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| 1 | Influence of Tip Clearance on Performance of a Contra-Rotating Fan显示文摘Influences of tip clearance on the tip flow and associated loss mechanism in a contra-rotating axial flow fan hasbeen studied in the paper, based on three dimensional numerical results. The results with different tip clearanceare compared in terms of stage efficiency, relative total pressure loss coefficient, flow angle. It is found that theefficiency of the contra-rotating fan changes almost linearly with increment of the tip clearance, however, efficiencyof the rear rotor is observed to decrease more dramatically than that of the forward rotor given same tipclearance variation. The analysis on the flow structure indicates that the tip region flow field is qualitatively similarin both rotors. However, with the same clearance value, the leakage flow in the rear rotor is effected by a tipleakage vortex of greater intensity caused by relative loading levels and the inter rotor interaction. | Jian Xu Chunqing Tan Haisheng Chen Yangli Zhu Dongyang Zhang | 2009 | Journal of Thermal Science2009，18，3： | 6 |
| 2 | Quantitative Diagnosis of Fault Severity Trend of Rolling Element Bearings显示文摘The condition monitoring and fault diagnosis of rolling element bearings are particularly crucial in rotating mechanical applications in industry. A bearing fault signal contains information not only about fault condition and fault type but also the severity of the fault. This means fault severity quantitative analysis is one of most active and valid ways to realize proper maintenance decision. Aiming at the deficiency of the research in bearing single point pitting fault quantitative diagnosis, a new back-propagation neural network method based on wavelet packet decomposition coefficient entropy is proposed. The three levels of wavelet packet coefficient entropy(WPCE) is introduced as a characteristic input vector to the BPNN. Compared with the wavelet packet decomposition energy ratio input vector, WPCE shows more sensitive in distinguishing from the different fault severity degree of the measured signal. The engineering application results show that the quantitative trend fault diagnosis is realized in the different fault degree of the single point bearing pitting fault. The breakthrough attempt from quantitative to qualitative on the pattern recognition of rolling element bearings fault diagnosis is realized. | CUI Lingli MA Chunqing ZHANG Feibin WANG Huaqing | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 6 |
| 3 | A 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene is associated with the red skin of“Zaosu Red”pear(Pyrus pyrifolia White Pear Group):a deletion in the PpBBX24 gene is associated with the red skin of pear显示文摘Red skin is an important quality trait for pear fruits and is determined by the concentration and composition of anthocyanins.The regulatory mechanism underlying anthocyanin accumulation is a popular topic in fruit research.Red mutants are ideal materials for studying the molecular mechanism of color diversity in pear.Although several red pear mutants have been cultivated and are in production,no exact locus containing the responsible genetic mutation has been identified.In this study,by combining the bulked segregant analysis with whole-genome sequencing,we identified a 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene from the red pear mutant“Zaosu Red”.We further verified that the deletion was present only in the red mutant of“Zaosu”and in its red offspring,which was different from that which occurred in other red pear fruits.This deletion results in a coding frame shift such that there is an early termination of the PpBBX24 gene and loss of key NLS and VP domains from PpBBX24.The lost domains may reduce or alter the normal function of PpBBX24.In addition,we found that the transcript levels of the PpMYB10 and PpHY5 genes in red samples were significantly higher than those in green samples,whereas the results for the normal-type PpBBX24 gene were the opposite.We ultimately revealed that the 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene is associated with the red skin of the“Zaosu Red”pear.This finding of somatic mutational events will be helpful for breeding new red pear cultivars and for understanding the regulatory mechanisms involved in pear skin pigmentation. | Chunqing Ou Xiaoli Zhang Fei Wang Liyi Zhang Yanjie Zhang Ming Fang Jiahong Wang Jixun Wang Shuling Jiang Zhihong Zhang | 2020 | Horticulture Research2020，7，1： | 4 |
| 4 | Non-probe compensation of optical vortices carrying orbital angular momentum显示文摘In this paper, we demonstrate a scheme for compensating distorted optical vortex beams carrying orbital angular momentum. By inputting the intensity profile into the Gerchberg–Saxton algorithm [Optik 35, 237(1972)], the pre-compensation phase mask can be acquired. No additional probe beams are introduced, and all the computing is aiming at the transmitted vortex beams. The distorted vortex beams are investigated experimentally before and after pre-compensation, showing favorable compensation performance. This scheme will find applications in the areas of rotation detection, optical communications, and so on. | SHIYAO FU TONGLU WANG SHIKUN ZHANG ZHEYUAN ZHANG YANWANG ZHAI CHUNQING GAO | 2017 | Photonics Research2017，5，3： | 3 |
