|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 2 | Clinical Research on Alzheimer's Disease: Progress and Perspectives显示文摘Alzheimer's disease(AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD.In this review, we summarize the latest achievements,including diagnostic biomarkers, polygenic hazard score,amyloid and tau PET imaging, clinical trials targeting amyloid-beta(Ab), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease. | Bin-Lu Sun Wei-Wei Li Chi Zhu Wang-Sheng Jin Fan Zeng Yu-Hui Liu Xian-Le Bu Jie Zhu Xiu-Qing Yao Yan-Jiang Wang | 2018 | Neuroscience Bulletin2018，34，6： | 29 |
| 3 | Expression of insulin-like growth factor Ⅱ and its receptor in hepatocellular carcinogenesis显示文摘INTRODUCTIONInsulin-like growth factor Ⅱ(IGF-Ⅱ) is a mitogenic peptide of 74 kD and is mostly synthesized in fetal liver tissue .IGF-Ⅱ is believed to play an important role in fetal growth and development and is involved in cellular proliferation and differentiation[1-5]. Recently ,several researchers have reported increased expression of the IGF-Ⅱgene in human hepatocellular carcinoma (HCC) and adjacent non-cancerous liver tissues [6-10]. | Zi Rong Fan Dong Hua Yang Jun Cui Han Rong Qin Chun Chi Huang Department of Gastroenterology, Zhujiang Hospital. The First Military Medical University, Guangzhou 510282.Guangdong Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 24 |
| 4 | Biostratigraphy and geography of the Ordovician-Silurian Lungmachi black shales in South China显示文摘Based on the new material of seven Ordovician-Silurian boundary sections investigated recently, together with previously published data, we analyze the temporal and spatial distributions of the Lungmachi black shales, a key petroleum source bed widely distributed in South China. The Lungmachi black shales range in age from the Normalograptus persculptus Biozone of the uppermost Ordovician to the Spirograptus guerichi Biozone of the lower Telychian, and ten graptolite biozones can be recognized within this unit. The basal and upper contacts of the Lungmachi black shales are diachronous. The basal contact ranges from the N. persculptus to the C. cyphus biozones, a span of five graptolite biozones over two stages. The upper contact ranges from the D. pectinatus-M. argenteus Biozone to the Spirograptus guerichi Biozone, which spans four graptolite biozones over two stages. The Yichang Uplift resulted in the formation of the Hunan-Hubei Submarine High in the border area of Hubei, Hunan, and Chongqing. This is supported by a break in sedimentation in this area spanning all or part of the Hirnantian, and in many areas extending into the underlying Katian and overlying Rhuddanian. Comparison of the distribution of the Katian to Rhuddanian strata in this area indicates a growth and subsequent reduction in area of the Hunan-Hubei Submarine High particularly in the Hirnantian to early Rhuddanian. This may partly represent the influence of the process of formation and melting of ice sheet in Ordovician South Pole and consequent sea level change. | FAN JunXuan Michael J MELCHIN CHEN Xu WANG Yi ZHANG YuanDong CHEN Qing CHI ZhaoLi CHEN Feng | 2011 | Science China Earth Sciences2011，54，12： | 24 |
| 5 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 6 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 7 | Extant primates and development of primatology in China: Publications, student training, and funding显示文摘China supports the richest non-human primate diversity in the northern hemisphere, providing an excellent opportunity for Chinese primatologists to take a leading role in advancing the study of primatology.Primatology in China began to flourish after 1979. To date, Chinese primatologists have published more than 1 000 papers in journals indexed by the Chinese Science Citation Database and the Web of Science Core Collection, and universities and academic institutions have trained 107 PhD students and 370 Masters students between 1984 and 2016. In total,the National Science Foundation of China has funded129 primate projects(RMB 71.7 million) supporting 59 researchers from 28 organizations. However, previous research has also shown obvious species bias.Rhinopithecus roxellana, Rhinopithecus bieti, and Macaca mulatta have received much greater research attention than other species. Researchers have also tended to continue to study the same species(55.2%)they studied during their Ph D training. To promote the development of primatology in China, we suggest(1)the need for a comprehensive primatology textbook written in Chinese,(2) continued training of more Ph D students, and(3) encouragement to study less well-known primate species. | Peng-Fei Fan Chi Ma | 2018 | Zoological Research2018，39，4： | 9 |
