|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 2 | Diffusion-weighted imaging of the liver:Current applications显示文摘Diffusion-weighted imaging(DWI) of the liver can be performed using most commercially available machines and is currently accepted in routine sequence. This sequence has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis. The added value of DWI in contrastenhanced magnetic resonance imaging was established in the detection of malignant liver lesions. However, some limitations remain in terms of lesion characterization and fibrosis detection. Furthermore, the methodologies of image acquisition and data analysis have been inconsistent. Therefore, researchers should make every effort to not only improve accuracy and reproducibility but also standardize imaging parameters. | Kazuhiro Saito Yu Tajima Taiyo L Harada | 2016 | World Journal of Radiology2016，8，11： | 8 |
| 3 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 4 | Effects of stand characteristics on tree species richness in and around a conservation area of northeast Bangladesh显示文摘We investigated the effect of tree cover,forest patch and disturbances on tree species richness in a highly diverse conservation area of northeast Bangladesh.A systematic sampling protocol was adopted and 80 sub-plots from twenty five 1 ha plots were used for the vegetation survey.Linear regression analysis was performed to understand the effect of patch area,disturbances and tree cover on tree species richness.Ordination using Redundancy analysis(RDA) and Non-metric Multi Dimensional Scaling(NMDS) were also performed to explore the tree species compositional similarities along the stand characteristics gradient and locations of the sample plots.Our study revealed that,forest patch size has greater influence on species richness.Areas with medium level of disturbances have shown greater species richness.In constrained ordination the selected explanatory variables regulated the richness of common species.Our findings can be useful for better forest management and restoration of landscapes of conservation needs using ecologically important species. | Muha Abdullah Al PAVEL SharifA.MUKUL Mohammad Belal UDDIN Kazuhiro HARADA Mohammed A.S.ARFIN KHAN | 2016 | Journal of Mountain Science2016，13，6： | 2 |
| 5 | Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors显示文摘BACKGROUND The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors(SNADETs)is controversial.AIM To compare the efficacy and safety of endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)for SNADETs.METHODS We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs,which included eight hospitals in Fukuoka,Japan,between April 2001 and October 2017.A total of 142 patients with SNADETs treated with EMR or ESD were analyzed.Propensity score matching was performed to adjust for the differences in the patient characteristics between the two groups.We analyzed the treatment outcomes,including the rates of en bloc/complete resection,procedure time,adverse event rate,hospital stay,and local or metastatic recurrence.RESULTS Twenty-eight pairs of patients were created.The characteristics of patients between the two groups were similar after matching.The EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group[median procedure time(interquartile range):6(3-10.75)min vs 87.5(68.5-136.5)min,P<0.001,hospital stay:8(6-10.75)d vs 11(8.25-14.75)d,P=0.006].Other outcomes were not significantly different between the two groups(en bloc resection rate:82.1%vs 92.9%,P=0.42;complete resection rate:71.4%vs 89.3%,P=0.18;and adverse event rate:3.6%vs 17.9%,P=0.19,local recurrence rate:3.6%vs 0%,P=1;metastatic recurrence rate:0%in both).Only one patient in the ESD group underwent emergency surgery owing to intraoperative perforation.CONCLUSION EMR has significantly shorter procedure time and hospital stay than ESD,and provides acceptable curability and safety compared to ESD.Accordingly,EMR for SNADETs is associated with lower medical costs. | Mitsuru Esaki Kazuhiro Haraguchi Kazuya Akahoshi Naru Tomoeda Akira Aso Soichi Itaba Haruei Ogino Yusuke Kitagawa Hiroyuki Fujii Kazuhiko Nakamura Masaru Kubokawa Naohiko Harada Yosuke Minoda Sho Suzuki Eikichi Ihara Yoshihiro Ogawa | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 2 |
| 6 | Adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery显示文摘这份报告由帮助 laparoscopic 的外科描述脐肠系膜包囊 resected 的一个极其稀罕的成年案例。A 29-years-old 日语人被提交并且因为一个腹的团和提高的浆液 CEA (carcinoembryonic 抗原) ,承认了到九州大学医院在 2001 年 8 月的水平(21.3 ng/mL ) 。腹的 CT 和美国与中隔和石灰化表明了一个膀胱的团。腹腔镜检查显示了一个大团被纳入他的腹壁,测量 110 公里 x 70 公里 x 50 公里并且充满了粘液。团是由帮助 laparoscopic 的外科的 resected。它的墙的组织检查所见显示出纤维肌性织物,脂肪组织,石灰化,和肠的结构。是脐肠系膜包囊最后被诊断。 | Fumi Sawada Rie Yoshimura Kenichi Ito Kazuhiko Nakamura Hajime Nawata Kazuhiro Mizumoto Shuji Shimizu Takahiro Inoue Takashi Yao Masazumi Tsuneyoshi Atushi Kondo Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 7 | SREBP-1c, regulated by the insulin and AMPK signaling pathways, playsa role in nonalcoholic fatty liver disease显示文摘 | Motoyuki Kohjima Nobito Higuchi Masaki Kato Kazuhiro Kotoh Tsuyoshi Yoshimoto Tatsuya Fujino Masayoshi Yada Ryoko Yada Naohiko Harada Munechika Enjoji Ryoichi Takayanagi Makoto Nakamuta | 2008 | International Journal of Molecular Medicine2008，，4： | 2 |