| 5 | Economic Analysis of using Above Ground Gas Storage Devices for Compressed Air Energy Storage System显示文摘Above ground gas storage devices for compressed air energy storage(CAES) have three types:air storage tanks,gas cylinders,and gas storage pipelines.A cost model of these gas storage devices is established on the basis of whole life cycle cost(LCC) analysis.The optimum parameters of the three types are determined by calculating the theoretical metallic raw material consumption of these three devices and considering the difficulties in manufacture and the influence of gas storage device number.The LCCs of the three types are comprehensively analyzed and compared.The result reveal that the cost of the gas storage pipeline type is lower than that of the other two types.This study may serve as a reference for designing large-scale CAES systems. | LIU Jinchao ZHANG Xinjing XU Yujie CHEN Zongyan CHEN Haisheng TAN Chunqing | 2014 | Journal of Thermal Science2014，23，6： | 3 |
| 6 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 7 | On the use of the upper-bound method for load determination in H-beam rolling显示文摘 | ZHANG Wenzhi ZHU Chunqing WIDERA G E O | 1996 | Journal of Materials Processing Technology1996，56，14： | 1 |
| 8 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 9 | Synthesis of dendrigraft star-comb polybutadienes by anionic polymeriza- tion and grafting-onto methodology显示文摘 | Zhang Hongxia Li Yang Zhang Chunqing | 2009 | Macromoleeules2009，42，14： | 1 |
| 10 | Relationship between heterogeneity of source rocks and genetic mechanism of abnormally high pressure显示文摘Based on the micro-fluorescence observation of polished sections of source rocks,two types of micro-layers with different wetting properties formed in thermal evolution,i.e.,oil-wetting and water-wetting micro-layers,are distinguished.The wetting property is found closely related to the abundance of organic matter and its occurrences with inorganic minerals.The alternating distribution and intercrossing of two types of micro-layers formed many separated spaces with different wettabilities.The strong capillary forces in these separated spaces with different wettibilities obstruct the cross flows of pore fluids and result in nearly independent and closed fluid systems.As a consequence,these spatially superposed spaces in source rocks bear the overburden pressure and then abnormally high pressures have developed in the whole source rock unit.Therefore,the abundance and occurrences of organic matter are the main inner factors influencing the formation of abnormally high pressures,whereas the formation,distribution and development of micro-layers with different wettabilities during the evolution of source rock determine the intensity and spatial distribution of abnormally high pressures. | ZHANG XueJun XU XingYou WANG YongShi SONG GuoQi GUO ChunQing LIU Qing LI Ping | 2013 | Science China Earth Sciences2013，56，11： | 1 |
| 11 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 12 | On the Use of the Upper-bound Method for Load Determination in H-beam Rolling显示文摘 | Zhang Wenzhi Zhu Chunqing Widera G E O | 1996 | Journal of Materials Processing Technology1996，56，： | 1 |
| 13 | Synthesis of dendrigraft star comb polybutadienes by anionic polymerization and grafting-onto methodology 显示文摘 | Zhang Hongxia Li Yang Zhang Chunqing | 2009 | Macromolecules2009，42，14： | 1 |
| 14 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 15 | von Willebrand factor as a novel noninvasive predictor of portal hypertension and esophageal varices in hepatitis B patients with cirrhosis显示文摘 | Hao Wu Shiping Yan Guangchuan Wang Shaobo Cui Chunqing Zhang Qiang Zhu | 2015 | Scandinavian Journal of Gastroenterology2015，，9： | 1 |
| 16 | In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion显示文摘In situ tissue engineering is a powerful strategy for the treatment of bone defects.It could overcome the limitations of traditional bone tissue engineering,which typically involves extensive cell expansion steps,low cell survival rates upon transplantation,and a risk of immuno-rejection.Here,a porous scaffold polycaprolactone(PCL)/decellularized small intestine submucosa(SIS)was fabricated via cryogenic free-form extrusion,followed by surface modification with aptamer and PlGF-2_(123-144)*-fused BMP2(pBMP2).The two bioactive molecules were delivered sequentially.The aptamer Apt19s,which exhibited binding affinity to bone marrow-derived mesenchymal stem cells(BMSCs),was quickly released,facilitating the mobilization and recruitment of host BMSCs.BMP2 fused with a PlGF-2_(123-144)peptide,which showed“super-affinity”to the ECM matrix,was released in a slow and sustained manner,inducing BMSC osteogenic differentiation.In vitro results showed that the sequential release of PCL/SIS-pBMP2-Apt19s promoted cell migration,proliferation,alkaline phosphatase activity,and mRNA expression of osteogenesis-related genes.The in vivo results demonstrated that the sequential release system of PCL/SIS-pBMP2-Apt19s evidently increased bone formation in rat calvarial critical-sized defects compared to the sequential release system of PCL/SIS-BMP2-Apt19s.Thus,the novel delivery system shows potential as an ideal alternative for achieving cell-free scaffold-based bone regeneration in situ. | Tingfang Sun Chunqing Meng Qiuyue Ding Keda Yu Xianglin Zhang Wancheng Zhang Wenqing Tian Qi Zhang Xiaodong Guo Bin Wu Zekang Xiong | 2021 | Bioactive Materials2021，6，11： | 1 |
| 17 | On the use of the upper-bound method for load determination in H-beam rolling显示文摘 | ZHANG Wenzhi ZHU Chunqing WlDERA G E O | 1996 | Journal of Material Processing Technology1996，，56： | 1 |
| 18 | On the Use of the Upper-bound Method for Load Determination in H- beam Rolling 显示文摘 | Weizhi Zhang Chunqing Zhu Widera G E O | 1999 | Journal of Material Processing Technology1999，94，： | 1 |
| 19 | Calculation of temperature and determination of deformation resistance in H-beam rolling (1) temperature variation in a stand显示文摘 | ZHANG Wenzhi ZHOU Qingtian ZHU Chunqing | 1999 | Journal of Material Processing Technology1999，，94： | 1 |
| 20 | Synthesis of Dendrigraft Star-Comb Polybutadienes by Anionic Polymeri- zation and Grafting-onto Methodology显示文摘 | Zhang Hongxia Li Yang Zhang Chunqing | 2009 | Macromolecules2009，42，14： | 1 |
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