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| 1 | Effects of Sb,Sm, and Sn additions on the microstructure and mechanical properties of Mg-6Al-1.2Y-0.9Nd alloy显示文摘The microstructure and mechanical properties of Mg-6Al-1.2Y-0.9Nd magnesium alloy with Sb, Sm, or Sn addition were investigated through X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). The results show that small amounts of Sb, Sm, and especially Sn can refine the grains of the alloy. High melting point Sb3Y5, Al2Sm, and Nd5Sn3 intermetallic compounds can be formed respectively when Sb, Sm, and Sn are added to the alloy. Sb and Sm can improve the tensile strength of the alloy at ambient and elevated temperatures. The tensile strength of the alloy with Sm addition is the highest at 293 and 423 K. However, the tensile strength of the alloy with Sn addition is the highest at 448 K. | LI Kejie LI Quanan JING Xiaotian CHEN Jun ZHANG Xingyuan | 2009 | Rare Metals2009，28，5： | 39 |
| 2 | Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives显示文摘Ginseng is among the oldest traditional Chinese medicinal herbs and is widely used in China and Southeast Asia. Over the past 50 years, considerable research has focused on the chemical constituents, pharmacological action, and clinical applications of ginseng. In this review, we examine the current state of research on ginseng, including the main active ingredient ginsenoside, its pharmacological effects on the cardiovascular system, and mechanisms of action. We focus on what is known of the effects of ginseng against atherosclerosis, arrhythmia, myocardial ischemia, and its inhibition of ventricular remodeling, providing a basis for expanding the clinical applications of ginseng. | Yingying Sun Yue Liu Keji Chen | 2016 | Science China(Life Sciences)2016，59，3： | 20 |
| 3 | Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine显示文摘The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatment of cardiovascular and cerebrovascular diseases.Recent advances in platelet proteomics have provided a technology platform for high-quality research of platelet pathophysiology and the development of new antiplatelet drugs.The study of blood stasis syndrome(BSS)and activated blood circulation of traditional Chinese medicine(TCM)is one of the most active fields where the integration of TCM and western medicine in China has been successful.Activated blood circulation herbs(ABC herbs)of Chinese medicine are often used in the treatment of BSS.Most ABC herbs have antiplatelet and anti-atherosclerosis activity,but knowledge about their targets is lacking.Coronary heart disease(CHD),BSS,and platelet activation are closely related.By screening and identifying activated platelet proteins that are differentially expressed in BSS of CHD,platelet proteomics has helped researchers interpret the antiplatelet mechanism of action of ABC herbs and provided many potential biomarkers for BSS that could be used to evaluate the clinical curative effect of new antiplatelet drugs.In this article the progress of platelet proteomics and its advanced application for research of BSS and ABC herbs of Chinese medicine are reviewed. | LIU Yue YIN HuiJun CHEN KeJi | 2013 | Science China(Life Sciences)2013，56，11： | 14 |
| 4 | Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq显示文摘抄写和 post-transcriptional 过程例如其他的拼接,在在 metazoans 控制发展节目起关键作用。最近出现的 RNA-seq 方法把我们真核细胞的 transcriptomes 的理解带到新水平,因为它能两个都同时解决基因表示水平和其他的拼接事件。在性腺获得细胞的区别的更好的理解,我们用 RNA-seq 从果蝇睾丸和卵巢分析了 mRNA 侧面。我们识别了有性特定的 isoforms 在的一套基因野类型(WT ) 性腺,包括几个抄写因素。我们发现从无差别的细菌房间的精子的区别导致了拼接的 RNA 的戏剧的 downregulation 因素。我们的数据证实 RNA 拼接事件是显著地在云石(欺骗) 的无差别的充实房间的袋子里更经常在在 WT 的区别之上的变异的睾丸,而是 downregulated 睾丸。与这一致,我们证明基因在 WT 为成熟分裂和终端区别要求睾丸主要在 transcriptional 水平被调整,然而并非由选择拼接。出人意料地,我们在在无差别的充实房间的欺骗睾丸改变因素和 histone 修改酶的染色质的所有家庭的表示观察了增加。更有趣地,有相反的酶的活动的染色质管理者和 histone 修改酶是在在睾丸的无差别的房间的 coenriched,建议这些房间可以拥有动态染色质建筑学。最后,我们的数据表明果蝇 gonadal transcriptomes 的许多新特征,和愿望导致的更全面的理解微分基因表示并且拼接在果蝇调整 gametogenesis。我们的数据为在果蝇在细菌房间生物学的许多有趣的区域拼接的基因表示和选择的系统的学习提供了一个基础,例如性同种二形和在 germline 干细胞系的增长对终端区别程序的规定的分子的基础。为未加工、分析的 RNA-seq 数据的 GEO 就职数字是 GSE16960。 | Qiang Gan Iouri Chepelev Gang Wei Lama Tarayrah Kairong Cui Keji Zhao Xin Chen | 2010 | Cell Research2010，20，7： | 9 |
