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| 1 | Ginsenoside Rg1 ameliorates bloodebrain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release显示文摘During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic feature.Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and bloodebrain barrier(BBB)permeability,reduce nerve apoptosis,restore neural function and ameliorate TBI.We evaluated the role of macrophage derived exosomes-miR-21(M-Exos-miR-21)in disrupting BBB,deteriorating TBI,and Rg1 interventions.IL-1β-induced macrophages(ⅡA)-Exos-miR-21 can activate NF-kB signaling pathway and induce the expressions of MMP-1,-3 and-9 and downregulate the levels of tight junction proteins(TJPs)deteriorating the BBB.Rg1 reduced miR-21-5 p content in ⅡA-Exos(RⅡA-Exos).The interaction of NMIIAe HSP90 controlled the release of Exos-miR-21,this interaction was restricted by Rg1.Rg1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain,enhancing TIMP3 protein expression,MMPs proteolysis,and restricting TJPs degradation thus protected the BBB integrity.Conclusively,Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease. | Kefeng Zhai Hong Duan Wei Wang Siyu Zhao Ghulam Jilany Khan Mengting Wang Yuhan Zhang Kiran Thakur Xuemei Fang Chao Wu Jianbo Xiao Zhaojun Wei | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 6 |
| 2 | New Half-sandwich Zirconium(Ⅳ) Complexes Containing Salicylaldimine Ligands: Synthesis, Characterizations and Catalytic Properties显示文摘 | LIU Kefeng YAO Gang WU Wenlei GAO Bo | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 3 | Streamer dynamics and charge self-erasing of two counter-propagating plasmas in repetitively pulsed surface dielectric barrier discharge显示文摘The streamer dynamics and charge self-erasing of two counter-propagating plasmas generated by repetitively pulsed surface dielectric barrier discharge are investigated using electrical and optical diagnosis,and a two-dimensional fluid model.Three distinct discharge phases of primary,transitional and secondary streamers are identified in a single-pulse discharge through the time-resolved plasma images.Moreover,a merging phenomenon of the two opposing primary streamers is observed at the middle position of the discharge gap.Compared to the first pulse,a low streamer propagation velocity of the primary streamer is measured during the subsequent discharge process due to the limitation of residual surface charges left by the previous discharge.No significant dif-ferences of the transferred charge and the deposited energy are obtained in the sequential pulses at a discharge gap of 9 mm.Numerical simulations show that a reduction for the plasma intensity of the approached two primary streamers is attributed by the accumu-lated charge on the dielectric surface and gathered positive charges in the streamer head.Numerical and experimental studies indicate that the residual charges can be erased by the secondary streamer through the drifted electrons,namely that a phenomenon of charge self-erasing can be realized in the individual pulse. | Bangfa Peng Nan Jiang Kefeng Shang Na Lu Jie Li Yan Wu | 2022 | High Voltage2022，7，4： | 2 |
| 4 | Region-based classification of polarimetric SAR images using Wishart MRF 显示文摘 | Wu Yonghui Ji Kefeng Yu Wenxian | 2008 | IEEE Geoscience and Remote Sensing Letters2008，5，4： | 1 |
| 5 | Regionbased classification of polarimetric SAR images using wishart MRF显示文摘 | WU Yonghui JI Kefeng YU Wenxian | 2008 | IEEE Geoscience and Remote Sensing Letters2008，5，4： | 1 |
| 6 | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma显示文摘Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)progression.However,the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated.We conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ccRCC.Methods:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC samples.Luciferase reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer cells.Results:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and transactivation.JUP knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in vivo.Importantly,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment outcomes.Conclusion:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target. | Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen Zhangqun Ye Hua Xu | 2021 | Cancer Communications2021，41，4： | 1 |
| 7 | Improved phenol decomposition and simultaneous regeneration of granular activated carbon by the addition of a titanium dioxide catalyst under a dielectric barrier discharge plasma显示文摘 | Shoufeng Tang Na Lu Jie Li Kefeng Shang Yan Wu | 2012 | Carbon2012，，： | 1 |
