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| 1 | Expression of E-selectin, integrinβ_1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance显示文摘AIM: To study the expression levels of E- selectin, integrinβ1 and immunoglobulin supperfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma. METHODS: The serum contents of E-selectin, integrinβ1 and ICAM-1 were detected by enzyme-linked immuno-sorbent assay (ELISA), in 47 healthy individuals (control group) and in 57 patients with gastric carcinoma (gastric carcinoma group) respectively prior to operation and 7 d after operation. RESULTS: The serum E-selectin, ECAM-1 and integrinβ1 were found to be expressed in both control and gastric carcinoma groups. However, they were highly expressed in patients with gastric carcinoma patients before operation or with unresectable tumours. The expression levels of ICAM-1 and integrinβ1 were significantly higher in gastric carcinoma patients than in controls (P < 0.01). A comparison of the E-selectin levels between the two groups showed statistically insignificant differnce (P = 0.64). In addition, the expression levels were all decreased substantially in the postoperative patients subjected to radical resection of the tumours, indicating that the high level expressions of these compounds might be the important factor for predicting the prognosis of these patients. CONCLUSION: Serum E-selectin, ICAM-1 and integrin pi expression levels are probably related to the metastasis and relapse of gastric cancer. | Jin-Jing Ke Qin-Shu Shao Zhi-Qiang Ling | 2006 | World Journal of Gastroenterology2006，12，22： | 23 |
| 2 | Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9显示文摘透镜的 apoptosis 上皮的房间作为奔流形成的普通基础被建议了,与是的氧化应力主要原因。这研究被执行对人的透镜的导致 oxidativestress 的 apoptosis 调查草药的成分 parthenolide 的保护的效果上皮(HLE ) 房间和可能的分子的机制包含了。HLE 房间(SRA01-04 ) 在 parthenolide (10, 20 和 50 microM ) 的不同剂量的缺席或存在与 50 microM H (2 ) O (2 ) 被孵化。到学习 apoptosis,房间被词法检查和 Annexin V-propidium 碘化物估计两倍染色的流动 cytometry;调查内在的分子的机制, caspase-3 和 caspase-9 的表示旁边是 assayed 西方的污点和量的 RT-PCR,和 caspase-3 和 caspase-9 的活动我们由 Chemicon caspase 的 remeasured 比色的活动试金工具包。为 18 h 与 H (2 ) O (2 ) 刺激了,, HLE 房间的高部分面对不同集中的 parthenolide 经历了 apoptosis, HLE 房间 apoptosis 堵住的剂量依赖者被观察。H (2 ) O (2 ) 在 HLE 房间导致的表示 ofcaspase-3 和 caspase-9 被 parthenolideboth 显著地在蛋白质和信使 rna 层次减少,并且 caspase-3 和 caspase-9 的激活被 parthenolide 也以一种剂量依赖者方式压制。在结论, parthenolide 通过 caspase-3 andcaspase-9 的激活的抑制阻止 HLEcells 氧化导致压力的 apoptosis,建议对奔流形成的潜在的保护的效果。 | Hangping Yao Xiajing Tang Xueting Shao Lei Feng Nanping Wu Ke Yao | 2007 | Cell Research2007，17，6： | 16 |
| 3 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 4 | Prognostic factors of spontaneously ruptured hepatocellular carcinoma显示文摘AIM: To evaluate the prognostic factors in patients with spontaneously ruptured hepatocellular carcinoma(HCC). METHODS: Seventy-nine patients experiencing spontaneous rupture of HCC between April 2004 and August 2014 were enrolled in this study. The clinical features, treatment modalities and outcomes were reviewed. The statistical methods used in this work included univariate analysis, Kaplan-Meier survival analysis with log-rank tests, and multivariate analysis using a Cox regression hazard model. RESULTS: Of the 79 patients with HCC rupture, 17(21.5%) underwent surgery, 32(40.5%) underwent transarterial embolization(TAE), and 30(38%) received conservative treatment. The median survival time was 125 d, and the mortality rate at 30 d was 27.8%. Multivariate analysis revealed that lesion length(HR = 1.46, P < 0.001), lesion number(HR = 1.37, P = 0.042), treatment before tumor rupture(HR = 4.36, P = 0.019), alanine transaminase levels(HR = 1.0, P = 0.011), bicarbonate levels(HR = 1.18, P < 0.001), age(HR = 0.96, P = 0.026), anti-tumor therapy during the followup period(HR = 0.21, P = 0.008), and albumin levels(HR = 0.89, P = 0.010) were independent prognostic factors of survival after HCC rupture. The BarcelonaClinic Liver Cancer(BCLC) stage was also an important prognostic factor; the median survival times for BCLC stages A, B and C were 251, 175 and 40 d, respectively(P < 0.001).CONCLUSION: Anti-tumor therapy during the followup period, without a history of anti-tumor therapy prior to HCC rupture, small tumor length and number, and early BCLC stage are the most crucial predictors associated with satisfactory overall survival. Other factors play only a small role in overall survival. | Xiang-Jun Han Hong-Ying Su Hai-Bo Shao Ke Xu | 2015 | World Journal of Gastroenterology2015，21，24： | 11 |
