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| 1 | Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography显示文摘AIM:To assess the diagnostic ability of endoscopic ultrasonography(EUS)for evaluating causes of dista biliary strictures shown on endoscopic retrograde chol angiopancreatography(ERCP)or magnetic resonance cholangiopancreatography(MRCP),even without iden tifiable mass on computed tomography(CT). METHODS:The diagnostic ability of EUS was retro spectively analyzed and compared with that of routine cytology(RC)and tumor markers in 34 patients with distal biliary strictures detected by ERCP or MRCP a Dokkyo Medical School Hospital from December 2005 to December 2008,without any adjacent mass or ec centric thickening of the bile duct on CT that could cause biliary strictures.Findings considered as benign strictures on EUS included preservation of the normasonographic layers of the bile duct wall,irrespective of the presence of a mass lesion.Other strictures were considered malignant.Final diagnosis of underlying diseases was made by pathological examination in 18 cases after surgical removal of the samples,and by clinical follow-up for>10 mo in 16 cases. RESULTS:Seventeen patients(50%)were finally di- agnosed with benign conditions,including 6'normal' subjects,while 17 patients(50%)were diagnosed with malignant disease.In terms of diagnostic ability,EUS showed 94.1%sensitivity,82.3%specificity,84.2% positive predictive value,93.3%negative predictive value(NPV)and 88.2%accuracy for identifying ma- lignant and benign strictures.EUS was more sensi- tive than RC(94.1%vs 62.5%,P=0.039).NPV was also better for EUS than for RC(93.3%vs 57.5%,P= 0.035).In addition,EUS provided significantly higher sensitivity than tumor markers using 100 U/mL as the cutoff level of carbohydrate antigen 19-9(94.1%vs 53%,P=0.017).On EUS,biliary stricture that was fi- nally diagnosed as malignant showed as a hypoechoic, irregular mass,with obstruction of the biliary duct and invasion to surrounding tissues. CONCLUSION:EUS can diagnose biliary strictures caused by malignant tumors that are undetectable on CT.Earlier detection by EUS would provide more therapeutic options for patients with early-stage pancreaticobiliary cancer. | Yasuyuki Saifuku Michiko Yamagata Takero Koike Genyo Hitomi Kazunari Kanke Hidetaka Watanabe Toshimitsu Murohisa Masaya Tamano Makoto Iijima Keiichi Kubota Hideyuki Hiraishi | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 2 | Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil显示文摘 | Tsutomu Mizoshita Hiromi Kataoka Eiji Kubota Yasuyuki Okamoto Takaya Shimura Yoshinori Mori Tsuneya Wada Naotaka Ogasawara Makoto Sasaki Takeshi Kamiya Takashi Joh | 2008 | International Journal of Clinical Oncology2008，，4： | 1 |
| 3 | Field experiments and analyses on a hybrid solar collector显示文摘 | Hisashi Saitoh Yasuhiro Hamada Hideki Kubota Makoto Nakamura Kiyoshi Ochifuji Shintaro Yokoyama Katsunori Nagano | 2003 | Applied Thermal Engineering2003，，16： | 1 |
| 4 | Mohen Steel Flow Control under Electromagnetic Level Accelerator in Continuous Casting Mold 显示文摘 | Noriko Kubo Jun Kubota Makoto Suzuki | 2007 | ISU International2007，47，7： | 1 |
| 5 | Water-Soluble Fluorine-Containing Amphiphilic Block Copolymer:Synthesis and Aggregation Behavior in Aqueous Solution显示文摘 | Matsumoto Kozo Kubota Makoto Matsuoka Hideki | 1999 | Macromolecules1999，32，10： | 1 |
| 6 | Role of KIT-Positive Interstitial Cells of Cajal in the Urinary Bladder and Possible Therapeutic Target for Overactive Bladder显示文摘 | Yasue Kubota Yoshiyuki Kojima Yasuhiro Shibata Makoto Imura Shoichi Sasaki Kenjiro Kohri John PFA Heesakkers | 2011 | Advances in Urology2011，，： | 1 |
| 7 | Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores β-catenin mRNA expression in volume-overloaded rabbit hearts显示文摘 | Makoto Itoh Y. Takeishi Shigekazu Nakada Takuya Miyamoto Yuichi Tsunoda Hiroki Takahashi Isao Kubota Hitonobu Tomoike | 2002 | Heart and Vessels2002，，1： | 1 |
| 8 | Field Measurements and Analyses for a Hybrid System for Snow Storage/Melting and Air Conditioning by Using Renewable Energy显示文摘 | Yasuhiro Hamada Makoto Nakamura Hideki Kubota | 2007 | Applied Energy2007，，84： | 1 |