| 8 | Characteristics and genesis of microbial lumps in the Maozhuang Stage(Cambrian Series 2),Shandong Province,China显示文摘Microbial lumps have been found in the Maozhuang Stage(Cambrian Series 2) in the Liangcheng section,Shandong Province,China.Their macro-and micro-scale features distinguish them from other carbonate particles such as intraclasts and oncoids.Most lumps have a coarse sand to pebble size.They were mostly rounded during sedimentation or combined to form irregular shapes.A distinct boundary is present between the lumps and the surrounding cement of sparry calcite.The lumps contain either no core at all or several irregular 'cores',without a distinct inner texture.They are composed mainly of calcified(micritized) microbes,most likely cyanobacteria.The microbes drilled holes in carbonate grains,after which lumps formed by micritization,cementation,and agglutination by an extracellular polymeric substance(EPS) in a high-energy shallow-marine,subtidal environment.As the lumps are directly related to microbes,they should be considered as microbialites. | YANG RenChao FAN AiPing HAN ZuoZhen CHI NaiJie HAN Yu | 2013 | Science China Earth Sciences2013，56，3： | 8 |
| 9 | Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives显示文摘Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.Therefore,the Aβ-targeted therapeutic strategy on treating this complex disease needs to be re-evaluated.In this review,we analyzed the challenges and critical points of the current anti-Aβtherapeutic strategies.In addition to Aβ,multiple pathological events such as tau hyperphosphorylation,oxidative stress,and neuroinflammation,which are involved in AD pathogenesis and synergistically drive disease progression,could be important targets for AD treatment.Tertiary prevention strategies are needed for the successful management of AD due to its complex and dynamic pathogenesis.Systemic perspective addressing the disease pathogenesis within and outside the brain,as well as the multidomain intervention targeting risk factors and comorbidities,are important approaches for the therapeutic solutions of AD. | Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang | 2021 | Science China(Life Sciences)2021，64，6： | 8 |
| 10 | Chinese herb microneedle patch for wound healing显示文摘Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement.Attempts in this area tend to develop new forms to make their applications more convenient and wider.Here,we propose a novel Chinese herb microneedle(CHMN)patch by integrating the herbal extracts,Premna microphylla and Centella asiatica,with microstructure of microneedle for wound healing.Such path is composed of sap extracted from the herbal leaves via traditional kneading method and solidified by plant ash derived from the brine induced process of tofu in a well-designed mold.Because the leaves of the Premna microphylla are rich in pectin and various amino acids,the CHMN could be imparted with medicinal efficacy of heat clearing,detoxicating,detumescence and hemostatic.Besides,with the excellent pharmaceutical activity of Asiatic acid extracted from Centella asiatica,the CHMN is potential in promoting relevant growth factor genes expression in fibroblasts and showing excellent performance in anti-oxidant,anti-inflammatory and anti-bacterial activity.Taking advantages of these pure herbal compositions,we have demonstrated that the derived CHMN was with dramatical achievement in anti-bacteria,inhibiting inflammatory,collagen deposition,angiogenesis and tissue reconstruction during the wound closure.These results indicate that the integration of traditional Chinese herbs with progressive technologies will facilitate the development and promotion of traditional Chinese medicine in modern society. | Junjie Chi Lingyu Sun Lijun Cai Lu Fan Changmin Shao Luoran Shang Yuanjin Zhao | 2021 | Bioactive Materials2021，6，10： | 8 |