| 5 | Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao,China显示文摘Objective To determine whether elevated serum uric acid(UA)levels are associated with type 2 diabetes diagnosed using Hb A1 c levels among Chinese adults.Methods We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009.A total of 6894(39.4% men)subjects aged 35-74 years were included in the data analysis.Newly diagnosed diabetes was defined as Hb A1 c level of ≥6.5%,and prediabetes was classified as Hb A1 c level between 5.7% and 6.4% according to the International Diabetes Federation criteria.Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c(Hb A1 c levels.Results Subjects with prediabetes had higher UA levels than those with normal glucose tolerance,newly diagnosed diabetes,and known diabetes,with corresponding values of 325.1(82.5)μmol/L,310.9(84.2)μmol/L,291.3(81.7)μmol/L,305.2(83.6)μmol/L,respectively(P<0.001 for all comparisons).Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using Hb A1 c levels,and the second quartile of UA levels had a higher odds ratio(OR:4.088;95% CI:2.900-5.765)for Hb A1 c than the other quartiles after adjusting for age,body mass index,sex,marital status,education,income,alcohol consumption,smoking,and cardiometabolic parameters.Conclusion Serum UA is significantly associated with type 2 diabetes diagnosed using Hb A1 c levels,independent of other cardiometabolic parameters. | XUE Bai TAN Ji Bin NING Feng SUN Jian Ping ZHANG Ke Yi LIU Li WANG Shao Jie ZHANG Dong Feng QIAO Qing PANG Zeng Chang | 2015 | Biomedical and Environmental Sciences2015，28，12： | 9 |
| 6 | Excavation-induced microseismicity: microseismic monitoring and numerical simulation显示文摘The volume of influence of excavation at the right bank slope of Dagangshan Hydropower Station, southwest China, is essentially determined from microseismic monitoring, numerical modeling and conventional measurements as well as in situ observations. Microseismic monitoring is a new application technique for investigating microcrackings in rock slopes. A microseismic monitoring network has been systematically used to monitor rock masses unloading relaxation due to continuous excavation of rock slope and stress redistribution caused by dam impoundment later on, and to identify and delineate the potential slippage regions since May, 2010. An important database of seismic source locations is available. The analysis of microseismic events showed a particular tempo-spatial distribution. Seismic events predominantly occurred around the upstream slope of 1180 m elevation, especially focusing on the hanging wall of fault XL316-1. Such phenomenon was interpreted by numerical modeling using RFPA-SRM code (realistic failure process analysis-strength reduction method). By comparing microseismic activity and results of numerical simulation with in site observation and conventional measurements results, a strong correlation can be obtained between seismic source locations and excavation-induced stress distribution in the working areas. The volume of influence of the rock slope is thus determined. Engineering practices show microseismic monitoring can accurately diagnose magnitude, intensity and associated tempo-spatial characteristics of tectonic activities such as faults and unloading zones. The integrated technique combining seismic monitoring with numerical modeling, as well as in site observation and conventional surveying, leads to a better understanding of the internal effect and relationship between microseismic activity and stress field in the right bank slope from different perspectives. | Nu-wen XU Chun-an TANG Hong LI Feng DAI Ke MA Jing-dong SHAO Ji-chang WU | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，6： | 9 |
