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| 1 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Skull metastasis from hepatocellular carcinoma with chronic hepatitis B显示文摘A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.Assays for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade A.Our diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis B.He was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for HCC.But he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and died.Dissection showed HCC with multiple bone metastases.The liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular type.In the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting plates.Piecemeal necrosis was not obvious.No fibrosis was noted.An 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial bone.The lesion was osteolytic and showed invasion into the dura mater.Neither the subdural cavity nor the brain showed involvement from the metastatic tumor.However,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of life.Therefore,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC. | Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 2 |
| 3 | Clinicopathological analysis for recurrence of stage Ib gastric cancer (according to the second English edition of the Japanese classification of gastric carcinoma)显示文摘 | Takashi Yokoyama Kiyoshi Kamada Yoshikazu Tsurui Hisanori Kashizuka Eiji Okano Sanehito Ogawa Shinsaku Obara Mitsutoshi Tatsumi | 2011 | Gastric Cancer2011，，4： | 1 |
| 4 | Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease显示文摘 | Hiromasa Takaishi Takahiro Matsuki Atsushi Nakazawa Toshihiko Takada Shoichi Kado Takashi Asahara Nobuhiko Kamada Atsushi Sakuraba Tomoharu Yajima Hajime Higuchi Nagamu Inoue Haruhiko Ogata Yasushi Iwao Koji Nomoto Ryuichiro Tanaka Toshifumi Hibi | 2007 | International Journal of Medical Microbiology2007，，： | 1 |
| 5 | Interactive effects of carbon footprint information and its accessibility on value and subjective qualities of food products 显示文摘 | Atsushi Kimura Yuji Wada Akiko Kamada Tomohiro Ma- suda Masako Okamoto Sho - ichi Goto Daisuke Tsuzuki Dongsheng Cai Takashi Oka Ippeita Dan | 2010 | Appetite2010，55，： | 1 |
| 6 | Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease显示文摘 | Hiromasa Takaishi Takahiro Matsuki Atsushi Nakazawa Toshihiko Takada Shoichi Kado Takashi Asahara Nobuhiko Kamada Atsushi Sakuraba Tomoharu Yajima Hajime Higuchi Nagamu Inoue Haruhiko Ogata Yasushi Iwao Koji Nomoto Ryuichiro Tanaka Toshifumi Hibi | 2007 | International Journal of Medical Microbiology2007，，5： | 1 |
| 7 | RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts显示文摘 | Yoshihiro Yoshikawa Tatsuya Yoshizawa Eisuke Domae Yohki Hieda Akira Takeyama Shuitsu Hirota Akiyo Kawamoto Seiji Goda Isao Tamura Aiko Kamada Yutaka Komasa Shosuke Morita Kazuya Yamagata Takashi Ikeo | 2015 | Archives of Oral Biology2015，，9： | 1 |
| 8 | Health‐related quality of life after carbon‐ion radiotherapy for prostate cancer: A 3‐year prospective study显示文摘 | Hiroyuki Katoh Hiroshi Tsuji Hitoshi Ishikawa Tadashi Kamada Masaru Wakatsuki Naoki Hirasawa Hiroyoshi Suzuki Koichiro Akakura Takashi Nakano Jun Shimazaki Hirohiko Tsujii | 2014 | Int J Urol2014，，： | 1 |
| 9 | Optimizing the preparation of multi-layered polyamide membrane via the addition of a co-solvent显示文摘 | Takashi Kamada Tomomi Ohara Takuji Shintani Toshinori Tsuru | 2014 | Journal of Membrane Science2014，，： | 1 |
| 10 | Controlled surface morphology of polyamide membranes via the addition of co-solvent for improved permeate flux显示文摘 | Takashi Kamada Tomomi Ohara Takuji Shintani Toshinori Tsuru | 2014 | Journal of Membrane Science2014，，： | 1 |
| 11 | Co-solvent-mediated synthesis of thin polyamide membranes显示文摘 | Chunlong Kong Takuji Shintani Takashi Kamada Viatcheslav Freger Toshinori Tsuru | 2011 | Journal of Membrane Science2011，，1： | 1 |
| 12 | Controlled surface morphology of polyamide membranes via the addition of co- solvent for improved permeate flux显示文摘 | Takashi Kamada Tomomi Ohara Takuji Shintani | 2014 | Journal of Membrane Science2014，467，： | 1 |
| 13 | Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin显示文摘 | Akiko Shiotani Takashi Sakakibara Yoshiyuki Yamanaka Hiroshi Imamura Ken-Ichi Tarumi Noriaki Manabe Tomoari Kamada Hiroaki Kusunoki Jiro Hata Ken Haruma | 2009 | Journal of Gastroenterology2009，，2： | 1 |
| 14 | Enhanced performance of inorganic-polyamide nanocomposite membranes prepared by metal-alkoxide-assisted interfacial polymerization 显示文摘 | Chunlong Kong Akira koushima Takashi Kamada | 2011 | Journal of Membrane Science2011，366，12： | 1 |
| 15 | Unidirectional solidification of TbFe 2 alloy using magnetic field in microgravity显示文摘 | Hideki Minagawa Keiji Kamada Tomoya Konishi Takashi Tsurue Hideaki Nagai Yoshinori Nakata Masataka Sasamori Takeshi Okutani | 2001 | Journal of Magnetism and Magnetic Materials2001，，3： | 1 |
| 16 | Bequest motives and fertility decisions显示文摘 | Ritsuko Futagami Kimiyoshi Kamada Takashi Sato | 2006 | Economics Letters2006，，3： | 1 |
| 17 | Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin显示文摘 | Akiko Shiotani Takashi Sakakibara Yoshiyuki Yamanaka Hiroshi Imamura Ken-Ichi Tarumi Noriaki Manabe Tomoari Kamada Hiroaki Kusunoki Jiro Hata Ken Haruma | 2009 | Journal of Gastroenterology2009，，2： | 1 |
| 18 | A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hirofumi Kogure Keiji Hanada Hiroyuki Maguchi Naoki Sasahira Hideki Kamada Tsuyoshi Mukai Yoshihiro Okabe Osamu Hasebe Iruru Maetani Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
| 19 | Phase II trial of combined regional hyperthermia and gemcitabine for locally advanced or metastatic pancreatic cancer显示文摘 | Takeshi Ishikawa Satoshi Kokura Naoyuki Sakamoto Takashi Ando Eiko Imamoto Takeshi Hattori Hirokazu Oyamada Naomi Yoshinami Masafumi Sakamoto Kazutomo Kitagawa Yoko Okumura Naohisa Yoshida Kazuhiro Kamada Kazuhiro Katada Kazuhiko Uchiyama Osamu Handa Tomo | 2012 | International Journal of Hyperthermia2012，，7： | 1 |
| 20 | Prevalence of H elicobacter pylori Infection by Birth Year and Geographic Area in Japan显示文摘 | Junko Ueda Masahiko Gosho Yoshikatsu Inui Toru Matsuda Masatoshi Sakakibara Katsuhiro Mabe Shigemi Nakajima Tadashi Shimoyama Mitsugi Yasuda Takashi Kawai Kazunari Murakami Tomoari Kamada Motowo Mizuno Shogo Kikuchi Yingsong Lin Mototsugu Kato | 2014 | Helicobacter2014，，2： | 1 |
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