| 8 | Inactivation Mechanisms of Escherichia Coli in Drinking Water Using Reactive Species Generated from a Surface Discharge显示文摘Bacterial and chemical contaminations of drinking water imperil the health of people.A reactive species injection method is presented for sterilizing drinking water.To produce reactive species,a gas phase surface discharge reactor(SDR)is designed:a spiral stainless steel wire attached on the inside wall of a quartz glass tube is used as the high voltage electrode,and the drinking water is the ground electrode.The performance and mechanisms of the method in inactivating of Escherichia coli(E.coli)are analyzed.Experimental results show that 500 mL E.coli-contaminated drinking water(108CFU/mL)is completely sterilized within 4 min.Based on the scanning electron microscope(SEM)analysis,there were plasma-induced cell structure damages of the E.coli in the sterilized water,and the damage resulted in the leakage of protein,which was proved by chemical analyses.Meanwhile,the heating effect concomitantly generated by discharge plasma does not influence E.coli inactivation,and the contribution of direct ultraviolet(UV)irradiation could be neglected too.The ozone generated by SDR and the hydroxyl radicals(·OH)subsequently generated in drinking water play the decisive roles in E.coli inactivation because these reactive species cause the cell rupture. | LI Jie SHANG Kefeng WANG Tiecheng LU Na WANG Tianwei WU Yan | 2013 | 高电压技术2013，39，9： | 1 |
| 9 | Perventricular Device Closure of Doubly Committed Subarterial Ventral Septal Defect Through Left Anterior Minithoracotomy on Beating Hearts显示文摘 | Silin Pan Quansheng Xing Qian Cao Pingshan Wang Shuhua Duan Qin Wu Kefeng Hou | 2012 | The Annals of Thoracic Surgery2012，，6： | 1 |
| 10 | Abatement of mixed volatile organic compounds in a catalytic hybrid surface/packed-bed discharge plasma reactor显示文摘 | Lianjie Guo Nan Jiang Jie Li Kefeng Shang Na Lu Yan Wu | 2018 | Frontiers of Environmental Science & Engineering2018，12，2： | 1 |
| 11 | The experimental research on electrode configuration and discharge characteristics of pulse discharge 显示文摘 | Li Jie Shang Kefeng Wu Yan | 2007 | J Electrochem2007，65，4： | 1 |
| 12 | Perventricular Device Closure of Doubly Committed Subarterial Ventral Septal Defect Through Left Anterior Minithoracotomy on Beating Hearts显示文摘 | Silin Pan Quansheng Xing Qian Cao Pingshan Wang Shuhua Duan Qin Wu Kefeng Hou | 2012 | The Annals of Thoracic Surgery2012，，6： | 1 |
| 13 | Slope Collapse Detection Method Based on Deep Learning Technology显示文摘Sofar,slope collapse detectionmainlydepends onmanpower,whichhas the followingdrawbacks:(1)lowreliability,(2)high risk of human safe,(3)high labor cost.To improve the efficiency and reduce the human investment of slope collapse detection,this paper proposes an intelligent detection method based on deep learning technology for the task.In thismethod,we first use the deep learning-based image segmentation technology to find the slope area from the captured scene image.Then the foreground motion detection method is used for detecting the motion of the slope area.Finally,we design a lightweight convolutional neural network with an attentionmechanismto recognize the detected motion object,thus eliminating the interference motion and increasing the detection accuracy rate.Experimental results on the artificial data and relevant scene data show that the proposed detection method can effectively identify the slope collapse,which has its applicative value and brilliant prospect. | Xindai An Di Wu Xiangwen Xie Kefeng Song | 2023 | Computer Modeling in Engineering & Sciences2023，，2： | 0 |
| 14 | Et2Zn-promoted β-trans-selective hydroboration of ynamide显示文摘The trans-hydroboration of alkyne represents a challenging task in organic synthesis.Reported herein is an Et2 Zn promotedβ-trans hydroboration of ynamides by using N-heterocyclic carbene(NHC)-ligated borane as boryl source.The reaction leads to a stereoselective construction of enamides bearing a valuable boryl substituent.Both aromatic and aliphatic ynamides were applicable to the reaction.Synthetic transformation of the C-B bond in the product via Suzuki-Miyaura coupling provides a simple and stereospecific route to multi-substituted enamides.Mechanistic studies were conducted and the possible mechanism was discussed. | Kefeng Wang Zixi Zhuang Huihui Ti Peishan Wu Xin Zhao Honggen Wang | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 15 | Numerical Study of Convective and Radiation Heat Transfer Characteristics in an Upward-Facing Cylindrical Cavity under Back-Side Windy Condition显示文摘Under the back-side windy condition,the convection and radiation heat transfer characteristics in an iso-flux upward-facing cylindrical cavity were studied by three-dimensional numerical simulation.The impacts of cavity tilt angle,wind incident angle and wind speed on convection and radiation heat transfer Nusselt number Nuc and Nur were analyzed,and the possible explanations for their impacts were presented.Results show that due to the disturbance of wind,the influence of cavity tilt angle becomes more complicated and is related to wind incident angle and wind speed.The variation of Nuc or Nur with wind incident angle is different for different cavity tilt angles.Despite of the changes of cavity tilt angle or wind incident angle,the Nuc increases with the wind speed while the Nur presents a declination with the increasing of wind speed.Hence,compared with cavity tilt angle and wind incident angle,wind speed may be the dominant factor affecting or controlling the convective and radiation heat transfer of cavity. | WANG Zehui WU Kefeng WANG Ti XIA Liangwei YU Qiang HUANG Ying SUN Hao WEI Guohua GUAN Jingyu YAN Yanfei | 2021 | Journal of Thermal Science2021，30，1： | 0 |