| 7 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 8 | Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population显示文摘This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern. | Xiaowei Li Ke Xie Bing Yue Yunyun Gong Yi Shao Xiaohong Shang Yongning Wu | 2015 | Science China(Information Sciences)2015，58，12： | 7 |
| 9 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 10 | Synthesis and antibacterial activities of pleuromutilin derivatives显示文摘六新 pleuromutilin 衍生物被设计并且综合,由 MS,红外和 1 H NMR 技术。并且抗菌剂活动首先在 vitro 被评估。结果显示大多数衍生物比 pleuromutilin 的对相应细菌的种类显示出更多的有势力活动。特别,混合物 4d 和 5b 与 pleuromutilin 相比对沙门氏菌举办了明显的活动。 | Yuan Yuan Zhang Ke Ping Xu Dan Ren Shao Rong Ge Yu Liang Wang Yu Zhong Wang | 2009 | Chinese Chemical Letters2009，20，1： | 5 |
| 11 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 12 | The Mechanism and Influence of AKAP12 in Different Cancers显示文摘The development of cancer is a complex process that requires the participation of many factors, including mutations in genes, regulation of signaling pathways, disruption of homeostasis, and failure of self-monitoring mechanisms. Sufficient evidence has shown that the A kinase anchoring protein (AKAP) family plays an important role in signal transduction in cancer. AKAP12 and AKAP12-regulated signaling pathways are critically involved in the development and progression of a variety of tumors. | WU Xuan WU Tong LI Ke LI Yuan HU Ting Ting WANG Wei Feng QIANG Su Jing XUE Shao Bo LIU Wei Wei | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 13 | Effects of SO_2 and SO_3 on the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans by de novo synthesis显示文摘The effects of SO2,SO3 on de novo synthesis of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) were studied using model fly ashes incorporating copper oxide and activated carbon. It was found that the inhibitive effect of SO2 on PCDD/Fs formation is similar to that of SO3. To investigate the inhibition mechanism,CuSO4 formations from both CuO and CuCl2 were examined. The ability of SO3 to convert CuCl2 and CuO on a silica support into sulfate is much stronger than that of SO2. However,replacing silica by activated carbon leads to a much high conversion of CuCl2 to CuSO4 in the presence of SO2. The promotion by activated carbon is explained by the reduction of CuCl2 to Cu2Cl2 and the eventual conversion of Cu2Cl2 into CuSO4 is the main inhibition mechanism of SO2 on de novo synthesis of PCDD/Fs. | Ke SHAO Jian-hua YAN Xiao-dong LI Sheng-yong LU Mu-xing FU Ying-lei WEI | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，5： | 4 |
| 14 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 15 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 16 | Spatiotemporal change of carbon storage in the Loess Plateau of northern Shaanxi, based on the In VEST Model显示文摘In recent years, land use and land cover have under gone tremendous change on the Loess Plateau, leading to temporal and spatial variation over many ecological factors, such as carbon storage. Based on four series of land-use data from remote-sensing imaging, spatiotemporal changes of land-use types and volume changes were analyzed. Combined with carbon-stock-assessment modules of the In VEST(integrated valuation ecosystem services and tradeoffs) model, the carbon-storage change was estimated and analyzed at the subcounty and subbasin scales. The results show that(1) cultivated land and grassland area decreased, while woodland and urban land area increased in northern Shaanxi;(2) the average carbon storage in Huangling County and the Beiluo River Basin is the largest, while that of Yuyang County and the Xinshui River Basin is the minimum, and that of Wuqi County showed the greatest