|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles显示文摘 | Kun C Guanghua T Dahai H | 2002 | Biochem Biophys Res Commun2002，296，： | 1 |
| 4 | Nitrogen doped porous carbon fibres as anode materials for sodium ion batteries with excellent rate performance显示文摘 | LIJUN F KUN T KEPENG S | 2014 | Nanoscale2014，6，： | 1 |
| 5 | Grit-versus-host di- sease prevents the maturation of plasma cytoid dendritic cells 显示文摘 | Banovic T Markey KA Kuns RD | 2009 | J Immunol2009，182，2： | 1 |
| 6 | High-Performance Liquid Chromatographic Determination of Mitoxantrone in Plasma Utilizing Non-Bonded Silica Gel for Solid-Phase Isolation to Reduce Adsorptive Losses on Glass During Sample Preparation 显示文摘 | Kun T Lin Georges E Rivard Jean-Marie Leclerc | 1989 | Journal of Chromatography A1989，465，： | 1 |
| 7 | Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation显示文摘 | Markey KA Banovic T Kuns RD | 2009 | Blood2009，113，22： | 1 |
| 8 | Language policy, language teachers' beliefs and classroom practices 显示文摘 | Farrell T S C & Kun S T K | 2007 | Applied Linguistics2007，29，3： | 1 |
| 9 | LMS algorithm with gradient descent filter length显示文摘 | Yuantao G Kun T Huijuan C | | 0，，03： | 1 |
| 10 | Staphylococcal cassettechromosome mec(SCCmec)characterization and molecu-lar analysis for methicillin-resistant Staphylococcus au-reus and novel SCCmec subtype IVg isolated from bovinemilk in Korea显示文摘 | Nam HK Kun T San MJ | 2005 | J Antimicrob Chemother2005，56，4： | 1 |
| 11 | Bcl-2 antisense treatment prevent induction of tolerance to focal iscchemia in the rat brain显示文摘 | Shimizu S Nagayama T Kun LJ | 2001 | J Cereb Blood Flow Metab2001，21，3： | 1 |
| 12 | Effect of the nitrogen heterocyclic compounds on hydro-desulfurization using in situ hydrogen anda dispersed Mo catalyst 显示文摘 | LIU Kun FLORA T T | 2010 | Catalysis Today2010，149，12： | 1 |
| 13 | Effct of the nitrogen heterocyclic com- pounds on hydrodesulfurization using in situ hydrogen and dis- persed Mo catalyst 显示文摘 | Kun Liu Flora T T Ng | 2010 | Catalysis Today2010，149，12： | 1 |
| 14 | Sewer pipe deformation assessment by image analysis of video surveys 显示文摘 | Xu Kun Luxmoore A R Davies T | 1998 | Pattern Recognition1998，31，2： | 1 |
| 15 | Particle in Flight Behavior and Its Influence on the Microstructure and Mechanical Property of Plasma Sprayed La2Ce2O7 Thermal Barrier Coatings显示文摘 | KUN L JIAN J T YU B | 2015 | Materials Science and Engineering A2015，625，： | 1 |
| 16 | Preparation of 5-hydroymethylfurfural by dehydration of fructose in the presence of acidic ionic liquid 显示文摘 | BAO Quanxin QIAO Kun DAISUKE T | 2008 | Catalysis Communications2008，9，6： | 1 |
| 17 | Effect of nitrocellulose on the properties of PU NC semi-IPN wood coatings显示文摘 | Kun T L Cheng T L Hong L L | 2002 | Journal of Applied Polymer Science2002，89，8： | 1 |
| 18 | The role of HER2 in cancer therapy and targeted drug delivery显示文摘 | Wanyi T Rubi M Kun Ch | 2010 | Control Release2010，146，3： | 1 |
| 19 | Conventional den- dritic ceils are the critical donor APC presenting alloantigen after experimental bone marrow transplantation显示文摘 | Markey K A Banovic T Kuns R D | 2009 | Blood2009，113，： | 1 |
| 20 | Acceptance of domestic cat mitochondrial DNA in a criminal proceeding显示文摘 | Lyons L A Grahn R A Kun T J | 2014 | Forensic Sci Int2014，13，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员