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| 1 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 4 | Nonirtherited risk factors and congenital cardiovascular defects 显示文摘 | Kathy J J Adolfo C Jeffrey A F | 2007 | Circulation2007，115，： | 1 |
| 5 | Molecular characterisation of hepatopancreatic parvovirus (PmergDNV) from Australian Penaeus merguiensis显示文摘 | Kathy A L Jennifer E Leigh O | 2007 | Virology2007，362，： | 1 |
| 6 | Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism显示文摘 | Valeria A T Kathy O K Maylene Loo Robert J H | 2008 | Applied and Environmental Microbiology2008，74，3： | 1 |
| 7 | A new Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation显示文摘 | Mary E Charlson Peter Pompei Kathy L A | 1987 | J Chron Dis1987，，40： | 1 |
| 8 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 9 | CT healthcare failure mode effect analy- sis(HFMEA) :The misadministration of IV contrast in outpatients 显示文摘 | Kathy OP Ben A June C | 2007 | Radiology Management2007，29，1： | 1 |
| 10 | Randomized phase Ⅲ trial of capecitabine comparedd with bevacizumab plus capecitabine in patients with pmvmusly treated metastatic breast cancer显示文摘 | Linnea I Frankie A | 2005 | J Clin Oncol2005，23，4： | 1 |
| 11 | Disruption of FEM1C-W gene in zebra finch evolutionary insights on avian ZW genes 显示文摘 | Yuichiro I Kathy K Arthur P A | 2009 | Chromosoma2009，118，3： | 1 |
| 12 | The specific role of isoflavones on estrogen metabolism in premenopausal women 显示文摘 | Kumar Nagi B Cantor A Kathy A | 2002 | Cancer2002，94，4： | 1 |
| 13 | Hyperhomocysteinemiaactivates nuclear factor-κβin endothelial cells viaoxidative stress显示文摘 | Kathy KW Yeung A Conniew H | 2004 | Circ Res2004，94，： | 1 |
| 14 | Improving the processof supplying central supply instruments to the OR by ap-plying lean显示文摘 | Kathi M Jacqueline D Gregory A | 2010 | Am J Infect Cont2010，5，38： | 1 |
| 15 | Knowledge contribution in virtual communities: accounting for multiple dimensions of social presence through social identity 显示文摘 | Kathy Ning Shen Angel a Yan Yub Mohamed Khali fa | 2010 | Behavior & Information Technology2010，，4： | 1 |
| 16 | In- terferon-tau suppresses prostaglandin F2a secretion independently of the Mitogen-activated protein kinase and nuclear factor κB pathway显示文摘 | JAMES K P RUEDA B R KATHY J A | 2001 | Biol Reprod2001，64，： | 1 |
| 17 | Integrating 'Back to Sleep' recommendations into neonatal ICU practice显示文摘 | Polina Gelfer Ricci Cameron Kathy Masters Kathleen A Kennedy | 2013 | Pediatrics2013，131，4： | 1 |
| 18 | Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials显示文摘 | Elisabeth M Hodson Cheryl A Jones Angela C Webster Giovanni FM Strippoli Peter G Barclay Kathy Kable Dushyanthi Vimalachandra Jonathan C Craig | 2005 | The Lancet2005，，9477： | 1 |
| 19 | Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy显示文摘 | McCarthy Douglas D Kujawa Julie Wilson Cheryl Papandile Adrian Poreci Urjana Porfilio Elisa A Ward Lesley Lawson Melissa A E Macpherson Andrew J McCoy Kathy D Pei York Novak Lea Lee Jeannette Y Julian Bruce A Novak Jan Ranger Ann Gommerman | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 20 | TaqMan real-time PCR for detection of hepatopancreatic parvovirus from Australia显示文摘 | Kathy A L Ramon L Leigh O | 2007 | J Virol Methods2007，140，： | 1 |
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