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| 1 | Influence of the interaction of components on the pyrolysis behavior of biomass 显示文摘 | Wang Shurong Guo Xiujuan Wang Kaige | 2011 | Journal of Analytical and Applied Pyrolysis2011，91，1： | 1 |
| 2 | Highly Dispersed Pd Nanoparticles Supported on Zr-Doped MgAl Mixed Metal Oxides for 2-Ethylanthraquinone Hydrogenation显示文摘In this study,Pd-Mg(Al)-LDH/γ-Al2O3 and Pd-Mg(Al)Zr-LDH/γ-Al2O3 precursors were synthesized by impregnating Na2PdCl4 on Mg(Al)-LDH/γ-Al2O3 and Mg(Al)Zr-LDH/γ-Al2O3,and then the precursors were calcinated and reduced to obtain Pd-Mg(Al)-MMO/γ-Al2O3 and Pd-Mg(Al)Zr-MMO/γ-Al2O3 catalysts.Compared with Pd/γ-Al2O3 catalyst,the hydrogenation efficiency of Pd-Mg(Al)-MMO/γ-Al2O3 and Pd-Mg(Al)Zr-MMO/γ-Al2O3 increased by 15.7%and 24.0%,respectively.Moreover,the stability of Pd-Mg(Al)Zr-MMO/γ-Al2O3 catalyst was also higher than that of Pd/γ-Al2O3.After four runs,the hydrogenation efficiency of Pd/γ-Al2O3 decreased from 12.1 to 10.0 g/L,while that of Pd-Mg(Al)Zr-MMO/γ-Al2O3 decreased from 15.0 to 14.3 g/L.The active aquinones selectivities of all catalysts were almost 99%.The structures of the catalysts were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),N2 adsorption–desorption,inductively coupled plasma-atomic emission spectrometry(ICP-AES),CO chemisorption analysis,transmission electron microscopy(TEM),temperature-programmed reduction with hydrogen(H2-TPR),and X-ray photoelectron spectroscopy(XPS).The results indicate that the improved catalytic performance is attributed to the stronger interaction between Pd and Mg(Al)Zr-MMO/γ-Al2O3,smaller Pd particle size and higher Pd dispersion.This work develops an effective method to synthesize highly dispersed Pd nanoparticles based on the layered double hydroxides(LDHs)precursor. | Yunhao Wang Kaige Gao Chenliang Ye Ang Li Cuili Guo Jinli Zhang | 2019 | Transactions of Tianjin University2019，25，6： | 1 |
| 3 | Analysis on Operational Safety and Efficiency of FAO System in Urban Rail Transit显示文摘This paper discusses two urgent problems that need to be solved in fully automatic operation(FAO)for urban rail transit.The first is the analysis of safety in FAO,while another is the analysis of efficiency in FAO.Firstly,this paper establishes an operational safety evaluation index system from the perspective of operation for the unique or typical risk sources of the FAO system,and uses the analytic hierarchy process(AHP)to evaluate the indicators,analyzes various factors that affect the safe operation of FAO,and provides safety management recommendations for FAO lines operation to maintain the FAO system specifically.Secondly,taking the Yanfang Line as an example,this paper uses OpenTrack software to analyze the efficiency of FAO operation,and conducts simulation calculations for key links such as the mainline tracking interval,train entry and exit,and return limit interval.The fault impact surface of the FAO trains is simulated and discussed to verify whether FAO can meet the long-term operation requirements of Yanfang Line.Finally,this paper compares the simulation data of FAO on the Yanfang Line with manual operation(MO)to verify the advantages of FAO and guide the engineering construction of subsequent fully automated driving lines. | Kaige Guo Jin Zhou Xiaoming Zhang Di Sun Zishuo Wang Lixian Zhao | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 4 | An overview on transparent ceramics with pyrochlore and fluorite structures显示文摘Transparent ceramics have potential applications in various areas,including aerospace,relativistic optics industries,medical cares and defense.Specifically,they can be used as laser gain media,armor windows,IR domes,solid-state phosphors,scintillators and electro-optical components.From crystal structure point of view,transparent ceramic materials should have high crystallographic symmetries(cubic,tetragonal and hexagonal),which have minimal birefringent effect.Currently,transparent ceramics are dominantly based on oxide materials,although there are also nonoxides,such as fluorides and nitrides(oxynitrides).Transparent ceramics with pyrochlore and fluorite structures have attracted much attention in recent years,whereas fluorides are not well described in the open literature.Therefore,this paper is aimed to deliver an overview on the progress of the two categories of transparent ceramics,from material processing and characterization point of view. | Yu He Kaige Liu Bingxi Xiang Chaolan Zhou Ling Zhang Gang Liu Xiaoyang Guo Jianpang Zhai Tao Li Ling Bing Kong | 2020 | Journal of Advanced Dielectrics2020，10，3： | 0 |