| 11 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 12 | A Facile Strategy for Non-fluorinated Intrinsic Low-k and Low-loss Dielectric Polymers: Valid Exploitation of Secondary Relaxation Behaviors显示文摘High-performance low-k and low-loss circuit materials are urgently needed in the field of microelectronics due to the upcoming FifthGeneration Mobile Communications Technology(5 G Technology).Herein,a facile design strategy for non-fluorinated intrinsic low-k and low-loss polyimides is reported by fully considering the secondary relaxation behaviors of the polymer chains.A new amorphous non-fluorinated polymer(TmBPPA)with a k value of 2.23 and a loss tangent lower than 3.94×10^-3 at 104 Hz has been designed and synthesized,which to the best of our knowledge is the lowest value amongst the non-fluorinated and non-porous polymers reported in literature.Meanwhile,TmBPPA exhibits excellent overall properties,such as excellent thermostability,good mechanical properties,low moisture absorption,and high bonding strength.As high-performance flexible circuit materials,all these characteristics are highly expected to meet the present and future demands for high density,high speed,and high frequency electronic circuit used in 5 G wireless networks. | Chao Qian Zhen-Guo Fan Wei-Wen Zheng Run-Xin Bei Tian-Wen Zhu Si-Wei Liu Zhen-Guo Chi Matthew P.Aldred Xu-Dong Chen Yi Zhang Jia-Rui Xu | 2020 | Chinese Journal of Polymer Science2020，38，3： | 7 |
| 13 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 14 | IL-6 and INF-γ levels in patients with brucellosis in severe epidemic region,Xinjiang,China显示文摘Background:The incidence of brucellosis,which is caused by the Brucella species of bacteria,is rapidly rising worldwide;however,few studies have investigated the immune response to this pathogen and clinical biochemical features.In this paper,we examined the levels of various cytokines and inflammatory factors as well as clinical course characteristics in patients with brucellosis,in order to provide evidence for the diagnosis,assessment,and prognosis of this infectious disease.Methods:A total of 191 brucellosis inpatients(50 acute cases and 141 chronic cases),as well as 60 healthy control subjects,were included in the analysis.We investigated changes in the levels of six cytokines(IL-4,IL-6,IL-10,IL-17,TNF-α,INF-γ)and related clinical biochemical markers in patients with acute and chronic brucellosis in Xinjiang,China.Possible factors were statistically analyzed using the t test,χ2 test,z test and a multivariate logistic stepwise regression test.Results:We found that IL-4,IL-6,IL-10,IL-17,IFN-γ,and TNF-αlevels were higher in those with brucellosis than in controls(P<0.05).With regard to disease progression,procalcitonin(PCT)and C-reactive protein(CRP)levels were significantly higher in those with an acute infection compared to chronic cases(P<0.05).We found that the expression of all six cytokines tested was closely related to the degree of brucellosis using univariate logistic regression;however,only IL-6 and INF-γlevels were independent factors associated with the severity of brucellosis.Conclusions:Assessing cytokine levels in patients with acute and chronic brucellosis is not only useful for detecting the immune response,but can also be indicative of the severity of brucellosis.In particular,we propose IL-6 and INF-γlevels may be useful independent predictive factors in the clinical evaluation and diagnosis of brucellosis. | Zhi-Qiang Lin Guo-Yue Lin Wen-Wen He Chi Zhang Rui Zhang Yuan-Da Li Fan Wang Ying Qin Li Duan Dou-Dou Zhao Xiao-Juan Qu Hui Gao Hai Jiang | 2020 | Infectious Diseases of Poverty2020，9，3： | 7 |
| 15 | Recent advances in emerging techniques for non-destructive detection of seed viability: A review显示文摘Over the past decades,imaging and spectroscopy techniques have been developed rapidly with widespread applications in non-destructive agro-food quality determination.Seeds are one of themost fundamental elements of agriculture and forestry.Seed viability is of great significance in seed quality characteristics reflecting potential seed germination,and there is a great need for a quick and effective method to determine the germination condition and viability of seeds prior to cultivate,sale and plant.Some researches based on spectra and/or image processing and analysis have been explored in terms of the external and internal quality of a variety of seeds.Many attempts have been made in image