| 5 | Correlation between platelet gelsolin levels and different types of coronary heart disease显示文摘Gelsolin is an important cytoskeletal protein of platelets and studies have shown a close relationship between gelsolin and cardiovascular disease.However,the role of gelsolin in the development of coronary heart disease(CHD) is unclear.In this study,we record the distribution of gelsolin in human platelets and plasma and its association with different types of CHD.This study included 114 cases,with 33 stable angina pectoris(SAP) cases,81 acute coronary syndrome(ACS) cases—composed of 39 unstable angina pectoris(UAP) and 42 acute myocardial infarction(AMI) cases,and 31 healthy control participants.Gelsolin concentration in platelet rich plasma(PRP) and platelet poor plasma(PPP),actin filament(F-actin) and Gc-globulin of PPP were determined by enzyme-linked immunoadsorbent assay(ELISA).The fluorescence intensity of CD62p and cytoplasmic calcium([Ca2+] i) in human platelets measured by flow cytometry.We also used turbidimetry to detect the platelet aggregation rate(PAR).We analyzed the correlation between platelet gelsolin concentration and CD62p or plasma F-actin levels among each different patient group.Compared with the control group,the gelsolin level in PRP of UAP and AMI groups increased significantly(P<0.01),while the gelsolin level in PPP of all the three patient groups decreased markedly(P<0.01),and the CD62p,PAR,[Ca2+] i of platelets,F-actin and Gc-globulin of the UAP and AMI groups increased significantly(P<0.01).Compared with the SAP group,the gelsolin level in PRP,the PAR,[Ca2+] i of platelets and CD62p of other two groups increased significantly(P<0.01),F-actin of the AMI group increased markedly(P<0.01).Platelet cytoskeleton protein dynamics vary among the different types of CHD.Platelet gelsolin levels are markedly increased and accompanied by increased platelet activity,F-actin and [Ca2+] i of ACS patients,while gelsolin levels in PPP are markedly lower.Abnormally increased platelet gelsolin levels show high positive correlation with the level of platelet activity.Therefore,platelet gelsolin might be a novel molecular marker and/or a new potential therapeutic target of anti-platelet therapy of ACS. | LIU Yue YIN HuiJun JIANG YueRong XUE Mei CHEN KeJi | 2012 | Chinese Science Bulletin2012，57，6： | 8 |
| 6 | Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases显示文摘Cardiometabolic disease(CMD), characterized with metabolic disorder triggered cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger chronic low-grade inflammation, and actually, a new concept of metaflammation has been proposed to define the state of metabolism connected with immunological adaptations. Amongst the continuously increased list of systemic metabolites in regulation of immune system, bile acids(BAs) represent a distinct class of metabolites implicated in the whole process of CMD development because of its multifaceted roles in shaping systemic immunometabolism. BAs can directly modulate the immune system by either boosting or inhibiting inflammatory responses via diverse mechanisms. Moreover, BAs are key determinants in maintaining the dynamic communication between the host and microbiota. Importantly, BAs via targeting Farnesoid X receptor(FXR) and diverse other nuclear receptors play key roles in regulating metabolic homeostasis of lipids, glucose, and amino acids. Moreover, BAs axis per se is susceptible to inflammatory and metabolic intervention, and thereby BAs axis may constitute a reciprocal regulatory loop in metaflammation. We thus propose that BAs axis represents a core coordinator in integrating systemic immunometabolism implicated in the process of CMD. We provide an updated summary and an intensive discussion about how BAs shape both the innate and adaptive immune system, and how BAs axis function as a core coordinator in integrating metabolic disorder to chronic inflammation in conditions of CMD. | Baoyi Guan Jinlin Tong Haiping Hao Zhixu Yang Keji Chen Hao Xu Anlu Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 7 |
