppressor concanavalin A (ConA ) 通过压制 T 房间增长导致了肝炎。我们在 ConA 治疗的早舞台在老鼠怒气和肝在 MDSC 的频率观察了增加,含有 MDSC 可能对调停 ConA 的发炎涉及老鼠的起始的抵抗。Subpopulation 分析证明在导致 ConA 的老鼠的肝的 MDSC 主要是 granulocytic MDSC。骨头的采纳转移进对待 ConA 的老鼠的导出髓的 MDSC 证明 MDSC 移居了进他们通过 ROS 压制了 T 房间增长的肝和怒气小径。另外,在老鼠的 MDSC 的频率被处理显著地也与有免疫力的 suppressor glucocorticoids 增加。进规章的 T 房间(Treg ) 的 MDSC 的转移弄空老鼠证明导致 ConA 的肝炎上的 MDSC 的保护的效果是 Treg 独立的。在结论,我们的结果证明 MDSC 在 T 调停房间的肝炎拥有一个直接保护的角色,并且由采纳转移或 glucocorticoid 治疗增加 MDSC 的频率为急性煽动性的疾病代表潜在的基于房间的治疗学的策略。 | Wenli Diao Fangfang Jin Bing Wang Chen-Yu Zhang Jiangning Chen Ke Zen Limin Li | 2014 | Protein & Cell2014，5，9： | 7 |
| 6 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 7 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 8 | SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration显示文摘SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals.However,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic mice.Moreover,the permeability of the infected vessel was in creased.Furthermore,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans blue.Interestingly,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected animals.Using an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the BMECs.Consistent with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected BMECs.Besides,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 infection.Overall,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs. | Ling Zhang Li Zhou Linlin Bao Jiangning Liu Hua Zhu Qi Lv Ruixue Liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-Hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu Zhang Xiuping Sun Xuan Yu Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 9 | The decay kinetics of residual chlorine in cooling seawater simulation experiments显示文摘To find out the decay character of residual chlorine (RC) in the sea water, the concentration of RC was analyzed by N, N-diethyl-p-phenylenediamine (DPD) method under different simulation experimental conditions, in which salinity, temperature, and Chemical Oxygen Demand (COD) were selected. The water used in the experiment was the mixture of aging ocean water, coastal water and extracting solution of coastal sediment at appropriate level. Results are shown as follows: (1) Piecewise function can well reffect the decay dynamics of RC in the cooling seawater. Concretely, the decay dynamics of first 1 min is too rapid to ascertain using a specific kinetic function, and that of the time from 1 to 30 min is fit for the first-order kinetic model. (2) The results could be the foundation of the chemical behavior of RC in seawater, and be used as not only the guidance of the coastal power plants production and sea water desalting companies, but also the establishment of the correlative trade standard. | ZENG Jiangning JIANG Zhibing CHEN Quanzhen ZHENG Ping HUANG Yijun | 2009 | Acta Oceanologica Sinica2009，28，2： | 2 |
| 10 | Seasonal Variability of Phytoplankton Community Structure in Relation to Different Nitrogen-Phosphorus Ratios in the Southern Coastal Waters of Zhejiang, China显示文摘With the rapid development of economy and increase of population in the drainage areas,the nutrient loading has increased dramatically in the Changjiang estuary and adjacent coastal waters.To properly assess the impact of nutrient enrichment on phytoplankton community,seasonal microcosm experiments were conducted during August 2010 July 2011 in the coastal waters of Zhejiang Province.The results of the present study indicated that the chl a concentration,cell abundance,diversity indices,species composition and community succession of the phytoplankton varied significantly with different N/P ratios and seasons.Higher growth was observed in the 64:1(spring),32:1(summer),16:1(autumn)and 128:1,256:1(winter)treatments,respectively.The values of Shannon-Wiener index(H′)and Pielou evenness index(J)were lower in the 8:1 and 16:1 treatments in autumn test,while H'value was higher in the 128:1 and 8:1 treatments in winter test.A definite community succession order from diatoms to dinoflagellates was observed in the autumn and winter tests,while the diatoms dominated the community throughout the culture in the spring and summer tests. | HUANG Wei ZHU Xuyu CHEN Quanzhen HE Qing LIAO Yibo DU Ping ZHANG Peng ZENG Jiangning | 2013 | Journal of Ocean University of China2013，12，4： | 2 |
| 11 | Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte - targeting 显示文摘 | Shuying Gao Jiangning Chen Xuerong Xu | 2003 | International Journal of Pharmaceutics2003，225，： | 1 |
| 12 | Bletilla striata polysac- charide stimulates inducible nitric oxide synthase and proinflam- matory cytokine expression in macrophages显示文摘 | Huajia Diao Xin Li Jiangning Chen | 2008 | Journal of Bio- science and Bioengineering2008，105，2： | 1 |
| 13 | An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease显示文摘 | Zhen Huang Jingjing Gan Lixin Jia Guangxing Guo Chunming Wang Yuhui Zang Zhi Ding Jiangning Chen Junfeng Zhang Lei Dong | 2015 | Biomaterials2015，，： | 1 |
| 14 | Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages显示文摘 | Huajia Diao Xin Li Jiangning Chen Yi Luo Xi Chen Lei Dong Chunming Wang Chenyu Zhang Junfeng Zhang | 2007 | Journal of Bioscience and Bioengineering2007，，2： | 1 |
| 15 | A Polysaccharide Isolated from the Medicinal Herb Bletilla striata Induces Endothelial Cells Proliferation and Vascular Endothelial Growth Factor Expression in vitro显示文摘 | Chunming Wang Jiantao Sun Yi Luo Weihua Xue Huajia Diao Lei Dong Jiangning Chen Junfeng Zhang | 2006 | Biotechnology Letters2006，，8： | 1 |
| 16 | Bletilla striata polysaccharide stimulates inducible nitric oxide synthase and proinflammatory cytokine expression in macrophages 显示文摘 | Huajia Diao Xin Li Jiangning Chen | 2008 | Journal of Bioscience and Bioengineering2008，105，2： | 1 |
| 17 | Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte-targeting显示文摘 | Shuying Gao Jiangning Chen Xuerong Xu | 2003 | International Journal of Pharmaceutics2003，225，： | 1 |
| 18 | Bletilla striata poly saccha- ride stimulates inducible nitric oxide synthase a proinflammatory cytokine expression in macrophages 显示文摘 | Huajia Diao Xin Li Jiangning Chen | 2008 | Journal of Bioscience and Bioengineering2008，105，2： | 1 |
| 19 | Bletilla striata poly- saccharide stimulates inducible nitric oxide synthase and proin- flammatory eytokine expression in macrophages 显示文摘 | Huajia Diao Xin Li Jiangning Chen | 2008 | Journal of bi- oscienee and bioengineering2008，105，2： | 1 |
| 20 | Bletilla striata poly saceharide stimulates inducible nitric oxide synthase a proinflammatgry cytokine expression in macrophages显示文摘 | Huajia Diao Xin Li Jiangning Chen | 2008 | Joumal of Bioscience and Bioengineering2008，105，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员