segmentation and spectra correction methods to predict seed quality using various traditional and novel methods.This review focuses on the comparative introduction,development and applications of emerging techniques in the analysis of seed viability,in particular,near infrared spectroscopy,hyperspectral and multispectral imaging,Raman spectroscopy,infrared thermography,and soft X-ray imaging methods.The basic theories,principle components,relative chemometric processing,analytical methods and prediction accuracies are reported and compared.Additionally,on the foundation of the observed applications,the technical challenges and future outlook for these emerging techniques are also discussed. | Yu Xia Yunfei Xu Jiangbo Li Chi Zhang Shuxiang Fan | 2019 | Artificial Intelligence in Agriculture2019，，1： | 7 |
| 16 | Occurrence and formation potential of nitrosamines in river water and ground water along the Songhua River, China显示文摘The presence of mutagenic and carcinogenic nitrosamines in water is of great concern. In this study, seven nitrosamines including N-nitrosodimethylamine(NDMA), N-nitrosodiethylamine(NDEA), N-nitrosomethylethylamine(NMEA), N-nitrosopyrrolidine(NPyr), N-nitrosopiperidine(NPip), N-nitrosodi-n-propylamine(NDPA), and N-nitrosodi-n-butyl-amine(NDBA) were investigated in river water and ground water samples collected from 5 representative cities(Jilin, Songyuan, Harbin, Jiamusi and Tongjiang) along the Songhua River. The total concentrations of nitrosamines in ground water were n.d.(not detected) to 60.8 ng/L, NDMA was the most frequently detected nitrosamines in ground water, followed by NDEA and NPip.Relatively high detected frequency and concentrations of NDMA were also observed in river water samples, and the total nitrosamines' concentration at midstream is always higher than that at upstream and downstream. After 24 hr chlorination, concentration of NDMA, NDBA was obviously increased but NDEA was reduced. Furthermore, UV_(254) showed a better relationship with NDMA-FP rather than dissolved organic carbon(DOC), NH_4-N, and TDN. | Xianze Wang Zhongmou Liu Chi Wang Zhian Ying Wei Fan Wu Yang | 2016 | Journal of Environmental Sciences2016，28，12： | 7 |
| 17 | Bathymetric Prediction from Multi-source Satellite Altimetry Gravity Data显示文摘According to the 'theoretical admittance ' and the 'observation admittance' of the actual data,the theoretical value of effective elastic thickness in the study area was 10 km.Combining the gravity anomalies and vertical gravity gradient anomalies,the admittance function is used to construct the 1′×1′ bathymetry model over the Philippine Sea by using the adaptive weighting technique.It is found that the accuracy of the bathymetry model constructed is the highest when the ratio of inversion result of vertical gravity gradient anomalies and inversion result of gravity anomalies is 2∶3.At the same time,using multi-source gravity data to predict bathymetry could synthesize the superiority of gravity anomalies and vertical gravity gradient anomalies on the different seafloor topography,and the accuracy is better than bathymetry model that only used gravity anomalies or vertical gravity gradient anomalies.Taking the ship test data as the checking condition,the accuracy of predicting model is slightly lower than that of V18.1 model and improved by 27.17% and 39.02% respectively compared with the ETOPO1 model and the DTU10 model.Check points which the absolute value of the relative error of the predicting model is in the range of 5% accounted for 94.25% of the total. | Diao FAN Shanshan LI Shuyu MENG Chi ZHANG Jinkai FENG Yan HUANG Jiawei DU Zhibin XING | 2019 | Journal of Geodesy and Geoinformation Science2019，2，1： | 6 |
| 18 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 19 | Acute and Chronic Changes and Predictive Value of Tpeak-Tend lor Ventricular Arrhythmia Risk in Cardiac Resynchronization Therapy Patients显示文摘 | Cong Xue Wei Hua Chi Cai Li-Gang Ding Zhi-Min Liu Xiao-Han Fan Yun-Zi Zhao Shu Zhang | 2016 | Chinese Medical Journal2016，，18： | 6 |
| 20 | Molecular phylogeny and divergence time of Trachypithecus: with implications for the taxonomy of T. phayrei显示文摘 | Kai HE Naiqing HU Joseph D.ORKIN Daw Thida NYEIN Chi MA Wen XIAO Pengfei FAN Xuelong JIANG | 2012 | Zoological Research2012，33，6： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员