| 3 | New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan显示文摘We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,Japan.This specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities. | Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo Kosuke Sato Takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi Abe Norio Kikuchi Minoru Suzuki | 2022 | Natural Products and Bioprospecting2022，12，1： | 0 |
| 4 | Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway显示文摘Here, we report a case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway. A 57-year-old Japanese woman presented with epigastric tenderness, and distal gastrectomy was performed. In the surgical specimen, histologically, the tumor tissue was composed of three subtypes of tumor components showing different histological architecture and cellular atypia, diagnosed as neuroendocrine tumor(NET) G2, NET G3, and neuroendocrine carcinoma(NEC) components. Immunohistochemically, the Ki-67-positive rates of NET G2, NET G3, and NEC components were 6.5%, 99.5% and 88.1%, respectively. Although allelic imbalance(AI) on chromosomes 1p, 3p, 8q, TP53, 18q and 22 q was commonly found in all components, AI of 4p was found in NET G3 and NEC components(but not in the NET G2 component). In contrast, AIs of 5q and 9p were found in only the NEC component. Thus, we showed the progression from NET G2 to NEC, via NET G3, within the same tumor. | Noriyuki Uesugi Ryo Sugimoto Makoto Eizuka Yasuko Fujita Mitsumasa Osakabe Keisuke Koeda Takashi Kosaka Shunichi Yanai Kazuyuki Ishida Akira Sasaki Takayuki Matsumoto Tamotsu Sugai | 2017 | World Journal of Clinical Cases2017，5，11： | 0 |
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