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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 3 | Synergistic effect of fluorinated solvent and Mg^(2+)enabling 4.6 V LiCoO_(2)performances显示文摘Increasing the charging cut-off potential of lithium cobalt oxide(LiCoO_(2),LCO)can effectively improve the energy density of the lithium-ion batteries,which are the mainstream energy storage devices used in 3C electronic products.However,the continuous decomposition of the electrolyte and dissolution of Co from the electrode will occur at high-potential operation,which deteriorate the performances of LCO.Here,a cathode-electrolyte interface(CEI)layer containing Mg F_(2)is constructed to enhance the electrochemical stability of LCO at 4.6 V(vs.Li^(+)/Li).The Mg^(2+)added to the cathode gradually releases into the electrolyte during cycling,which forms a stable Mg F_(2)-rich protective layer.In addition,1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropylether(TTE)is added to the electrolyte acting as a F source to increase the content of Mg F_(2)in the CEI layer.The Mg F_(2)-rich CEI layer effectively suppresses the decomposition of electrolyte components and the dissolution of Co of LCO,which makes the Li||LiCoO_(2)(Li||LCO)cell cycled stably at 3~4.6 V(vs.Li^(+)/Li)in 200 cycles with a retention of 83.9%. | Yijia Huang Yidan Zhu Hongyu Cheng Meng Liu Yingying Song Xiaoliang Ding Kaiyun Xu Yinping Qin Yang Liu Bingkun Guo | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 4 | Diverse electronic and magnetic properties of CrS_(2) enabling strain-controlled 2D lateral heterostructure spintronic devices显示文摘Lateral heterostructures of two-dimensional(2D)materials,integrating different phases or materials into a single piece of nanosheet,have attracted intensive research interests for electronic devices.Extending the 2D lateral heterostructures to spintronics demands more diverse electromagnetic properties of 2D materials.In this paper,using density functional theory calculations,we survey all IV,V,and VI group transition metal dichalcogenides(TMDs)and discover that CrS_(2)has the most diverse electronic and magnetic properties:antiferromagnetic(AFM)metallic 1T phase,non-magnetic(NM)semiconductor 2H phase,and ferromagnetic(FM)semiconductor 1T′phase with a Curie temperature of~1000 K.Interestingly,we find that a tensile or compressive strain can turn the 1T′phase into a spin-up or spin-down half-metal.Such strain tunability can be attributed to the lattice deformation under tensile/compressive strain that selectively promotes the spin-up/spin-down VBM(valence band bottom)orbital interactions.The diverse electromagnetic properties and the strain tunability enable strain-controlled spintronic devices using a single piece of CrS_(2)nanosheet with improved energy efficiency.As a demo,a prototypical design of the spin-valve logic device is presented.It offers a promising solution to address the challenge of high energy consumption in miniaturized spintronic devices. | Kaiyun Chen Junkai Deng Yuan Yan Qian Shi Tieyan Chang Xiangdong Ding Jun Sun Sen Yang Jefferson Zhe Liu | 2021 | npj Computational Materials2021，，1： | 0 |
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