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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Breast cancer in China显示文摘 | Fan L Kathrin S W Jun JL | 2014 | L a n c e Oncol2014，15，7： | 1 |
| 3 | Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease: Role of High-Density Lipoprotein–Proteome Remodeling显示文摘 | Meliana Riwanto Lucia Rohrer Bernd Roschitzki Christian Besler Pavani Mocharla Maja Mueller Damir Perisa Kathrin Heinrich Lukas Altwegg Arnold von Eckardstein Thomas F. Lüscher Ulf Landmesser | 2013 | Circulation2013，，8： | 1 |
| 4 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 5 | Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex:a dose-finding and safety study显示文摘 | Iben F S Kathrine N Per Bo L | 2006 | Anesthesiology2006，104，4： | 1 |
| 6 | Presence of E6 and E7 mRNA from human papillomavirus types 16,18,31,33,and 45 in the majority of cervical carcinomas显示文摘 | Kraus TM Holm R Kathrine L | | 0，，04： | 1 |
| 7 | Expression two major genes of Trichoderma atroviride is triggered by different regulatory signals显示文摘 | Robert L M Clemens K P Kathrin P | 1999 | Applied Environmental Microbiology1999，65，5： | 1 |
| 8 | Tracking the bioreduction of disulfide-containing cationic dendrimers 显示文摘 | Briilisauer L Kathriner N Prenrecaj M | 2012 | Angew Chem lnt Ed Engl2012，51，12： | 1 |
| 9 | Effect of high pressure , temperature , and storage on the color of porcine longissimus dorsi显示文摘 | Kathrine H B Gunilla L Anders H K et 01 | 2012 | Meat Science2012，92，4： | 1 |
| 10 | Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infangts with idiopathic apnea显示文摘 | Jacqueline B Kathrin M Otwin L | 2001 | Pediatrics2001，107，4： | 1 |
| 11 | High pressure effect on the color of minced cured restructured ham at different levels of drying,pH,and NaCl显示文摘 | Kathrine H B Gunilla L Anders H K et 01 | 2012 | Meat Science2012，90，： | 1 |
| 12 | Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer显示文摘 | Gunter von Minckwitz Kathrin Schwedler Marcus Schmidt Jana Barinoff Christoph Mundhenke Tanja Cufer Eduard Maartense Felix E. de Jongh Klaus H. Baumann Joachim Bischoff Nadia Harbeck Hans-Joachim Lück Nicolai Maass Christoph Zielinski Michael Andersson Ro | 2011 | European Journal of Cancer2011，，15： | 1 |
| 13 | Expression of p27,p21,and p16 protein in early squamous cervical cancer and its relation to prognosis显示文摘 | Gregg V Ruth H Kathrine L | 2003 | Gynecol Oncol2003，89，： | 1 |
| 14 | The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin显示文摘 | Susanne V Schmidt Wolfgang Krebs Thomas Ulas Jia Xue Kevin BalBer Patrick Gunther Anna-Lena Hardt Hartmut Schultze Jil Sander Kathrin Klee Heidi Theis Michael Kraut Marc Beyer Joachim L Schultze | 2016 | Cell Research2016，26，2： | 1 |
| 15 | Lumbar Spine Radiography:Digital Flat-panel Detector Versus Screen-Film and Storage-Phosphor Systems in Monkeys as a Pediatric Model显示文摘 | Karl L Kathrin A Dag W | 2003 | Radiology2003，229，1： | 1 |
| 16 | Breast cancer in China显示文摘 | Lei Fan Kathrin SW Jun-Jie L | 2014 | Lancet Oncol2014，15，7： | 1 |
| 17 | An optimised PCR/T-RFLP fingerprinting approach for the investigation of protistan communities in groundwater environments 显示文摘 | Kathrin Euringer T L | 2008 | Journal of Microbiological Methods2008，75，： | 1 |
| 18 | Effect of antecedent soil moisture on preferential flow in a texture-contrast soil显示文摘 | Marcus A H William E C Richard B D Greg H Shaun L Kathrin M | 2011 | Journal of Hydrology2011，398，34： | 1 |
| 19 | The effects of incentives and instructions on children's allocation of study time 显示文摘 | Kathrin L Wolfgang S | 2004 | European Journal of Devel- opmental Psychology2004，1，2： | 1 |
| 20 | Association between gout and all-cause as well as cardiovascular mortality:a systematic review显示文摘 | Kathrin L Chen XY Peter K | 2012 | Curr Rheumatol Rep2012，22，14： | 1 |
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