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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Direct observation of stray crystal formation in unidirectional solidification of Sn–Bi alloy by X-ray imaging显示文摘 | Hideyuki Yasuda Itsuo Ohnaka Koichi Kawasaki Akira Sugiyama Tetsutaro Ohmichi Jun Iwane Keiji Umetani | 2003 | Journal of Crystal Growth2003，，1： | 2 |
| 3 | Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells显示文摘 | Minori Saitoh Katsunari Taguchi Kazuhiro Momose Kazutaka Suga Noriyuki Yamazaki Chizuko Ono Tatsuo Suzuki Osamu Takeuchi Shuhei Yasuda Keiji Miyata | 2001 | Cancer Chemotherapy and Pharmacology2001，，2： | 1 |
| 4 | Rendezvous gastrotomy technique using direct percutaneous endoscopic gastrostomy for transgastric cholecystectomy in hybrid natural orifice translumenal endoscopic surgery显示文摘 | Maki Sugimoto Hideki Yasuda Keiji Koda Masato Suzuki Masato Yamazaki Tohru Tezuka Chihiro Kosugi Ryota Higuchi Yoshihisa Watayo Yohsuke Yagawa Shuichiro Uemura Hironori Tsuchiya Atsushi Hirano Ro Shoki | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 1 |
| 5 | Multicenter retrospective study of endoscopic ultrasound‐guided biliary drainage for malignant biliary obstruction in J apan显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Hironari Kato Takao Itoi Hiroshi Kawakami Keiji Hanada Hirotoshi Ishiwatari Ichiro Yasuda Hirofumi Kawamoto Fumihide Itokawa Masaki Kuwatani Tomohiro Iiboshi Tsuyoshi Hayashi Shinpei Doi Yousuke Nakai | 2014 | J Hepatobiliary Pancreat Sci2014，，5： | 1 |
| 6 | Chinese word segmentation and statistical machine translation 显示文摘 | Ruiqiang Zhang Keiji Yasuda Eh'chiro Sumita | 2008 | ACM Transactions on Speech and Language Processing (TSLP)2008，5，2： | 1 |
| 7 | Ultrasonic irradiation effect on porphyrin and its application for quantification of ultrasonic intrnsity显示文摘 | Nomura H iroyasu Koala Shinobu Yasuda Keiji | 1996 | Ultrasonics1996，34，： | 1 |
| 8 | Effect of CaO on Drying Characteristics of Municipal Solid Waste 显示文摘 | TATEMOTO Yuji BANDO Yoshiyuki YASUDA Keiji NAKAMURA Masaaki AZEGAMI Muneo | 1999 | Kagaku Kogaku Ronbunshu1999，25，3： | 1 |
| 9 | Image overlay navigation by markerless surface registration in gastrointestinal, hepatobiliary and pancreatic surgery显示文摘 | Maki Sugimoto Hideki Yasuda Keiji Koda Masato Suzuki Masato Yamazaki Tohru Tezuka Chihiro Kosugi Ryota Higuchi Yoshihisa Watayo Yohsuke Yagawa Shuichiro Uemura Hironori Tsuchiya Takeshi Azuma | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，5： | 1 |
| 10 | A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hirofumi Kogure Keiji Hanada Hiroyuki Maguchi Naoki Sasahira Hideki Kamada Tsuyoshi Mukai Yoshihiro Okabe Osamu Hasebe Iruru Maetani Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
| 11 | Auto-infection system for the sweetpotato weevil,Cylas formicarius (Fabricius) (Coleoptera:Curculionidae) with entomopathogenic fungi,Beauveria bassiana using a modifial sex pheromone trap in the field显示文摘 | Keiji Yasuda | 1999 | Applied Entomology and Zoology1999，34，4： | 1 |
| 12 | Treatment outcomes of chemotherapy between unresectable and recurrent biliary tract cancer显示文摘AIM:To evaluate the differences in the treatment outcomes between the unresectable and recurrent biliary tract cancer patients who received chemotherapy.METHODS:Patients who were treated with gemcitabine and S-1 combination therapy in the previous prospective studies were divided into groups of unresectable and recurrent cases.The tumor response,time-toprogression,overall survival,toxicity,and dose intensity were compared between these two groups.RESULTS:Response rate of the recurrent group was higher than that of the unresectable group(40.0%vs25.5%;P=0.34).Median time-to-progression of the recurrent and unresectable groups were 8.7 mo(95%CI),1.2 mo,not reached)and 5.7 mo(95%CI:4.0-7.0 mo),respectively(P=0.14).Median overall survival of the recurrent and the unresectable groups were 16.1 mo(95%CI:2.0 mo-not reached)and 9.6 mo(95%CI:7.1-11.7 mo),respectively(P=0.10).Dose intensities were significantly lower in the recurrent groups(gemcitabine:recurrent group 83.5%vs unresectable group 96.8%;P<0.01,S-1:Recurrent group 75.9%vs unresectable group 91.8%;P<0.01).Neutropenia occurred more frequently in recurrent group(recurrent group 90%vs unresectable group 55%;P=0.04).CONCLUSION:Not only the efficacy but also the toxicity and dose intensity were significantly different between unresectable and recurrent biliary tract cancer. | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hiroshi Yagioka Saburo Matsubara Keiji Hanada Hiroyuki Maguchi Hideki Kamada Osamu Hasebe Tsuyoshi Mukai Yoshihiro Okabe Iruru Maetani Kazuhiko Koike | 2014 | World Journal of Gastroenterology2014，20，48： | 0 |
| 13 | Direct Observation of Thermoelectric Magnetic Convection in Unidirectionally Solidified Al-Cu Alloys显示文摘This study performed the time-resolved and in-situ observation of unidirectional solidification of A1-Cu and Sn-Bi alloys under a static magnetic field up to 0.45 T.Irt the case of Sn-Bi alloy,the static magnetic field reduced the local convection around the primary dendrite arms.No thermoelectric convection was detected.On the other hand,the thermoelectric convection was clearly observed in Al-Cu alloy.The observed convection was consistently explained by the thermoelectric magnetic convection.According to a simplified model,the thermoelectric magnetic convection can be induced if the difference in the thermoelectric power between the solid and the liquid phases is in the order of 1μV/K and temperature gradient is several K/mm. | Hideyuki Yasuda Keisuke Inoue Yudai Minami Tomoya Nagira Masato Yoshiya Kentaro Uesugi Keiji Umetani | 2012 | Journal of Iron and Steel Research(International)2012，19，S1： | 0 |
| 14 | Fabrication of Bulk β-FeSi_2 Crystal With ThreeDimensional Alignment by an Oscillating Magnetic Field显示文摘It has been reported that an anisotropic magnetic field could produce the three-dimensional alignment of fine single-crystal particles with the orthorhombic crystal structure.However,the three-dimensional alignment was achieved only in suspensions.Fabrication of bulk'single'materials that have the three-dimensional alignment of grains has been desired.This study proposes a procedure for the fabrication,which consists of slip casting under an oscillating magnetic field and sintering.Optimization of casting and sintering conditions achieved the three-dimensionally aligned bulkβ-FeSi_2. | Noriaki Nakatsuka Keiji Kurokawa Tomoya Nagira Masato Yoshiya Hideyuki Yasuda | 2012 | Journal of Iron and Steel Research(International)2012，19，S1： | 0 |
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