growth;(3) carbon storage in the study area showed a definite decrease in 2000, but in general has increased from 1995 to 2010;(4) carbon-storage figures of subbasins and counties are all restricted by the natural status and land-use landscape of the whole study area. From the results,it can be seen that the effect of ecological policies is remarkable. This study has important implications for the rational planning of land use, adjustment of the ecosystem carbon cycle, and related policies. | Shao Yang Liu Ning Ke Hu Jin Zhang Zhi Chao Lv | 2018 | Research in Cold and Arid Regions2018，10，3： | 3 |
| 17 | Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients显示文摘Azvudine(FNC)is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-19 patients.FNC monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC_(50) between 1.2 and 4.3 μM,depending on viruses or cells,and selective index(SI)in 15-83 range.Oral administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest X-ray.Sin gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31)showed that oral FNC(5 mg,qd)cured all COVID-19 patients,with 100%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1-9 days)and 100%hospital discharge rate in 9.00±4.93 days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 16.12%(5/31)patients.Thus,FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity. | Jin-Lan Zhang Yu-Huan Li Lu-Lu Wang Hong-Qi Liu Shuai-Yao Lu Yong Liu Ke Li Bin Liu Su-Yun Li Feng-Min Shao Kun Wang Ning Sheng Rui Li Jin-Jin Cui Pei-Chun Sun Chun-Xia Ma Bo Zhu Zhe Wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang Wang Chen Wang Qiangqian Zhang Li-Min Zhao Xiao-Zhong Peng Zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 3 |
| 18 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 19 | Association between Vitamin D Levels and the Risk of Metabolic Syndrome in a Rural Chinese Population显示文摘Metabolic syndrome(MS)is a cluster of metabolic abnormalities that include obesity,dyslipidemia,hyperglycemia,and high blood pressure(BP)[1].Previous studies have shown that the prevalence of MS is increasing in both developing and developed countries[2].Currently,about a quarter of the adult population worldwide have MS,which has become a serious global public health problem. | SUN Hua Lei LONG Shao Rong FU San Xian CHEN Gai Yun WANG Ya Juan LIANG Rui WANG Su Fan ZHANG Li Ke ZHOU Li Wei LU Quan Jun LI Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 20 | Winter sea ice albedo variations in the Bohai Sea of China显示文摘Sea ice conditions in the Bohai Sea of China are sensitive to large-scale climatic variations. On the basis of CLARA-A1-SAL data, the albedo variations are examined in space and time in the winter(December, January and February) from 1992 to 2008 in the Bohai Sea sea ice region. Time series data of the sea ice concentration(SIC), the sea ice extent(SIE) and the sea surface temperature(SST) are used to analyze their relationship with the albedo. The sea ice albedo changed in volatility appears along with time, the trend is not obvious and increases very slightly during the study period at a rate of 0.388% per decade over the Bohai Sea sea ice region.The interannual variation is between 9.93% and 14.50%, and the average albedo is 11.79%. The sea ice albedo in years with heavy sea ice coverage, 1999, 2000 and 2005, is significantly higher than that in other years; in years with light sea ice coverage, 1994, 1998, 2001 and 2006, has low values. For the monthly albedo, the increasing trend(at a rate of 0.988% per decade) in December is distinctly higher than that in January and February. The mean albedo in January(12.90%) is also distinctly higher than that in the other two months. The albedo is significantly positively correlated with the SIC and is significantly negatively correlated with the SST(significance level 90%). | ZHENG Jiajia KE Changqing SHAO Zhude | 2017 | Acta Oceanologica Sinica2017，36，1： | 2 |
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