| 16 | Assessment of Meteorological Threats to the Coordinated Search and Rescue of Unmanned/Manned Aircraft显示文摘The architecture and working principle of coordinated search and rescue system of unmanned/manned aircraft,which is composed of manned/unmanned aircraft and manned aircraft,were first introduced,and they can cooperate with each other to complete a search and rescue task.Secondly,a threat assessment method based on meteorological data was proposed,and potential meteorological threats,such as storms and rainfall,can be predicted by collecting and analyzing meteorological data.Finally,an experiment was carried out to evaluate the performance of the proposed method in different scenarios.The experimental results show that the coordinated search and rescue system of unmanned/manned aircraft can be used to effectively assess meteorological threats and provide accurate search and rescue guidance. | Fei YAN Chuan LI Xiaoyi FU Kefeng WU Yuying LI | 2024 | Meteorological and Environmental Research2024，15，1： | 0 |
| 17 | Covert Communication in Integrated High Altitude Platform Station Terrestrial Networks显示文摘In recent years,Internet of Things(IoT)technology has emerged and gradually sprung up.As the needs of largescale IoT applications cannot be satisfied by the fifth generation(5G)network,wireless communication network needs to be developed into the sixth generation(6G)network.However,with the increasingly prominent security problems of wireless communication networks such as 6G,covert communication has been recognized as one of the most promising solutions.Covert communication can realize the transmission of hidden information between both sides of communication to a certain extent,which makes the transmission content and transmission behavior challenging to be detected by noncooperative eavesdroppers.In addition,the integrated high altitude platform station(HAPS)terrestrial network is considered a promising development direction because of its flexibility and scalability.Based on the above facts,this article investigates the covert communication in an integrated HAPS terrestrial network,where a constant power auxiliary node is utilized to send artificial noise(AN)to realize the covert communication.Specifically,the covert constraint relationship between the transmitting and auxiliary nodes is derived.Moreover,the closed-form expressions of outage probability(OP)and effective covert communication rate are obtained.Finally,numerical results are provided to verify our analysis and reveal the impacts of critical parameters on the system performance. | Zeke Wu Kefeng Guo Rui Liu Shibin Zhu | 2023 | Computer Modeling in Engineering & Sciences2023，，4： | 0 |
| 18 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 19 | A rapid method for the detection of humic acid based on the poly(thymine)-templated copper nanoparticles显示文摘This work described a new method for the detection of humic acid(HA) based on the poly(thymine)(polyT)-templated copper nanoparticles(CuNPs). Without the presence of HA, the formation of poly Ttemplated CuNPs could take place, resulting in strong fluorescence emission peaks at 610 nm(upon excitation at 340 nm). On the other hand, when HA was present, strong interaction between HA and Cu^(2+)took place, which then hampered the effective formation of fluorescent CuNPs, leading to the decrease in fluorescence intensity. Furthermore, under the optimal experimental conditions, the method exhibited a high specificity to HA with a detection limit of 0.4 mg/L. This work has demonstrated a low-cost and convenient method that could be accomplished within 10 min. The method could provide a simple, rapid,and sensitive fluorescent platform for the detection of HA. | Changbei Ma Mingjian Chen Haisheng Liu Kefeng Wu Hailun He Kemin Wang | 2018 | Chinese Chemical Letters2018，29，1： | 0 |
| 20 | Glypican-3 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis显示文摘Objective:To assess the diagnostic accuracy of serum GPC3 versus alpha-fetoprotein(AFP)for HCC by using the method of system review.Methods:PubMed and EMBASE were searched from its inception to 20,April 2014 for studies that compared diagnostic accuracy of serum GPC3 with AFP for HCC.Sensitivity,specificity and other measures were pooled using random-effects models.Summary receiver operating characteristic curve analysis was used to summarize the overall test performance.Results:Fourteen studies were included in this meta-analysis.Summary estimates for serum GPC3 and AFP in diagnosing HCC were as follows:sensitivity,69%(95%confidence interval(CI),56-80%)vs.60%(95%CI,50-69%);specificity,91%(95%CI,76-97%)vs.92%(95%CI,84-98%);diagnostic odds ratio(DOR),22(95%CI,6-83)vs.18(95%CI,8-41);and area under sROC,0.85(95%CI,0.81-0.88)vs.0.80(95%CI,0.76-0.83).The pooled sensitivity and specificity for(GPC3+AFP)and AFP were:sensitivity 80%(95%CI,75-85%)vs.64%(95%CI,53-73%)and specificity 86%(95%CI,74-93%)vs.96%(95%CI,86-99%).A significant heterogeneity was found among the ten studies,and meta-regression and subgroup meta-analysis suggested that race and assay type were probably responsible for the heterogeneity.Conclusions:Serum GPC3 may be a promising diagnostic marker of HCC and it was helpful for early detection of primary hepatocellular carcinoma when combined with AFP.More studies for specific race of patients,and using certain methods for detecting GPC3 are required to further confirm the diagnostic value of GPC3 for HCC. | Weiyu FU Hongyu LU Li LI Kefeng WU Yanping LI Yi LIU Jianli HU | 2015 | BIOCELL2015，39，2： | 0 |
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