| 7 | Microstructure and mechanical properties of Mg-6Al magnesium alloy with yttrium and neodymium显示文摘The effects of rare earth(RE) elements Y and Nd on the microstructure and mechanical properties of Mg-6Al magnesium alloy were investigated.The results show that a proper level of RE elements can obviously ref ine the microstructure of Mg-6Al magnesium alloys,reduce the quantity of β-Mg17Al12 phase and form Al2Y and Al2Nd phases.The combined addition of Y and Nd dramatically enhances the tensile strength of the alloys in the temperature range of 20-175℃.When the content of RE elements is up to 1.8%,the values of tensile strength at room temperature and at 150℃ simultaneously reach their maximum of 253 MPa and 196 MPa,respectively.The main mechanisms of enhancement in the mechanical properties of Mg-6Al alloy with Y and Nd are the grain ref ining strengthening and the dispersion strengthening. | Chen Jun Li Quanan Li Jianghong Li Xiaofeng Li Kejie Zhang Xingyuan | 2009 | China Foundry2009，6，2： | 5 |
| 8 | Chinese Expert Consensus on Clinical Application of Oral Ginkgo biloba Preparations (2020)显示文摘Ginkgo(Ginkgo biloba L.)is aperennial deciduous tree of the Ginkgoaceae family,and its seeds(ginkgo nut)and leaves have high medicinal values.G.biloba was firstly recorded in Materia Medica in Shaoxin Medica;previous texts on Materia Medica have mostly listed ginkgo nuts. | Chinese Association of Integrative Medicine Chinese Medical Doctor Association National Clinical Research Center for Chinese Medicine Cardiology Cardiovascular Disease Working Group Encephalopathy Disease Working Group China Center for Evidence-Based Chinese Medicine CHEN Keji LIU Yue YANG Hua LIU Long-tao FU Chang-geng | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 3 |
| 9 | Investigation of gene expression profiles in coronary heart disease and functional analysis of target gene显示文摘The research outlined here includes constitution of the differential gene expression profile by means of oligonucleotide gene microarray and functional analysis of the target gene for coronary heart disease (CHD). In a microarray screening experiment, the predominance of inflammation- and immune-related genes is presented in the expression profile of 107 differential genes based on the analysis of gene ontology and gene pathway. IL-8, an inflammatory factor, is identified as one of the genes that were markedly up-regulated in CHD. The plasma level of IL-8 is significantly raised in patients with CHD (n = 30) compared with healthy controls (n = 40), which underscores the clinical relevance of the in vitro finding. The further functional analysis shows that IL-8 affects platelet aggregation percentage, ex-pression of CD62p and platelet aggregation morphology in 12 healthy volunteers to some extent. These findings suggest the relevance of inflammation and immune responses to CHD at the DNA level. Moreover, IL-8 may be involved in the pathogenesis of CHD through the pathway of platelet activation. | YIN HuiJun MA XiaoJuan JIANG YueRong SHI DaZhuo CHEN KeJi | 2009 | Chinese Science Bulletin2009，54，5： | 3 |