| 9 | Water-soluble fluorine-containing amphiphilic block copolymer:synthesis and aggregation behavior in aqueous solution显示文摘 | MATSUMOTO KOZO KUBOTA MAKOTO MATSUOKA HIDEKI | 1999 | Macromolecules1999，32，10： | 1 |
| 10 | C-Reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation显示文摘 | Tetsu Watanabe Yasuchika Takeishi Osamu Hirono Makoto Itoh Motoyuki Matsui Kazuharu Nakamura Yoshiaki Tamada Isao Kubota | 2005 | Heart and Vessels2005，，2： | 1 |
| 11 | Interleukin‐18 may lead to benign prostatic hyperplasia via thrombospondin‐1 production in prostatic smooth muscle cells显示文摘 | Takashi Hamakawa Shoichi Sasaki Yasuhiro Shibata Makoto Imura Yasue Kubota Yoshiyuki Kojima Kenjiro Kohri | 2014 | Prostate2014，，6： | 1 |
| 12 | Field performance of an energy pile system for space heating显示文摘 | Yasuhiro Hamada Hisashi Saitoh Makoto Nakamura Hideki Kubota Kiyoshi Ochifuji | 2006 | Energy & Buildings2006，，5： | 1 |
| 13 | Clinical features and progress of ischemic gastritis with high fatalities: Seven case reports显示文摘BACKGROUND Ischemic gastritis is a clinically rare and highly fatal disease that occurs when the hemodynamics of a patient with vascular risk is disrupted.Early diagnosis and treatment are possible only with upper endoscopy after symptom appearance.We report seven cases of ischemic gastritis and its clinical features,prognosis,and indicators that may help in early detection.CASE SUMMARY Of the seven patients,six had vascular risk and five died within 2 wk of diagnosis.Their symptoms included hematemesis and hypotension.Although surgery is a choice for radical treatment,not all patients were tolerant.For such patients,conservative treatment was selected,but all of them died.In contrast,patients who underwent repeat endoscopy showed improved mucosal findings,suggesting that this improvement may not affect prognosis.Some ischemic changes such as wall thickening,mural emphysema,and fluid retention in the stomach were observed before diagnosis through endoscopy and computed tomography(CT).The CT scan can be effective for early detection,and improvement in circulatory failure and aggressive treatment may save the lives of patients with this disease.CONCLUSION The characteristic CT findings enable early detection of ischemic gastritis.Early diagnosis increases the chance of survival if early therapeutic intervention and improvement of circulatory dynamics can be achieved in this highly fatal disease. | Kento Shionoya Akiko Sasaki Hidekazu Moriya Karen Kimura Takashi Nishino Jun Kubota Chihiro Sumida Junichi Tasaki Chikamasa Ichita Makomo Makazu Sakue Masuda Kazuya Koizumi Jun Kawachi ToshitakaTsukiyama Makoto Kako | 2022 | World Journal of Clinical Cases2022，10，24： | 1 |
| 14 | Field performance of an energy pile system for space heating显示文摘 | Yasuhiro Hamada Hisashi Saitoh Makoto Nakamura Hideki Kubota Kiyoshi Ochifuji | 2007 | Energy and Buildings2007，，39： | 1 |
| 15 | The effect of biliary decompression on antibiotic biliary excretion显示文摘 | Skin Yamamoto MD Yoshitsugu Kubota MD Makoto Takaoka MD | 2002 | Hepato-Gastroenterology2002，49，： | 1 |
| 16 | Field measurements and analyses for a hybrid system for snow storage/melting and air conditioning by using renewable energy显示文摘 | Yasuhiro Hamada Makoto Nakamura Hideki Kubota | 2007 | Applied Energy2007，84，2： | 1 |
| 17 | C-Reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation显示文摘 | Tetsu Watanabe Yasuchika Takeishi Osamu Hirono Makoto Itoh Motoyuki Matsui Kazuharu Nakamura Yoshiaki Tamada Isao Kubota | 2005 | Heart and Vessels2005，，2： | 1 |
| 18 | IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells显示文摘 | Yusuke Itoh Takashi Joh Satoshi Tanida Makoto Sasaki Hiromi Kataoka Keisuke Itoh Tadayuki Oshima Naotaka Ogasawara Shouzo Togawa Tsuneya Wada Hidetsugu Kubota Yoshinori Mori Hirotaka Ohara Tomoyuki Nomura Shigeki Higashiyama Makoto Itoh | 2005 | Cytokine2005，，6： | 1 |
| 19 | Field Measurements and Analyses for a Hybrid System for Snow Storage/Melting and Air Conditioning by Using Renewable Energy显示文摘 | Yasuhiro Hamada Makoto Nakamura Hideki Kubota | 2007 | Applied Energy2007，84，： | 1 |
| 20 | Reaction Milled and Spark Plasma Sintered Al-alb2 Composite Materials显示文摘 | Masahiro Kubota Makoto Sugamata | 2008 | Reviews on Advanced Materials Science2008，18，3： | 1 |
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