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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Particle in Flight Behavior and Its Influence on the Microstructure and Mechanical Property of Plasma Sprayed La2Ce2O7 Thermal Barrier Coatings显示文摘 | KUN L JIAN J T YU B | 2015 | Materials Science and Engineering A2015，625，： | 1 |
| 3 | Effect of nitrocellulose on the properties of PU NC semi-IPN wood coatings显示文摘 | Kun T L Cheng T L Hong L L | 2002 | Journal of Applied Polymer Science2002，89，8： | 1 |
| 4 | Acceptance of domestic cat mitochondrial DNA in a criminal proceeding显示文摘 | Lyons L A Grahn R A Kun T J | 2014 | Forensic Sci Int2014，13，： | 1 |
| 5 | Control of variable speed gaits for a biped robot显示文摘 | Kun A L Miller W T III | 1999 | IEEE Robotics and Automation Magazine1999，6，3： | 1 |
| 6 | Correlation between promoter methylation of pl 4 ( ARF), TMSI/ASC, and DAPK, and p53 mutation with prognosis in cholangiocarcinoma显示文摘 | Xiaofang L Kun T Shaoping Y | 2012 | World J Surg Onco12012，10，： | 1 |
| 7 | The effect of alkyd resins on the properties of AA-NC semi-IPNs as binders in wood finish 显示文摘 | Kun T L Cheng T L Shih M L | 2004 | Journal of Applied Polymer Science2004，93，4： | 1 |
| 8 | Model-based analysis of hand posture显示文摘 | LEE J KUNⅡ T L | 1995 | IEEE Computer Graphics Application1995，5，5： | 1 |
| 9 | Efficacy and safety of canagliflozin versus glimepiride in patients w ith type 2 diabetes inadequately controlled w ith metformin(CANTATA-SU):52 w eek results from a randomised,double-blind,phase 3 non-inferiority trial显示文摘 | WILLIAM T C LAWRENCE A L KUN Y | 2013 | Lancet2013，382，21： | 1 |
| 10 | Modeling of Ceramic grinding processes part I,Number of cutting points and grinding forces per grit 显示文摘 | Kun L Liao T W | 1997 | Journal of Materials Processing Technology1997，65，13： | 1 |
| 11 | The effect of alkyd resins on the properties of AA - NC semi - IPNs as binders in wood finish显示文摘 | KUN T L CHENG T L SHIH M L | 2004 | Journal of Applied Polymer Science2004，93，4： | 1 |
| 12 | Zn-A1 layer double hydrox-ides as photocatalysts for oxidation of phenol in aqueous solution显示文摘 | PATZKO A KUN R HORNOK V DEKANY L ENGELHARDT T SCHALL N | 2005 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2005，265，1： | 1 |
| 13 | Effect of nitrocellulose on the properties of PU - NC semi - 1PN wood coatings显示文摘 | KUN T L CHENG T L HONG L L | 2002 | Journal of Ap- plied Polymer Science2002，89，8： | 1 |
| 14 | Preparation,characterization and curing properties of epoxy-terminated poly(alky-phenylene ox- ide)显示文摘 | Chia T S Kun Y L Tzung J L | 2010 | European Polymer Journal2010，46，7： | 1 |
| 15 | Software ompensation of rapid prototyping machines显示文摘 | KUN T AMINE E L SANJAY J | 2004 | Precision Engineering2004，28，3： | 1 |
| 16 | Modeling of ceramic grinding processes part Ⅰ number of cutting points and grinding forces per grit 显示文摘 | KUN L T WARREN Liao | 1997 | Journal of Material Processing Technology1997，65，： | 1 |
| 17 | Correlation between pro moter methylation of p14ARF, TMS1/ASC, and DAPK, and p53 mutation with prognosis in cholangioearcinoma显示文摘 | Xiaofang L Kun T Shaoping Y | 2012 | World J Surg Oncol2012，10，： | 1 |
| 18 | Prospective case control studyof surgical efficiency of ultrasonic shear ( harmonic scalpel ) thy-roidectomy compared with convention althyroidectomy显示文摘 | Kang SK Kun anandam T Clark L | 2008 | J Laryn-gol Otol2008，122，11： | 1 |
| 19 | Preparation, characterization and curing properties of epoxy-terminated poly(alkyl-phenylene oxide)显示文摘 | Chia T S Kun Y L Tzung J L | 2010 | European Polymer Journal2010，46，7： | 1 |
| 20 | Surface/subsurface damage and the fracture strength of ground ceramics显示文摘 | Kun L Liao T W | 1996 | J Mater Proc Technol1996，57，3： | 1 |
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