| 10 | MULTIAXIAL BEHAVIOR OF NANOPOROUS SINGLE CRYSTAL COPPER:A MOLECULAR DYNAMICS STUDY显示文摘The stress-strain behavior and incipient yield surface of nanoporous single crystal copper are studied by the molecular dynamics(MD) method.The problem is modeled by a periodic unit cell subject to multi-axial loading.The loading induced defect evolution is explored.The incipient yield surfaces are found to be tension-compression asymmetric.For a given void volume fraction,apparent size effects in the yield surface are predicted:the smaller behaves stronger.The evolution pattern of defects(i.e.,dislocation and stacking faults) is insensitive to the model size and void volume fraction.However,it is loading path dependent.Squared prismatic dislocation loops dominate the incipient yielding under hydrostatic tension while stacking-faults are the primary defects for hydrostatic compression and uniaxial tension/compression. | Kejie Zhao Liangliang Fan Changqing Chen | 2009 | Acta Mechanica Solida Sinica2009，22，6： | 2 |
| 11 | Epitaxy of rare earth element fluorcarbonate minerals from carbonatite dyke at Bayan Obo, Inner Mongolia, China显示文摘Rare earth element fluorocarbonate minerals such as bastnaesite and parisite are firstly discovered in carbonatite dykes from Bayan Obo, Inner Mongolia, China. Bastnaesite rarely occurs as homogeneously single crystal, but contains microfine phase of parisite. They form regular intergrowth along (0001) plane net, which is identified as epitaxy. This eptactic texture results from the variation of chemical composition of crystallizing agents of those minerals that crystallize directly from carbonatite magma. | Xueming Yang Peishan Zhang Kejie Tao Xiaoyong Yang Shuangxi Chen Minglong Zou M. J. Le Bas R. N. Wilson R. Ranson L. S. Campbell et al. | 1998 | Chinese Science Bulletin1998，43，13： | 2 |
| 12 | Mild hydrothermal preparation of a layered metal hydroxide salt with microtube/rod morphology显示文摘Microtubes/rods of the layered metal hydroxide salt compound Cd 2 (OH) 3 (DS)·nH 2 O, where DS stands for dodecyl sulfate sandwiched between two adjacent inorganic sheets, have been synthesized for the first time through a mild hydrothermal reaction route. The microtubes/rods have a diameter of about 1 m and a length ranging from several microns to 20 m. The growth process of microtubes/rods under the experimental conditions employed follows a dissolution–recrystallization route. | He Zhang Hongbin Li Ying Guo Guodong Li Chi Fan Keji Wang Jiesheng Chen | 2010 | Particuology2010，8，3： | 1 |
| 13 | Oil‐paper insulation partial discharge ultrasonic multifrequency sensing array based on fibre‐optic Fabry-Perot sensor显示文摘In order to improve the sensitivity and accuracy of oil‐paper insulation partial discharge detection by the fibre‐optic Fabry-Perot(FP)ultrasonic sensor,this work studied the ultrasonic signal’s frequency characteristics of typical oil‐paper insulation partial dis-charges and the vibration characteristics of the FP sensor’s diaphragm in the liquid environment.Based on the works above,a multifrequency FP sensor array is proposed,consisting of several FP sensors with different resonant frequencies to detect partial discharges.The experimental results show that the liquid environment has a significant effect on the vibration characteristics of the FP sensor’s diaphragm,and the sensitivity and accuracy of partial discharge detection can be improved based on the multifrequency FP sensing array,which can also be applied in the pattern recognition and localisation of partial discharges. | Zhixian Zhang Jiali Lei Weigen Chen Tianhe Yang Yuxuan Song Kejie Wu Fan Liu | 2022 | High Voltage2022，7，2： | 1 |
| 14 | Optimizing Prescription of Chinese Herbal Medicine for Unstable Angina Based on Partially Observable Markov Decision Process显示文摘 | Yan Feng Yu Qiu Xuezhong Zhou Yixin Wang Hao Xu Baoyan Liu Keji Chen | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 15 | Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats显示文摘 | Junghyun Kim Eunjin Sohn Chan-Sik Kim Yun Mi Lee Kyuhyung Jo Jin Sook Kim Keji Chen | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 16 | Diabetic vascular diseases:molecular mechanisms and therapeutic strategies显示文摘Vascular complications of diabetes pose a severe threat to human health.Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes.Diabetic panvascular disease(DPD)is a clinical syndrome in which vessels of various sizes,including macrovessels and microvessels in the cardiac,cerebral,renal,ophthalmic,and peripheral systems of patients with diabetes,develop atherosclerosis as a common pathology.Pathological manifestations of DPDs usually manifest macrovascular atherosclerosis,as well as microvascular endothelial function impairment,basement membrane thickening,and microthrombosis.Cardiac,cerebral,and peripheral microangiopathy coexist with microangiopathy,while renal and retinal are predominantly microangiopathic.The following associations exist between DPDs:numerous similar molecular mechanisms,and risk-predictive relationships between diseases.Aggressive glycemic control combined with early comprehensive vascular intervention is the key to prevention and treatment.In addition to the widely recommended metformin,glucagon-like peptide-1 agonist,and sodium-glucose cotransporter-2 inhibitors,for the latest molecular mechanisms,aldose reductase inhibitors,peroxisome proliferator-activated receptor-γagonizts,glucokinases agonizts,mitochondrial energy modulators,etc.are under active development.DPDs are proposed for patients to obtain more systematic clinical care requires a comprehensive diabetes care center focusing on panvascular diseases.This would leverage the advantages of a cross-disciplinary approach to achieve better integration of the pathogenesis and therapeutic evidence.Such a strategy would confer more clinical benefits to patients and promote the comprehensive development of DPD as a discipline. | Yiwen Li Yanfei Liu Shiwei Liu Mengqi Gao Wenting Wang Keji Chen Luqi Huang Yue Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 17 | An efficient approach to representing and mining knowledge from Qing court medical records显示文摘在 Qing 法庭上研究医药记录(RQCMR ) 是被第六合作者 Keji,陈和他的同事编辑并且注解的一本大卷的书,并且由帝国家庭的所有医药记录和 Qing 王朝的贵族组成。为了揭示并且利用他们的高度,在繁体中文药研究和现代临床的实践珍视两个,我们开发了转变 Qing 场的一个方法医药记录(QCMR ) 进一个机器可读的、结构化的代表,以便统计分析和数据采矿能精确地被执行。方法由框架本体论组成基于的医药语言,叫了 MedL 代表 QCMR,为编 MedL 框架进一个数据库的一个分析器,和一个探险模式采矿技术。与这个方法,全部 RQCMR 体积被转变成一个数据库,医药模式可以是从数据库的 mined。 | Weimin WANG Jingchun ZHANG Cong CAO Tao HOU Yue LIU Keji CHEN | 2011 | Frontiers of Computer Science2011，5，4： | 1 |
| 18 | Glucose endothelial cytotoxicity and protection by Dan Gua-Fang,a Chinese herb prescription in huVEC in hyperglycemia medium显示文摘 | Heng Xianpei Chen Keji Hong Zhengfeng et a1 | 2009 | J Diabetes Complications2009，23，5： | 1 |
| 19 | Some Aspects to Improve the Financial Accounting Report under Cyber-economy Background显示文摘 | Wenjun Chen Kejie Yue | 2006 | Journal of Modern Accounting and Auditing2006，2，2： | 1 |
| 20 | Inactivated Pseudomonas PE(△Ⅲ)exotoxin fused to neutralizing epitopes of PEDV S proteins produces a specific immune response in mice显示文摘Porcine epidemic diarrhea(PED)caused by the porcine epidemic diarrhea virus(PEDV),is a severe infectious and devastating swine disease that leads to serious economic losses in the swine industry worldwide.An increased number of PED cases caused by variant PEDV have been reported in many countries since 2010.S protein is the main immunogenic protein containing some B-cell epitopes that can induce neutralizing antibodies of PEDV.In this study,the construction,expression and purification of Pseudomonas aeruginosa exotoxin A(PE)without domain Ⅲ(PE△Ⅲ)as a vector was performed for the delivery of PEDV S-A or S-B.PE(△Ⅲ)PEDV S-A and PE(△Ⅲ)PEDV S-B recombinant proteins were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis.The immunogenicity of PEDV S-A and PEDV S-B subunit vaccines were evaluated in mice.The results showed that PEDV-S-B vaccine could not only induce specific humoral and Th1 type-dominant cellular immune responses,but also stimulate PEDV-specific mucosal immune responses in mice.PEDV-S-B subunit vaccine is a novel candidate mucosal vaccine against PEDV infection. | Leqiang Sun Yajie Tang Keji Yan Huanchun Chen Huawei Zhang | 2021 | Animal Diseases2021，1，3： | 1 |
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