| 5 | Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence显示文摘在里面 ribosomal 子单元的 vivo 汇编是高度复杂的进程与在蛋白质汇编和 rRNA 成熟事件之间的紧密的协作,例如选择的库的 rRNA 先锋,以及修正合拢并且处理。在房间,很多因素被要求保证子单元生产的效率和忠实。这里,我们描绘子单元在因素 0 Escherichia coli 紧张(rsgArbfA ) 积累了的不成熟的 30S。与在缓冲区系统改变盐集中孤立的不成熟的 30S 子单元在蛋白质作文和结构上显示出有趣的差别。明确地,中介在二个形成对照的盐条件下面发源(高、低) 多半反映二个特殊集会阶段, 3 领域集会的相对早、迟了的阶段分别地。详细结构的分析表明在 17S rRNA 的 5 结束和 30S 头域的汇编的成熟之间的机械学的联合,并且在协调这二个事件归因 S5 的一个唯一的角色。而且,我们的结构的结果多半揭示 17S rRNA 的 unprocessed 终端序列的地点,并且建议 17S rRNA 的成熟事件能在子单元生产和蛋白质翻译上作为质量控制机制被采用。 | Zhixiu Yang Qiang Guo Simon Goto Yuling Chen Ningning Li Kaige Yan Yixiao Zhang Akira Muto Haiteng Deng Hyouta Himeno Jianlin Lei Ning Gao | 2014 | Protein & Cell2014，5，5： | 0 |
| 6 | 环形RNA结构与降解调控PKR激活和天然免疫反应显示文摘文章简介环形RNA(circ RNA)来自RNA聚合酶II的转录本并以共价键形成闭环结构。虽然在哺乳动物细胞中普遍表达,但是绝大部分环形RNA的功能仍不清楚。外显子反向剪接成环发生效率很低,但产生的环形RNA非常稳定。该研究证明环形RNA分子倾向于形成长度为16-26bp双链RNA茎环结构,可以结合并抑制天然免疫因子PKR的活性。 | 刘楚霄 李响 南芳 Shan Jiang Xiang Gao Si-Kun Guo Wei Xue Yange Cui Kaige Dong Huihua Ding Bo Qu Zhaocai Zhou 沈南 杨力 陈玲玲 | 2020 | 科学新闻2020，，2： | 0 |
| 7 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy显示文摘Microphthalmia transcription factor(MITF)regulates melanocyte development and is the“lineage-specific survival”oncogene of melanoma.MITF is essential for melanoma initiation,progression,and relapse and has been considered an important therapeutic target;however,direct inhibition of MITF through small molecules is considered impossible,due to the absence of a ligand-binding pocket for drug design.Here,our structural analyses show that the structure of MITF is hyperdynamic because of its out-of-register leucine zipper with a 3-residue insertion.The dynamic MITF is highly vulnerable to dimer-disrupting mutations,as we observed that MITF loss-of-function mutations in human Waardenburg syndrome type 2 A are frequently located on the dimer interface and disrupt the dimer forming ability accordingly.These observations suggest a unique opportunity to inhibit MITF with small molecules capable of disrupting the MITF dimer.From a high throughput screening against 654,650 compounds,we discovered compound TT-012,which specifically binds to dynamic MITF and destroys the latter’s dimer formation and DNA-binding ability.Using chromatin immunoprecipitation assay and RNA sequencing,we showed that TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells.In addition,TT-012 inhibits the growth of high-MITF melanoma cells,and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.Together,this study demonstrates a unique hyperdynamic dimer interface in melanoma oncoprotein MITF,and reveals a novel approach to therapeutically suppress MITF activity. | Zaizhou Liu Kaige Chen Jun Dai Peng Xu Wei Sun Wanlin Liu Zhixin Zhao Steven P.Bennett Peifeng Li Tiancheng Ma Yuqi Lin Akinori Kawakami Jing Yu Fei Wang Chunxi Wang Miao Li Peter Chase Peter Hodder Timothy P.Spicer Louis Scampavia Chunyang Cao Lifeng Pan Jiajia Dong Yong Chen Biao Yu Min Guo Pengfei Fang David E.Fisher Jing Wang | 2023 | Cell Research2023，33，1： | 0 |
| 8 | Changes in hospitalizations for respiratory diseases following the COVID-19 epidemic显示文摘Tothe Editor:During the ongoing,coronavirus disease 2019(COVID-19)pandemic,hundreds of millions of people have been infected.The prevention and control measures guided by the Chinese government,including the wearing of,facemasks,maintaininghand hygiene,reducing gatherings,and physical distancing,have become commonplace across China.The protective measures have been confirmed to reduce the risk of severe acute respiratorysyndromecoronavirus 2(SARS-CoV-2)infection.In addition to COVID-19,other respiratory infectious diseases,such as viral pneumonia and bacterial pneumonia,remain a threat to inpatients.Whether the pandemic,and associated protective measures have impacted thespectrum of respiratorydiseases in inpatients in pulmonary and critical care medicine(PCCM)departments remains unclear. | Kaige Wang Li Guo Qianfeng Xiao Panwen Tian Dan Liu Weimin Li | 2022 | Chinese Medical Journal2022，135，19： | 0 |
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