| 8 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | Virol2012，，2： | 1 |
| 9 | Meteorological characteristics and dust distribution of the Tarim basin simulated by the nesting RAMS/CFORS dust model显示文摘 | Kazuhiro Harada Shinsuke Satake Yukari Hara | 2005 | J Meteor Soe Japan2005，83，： | 1 |
| 10 | A novel endoscopic submucosal dissection technique for proton pump inhibitor-refractory gastroesophageal reflux disease显示文摘 | Kazuhiro Ota Toshihisa Takeuchi Satoshi Harada Shoko Edogawa Yuichi Kojima Takuya Inoue Kazuhide Higuchi | 2014 | Scandinavian Journal of Gastroenterology2014，，12： | 1 |
| 11 | Biodegradation of diphenylarsinic acid to arsenic acid by novel soil bacteria isolated from contaminated soil显示文摘 | Naoki Harada Kazuhiro Takagi Koji Baba Kunihiko Fujii Akio Iwasaki | 2010 | Biodegradation2010，，3： | 1 |
| 12 | Meteorological characteristics and dust distribution of the Tarim Basin sim-ulated by the nesting RAMS/CFORS dust model 显示文摘 | Kazuhiro Harada Shinsuke Satake Yukari Hara | 2005 | Journal of the Meteorological Society of Japan2005，83，： | 1 |
| 13 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | J. Med. Virol2012，，2： | 1 |
| 14 | Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts显示文摘 | Takashi Matsubara Yasunori Sato Motoko Sasaki Kenichi Harada Kazuhiro Nomoto Koichi Tsuneyama Koichi Nakamura Toshifumi Gabata Osamu Matsui Yasuni Nakanuma | 2012 | Human Pathology2012，，12： | 1 |
| 15 | A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4 H -1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer’s disease显示文摘 | Katsuya Harada Kazuhiro Nakato Junko Yarimizu Mayako Yamazaki Masahiko Morita Shinji Takahashi Masaki Aota Kyoko Saita Hitoshi Doihara Yuichiro Sato Takayuki Yamaji Keni Ni Nobuya Matsuoka | 2012 | European Journal of Pharmacology (-)2012，，1： | 1 |
| 16 | Molecular characterization of carbapenem-non-susceptible Acinetobacter spp. in Japan: predominance of multidrug-resistant Acinetobacter baumannii clonal complex 92 and IMP-type metallo-β-lactamase-producing non-baumannii Acinetobacter species显示文摘 | Yuichi Kouyama Sohei Harada Yoshikazu Ishii Tomoo Saga Ayumi Yoshizumi Kazuhiro Tateda Keizo Yamaguchi | 2012 | Journal of Infection and Chemotherapy2012，，4： | 1 |
| 17 | Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study显示文摘 | Shigeatsu Endo Naoki Aikawa Seitaro Fujishima Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Hiroyuki Yamada Kazuaki Harada Shinji Satomura | 2008 | Journal of Infection and Chemotherapy2008，，3： | 1 |
| 18 | Multicenter prospective study of procalcitonin as an indicator of sepsis显示文摘 | Naoki Aikawa Seitaro Fujishima Shigeatu Endo Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Kazuaki Harada Shinji Satomura | 2005 | Journal of Infection and Chemotherapy2005，，3： | 1 |
| 19 | The different association of epicardial fat with coronary plaque in patients with acute coronary syndrome and patients with stable angina pectoris:Analysis using integrated backscatter intravascular ultrasound显示文摘 | Kazuhiro Harada Ken Harada Tadayuki Uetani | 2014 | Atherosclerosis2014，236，2： | 1 |
| 20 | Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population显示文摘AIM To investigate whether GNB3 C825 T single nucleotide polymorphism(SNP) contributes to systolic blood pressure(SBP) ≥ 130 mmH g in a large-scale cross-sectional study among the Japanese population with diastolic blood pressure(DBP) < 85 mmH g. METHODS We analyzed 11008 Japanese subjects, including 2797 cases(SBP ≥ 130 and DBP < 85 mmH g) who were not taking anti-hypertensive medication and 8211 controls(SBP < 130 and DBP < 85 mmH g), all of whom enrolled in the genome banking project of the 21 st Century COE(Center of Excellence) Program at Jichi Medical University. Subjects were divided into four groups according to gender(male and female) and age(≤ 49 years and ≥ 50 years). GNB3 gene polymorphism was determined using the TaqM an probe method. We compared the frequencies of alleles and genotypes between cases and controls by chi-squared test. The strength of the associations was estimated by odds ratios(ORs) and 95%CI by using logistic regression analysis. The ORs were adjusted for age and body mass index. RESULTS Allele and genotype distributions significantly differed between cases and controls only in males aged ≤ 49 years. Compared to the CC genotype, a significant OR was obtained in the TT genotype among males aged ≤ 49 years.CONCLUSION This study indicates that the TT genotype of the GNB3 C825 T SNP may contribute to SBP elevation of greater than 130 mmH g compared to the CC genotype in Japanese males aged ≤ 49 years. | Masahiko Eto Taro Takeshima Masanori Harada Shinji Fujiwara Maki Kumada Toyomi Kamesaki Kazuhiro Takamura Tsuneaki Kenzaka Yoshikazu Nakamura Takanori Aonuma Masanobu Okayama Eiji Kajii | 2017 | World Journal of Hypertension2017，7，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员